The drug has an antioxidant effect. "Mexifin" is used to correct disorders in the body during alcoholism and drug addiction, as well as to eliminate various diseases of the central nervous system.
The medication has antihypoxic, as well as local anesthetic, nootropic, anti-anxiety and anticonvulsant effects. The same effect is exerted by its substitute Mexidol. The trade name for ethyl methyl ethyl hydroxypyridine succinate is Mexifine.
Release form
A medication is available in the form of a solution for intravenous and intramuscular use.
Ampoules are placed in contour cells of five or ten pieces of 2 or 5 milliliters. The composition of Mexifin includes the following components:
- ethyl methyl hydroxypyridine succinate;
- water.
Pharmacological actions
The drug has antihypoxic as well as antioxidant, local anesthetic, nootropic and anticonvulsant effects. The drug belongs to the group of compounds of succinic acid and 3-hydroxypyridine.
According to the instructions, Mexifin acts as an inhibitor of free radicals. The main actions of the medication are:
- Enhanced activity of enzymes of the antioxidant system.
- Inhibition of the processes of oxidative lipid degradation, which occurs, as a rule, under the influence of free radicals.
- Modulating effect on membrane-bound enzymes.
- Restoration of the functions and structure of membranes that are impaired by various pathological processes.
- Improving the transport of neurotransmitters, as well as neurotransmission and the relationship of brain structures.
- Increased dopamine concentration in the brain.
What diseases does the medicine use
According to the instructions, the following conditions are indications for the use of Mexifin:
- Disorders of the microcirculation of the brain in the acute course.
- Vegetovascular dystonia (a complex of functional lesions, which is based on a violation of the regulation of vascular tone by the autonomic nervous system).
- Dyscirculatory encephalopathy (damage to the brain, which subsequently appears as a chronic slowly progressive disturbance of microcirculation of the brain of various origin).
- Mild cognitive impairment of atherosclerotic origin (decreased cognitive abilities compared to a higher premorbid level of an individual, which remains within the average statistical age norm or slightly deviates from it).
"Mexifine" is also used for such ailments:
- Neurotic conditions (a psychogenic disease that appears under the influence of psychotraumatic factors, subsequently violations of especially significant personality traits, manifested in the form of general neurotic clinical phenomena, as well as insomnia, migraine, various vegetative-visceral signs of a functional nature in the absence of psychotic phenomena).
- Acute intoxication with antipsychotics.
- Withdrawal syndrome (a complex of pathological symptoms that occur in alcoholics when refusing to drink alcohol).
- Coronary heart disease (a pathological condition characterized by an absolute or relative violation of the myocardial blood supply due to damage to the coronary arteries).
- Acute myocardial infarction (a source of ischemic myocardial necrosis, which develops subsequently in an acute violation of coronary microcirculation).
Contraindications
According to the instructions for use, Mexifin is forbidden to take in the following conditions:
- Diseases of the kidneys or liver.
- Pregnancy.
- Childhood.
- Lactation.
- Individual intolerance to the substances that make up the drug.
How to use the medicine
According to the instructions for use with Mexifin, it is known that the solution is administered intramuscularly or intravenously. Dosage is determined individually. The duration of the course depends on the severity of the disease and the effectiveness of the treatment.
Therapy should be started with 50-100 milligrams from one to three times a day. Dosage is gradually increased until a pharmacological effect is achieved. The maximum daily concentration of the drug is 800 milligrams per day.
With injections, Mexifin should first be diluted in physiological saline. Inkjet medicine is administered slowly over a period of five to seven minutes; drip rate is sixty drops per minute.
Recommended use of the drug:
- With discirculatory encephalopathy, the first two weeks of treatment, the drug is administered intravenously from two to three times a day, 100 milligrams, the next fourteen days - 100 mg per day intramuscularly.
- In case of discirculatory encephalopathy for prophylactic purposes, Mexifinum therapy is carried out for two weeks twice a day, 100 mg intramuscularly.
- In acute disorders of cerebral microcirculation: the first four days, treatment should be carried out intravenously by a drop of 200-300 milligrams, then injections are carried out intramuscularly three times a day, 100 milligrams each. The duration of treatment varies from ten to fourteen days.
The dosage of "Mexifin", according to the instructions, for different conditions is as follows:
- With alcohol withdrawal syndrome, it is necessary to use the drug for seven days three times a day (100-200 milligrams intramuscularly or twice a day intravenously).
