Endometriosis is an ailment with an unexplained reliable reason for its appearance. This disease is thoroughly studied, but many questions remain unanswered.
"Nestmestran" is a drug from the group of progestogens that suppresses the production of gonadotropin hormone.
Release form
The drug is available in the form of gelatin opaque milk capsules. Inside the tablet is a yellowish powder ground to small particles. The active substance of "Nemestran" is gestrinone.
Additional trace elements are the following substances:
- starch;
- a salt of magnesium and stearic acid;
- lactose;
- cellulose;
- silicon dioxide;
- talc.
The shell includes:
- gelatin;
- titanium dioxide.
Tablets are packaged in blisters of eight pieces, the kit includes a “calendar disk”.
The drug is strictly prescription in nature. It is necessary to store Nemestran away from sunlight, the shelf life of the medication is three years, after this period it is not recommended to use tablets.
The properties
According to the instructions for use of "Nemestran", the drug refers to synthetic agents, and is also a steroid hormone derived from progestin. The medicine has a weakening effect, has a slight androgenic effect.
An active trace element has a retaining effect on the tissue of the internal mucous membrane of the uterus. Under the influence of the drug, the release of gonadotropins is suppressed. The maximum content of the main component is achieved after about one hundred and twenty minutes.
The elimination half-life occurs within twenty-seven hours. Metabolism is realized in the main structural cell of the liver parenchyma due to hydroxylation. It is excreted in the urine by forty-five percent and thirty-five percent with a chair.
Indications
According to the instructions, the Nemestran drug can be used only for endometriosis (appearance of cells of the inner layer of the uterus on the peritoneum, in the ovaries, fallopian tubes).
Contraindications
According to the instructions for use, "Nemestran" can not be taken in the presence of the following deviations and conditions:
- with an "interesting situation";
- with thrombophlebitis (a disease characterized by an inflammatory process in the vein wall with a blood clot in its lumen);
- liver disease
- with breastfeeding;
- heart disease
- renal failure.
From the reviews of "Non-Country" it is known that it is used for diagnosed migraines.
How to take the drug?
According to the instructions for use with Nemestran, treatment of endometriosis with a medication is carried out as follows:
- Usually, the initial dosage of the drug is taken in an amount of two and a half milligrams on the first day of menstruation. The second dosage should be used on the fourth day.
- The standard treatment regimen is twice a week, always on the same day. At the discretion of the doctor, the number of tablets can be increased to three in seven days, especially if there is uterine bleeding during menstrual time.
The duration of the course can be six months. If a tablet was missed, it must be taken immediately the next day, in the future you need to adhere to the standard weekly treatment regimen.
If you miss more than two doses, then the therapy must be stopped and resumed on the first day of the next menstruation.
Overdose
In case of an overdose of Nemestran, you need to rinse your stomach as soon as possible. After this, you must consult a doctor.
Side effects
When taking the medicine, a number of negative reactions may occur:
- Uterine bleeding.
- Acne (an inflammatory skin disease caused by changes in pilosebased structures).
- Hirsutism (a condition manifested by excessive hair growth of androgen-dependent).
- Migraine.
- Baldness.
- Voice change.
In addition, taking the drug can cause other adverse reactions:
- The change in libido.
- Weight gain.
- Nervous excitability.
- Depressive state.
- Dyspeptic symptoms.
- Hyperpigmentation of the skin (focal or diffuse accumulation of pigment in the layers of the skin, leading to darkening of its color on the body).
- Arthralgia (joint pains that are volatile in the absence of objective symptoms of joint damage).
If any adverse reactions occur, you should consult your doctor.
Features
According to the instructions for use of "Nemestran", the use of the drug in a standard dosage can inhibit the release of a mature egg from the ovary, but the possibility of becoming pregnant with a representative of the fair half persists during therapeutic manipulations.
From this we can conclude that the drug does not belong to the group of contraceptives. Therefore, it is necessary to use protective methods during therapy. It is necessary to begin treatment strictly from the first day of the onset of menstruation.
Because the drug can cause fluid retention, the drug "Nemestran" should be used with caution in heart disorders and under the supervision of a doctor.
It is important for the patient to periodically monitor the liver strains, to monitor blood sugar, especially in people with diabetes.
Where in Penza do you sell Nemestran tablets? To find this medication is extremely problematic, you can replace it with a similar remedy with the permission of the attending physician.
Nestran: analogues
The drug has a number of substitute drugs:
- Gestrinon.
- Femicaps Easy Life.
- "Byzanne."
- "Lutein."
- "Epigallate."
- Miomin.
- "Epigaline."
- "Vizan".
- Quinol.
- "Stella".
- Zoladex.
Gestrinon
It is used to treat genital and extragenital endometriosis. Available in the form of tablets for oral administration. The drug is contraindicated in the presence of the following conditions:
- Porphyria (damage to pigment metabolism with a high content of porphyrins in the blood and tissues).
- Severe renal and hepatic failure.
- Androgen-dependent neoplasms.
- Individual intolerance to the components.
How to take Gestrinon? The tablets are used orally, with meals, two and a half milligrams on the first and fourth days of menstruation, then in the same dosage twice a week for six months. The maximum daily dosage leaves two and a half milligrams.
Vizanne
The drug is made in the form of tablets for oral administration. The medicine refers to progestogen antiandrogenic drugs. "Vizanna" is used to eliminate endometriosis in gynecology.
The drug in its composition contains the following active substance - dienogest. The tablets are placed in a blister pack in a total of twenty-eight capsules.
After the use of the drug "Vizanna", the active trace element is absorbed into the blood without residue, where it reaches its maximum content within an hour and a half after application. The active substance is evenly distributed throughout all body tissues, it is metabolized in the liver, and decay products are excreted from the body by kidneys with urine. The elimination half-life is on average from nine to ten hours. The cost of the drug varies from 3,000 to 9,000 rubles.