Diuretic drugs are used by patients with various pathologies of the bladder and kidneys. If the organs of the urinary system are not functioning properly, this can provoke the accumulation of excess fluid. The article contains useful information about Diuver. The instructions, price and reviews of real users will help readers make the right choice.
general information
"Diuver" is a diuretic drug that belongs to the group of urinary stimulating substances. The effect of the drug is directed to the loop of Henle. The effect of the Diuver preparation is aimed at inhibiting the reverse absorption of chlorine and sodium. This tool is prescribed to patients who suffer from hypertension. Unlike similar drugs, the effectiveness of this drug does not depend on food intake.
As a result of the use of the drug in humans, inhibition of renal reabsorption of water and excess fluid occur. Thus, the drug blocks ionic carriers in the apical part of the ascending part of the nephron loop. Since the cycle of the myocardium is lengthened, there is a decrease in the degree of sclerosis and fibrosis of tissues.
The drug allows you to reduce peripheral vascular resistance, which is confirmed by numerous positive reviews about "Diuver". The instruction contains information that the effect of the drug is based on stimulating the activity of potassium ions in the smooth cells of the muscle layer. As a result, there is a decrease in the response of the wall to the effects of biological pressors.
Structure
The composition of the drug "Diuver" includes the main active ingredient - torasemide, which has many positive properties, among which the following can be distinguished:
- long-term effect of treatment;
- high activity of the drug;
- hypokalemia does not develop.
Depending on the form of release, the composition of the medication includes the following excipients:
- corn starch;
- lactose monohydrate;
- magnesium stearate;
- sodium carboxymethyl starch;
- anhydrous silica;
Drug feature
Instructions "Diuvere" contains information that the drug is adsorbed from the gastrointestinal tract and is rapidly absorbed into the blood. The highest concentration is observed 1 hour after taking the tablets. The active substance binds to plasma proteins and provides a diuretic effect. The drug is metabolized in the liver under the influence of special enzymes.
The elimination of the drug from the body occurs mainly by the kidneys. Through hemofiltration and hemodialysis, an insignificant part of the metabolites is excreted. If therapy is carried out for a long time, the patient should keep under control the indicators of the clinical picture of blood. Patients suffering from renal failure are at risk of developing a water-salt balance. In this regard, the treatment of such persons is carried out under the supervision of a specialist. Instructions for use "Diuvere" recommends abandoning the management of complex mechanisms and driving a car while taking the drug.
Indications for use
Experts recommend using the drug if there is an edematous syndrome against a background of various pathologies. Also, Diuver can be included in complex therapy for diseases of the lungs, kidneys and liver. The use of loop diuretics allows you to effectively cure chronic heart failure. This is due to the fact that the drug helps to reduce the accumulation of fluid in the tissues. Relative to other diuretics, this drug has a longer and stronger effect.
Contraindications
It is not recommended to take Diuver in the following cases:
- renal failure;
- intolerance to active components;
- lactation period;
- hepatic coma;
- lactase deficiency;
- acute glomerulonephritis;
- cardiac glycoside intoxication;
- dehydration;
- increased venous pressure.
In addition to these cases, there are some pathological conditions in which it is recommended to take the drug only under the supervision of a specialist. These conditions include:
- atherosclerosis;
- arterial hypotension;
- diabetes;
- acute stage of the myocardium;
- hepatorenal syndrome.
Side effects
Side effects in patients develop quite rarely with the correct use of the drug. However, uncontrolled intake and individual sensitivity to active components can lead to the development of certain side effects. According to the instructions, Diuver may cause the following adverse reactions:
- lowering blood pressure;
- hydronephrosis;
- exicosis;
- metabolic alkalosis;
- hypertriglyceridemia;
- increase in blood viscosity;
- vomiting, diarrhea, nausea;
- the appearance of tinnitus;
- headache;
- dermatitis and itchy skin.
