Constant stress, stress at work and at home, and other negative factors often lead to more serious problems in the psycho-emotional sphere. Neuroses, neurotic and psychopathic conditions develop, they are accompanied by anxieties and fears, a depressed mood, irritability increases, sleep is disturbed ... It is almost impossible to deal with this on your own, and you should not start this state.
Modern medicine has a huge amount of funds that can relieve unpleasant symptoms and restore the joy of life. An important role in the treatment of such diseases is played by tranquilizers - sedatives and stress relievers. The doctor selects a medication depending on the condition of the patient. One of the highly effective tranquilizers can be called a relatively new drug, "Tranquesipam."
Benzodiazepine tranquilizers
Tranquesipam is an analogue of the well-known for many years Phenazepam, the first benzodiazepine tranquilizer. It was created in the USSR in the 70s of the last century. Benzodiazepine tranquilizers are second-generation tranquilizers that relieve anxiety, fear, and emotional tension. At the same time, they have little effect on cognitive functions, such as memory, attention, etc. Among their shortcomings is quick getting used to, so you can not use them longer than prescribed by the doctor. Most modern psychopharmacological agents belong to this group. Due to the complex effects on the human body, these drugs are strictly forbidden to be used without the appointment and supervision of a doctor.
If you want to know details about treatment with a medication such as Tranquesipam even before your visit to the doctor, the instructions and reviews on the Internet will give a fairly complete picture of the effect of this tranquilizer.
Indications for use
Tranquesipam is used to treat many diseases. It belongs to the most powerful benzodiazepines with a pronounced anti-anxiety effect.
In addition to treatment for increased anxiety, irritability, fears and phobias, this drug is indicated for such problems:
- neurotic and neurosis-like conditions;
- psychopathic and psychopathic conditions;
- instability of mood and its sharp changes;
- hypochondria;
- convulsive seizures;
- some types of epilepsy;
- instability of the autonomic nervous system (what is commonly called vegetovascular dystonia);
- increased muscle tone with the inability to relax, tics, etc.
It is also successfully used in withdrawal symptoms (alcoholism, substance abuse), in the treatment of schizophrenia and for preliminary medical preparation for induction of anesthesia. In addition, Tranquesipam is used in neurological practice and anesthesiology. The instruction for the drug contains a complete list of indications.
Release Forms
Tranquesipam is available in two forms:
Tranquesipam tablets contain the main substance of the drug bromidihydrochlorophenylbenzodiazepine in the amount of 0.5 and 1 mg per tablet. Pills are packaged in 50 pieces in jars of dark glass or packaged in 5 blisters for 10 tablets in cardboard boxes.
"Tranquesipamum" in ampoules contains 1 mg of bromodihydrochlorophenylbenzodiazepine per 1 ml of solution. Designed for intramuscular and intravenous administration, it is sold in ampoules in pallets or packages of 5 or 10 ampoules with an ampoule knife in the kit.
Drug exposure
"Tranquesipam" enhances the inhibitory effect of GABA (gamma-aminobutyric acid) on the transmission of nerve impulses. The drug has antifobic, sedative, hypnotic, anticonvulsant properties, is an excellent central muscle relaxant (that is, it reduces hypertonicity of skeletal muscles).
The antiphobic or anxiolytic effect is manifested in a decrease in emotional stress, feelings of fear, anxiety, anxiety. Thanks to the sedative effect, neurotic signs of anxiety and fear also disappear. The process of falling asleep and sleeping improves, anxious dreams disappear.
The use as an anticonvulsant drug suppresses a convulsive impulse, but does not remove the focus of excitation, therefore it can only be used as an additional tool in the treatment of seizures of various origins.
When taken "Tranquesipam" is well absorbed from the gastrointestinal tract, the maximum concentration is reached after 1-2 hours. It is excreted by the kidneys after 6-18 hours.
