Blood clots often cause many serious health problems. This can be a heart attack, stroke, embolism, etc. For the prevention of thrombosis, doctors usually prescribe special drugs to patients whose action is aimed at reducing blood coagulation. One such medicine is Zilt.
This tool prevents the formation of blood clots in the heart cavity and vascular bed. It acts very simply. In patients taking Zilt, the instructions for the use of which will be considered by us in the article, simply there is no accumulation of too many red blood cells in the vessels and their coagulation.
Release form and composition
This medicine is supplied to pharmacies exclusively in the form of tablets, pink-coated and packaged in blisters of 7 pcs. Each such pill has a white color and a rough surface. Blisters, in turn, are packed in cardboard boxes of 2, 4 or 12 pcs.
Together with the tablets, of course, the instruction for use of "Zilt" is also enclosed in the box. The composition of this medication includes clopidogrel sulfate as the main active substance. Each tablet of this component contains 97.875 mg. Often, the active substance of the drug "Zilt" is also just clopidogrel. Its composition includes 75 mg.
In addition, the components of the drug are:
lactose and cellulose;
starch;
Castor oil;
macrogol 6000.
Manufacturer and price
In Russia, the pharmaceutical company KRKA is producing Zilt medicine . Also, on the domestic market, you can sometimes find an imported drug supplied from Slovenia.
It is "Zilt", unfortunately, quite expensive. The price of this drug depends, first of all, on the number of blisters packaged in a box. For example, 14 tablets of this product cost about 500-600 r, depending on the supplier. For 12 blisters, you will have to pay more than 2000 p. In any case, this drug is dispensed in pharmacies only by prescription.
pharmachologic effect
In the place of vascular damage in the human body, platelets always begin to accumulate. At the same time, they stick together with each other and adhere to the tissues. This process ends with the formation of a blood clot.
The drug "Zilt", the instructions for use which is quite simple, begins to act beneficially on the patient very quickly - about 30 minutes after administration. When it enters the human body, inhibition of platelet aggregation occurs. With regular use of this drug after about 4-7 days, the maximum therapeutic effect occurs.
The peak concentration of this medicine in the body occurs a few hours after administration. Moreover, its content in the blood even during this period is usually quite low.
The drug is excreted from the body by both the kidneys and the intestines. The half-life after a single dose is approximately 6-8 hours.
Indications for use
Most often, this drug is prescribed to patients by doctors to prevent the development of atherothrombotic complications in patients with pathologies such as:
Also, this tool is used to prevent the formation of blood clots with atrial fibrillation in the event that indirect anticoagulants are contraindicated for any reason .
The drug "Zilt": instructions for use
This medicine is available, as already mentioned, only in pill form. Accordingly, they take it exclusively orally. Drink tablets 75 mg "Zilt" instructions for use allows both before meals, and after or during it. The methods of taking this drug depend on the specific disease.
A patient with myocardial infarction is usually prescribed one tablet 75 mg per day. The same dosages are provided for patients with ischemic cerebrovascular accident and arterial occlusion. In this case, for patients with myocardial infarction, this medicine can be prescribed in the period from 1 to 35 days of the development of the disease. Patients with ischemic stroke "Zilt" is usually prescribed from 7 days to six months.
In coronary syndrome with ST segment elevation, this medicine is also prescribed in an amount of 75 mg per day. But in this case, the patient previously takes a single loading dose in combination with aspirin and thrombolytics.
In coronary syndrome without ST elevation, a slightly different treatment regimen is used. In this case, the drug is usually taken as follows:
Moreover, in combination with medication with aspirin in the amount of 75-325 mg, the daily dose of Zilt should be 100 mg. With this regimen, the maximum effect in patients is usually observed after three months. The course of treatment most often is 12 months.
Such therapy is prescribed in most cases only to adult patients under the age of 75 years.
Instructions for use of the drug "Zilt": contraindications
Adolescents under 18 years of age "Zilt" for the prevention of thrombosis are not prescribed. It is also not recommended to take this medicine to lactating and pregnant women. Clopidogrel is able to penetrate, including, into breast milk.
Of course, you can not take this drug and those people who may develop an allergic reaction to any of its components. Are contraindications to the use of "Zilt":
acute bleeding;
lactose deficiency.
According to the instructions for use, "Zilt" should be taken with caution in the presence of problems such as:
hypersensitivity to thienopyridines;
low activity of CYP2C19;
impaired liver and kidney function;
diseases in which bleeding is possible;
surgical operations and injuries that can cause bleeding.
Interaction
In addition, with caution should be taken, according to the instructions for use, "Zilt" 75 mg simultaneously with such means as:
Iib / IIIa inhibitors;
warfarin;
heparin.
