Uncontrolled intake of various medications, especially antibiotics, as well as nutritional errors lead to the fact that the body has an increased growth of pathogenic microflora. This process inevitably ends with the appearance of various diseases, one of which is the well-known thrush.
This problem causes a lot of trouble to its "mistress", which manifests itself in the form of burning, itching, cheesy discharge from the vagina. Coming to the pharmacy to get rid of this scourge, it is very easy to get confused in the assortment of antifungal agents that are dazzled on shelves. In our article, we will talk about one of these tools, and the instructions for using the Futsis drug will be discussed in detail.
The composition of the drug and the form of release
The manufacturer produces the drug in the form of several forms:
- Tablets for oral administration.
- Dispersible tablets.
- The medicine is in the form of a gel.
- Solution for infusion.
Consider the composition of the drug. If we talk about tablets, then their composition includes the main active substance - fluconazole, the amount of which can vary depending on the weight of the tablet. They can be from 50 to 200 mg.
As aids, the tablet form includes:
- Microcrystalline cellulose.
- Lactose Monohydrate.
- Povidone K30.
- Talc.
- Magnesium stearate.
- Sodium starch glycolate.
- Croscarmellose sodium.
- Isopropyl alcohol.
Instructions for use of Fucis in the form of dispersible tablets contain information on the content of sodium saccharin as well as auxiliary ice cream, American ice cream flavoring DC129, and aerosil.
The solution preparation contains 200 mg of fluconazole, soluble in 100 ml of physiological solution of sodium chloride.
Such a dosage form as a gel, in its composition as the main substance contains 5 mg of fluconazole, and as additional components it contains:
- Carbomer.
- Benzyl alcohol.
- Polysorbate 80.
- Propylene glycol.
- 2-octyldodecanol.
- Sodium hydroxide.
- Fragrance De-lite.
- Purified water.
What form of the drug to choose for the treatment of thrush should be determined by the doctor, taking into account the condition of the patient and the characteristics of his body. For example, with a mild form of the disease, it will be sufficient to use Futsis 50 for therapy, the instructions for use of which contain detailed information about the treatment regimen and possible contraindications.
What effect does the drug have?
"Futsis" belongs to the group of medicines that have a pronounced antifungal effect, moreover, on a wide group of microorganisms. As a result of the penetration of the drug into the body, yeast cells lose their enzymatic activity. Ergosterol biosynthesis is disturbed in the cells of the fungus, which leads to the appearance of holes in the cell membrane, and this ends in its death.
If the doctor prescribes Futsis, the instructions for using the 150 mg pill from thrush recommend that you first determine the sensitivity of the flora, since not in each case such therapy may be effective.
Given that the half-life of the main active substance is more than a day, this makes it possible to use the medicine only once every 24 hours. Fluconazole is fairly well distributed throughout the body, its concentration in tissues and fluids is almost the same as in blood plasma.
Instructions for use "Futsis" suggests that most of the medicine is excreted by the kidneys.
Indications for the use of "Futsis"
This drug is used for various infectious diseases caused by fungi and having different localization. Most importantly, they are sensitive to fluconazole.
If “Futsis” is chosen for treatment, the instruction for use of the 200 mg tablet contains information on which problems such treatment will become effective. The following diseases can be noted:
- Candidemia.
- Candiduria
- Various forms of candidiasis.
- Infectious diseases of the organs of vision.
- Urinary system.
- Respiratory organs.
- Infectious diseases of the mucous membranes caused by Candida.
- Candidiasis diseases of the bronchopulmonary system.
- Fungal infection of the oral cavity in chronic form.
- Vaginal candidiasis in acute or chronic form.
- As a prophylactic in patients with chronic candidiasis.
- Candidiasis balanitis.
- Cryptococcal meningitis.
- Dermatomycosis.
- Onychomycosis.
- Pityriasis versicolor.
- Endemic mycoses.
Instructions for use "Futsis" claims that the drug is quite effective as a prophylaxis of the spread of fungal infection in patients who have immunodeficiency or undergo cytokinetic or radiation therapy.
"Futsis" in the form of a solution for injection is usually used for systemic fungal infections. This also includes all those diseases that were listed earlier.
To whom the drug is contraindicated
Any drug has contraindications, Futsis 200 is no exception. Instructions for use warns that there are conditions in which therapy with this drug is undesirable:
- If there is excessive sensitivity to the components of the drug.
- During pregnancy, such treatment is prohibited.
- A contraindication is the period of breastfeeding.
- If you familiarize yourself with the drug "Futsis", the instruction for use of the 50 mg tablet warns that this form is contraindicated in children under 7 years of age. Dispersed tablets can be given to babies after three years.
- Do not use Futsis if the patient is undergoing treatment with Terfenadine or Cisapride.
- The drug affects the ability to concentrate and respond quickly, so during therapy it is undesirable to drive a car and perform dangerous work.
