What can replace a drug like Lomefloxacin? Analogs of this medicine, its purpose, prohibitions and therapeutic properties will be discussed below. You will also learn how to properly use this tool, and in what dosage.
The form of the medication, its packaging and its constituent components
What packaging is the product in question? Where is its instructions for use? Lomefloxacin is a tablet placed in blisters and packaged in paper bundles along with an annotation.
What ingredients does this drug include? The active substance of this medication is lomefloxacin hydrochloride. Also, its composition includes other auxiliary components.
Therapeutic properties of the drug
What are Lomefloxacin tablets? The instruction claims that this is a bactericidal antimicrobial drug, which belongs to the group of antibiotic-like drugs, that is, fluoroquinolones, and represents the second generation of these drugs.
What determines the antimicrobial effectiveness of the medication in question? Such properties of the Lomefloxacin tablet (400 mg) were obtained due to the fact that their active substance is able to develop a blocking effect on DNA gyrase (that is, a bacterial enzyme) that provides supercoiling. In addition, this tool creates a stable compound (complex) with its tetramer, and also destroys the transcription and replication of DNA of bacterial cells, which causes their subsequent death.
The expressed activity of this medication is manifested in relation to such gram-negative aerobic bacteria as gonococci, salmonella, Pseudomonas aeruginosa, hemophilus and Escherichia coli, the causative agent of cholera, meningococci, shigella, morganella and so on. Also, the drug Lomefloxacin (400 mg) has a depressing effect on protea, chlamydia, campylobacter, mycoplasma, legionella, some pneumococci and staphylococci.
We can not say that the mentioned drug is highly effective against mycobacterium tuberculosis. He is able to reduce the time for their elimination, as well as the speedy resorption of existing infiltrates.
The therapeutic effect of "Lomefloxacin" is observed even at its low concentrations in the blood. Moreover , resistance is very rare.
Kinetic ability of medicinal tablets
How is the medication mentioned absorbed? What does the instructions for use say about this? "Lomefloxacin" has a good absorption capacity. After taking the medicine, its peak plasma concentration is reached within 55-85 minutes.
With plasma proteins, this medication binds only 10%. He also has good absorption properties in various organs and tissues (including genitals, joints, respiratory tract, ENT organs, pelvic organs, bones, peritoneum, soft tissues, etc.), where its content is 5-7 times higher plasma.
It should be specially noted that some of lomefloxacin is metabolized and forms several derivatives.
The withdrawal period of this medicine is 9 hours. It is excreted through tubular secretion together with urine (70-85%) and feces (25-30%).
Indications for the appointment of funds
Few people know, but in pharmacy chains you can find not only Lomefloxacin tablets, but also Lomefloxacin + Pyrazinamide + Protionamide + Ethambutol + Pyridoxine. In this case, both of the mentioned medications are indicated for use in:
- infections (purulent) of the skin, as well as soft tissues (including burns, infected wounds, etc.);
- osteomyelitis;
- chlamydia and gonorrhea (including blepharoconjunctivitis and chlamydial conjunctivitis);
- gastrointestinal tract infections (for example, with cholera, dysentery, typhoid fever, salmonellosis);
- respiratory infections (including relapses of chronic bronchitis);
- biliary tract infections;
- infections in the genitourinary sphere (for example, with urethritis, prostatitis, cystitis, pyelonephritis);
- pulmonary tuberculosis (including in the complex treatment of people with rapidly progressive forms of this disease, as well as with increased resistance to Isoniazid and Rifampicin and with resistance to chemotherapy);
- before and after transurethral surgery (for prophylactic purposes only).
Antimicrobial Prohibitions
In which cases can not use the medicine in question? What does the instructions for use report about this? "Lomefloxacin" is contraindicated for use with:
- bearing the fetus;
- breastfeeding;
- personal sensitivity of drugs belonging to the fluoroquinolone group;
- at a minor age (inhibition of skeletal development is possible).
Instructions for use
"Lomefloxacin" - tablets that are indicated only for oral administration. They should be taken once a day, regardless of the meal, with about 230 ml of ordinary water.
The duration of treatment with this medicine depends on the diagnosis, as well as on the severity of the pathology and the sensitivity of the pathogen.
Uncomplicated acute bronchitis and acute bronchopneumonia are treated with a dosage of 400 mg of the drug for ten days.
In the treatment of chlamydia (urogenital), including bacterial-chlamydial and gonorrhea-chlamydial infections, patients are prescribed 400-600 mg of the drug per day, with a duration of up to 28 days.
Relapse of complicated pneumonia and chronic bronchitis is treated in a daily dosage of 400-800 mg of the drug for two weeks.
With mycoplasmal infection , the medication in question is prescribed 400-800 mg per day, with the duration of taking the tablets in 3 weeks.