The same applies to complex treatment with Zilt and non-steroidal anti-inflammatory drugs.
The effect of taking this medication may decrease if the patient has undergone treatment using:
What patients need to know
Patients taking Zilt should definitely adhere to the following recommendations:
What side effects may occur
Like any other medicine, Zilt can have a negative effect on the patient’s body. Most often, when passing a course using this medicine, the following side effects are observed in patients:
Sometimes, those taking this drug may also appear:
itching or purpura;
- Dizziness
intracranial hemorrhage;
hemorrhages in the eyes;
ulcers.
In laboratory blood tests, a decrease in the number of platelets and neutrophils can sometimes be detected in patients.
There are, therefore, quite a few side effects to this medicine. Therefore, the instructions for use "Zilt" 75 mg should be observed without fail. Overdoses of this drug, of course, cannot be tolerated. If the patient suddenly forgets to take the pill one day, drinking a double dose on the next day is not recommended in any case.
According to the instructions for use, Zilt tablets, like any others, should not be drunk if you are allergic to any of their components. Such reactions when using this drug are rare. But sometimes an allergy in patients undergoing treatment using this remedy can still be observed. The most common reactions are:
What to do in case of overdose
Using the drug with violations of the instructions for use of "Zilt" leads to the occurrence of such problems as:
Treatment for overdoses with this medicine is symptomatic. Patients are usually transfused with platelet mass.
Analogues of the drug
It costs "Zilt", as already mentioned, quite expensive. Therefore, many patients, of course, are interested in what cheaper drug can replace this drug if necessary.
Synonyms of the drug "Zilt" are, for example:
Lopirel
Plavix
"Lirta";
"Troken."
All these funds in their composition have the same active substance as Zilt. If desired, this drug can be replaced at any time with one of the analogues on the list. Instructions for use with Zilt and its synonyms are almost identical. Reduce blood clotting, these drugs are quite effective. However, it is still allowed to change Zilt to any of these analogues only after preliminary consultation with a doctor.
Generics "Zilt" are medicines "Clopidogrel" (cost 190 p. For 14 pcs) and "Clopidogrel-Richter" (292 p).
Analogues of this drug, which also prevent blood coagulation, are as follows:
“Phenylin”;
Heparin
"Dicumarin."
"Phenilin" is prescribed to patients at 0.025-0.1 g 1-3 times a day. Patients may take Dikumarin in dosages from 0.05 to 0.1 g 2-3 times a day. Doctors prescribe Heparin to patients subcutaneously, intravenously or intramuscularly.
Also, the drug "Plavix" refers to the analogues of this medicine. "Zilt", the instructions for use of which we reviewed above, in fact, is itself a cheap substitute for this medicine. Many patients, given a sufficient amount of funds, are advised to choose Plavix for the prevention of thrombosis. In terms of effectiveness, Zilt is slightly inferior to this branded medicine.
Storage conditions
Of course, to take the prevention of blood clots should be exclusively unexpired drug "Zilt". It is recommended to store this medicine at temperatures up to +25 ° C. That is, in the summer these tablets are preferably placed in the refrigerator. The shelf life of the drug in sealed packaging is 3 years.
Reviews about the remedy from patients
Patients have a very good opinion about this medicine. Patients relate to its advantages:
This medicine dilutes the blood, according to most patients, much better than the same aspirin. That is, the risk of a repeated heart attack or stroke when used strictly in accordance with the instructions for use, Zilt, reviews of which in this regard are really only good, significantly reduces.
Some disadvantages of this medicine, patients consider:
Heart attacks and strokes occur, of course, in middle-aged people. But more often than not, older people still face this problem. And of course, buying such a relatively expensive retirement drug is usually difficult.
Zilt tablets are packaged in blisters that literally fall apart in the hands. Perhaps the manufacturer thus wanted to make the daily use of this medicine more convenient. However, according to most patients, it would be much better to release these pills in blisters that are stronger along the rupture line.
Another disadvantage of the Zilt medicine is that many patients consider that it affects the liver quite strongly. Most patients advise taking this medication exclusively under the supervision of a doctor.
What do doctors think about the medicine
Doctors themselves also consider Zilt to be a good way to reduce blood coagulation. The pluses of this medicine, doctors attribute primarily to the fact that it is well tolerated by most patients. Judging by the reviews, hemorrhages during its use are very rare.
The evidence base in terms of safety and efficacy of this drug, as many doctors note, is very good. However, they believe that the drug is in any case quite serious. Doctors do not recommend practicing self-medication with its use.