Mode of application
The tablet preparation is taken orally in the usual manner. If you take Tranquesipam tablets, the instructions limit their use to the following dosages:
- sleep disorders - 0.25-0.5 mg half an hour before bedtime;
- in neurotic, psychopathic and similar conditions - 0.5-1 mg 2-3 times a day (after 4 days you can increase the dose to 4-6 mg per day if the drug is well tolerated);
- with fear, anxiety - 3 mg per day, then the dose is increased until a result is obtained;
- with alcohol withdrawal - 2-5 mg per day;
- with muscle hypertonicity - 2-3 mg per day.
If you need to very quickly stop fear, anxiety or psychotic conditions, use the Tranquesipam solution. Instructions for use (in ampoules, this drug is prescribed less often than in tablets) gives information that it can be administered intravenously or intramuscularly, the result can be obtained starting with 0.5 mg. But even in the most severe cases, the maximum dose is 9 mg.
Detailed information on the dosage of the drug in other cases can be obtained by reading the instructions for Tranquesipam. However, it is worth remembering that the maximum daily dose cannot exceed 10 mg.
Be sure to check the doctor’s prescriptions with the recommendations that are given for treatment with a drug such as Tranquesipam, instructions for use. Tablets must be taken in strictly defined doses, otherwise treatment may be ineffective or even harm. Therefore, if you have doubts about the dosage and frequency of administration prescribed to you, or they do not comply with the instructions, be sure to inform your doctor.
Contraindications
Any tranquilizer has an extensive number of contraindications. I did not escape this fate and Tranquesipam. It is forbidden to take with severe myasthenia gravis, severe kidney and liver diseases (for example, with cirrhosis or Botkin’s disease). Contraindication is poisoning with medications, such as other tranquilizers, antipsychotics, sleeping pills, as well as poisoning with drugs and alcohol.
An almost absolute contraindication is pregnancy, especially in the first trimester. "Tranquesipam" is able to exert a teratogenic effect on the fetus (that is, disrupts the development of tissues and organs and leads to congenital malformations). If the mother took this drug during pregnancy, then among the other effects on the fetus, depression of the central nervous system, respiratory failure and suppression of the sucking reflex in newborns were noted. In addition, the continuous use of "Tranquesipam" during the expectation of a child can lead to the development of withdrawal syndrome in the newborn. Therefore, during pregnancy, "Tranquesipam" is used only for health reasons.
In addition, you should refuse to take the drug during lactation and choose another drug (or stop breastfeeding during treatment with this tranquilizer, if it is necessary). If, nevertheless, the condition requires treatment with such an agent as Tranquesipam, the instruction warns of possible complications after taking it.
The drug should not be taken until the age of 18, since its safety and effectiveness for children have not been investigated. In addition to this, contraindications include glaucoma (both in the stage of an acute attack and with a predisposition), acute respiratory failure, shock, coma. When using "Tranquesipam" during severe depression, suicidal tendencies are possible. And of course, you should refuse to take a tranquilizer for hypersensitivity to any of its components. Therefore, before treatment, it is necessary to consult a doctor, informing him of all the factors that may be an obstacle to taking the drug.
Side effects
The list of side effects of Tranquesipam, like any similar drug, is also quite large. The patient may experience dizziness, sometimes headache, suffer from fatigue, drowsiness, muscle weakness, complain of impaired memory, concentration of attention and coordination of movements and even dysarthria - problems with pronunciation (especially if high doses are prescribed), sometimes insomnia. This usually manifests itself at the beginning of treatment, more often in older people and for the first time taking Tranquesipam. Instructions for use contain mandatory information about possible side effects and their frequency.
Also undesirable, but possible manifestations include muscle reactions - tremors, uncontrolled movements, including the eye, muscle cramps.
Often there is an unexplained excited state, euphoria or, conversely, excessive irritability, depressed mood, depression, outbreaks of aggression. In extremely rare cases, suicidal tendencies and hallucinations occur. But most often these symptoms appear as a withdrawal syndrome - with a sharp withdrawal or a sharp decrease in the dose of the drug.
If you are sensitive to the medication, you may experience an allergic reaction, such as itching or a rash. Also, when taking Tranquesipam, patients may complain of dry mouth, nausea and diarrhea or constipation and other problems with the gastrointestinal tract, such as heartburn, vomiting, decreased appetite, and impaired liver function.