If the patient is in the hospital, he is prescribed a gastric lavage, and then left under the supervision of a specialist. If necessary, symptomatic treatment is worthwhile. Patients should be aware that there is no specific antidote to this drug. Taking the drug can increase the concentration of the active substance and increase the risk of developing the ototoxic effect of cephalosporins, chloramphenicol. With the simultaneous use of large doses of salicylates during therapy with torasemide increases the risk of a toxic effect. If you take a drug containing torasemide and cyclosporine at the same time, the risk of developing gouty arthritis significantly increases. Since this drug has many side effects, it should be prescribed by a qualified specialist.
How to use
The therapeutic course of treatment should be prescribed by a doctor, taking into account the specifics of the patient's body. The tablets are taken orally and washed down with warm water. Instructions for use "Diuver" recommends using the drug immediately after breakfast. To eliminate the edematous syndrome, the daily dose of the drug is 5 mg. Immediately after the elimination of edema, the drug should be discontinued.
In order to confirm the positive effect, you can use the McClure-Aldrich test for latent edema or control weighing. Instructions for use "Diuver" with arterial hypertension is somewhat different. If necessary, you can increase the daily dose to 5 mg, which will improve the effectiveness of treatment. During the observation of the patient, the doctor may adjust the treatment and the dose of the drug. It is not recommended to take such diuretics on your own due to the large number of side effects.
Overdose
Instructions for use indicate that uncontrolled use of the drug can cause the following symptoms:
- lowering blood pressure;
- frequent urination;
- circulating blood deficiency;
- gastrointestinal tract disorders;
- violation of acid-base balance;
- confusion.
With drug intoxication, gastric lavage can be performed or any other way to get rid of the contents of the stomach. You can apply both physiotherapeutic effects and drug therapy.
Interaction
Torasemide is an active component of the drug, which interacts with various drugs. Diuver reduces the effectiveness of hypoglycemic drugs and can cause irreversible changes in the microvasculature. Each package contains instructions for use. The price of Diuvere and reviews are fundamental factors that influence the decision-making process on the purchase of the drug. The cost of this drug is quite affordable, so the medication is in great demand.
Diuver should not be combined with drugs that contain cyclosporine. This restriction applies to patients at risk of developing kidney disease. Otherwise, gouty arthritis and deposition of urate may occur.
Analogs of Diuvere
Detailed information on the effect of the drug is contained in the instructions for Diuver and its analogues, the price of which is much lower. Among the most popular medicines that are included in the group of loop diuretics, the following can be distinguished:
- Britomar;
- Trigrim
- Furosemide;
- "Trifas".
You need to know that the likelihood of side effects and various undesirable reactions in analogues is many times greater.
Pregnancy and lactation
The active components of the drug can penetrate the placenta. Therefore, the medicine can have a negative effect on the formation of tissues and organs of the child. The instructions for use contain information that the drug can be used only if the benefits of its use exceed the potential risk to the development of the fetus. Experts recommend that you carry out treatment under the supervision of a doctor, as well as conduct regular additional studies.
During therapy, it is necessary to control blood pressure and general well-being. Therapy should be stopped immediately at the first appearance of a negative reaction from the fetus. The use of the drug during breastfeeding is strictly prohibited, since there is no reliable information on whether the active component of the drug penetrates into the mother’s milk. If therapy is necessary, it is better to abandon breastfeeding and transfer the baby to an adapted milk mixture.
Reviews about Diuvere
There are a large number of drug users who leave positive reviews about Diuver. The instruction, according to patients, is a very important part of the medicine, it will help to avoid problems with its use. Numerous positive reviews about the drug "Diuver" confirm its high effectiveness. Patients with kidney damage, chronic heart disease leave praise. The drug is actively used in inpatient treatment, which indicates a positive opinion of specialists.
After studying the instructions for use "Diuver" and reviews of real users, you can get an objective idea about this drug.
Comments state that Diuver has a long-lasting and powerful effect on other analogues. The cost of the drug varies over a wide range, and depends on the form of release and the mass fraction of torasemide. Before taking the drug, you need to consult a specialist, as well as study the information in the instructions for use of the Diuver. The price of the medicine (300-350 rubles) is affordable for the average resident of Russia.