In this article, we will consider instructions, analogues and reviews about Grandaxin. People in the modern world have become most exposed to a variety of stressful situations that adversely affect both mental and physical health. This is compounded by the fact that many people are not able to independently cope with states of anxiety, depression and other psychological manifestations. Therefore, in this case, without medications that will help in the fight against these problems, you can not do. One such drug is Grandaxin. Reviews about him are abundant.
This drug is widely used in modern medical practice. "Grandaxin" is a medicine that belongs to the group of so-called tranquilizers - drugs whose action is aimed at suppressing the state of fear and anxiety. Despite the fact that this drug is dispensed in the pharmacy network without a prescription from a doctor, you should not decide on treatment with this medication yourself.
Reviews of people about Grandaxin and well-being after it will be presented at the end of the article.
The action of the substances that make up its composition seriously changes the functioning of the nervous system, which can lead to the most unexpected and adverse consequences. To exclude the risk of developing concomitant disorders and diseases, it is necessary to obtain the recommendations of the attending physician before using it. The strong psychotropic effect of the drug "Grandaxinum" (according to reviews) can improve the well-being of a person, however, uncontrolled intake and improper dosage can, on the contrary, worsen it.
pharmachologic effect
"Grandaxinum" is a "daytime" anxiolytic with rapid action. The active substance of this medication is a diazepine derivative. It is a powder in the form of yellowish-white crystals that do not dissolve in water, and partially in ethanol.
The drug does not cause symptoms of addiction and can be prescribed to people suffering from various kinds of neuroses, autonomic disorders, mental disorders, anxiety conditions.
This is indicated by instructions for use with "Grandaxinum". Price, reviews, analogues are of interest to many.
The composition of the drug and the form of release
A tranquilizer of this category is available in the form of tablets having a rounded shape, slightly flattened, without signs of color and smell. On one side of the tablet is the name of the drug, on the other - risk.
The main active ingredient of the drug “Grandaxin” is tofisopam, which is contained in one tablet in a volume of 50 mg. Additional substances that make up the medication are:
- octadecanoic acid;
- talc;
- gelatin;
- magnesium salts of octadecanoic acid;
- lactose monohydrate;
- MCC;
- potato starch.
This describes the instruction. Reviews about Grandaxin are mostly positive.
The drug is packaged in cardboard boxes containing blisters with tablets, ten in each. In one box - two or six blisters. The pharmacological orientation is a tranquilizer from the benzodiazepine series, and its main effect is to provide anxiolytic (sedative) action. According to doctors, “Grandaxin” differs from other drugs of a similar nature in that it does not create a sedative, as well as hypnotic, anticonvulsant and muscle relaxant effect. The drug regulates the work of the autonomic system, eliminating all possible manifestations of this disorder. It has a slight stimulating effect. Similar pharmacological characteristics indicate that this medicine is related to “daytime” sedatives.
The drug is not contraindicated for people suffering from myosthenia, as well as myopathy, which is due to the lack of muscle-relaxing effect. The chemical formula of the main active ingredient of the drug is atypical, which significantly distinguishes it from other drugs used to achieve the anxiolytic effect, which gives it a number of undeniable advantages. These include:
- The drug does not enhance the effect of ethanol on the body.
- It does not cause symptoms of addiction and drug withdrawal. This is confirmed by the instructions for use and reviews of doctors about "Grandaxinum".
The mechanism of action of the main active substance
This action is associated with the stimulation of benzodiazepine receptors located in the human brain. Excitation of this kind provokes the sensitivity of GABA receptors to neurotransmitters. After this, more active work of the chlorine channels begins, hyperpolarization of cell membranes is stimulated, and at the same time, neural activity is weakened.
The drug "Grandaxinum" is taken orally, and within a short period of time it is completely absorbed from the small intestine. The highest concentration of active substances in the blood is observed approximately 1.5–2 hours after taking the drug, and then its gradual decrease occurs. These substances do not accumulate in body tissues. Six to eight hours is their elimination half-life, which is carried out mainly by the kidneys, as well as by the organs of the gastrointestinal tract. Reviews on the use of "Grandaxin" consider below.