Not so often, but urinary incontinence or retention, impaired renal function, are possible. In addition, there may be a decrease or increase in libido, dysmenorrhea in women. Do not forget about getting used to the drug.
This is not a complete list of side effects, but most of them are extremely rare and may not occur at all with controlled administration of Tranquesipam. To reduce or remove side effects, you can use a drug like Mesocarb.
Precautions While Taking "Tranquesipam"
It is necessary to carefully finish taking this drug: you need to stop taking it gradually, gradually reducing the dose so as not to cause withdrawal syndrome. A sudden cessation of intake can cause depression, irritability, insomnia, excessive sweating and other symptoms, especially if before that the drug was taken for more than 8-12 weeks.
"Tranquesipam" should not be taken while driving vehicles and those whose profession is associated with increased concentration of attention. At the time of treatment, alcohol should be discarded in any form.
If "Tranquesipam" is taken in the presence of renal or hepatic insufficiency, then it is necessary to control the liver enzymes and the picture of peripheral blood.
If the patient takes the tranquilizer for the first time, the dose of Tranquesipam should be lower than for patients who have already taken tranquilizers and antidepressants or are suffering from alcoholism.
Dependence on the drug occurs with prolonged use in doses of more than 4 mg per day. If you have been taking Tranquesipam for more than 3 weeks, the instructions for use recommend that you consult your doctor about further use.
The drug should be stopped immediately if the patient has such reactions as increased aggressiveness, convulsions, a sense of fear, especially thoughts of suicide or hallucination. Problems with falling asleep, superficial sleep, etc., are also grounds for drug withdrawal.
Interaction with other drugs
Since such drugs are taken in combination with other medicines, you need to know about their effects on each other. So, for example, Tranquesipam reduces the effectiveness of Levodopa, increases the toxicity of Zidovudine.
If neuroleptic, antiepileptic or hypnotic drugs or muscle relaxants are prescribed simultaneously with Tranquesipam, the effect of both drugs is enhanced. But the same interaction occurs with the simultaneous administration of a tranquilizer and ethanol, as a result of which alcohol poisoning may intensify.
Antihypertensive drugs increase the decrease in blood pressure during treatment with Tranquesipam.
If you think that your condition requires treatment with a drug such as Tranquesipam, the instructions for use should be studied in advance. If the medication is really shown to you, you must tell your doctor about what medicines are already being taken.
Analogs
Since Tranquesipam belongs to the most extensive and popular group of benzodiazepines, it is easy for him to find a suitable analogue if necessary. Tranquesipam itself is an analogue of Phenazepam, a fairly well-known tranquilizer. In addition to it, one can note such drugs with a similar effect:
- Fesipam.
- "Phenazepam-Ros."
- "Phenorelaxan".
- "Elzepam", as well as many others containing the same active substance in the base.
They are similar in effect, but may differ in price, some components and, as a result, in the presence and severity of side effects. In each specific case, the doctor should choose the drug, it is he who determines which drug is suitable for the patient - “Phenazepam” or “Tranquesipam”. Instructions for use do not consider analogues, but gives the name of the active substance by which it can be determined whether tranquilizers are from the same group, that is, whether they act in a similar way on the same disease.
Reviews
Most people taking Tranquesipam note that this is actually a good drug. A wide spectrum of action and, despite a large list, poorly manifested side effects, as well as effectiveness, allowed the tranquilizer to become one of the most popular drugs in its field. In simple words: this is an excellent sedative, good sleeping pill. In addition, it acts very quickly, has a cumulative effect. Patients' lives quickly return to normal and become calm and joyful. Reviews often mention the fact that a worthy replacement for Phenazepam is Tranquesipam.
Do not forget that treatment with this drug can only begin after the appointment of a doctor. The drug is sold only by prescription. Self-medication is extremely dangerous due to contraindications and possible side effects, so the first thing you should study after prescribing Tranquesipam is the instructions for use. The reviews of those who have already used the drug are quite positive, but almost every one has an important clarification: if you strictly follow the instructions of your doctor, Tranquesipam can solve many health problems without adding new ones, which will significantly change life for the better.