- For mild cognitive impairment, as well as anxiety disorders and people of retirement age, the medication is used for thirty days (100-300 milligrams intramuscularly).
- In case of neurotic disorders and vegetovascular dystonia: for two weeks (50-400 milligrams per day intramuscularly).
- In acute intoxication with antipsychotics, treatment is carried out for two weeks (50-300 milligrams per day intravenously).
Pregnancy and Mexifin
When carrying a future baby, the advisability of using a therapeutic drug is determined by a medical specialist. The use of "Mexifin" is allowed only when absolutely necessary. During lactation, it is required to stop breastfeeding - replace milk with specialized mixtures for feeding a newborn.
Mexifin and alcohol
According to the instructions for use, it is known that the described drug can be administered eighteen hours before drinking alcohol (for men). A woman should take "Mexifine" a day before the feast. After drinking alcohol, you can use the medicine after eight hours, and for women - fourteen hours.
If the conditions are violated, the drug increases the side effect of alcohol on the liver, stomach ulcers may occur. Less common is migraine, as well as tinnitus and lethargy. In advanced situations, this combination leads to bleeding.
"Mexifin" is an excellent drug that helps fight the negative signs of a hangover syndrome. This fast-acting medication is highly effective and has antioxidant, as well as antihypoxic and neuroprotective effects.
Adverse reactions
According to the instructions, Mexifine in ampoules can provoke the following negative effects:
- Xerostomia (insufficient salivation, accompanied by increased dryness of the oral mucosa).
- Flatulence (a pathological condition of the body that occurs due to excessive gas formation and accumulation of gases in the gastrointestinal tract).
- Diarrhea (an ailment in which there is frequent or single bowel movement, during which liquid stool is released).
- Nausea.
- Taste of metal in the oral cavity.
- Allergic reactions.
- Insomnia (a sleep disorder characterized by insufficient duration or poor quality of sleep or a combination of these phenomena over a significant period of time).
- Increase in blood pressure (pressure indicator in a middle-aged person is above the standard).
If side effects occur, it is necessary to inform the doctor about this.
Analogs of Mexifin
The following drugs are considered substitutes for the drug:
- "Instenon".
- "Neurotropin".
- "Metostabil."
- "Combilipen".
- Borizol
- Mexidol.
- "Intellan".
- Rilutec.
- Mexicor.
- The Celtican.
- Armadin.
- Nicomex
- "Antifront".
- "Medomeksi".
- Neurox.
- "Elfunat."
- Glycised.
- Hypoxene.
- Mexiprim.
- "Trigamma."
- Tenoten.
- Astrox
- Mexidol.
- "Cytoflavin".
- "Cerecard".
- Enerion.
- Mexidant.
- "Glycine".
- "Cerecard".
According to the instructions, "Mexifin" must be kept away from light and moisture, at room temperature. Keep the medicine away from children. Shelf life is three years. A prescription drug is released.
Mexifin or Mexidol?
The spectrum of effects of both drugs is absolutely no different. Both drugs prevent the aging process of the body as a result of the suppression of free radicals. "Mexifin" and "Mexidol" have a positive effect on the performance of the myocardium, and also affect the metabolism. The main result of the use of both drugs is considered to be a significant reduction in the risk of acute vascular disease.
Given the indications for use, composition, adverse reactions, it can be determined that Mexifin or Mexidol is better. The second drug has a wider spectrum of effects, it is produced in several dosage forms - tablets, solution. Therefore, it is prescribed much more often. "Mexifine" in tablets does not exist.
But the drug, "Mexifin" does not contain absolutely any additives and preservatives, therefore it is suitable for the treatment of people who are prone to allergies of various etiologies. In any situation, what is best suited for the treatment of a particular disease should only be decided by a medical specialist.
Both drugs activate metabolism, as well as microcirculation of the brain. Thanks to their use, blood quality improves, degenerative processes in the brain tissue are eliminated. "Mexifin" and "Mexidol" improve memory, as well as attention and well-being.
Reviews about "Mexifine"
Opinions about the medicine are usually positive. Patients note that with this medication, the level of anxiety decreases, and the functioning of the brain and sleep improve. In addition, the great advantage of “Mexifine” is its availability in drugstores and good tolerability.
There are also negative reviews about the medicine. The named drug can cause side effects, usually in the form of drowsiness.
Medical professionals describe Mexifine only on the good side. According to doctors, the drug is one of the most successful products that are produced in Russia. The drug has established itself as an effective medication that helps to reduce the severity of signs of chronic or acute disorders of the microcirculation of the brain.