Drug benefits
The medication is a universal CNS-active drug that has undergone many laboratory and clinical trials. It does not have a sedative and muscle relaxant effect, does not weaken the psychomotor, as well as mental function, which is fundamentally different from other benzodiazepine drugs. According to patients, “Grandaxin” is well tolerated, has a mild cognitive-stimulating effect, and reduces the risk of developing autonomic problems, which, as a rule, accompany most types of nervous conditions. Tofizopam does not give anticonvulsant effects and even in an increased dose does not have a sedative effect. This is confirmed by the instructions for use and reviews.
The price of Grandaxin's analogues will also be presented.
Drug research
Numerous studies have shown that a dosage of 200 mg applied to animals stimulates an antipsychotic effect. With the introduction of a dose of 10 mg per kilogram of weight, normalization of animal behavior and the prevention of stress dysrhythmia are noted.
The effectiveness of this drug in medicine was revealed in a variety of multicenter studies, in which more than 10 Russian clinics took part. At the same time, monitoring was carried out for 250 patients aged 18-60 years, who were diagnosed with psycho-vegetative symptoms. All patients were divided into two groups, one of which took "Grandaxinum", and the second - other drugs that reduce the manifestations of this disease.
In a group of people using Grandaxin, according to reviews, the symptoms of the disease disappeared much faster than in the rest.
Efficiency and safety
The use of the drug “Grandaxin” is of great interest in the fight against vegetative-vascular and mental disorders. This is due to the fact that taking classical sedative medications can be complicated by a number of negative effects. They, as a rule, greatly violate the concentration of attention, impair memorability, etc.
There is also evidence confirming the effectiveness of the drug during menopause. The quality of life of women who have entered the menopause is significantly improved.
There are numerous reviews about this.
Instructions for use of the Grandaxin analogue will not be considered in detail.
Therapeutic effect
The action of the main substances of the drug is manifested as follows:
- The elimination of feelings of anxiety.
- Normalization of sleep patterns.
- Increased attention span, improved memory.
- Reducing and eliminating the symptoms of vegetative-vascular disorders.
- Elimination of manifestations of depression, nervous disorders.
These effects are achieved due to the fact that a person has a general improvement in the psychoemotional state, which is not associated with hypnotic or sedative effects.
The treatment of patients with the drug “Grandaxin” in combination with vascular and metabolic drugs helps to increase the indicator of emotional status. In addition, this medicine is able to stop the manifestations of neurosis and neurotic conditions, and can also be used in the presence of severe vegetative-vascular dystonia.
What else does the instruction to Grandaksin tell us? According to reviews, it is very detailed.
Indications for use
The main indications for drug treatment are the following diseases and disorders:
- Apathy, anxiety.
- Vegetative dysfunctions.
- Psychoneurosis.
- Neurosis and emotional overstrain.
- Stress mental disorders.
- Cardialgia
- Obsessive mental states.
- Disorders of psycho-emotional adaptation (in cases where a person has suffered severe physical or emotional trauma).
- Menopausal neurosis (with complex treatment or separately).
- Heart pain (also in complex therapy).
- Withdrawal syndrome (with the abandonment of bad habits - smoking, drug use, alcohol).
- Premenstrual syndrome.
- Myasthenia gravis
- Myopathy
- An atrophic process in muscle tissue that is neurogenic.
This is exactly what the instruction points to Grandaksin. According to reviews, the price is somewhat overpriced.
The drug is widely used in narcology, as it helps to relieve symptoms of withdrawal symptoms, as well as stop delirious conditions when patients have excessive mental arousal and autonomic complications. The drug relieves opioid withdrawal symptoms when a post-withdrawal condition occurs.
Contraindications
The main contraindications for treatment with this medication are the following:
- Decompensated respiratory failure.