Infectious diseases of the urinary tract respond to therapy with 400 mg of the drug. In this case, treatment of uncomplicated cases is carried out within 5 days, and complicated - 14 days.
In acute gonorrhea, the drug "Lomefloxacin" is recommended to be taken in a dosage of 600 mg. As for the chronic form of this disease, its treatment is carried out in parallel with specific immunotherapy. In this case, the medication is taken in a similar daily dose for 5 days.
Therapy for pulmonary tuberculosis can take 14-30 days (in some cases up to 3 months). Such a disease is treated with a dosage of 200 mg of the drug twice a day.
With renal pathologies of severe or severe nature, as well as people undergoing hemodialysis, Lomefloxacin is prescribed in an amount of 400 mg per day, with its further decrease to 200 mg.
Negative phenomena
What negative effects can Lomefloxacin tablets cause? The instruction indicates the following reactions:
- bronchospasm, increased secretion of sputum, nausea, cough, dysphagia;
- dyspnea, vomiting, respiratory infections, diarrhea, dysbiosis;
- flu-like symptoms, taste perversion, epigastric pain, flatulence;
- increased levels of liver enzymes, dry mouth, gastrointestinal bleeding;
- constipation, arthralgia, calf cramps, discoloration of the tongue, myalgia;
- pseudomembranous colitis, headaches, changes in appetite, vasculitis, dizziness;
- insomnia, chest and back pain, asthenia, nervousness, a feeling of general malaise, depression, tremor;
- hyperkinesis, fatigue, convulsions, hallucinations;
- eye pain, noise and pain in the ears;
- dysuria, increased agitation, hematuria, paresthesia;
- crystalluria, visual impairment;
- albuminuria, glomerulonephritis, leukorrhea, edema, polyuria, epididymitis, difficulty urinating, orchitis, painful urges;
- cyanosis, anuria, hypotension, vaginitis, tachycardia, extrasystole, perineal pain, bradycardia;
- intermenstrual bleeding, thrombocytopenia, vaginal candidiasis, myocardial infarction, myocardiopathy, phlebitis;
- progression of heart failure and angina pectoris, purpura, cerebrovascular disorders, itching of the skin;
- pulmonary embolism, photosensitivity, increased fibrinolysis, urticaria, lymphadenopathy, hyperhidrosis;
- nosebleeds, exudative erythema (malignant), feeling of chills, gout, hot flashes;
- superinfection, hypoglycemia, candidiasis, thirst.
Overdose of pills
In case of an overdose of Lomefloxacin tablets, patients experience nausea, erosive lesions of the gastrointestinal mucosa, lengthening of the QT period, dizziness, convulsions, confusion, and an increase in adverse reactions.
Due to the fact that hemodialysis in case of an overdose with the considered drug is ineffective, the therapy of the above conditions is carried out based on the existing symptoms.
Interaction with other medicines
With the combination of "Lomefloxacin" with "Theophylline" its metabolism is almost not inhibited.
With the simultaneous administration of antacids or sucralfate, chelate complexes are formed that reduce the bioavailability of lomefloxacin. That is why the interval between taking these medications should be at least 4 hours.
The combined use of "Lomefloxacin" and high doses of caffeine lengthens the half-life of the latter.
When treating tuberculosis, you should not take a parallel administration of the drug in question with Rifampicin, otherwise it will lead to an antagonism of action.
Concomitant use of NSAIDs increases the toxicity of drugs and can cause seizures.
"Lomefloxacin" is able to increase the effectiveness of anticoagulants for oral administration.
Medicines, which are tubular secretion blockers, inhibit the elimination of "Lomefloxacin".
Special recommendations
In renal pathologies, a mandatory dose adjustment is required, which depends on the QC indicators.
At all times of therapy, it is necessary to refrain from the prolonged influence of any sources of ultraviolet radiation, including sunlight.
Vitamin preparations, including various mineral supplements, should be taken 120 minutes after or before taking the tablets in question.
Similar drugs
The medicine "Lomefloxacin" has many analogues. The main substitute drugs include the following: Abactal, Eleflox, Zanocin, Cifran, Avelox, Ciprolet, Zoflox, Ciprinol, Quintor, Ciprofloxacin, Levofloxacin ”,“ Tarivid ”,“ Levotek ”,“ Pefloxacin ”,“ Levoflox ”,“ Ofloxacin ”,“ Norbactin ”,“ Oflox ”,“ Norfloxacin ”.
Lomefloxacin tablets: reviews
With reliable identification of the causative agent of the infection, which is sensitive to the second generation of fluoroquinolones, as well as with the correct selection of medicinal doses and long-term treatment, the reviews on the drug in question are purely positive.
According to patients, this medication has established itself as an effective antimicrobial drug that adequately copes with various pathological microorganisms. However, some users claim that sometimes this drug causes the development of certain side effects, but, as a rule, they are mild or go away on their own immediately after the end of therapy.