- "Futsis" in the form of a gel is contraindicated for use up to 18 years.
Before starting treatment with the drug, the instructions for the use of "Futsis" recommends discussing this issue with your doctor.
Undesirable manifestations
Even if the patient has no contraindications to the use of this drug, this does not mean at all that side effects during treatment will bypass him. And they can be as follows:
- The appearance of dizziness and headache.
- Some patients complained of cramps and tremors of the limbs.
- Should be well studied by patients suffering from cardiovascular diseases, to "Futsis 200" instructions for use. Tablets can provoke arrhythmia or tachycardia.
- Some complain of a change in taste.
- The gastrointestinal tract may respond to nausea, vomiting, or pain in the epigastric region.
- Diarrhea may appear.
- In some cases, the development of liver failure was diagnosed.
- Exfoliative skin reactions.
- Allergic manifestations in the form of urticaria, skin itching, small rashes. In a more serious situation, there is a danger of developing Quincke's edema or Stevens-Johnson syndrome.
- If a blood test is done during the treatment, it often shows leukopenia, agranulocytosis or thrombocytopenia.
- Possible increase in blood cholesterol.
All these manifestations do not depend on the dosage in which the drug “Futsis” is prescribed; the instructions for use of the 150 mg tablet contain a list of the same side effects.
The scheme of therapy with the drug "Futsis"
With what dosage of the active substance to prescribe tablets and for how long - only the doctor determines according to the results of the examination. The dosage usually does not depend on the method of administration of the drug.
If the drug "Futsis" 200 mg is selected, the instruction for the use of the drug in different age groups pays great attention. It is allowed to use them in the treatment of adult patients, as well as children who are already 7 years old. Tablets are usually taken orally, they can be consumed at any time of the day and not be coordinated with food intake. Most often, the entire recommended dose is taken once a day.
Now consider in more detail the dosage and treatment regimen for various diseases:
- In the presence of invasive forms of candidiasis, most often the doctor prescribes 2 tablets of 200 mg on the first day of treatment, and then the dosage is reduced to 200 mg. If the infection is severe, then 400 mg is maintained.
- Patients suffering from oropharyngeal candidiasis are usually prescribed 1-2 tablets of 50 mg once a day. If the patient's immunity is normal, then the duration of the course is up to two weeks, with a reduced immune status, therapy is longer.
- With candidiasis of the oral cavity (it is often provoked by wearing dentures), it will be enough to take 50 mg of the drug once every 24 hours. The duration of therapy while taking antiseptics is two weeks.
- For the prevention of candidiasis in patients with immunodeficiency, Fucis 150 is prescribed, the instructions for use recommend that you take it once every 7 days after the completion of the initial therapy.
- In the presence of non-invasive infections of the mucous membranes, 50-100 mg of the drug is most often prescribed 1 time per day for two weeks. If necessary, the course can be extended up to 28 days.
- With genital candidiasis, Futsis will also help, the instructions for using the 150 mg tablet states that a single dose will be enough. For the prevention of relapse, it is necessary to take one tablet once a month for six months.
- Patients with an increased risk for the prevention of candidal infection need to take from 50 to 400 mg of "Futsis" once a day for several days before the alleged neutropenia.
- If cryptococcal meningitis is diagnosed , then 400 mg of the drug is indicated on the first day of therapy, and then 200 once a day. The duration of such treatment is usually at least 6-8 weeks.
- In the presence of fungal skin lesions, it is recommended to use 150 mg once a week or 50 mg every day. The duration of treatment depends on the severity of the disease and can range from 14 days to 2 months.
- Patients with pityriasis versicolor are recommended 2 tablets of 150 mg once a week. The duration of the course may vary depending on the complexity of the disease.
If the kidneys work fine in elderly patients, then dosage adjustment for them is not required. If there are kidney problems, “Futsis” is prescribed at a dose of 50 to 400 mg at the beginning of therapy, and then depending on the creatinine clearance.
The use of the drug in the treatment of children
It has already been repeatedly said that the drug can be used only in children older than 7 years. The dosage in each case is prescribed only by a doctor. It must be borne in mind that the daily dose should not be greater than that in adults.
If the child has candidal infections of the mucous membranes, a drug is prescribed at the rate of 3 mg per kilogram of weight 1 time per day. On the first day of treatment, the doctor may prescribe a single shock dose of 6 mg per 1 kg of body weight to achieve the maximum concentration of fluconazole in the body.
As a prophylactic, Futsis can be prescribed to a child at the rate of 3 to 12 mg per kilogram of weight. It must be remembered that the course of treatment can only be stopped when negative test results are obtained.
Features of the use of "Futsis" in the form of dispersed tablets
In the form of dispersed tablets, Futsis DT is available. Instructions for use advise before use to dissolve the pill in a teaspoon of water, if the tablet is 50 mg. In this form, the drug is allowed for use by adults as well as babies from the age of three.