- Psychomotor agitation, which are accompanied by aggressive conditions.
- Deep depression.
- Stop breathing in a dream (apnea).
- Early pregnancy.
- Treatment with medicines Cyclosporin, Tacrolimus, Sirolimus.
- The period of breastfeeding.
- Hypersensitivity to substances of the benzodiazepine group.
The drug "Grandaxinum" should be used with caution in the following cases:
- Chronic respiratory distress syndrome.
- Cases of acute respiratory failure.
- Angle-closure glaucoma.
- Epileptic disorders.
- Damage to the brain of organic origin.
The method of use of the drug "Grandaxin" and doses
The dosage of this drug is set by a specialist depending on the degree of disorders diagnosed in each case. It also takes into account the individual characteristics of the patient's body, susceptibility to the action of active substances, as well as the clinical manifestations of the disease. There is information about this in the instructions for use and reviews. The price of Grandaxin is listed below.
For use by adults, the drug is prescribed 50-100 mg of the substance three times a day. When performing episodic doses of the drug, as a rule, 1-2 tablets are taken. The maximum dose allowed by doctors for self-treatment is 300 mg per day. For people suffering from kidney failure, the maximum dose is not more than 150 mg per day.
The duration of treatment with the drug "Grandaxin" is determined by a specialist. As a rule, in order to correct mental and autonomic disorders during menopause, the duration of the drug is about three months. Symptoms of anxiety and depressive disorder begin to disappear on the 5-6th day of treatment, patients notice the disappearance of symptoms of mood lability and the disappearance of panic attacks.
The use of the drug in childhood (up to 14 years) is contraindicated.
Adverse Reactions and Overdose Symptoms
According to reviews of Grandaxin, signs of an overdose of a drug are:
- epileptic seizure;
- impaired consciousness;
- vomiting, nausea, impaired stool;
- coma;
- depression of respiratory functions.
The treatment of these conditions is to restore the patient's respiratory activity, normalize the work of the cardiovascular system. This is confirmed by the instructions and reviews to Grandaksin (the price of analogues can vary significantly).
From the side of the central nervous system, the following changes can be observed:
- cephalgia;
- irritability;
- sleep disturbance;
- increased muscle tone;
- blurred consciousness;
- convulsions (more often in people with epilepsy).
Side effects observed from the digestive tract:
- decreased appetite;
- bloating;
- nausea and dry mouth;
- yellowish skin and pallor.
With allergic reactions to the components of the drug, redness of the skin and itching can be observed. It also describes the instructions for use. Reviews about Grandaxin also confirm this.
special instructions
Side effects from taking the drug are more likely to occur in cases of liver or kidney failure, as well as in the elderly. In order to avoid serious negative consequences, in these cases, the dose of the drug is reduced, as a rule, by half. In the presence of chronic psychoses, a variety of obsessive states, as well as phobias, the drug is not recommended, since this can provoke the occurrence of suicidal thoughts and a high degree of aggression.
With deep depression, the drug "Grandaxin" is also not prescribed, due to the occurrence of anxiety conditions. With extreme caution, this drug should be prescribed to patients who have fixed organic damage to the brain. In epileptics undergoing treatment with the drug "Grandaxin", according to reviews, there is an increased convulsive readiness. The drug contains lactose, so people with hypersensitivity to it, the medication is prescribed with extreme caution.
As for the recommendations for driving cars, this medication does not affect the concentration of attention in people who use it. Therefore, driving a vehicle is not contraindicated.
The active ingredients of the drug are not able to enhance the effect of alcohol on the body, on the contrary, they have the ability to reduce the toxic effect of ethanol on the internal organs, as well as on the central nervous system.
Interaction with other drugs
The use of the drug “Grandaxin” in conjunction with drugs that inhibit the functions of the central nervous system, potentiates their effect. Such drugs include anesthetics, antihistamines, as well as drugs that have a sedative and hypnotic effect, analgesics. People’s reviews of Grandaxin and their well-being are often contradictory.