If there is a candidal infection in the oral cavity, it will be necessary to dissolve the drug in an amount of 50-100 mg in a small amount of water and rinse the oral cavity. Then the solution must be swallowed. This procedure must be done once a day for two weeks.
For other indications, the drug is prescribed according to generally accepted recommendations.
The instructions for use should be carefully studied by patients with reduced immunity to Futsis DT, tablets for such patients will have to take much longer.
The use of "Futsis" in the form of a gel and solution
If a woman is diagnosed with thrush, then a gel can be used for treatment. It must be remembered that it is advisable to take therapy simultaneously with a partner. In 1 gram of the drug contains 5 mg of the main active substance.
The Futsis gel is very convenient to use, and the instructions for use recommend once lubricating the affected areas with the fungus. Before you spread the gel, you need to cleanse the skin. Numerous reviews confirm the effectiveness of the drug in this form, only the duration of therapy is slightly increased.
It is impossible to use “Futsis-gel” during pregnancy, the instructions for use with thrush allow it to be used only when the risk from such therapy is lower than the threat to the fetus.
The gel can also be used to treat oral candidiasis in young children. Just do not prescribe such therapy on your own, you need a specialist consultation.
If there is a need to use the drug "Futsis" in the form of a solution for infusion, then for adults and children over 3 years the dosage does not change. It is necessary to pay attention to the treatment regimen in babies. If administration to a newborn no older than 4 weeks is required, the drug is prescribed in the same doses as the older ones, but it is administered only once every three days. This is taking into account the fact that the elimination of the drug is much slower from the body.
From 4 weeks to three years, the medicine must be administered in the same dosage, but once every two days. When treating babies with Futsis, it is necessary to carefully monitor the condition of the child and the manifestation of undesirable effects.
Interaction of "Futsis" with other medicines
If you take the drug at the same time as anticoagulants, then the effect of their use is enhanced, therefore, during such therapy, prothrombin time should be regularly monitored.
There is a risk of developing psychomotor reactions if Fucis is prescribed at the same time as Midazolam. Acceptance of the preparations "Benzodiazepine" and "Futsis DT" recommends that the instructions for use be carried out under the strict supervision of a doctor.
On the background of fluconazole therapy, when taking Cisapride, side effects are more pronounced, especially from the cardiovascular system. It is because of this that these two drugs are not prescribed at the same time.
It is necessary to adjust the dosage of Cyclosporine while treating it with Futsis, since there is an increase in plasma concentrations of the first drug.
In practice, there was no decrease in the effectiveness of hormonal contraceptives when taken with Futsis. If Rifabutin is being treated, then adding fluconazole can lead to the development of inflammatory diseases of the choroid.
In patients with diabetes mellitus, taking Fucis helps to increase the period of sulfonylurea elimination, therefore there is a risk of hypoglycemia.
Patients suffering from kidney disease should carefully approach the treatment with this drug, as there is a danger while taking Tacrolimus while enhancing nephrotoxicity.
Absorption of the drug is independent of food intake or antacid preparations.
Some guidelines for therapy "Futsisom"
We have already considered side effects that may occur during therapy with this drug. This does not mean that they will certainly appear, but it is necessary to know about them.
But there are still some special instructions for the use of Futsis. If the patient suffers from serious liver diseases, then you should not take risks when prescribing treatment with this drug. There were cases when such therapy ended in death, since toxic liver damage began.
The hepatoxic effect is reversible, and if you notice and cancel the drug on time, then all indicators return to normal.
Futsis can provoke anaphylactic reactions in some patients, therefore, patients from this risk group must be kept under medical supervision.
Patients diagnosed with AIDS are most often exposed to the development of skin reactions, which occur in a fairly severe form. If the appearance of a rash on the body is associated with treatment with Futsis, then its reception must be canceled.
If rashes appear in patients with invasive systemic fungal infections, careful monitoring is necessary. And with the development of erythema multiforme, therapy should be discontinued.
In patients with problems in the work of the cardiovascular system, the use of this drug can provoke an increase in the QT interval on the cardiogram.In addition, ventricular flutter may occur. Most often, such undesirable manifestations were diagnosed in patients with organic heart diseases, electrolyte imbalances. If there is such a danger, then treatment should be carried out with great care, and if possible, it is necessary to think about replacing the drug.
If there are diseases of the liver and kidneys, even in the anamnesis, then, before proceeding with the Futsis therapy, it is worth getting a consultation from the attending physician. If a “Fucis” gel is prescribed, the instructions for use clarify that the desired effect will be achieved a little later than during treatment with tablets.
If several days have passed after the start of therapy, and there is no improvement in the condition, then it is worth informing the doctor about this. Maybe it happened that the fungi were incorrectly identified, and therefore the drug does not have the desired effect.
Any disease, even at first glance very simple, requires a thorough approach to treatment. Only a correctly selected drug can give a 100% guarantee of getting rid of the disease. Do not self-medicate, sometimes it is expensive for health.