The metabolism of the active components of the drug is enhanced by pathogens of liver enzymes, which can lead to a decrease in the concentration of the drug in the blood.
Antimycotic drugs slow down the metabolic processes in the liver, which occurs while taking the drug "Grandaxinum", which means that its concentration in the body rises. Drugs that carry out a hypotensive effect also enhance its effect.
A certain interaction also arises in cases of the simultaneous administration of the Grandaxin medication with Warfarin, Disulfiram, Digoxin, antacids and oral contraceptives.
Reviews about "Grandaxin"
In the entire history of its existence, the drug has gained great fame. There are quite a lot of reviews of patients using this drug. Most of them are women, since they are the most susceptible to the occurrence of disorders such as vegetative-vascular dystonia, mental disorders and high anxiety states. In addition, women use the drug during menopause, which also affects this aspect.
The positive reviews of Grandaxin users contain a large amount of information that the drug helps to cope with the symptoms of a bad mood, improves muscle motility, improves performance and normalizes sleep patterns. Many patients noted significant changes in their psychoemotional state, when anxiety began to visit them less and less, and on the third or fifth day of using this medication completely disappeared. In addition, they were satisfied that the medicine rarely causes unwanted side effects, which plays a huge role in organizing everyday life.
Negative reviews reflect the opinions of patients for whom the drug “Grandaxin” did not help cure diseases of the psychoemotional sphere. This category of people claims that while taking this medicine, nervous excitability increases, which provokes a feeling of fear and psychological discomfort. Some of the patients who left a negative review are unhappy with the occurrence of side effects in the form of dizziness and nausea.
Reviews of specialists
. , . . , "", , .
Analogs
, «», «». , . .
, «» «» .
It is a powerful sedative that can be prescribed as a sedative before surgery and other important events that can cause anxiety and emotional stress.
The price of the Grandaksin analogue, according to reviews, is quite reasonable.
The drug "Adaptol" is a psychotropic medication that can replace Grandaxin. However, it is sold strictly according to the prescription, and this medication can cause severe adverse reactions in the field of sleep and increase nervousness.
Atarax is also an analogue of the drug, which, in addition to its sedative effect, also has an antihistamine and bronchostimulating effect, which is extremely important for those who suffer from respiratory failure.
Afobazolum (370-440 rubles) is an inexpensive Russian anxiolytic, the use of which is relevant for anxiety conditions, sleep problems, adaptation, neurasthenia, premenstrual and menopausal syndrome, alcohol withdrawal syndrome, as well as for some somatic diseases. Taking the drug does not cause drug dependence, the body easily tolerates the sudden withdrawal of the drug. The medicine is sold in tablets.
Novo-Passit. Phytopreparation in tablets or as a solution for oral administration. It is indicated for neurasthenia, insomnia, manager’s syndrome, nervous tension, accompanied by headache and migraine, with menopause, premenstrual syndrome. Country of origin - Czech Republic, Israel. The average price is 210-870 rubles. Choosing what to replace "Grandaxin", you should carefully read the instructions for use, since even similar in composition drugs can have different effects on various body systems.
Apaurin. Tranquilizer with anticonvulsant, sedative effect. Indications for therapy include neurosis, a feeling of tension, anxiety, fear, motor tension, and sleep disturbances. The active substance is diazepam, it is allowed in the 2nd, 3rd trimesters of pregnancy. Country of origin - Slovenia. The average price is 270-550 rubles.
Gidazepam. Tablets with the same active substance are taken as a daily tranquilizer for patients with neurotic, psychopathic asthenia, who are in an anxious, excitable state. Assigned for the relief of nicotine withdrawal symptoms. The average price is 150–365 rubles.
The price of Grandaxin
According to reviews, the cost of this tool is considered slightly overpriced. On sale it is available at a price of 350 to 950 rubles, depending on the dosage and number of tablets.
We reviewed the tool "Grandaxin" instructions, reviews and analogues.