The drug "Preductal" describes the instructions for use as a tool with antianginal and anti-ischemic effect. The active substance of the drug is trimetazidine hydrochloride. Among the auxiliary ones are calcium hydrogen phosphate dihydrate, magnesium stearate , hypromellose, anhydrous colloidal silicon, povidone.
The composition of the shell is as follows: E 171 (titanium dioxide), E 172 ( red iron oxide ), magnesium stearate, hypromellose, macrogol 6000, glycerol.
The drug "Preductal" is available in the form of tablets, characterized by a short duration. The active component of this tool stabilizes the energy metabolism of cells in the presence of hypoxia or ischemia. This is due to a decrease in the content of intracellular adenosine triphosphate.
The medicine "Preductal". Use in cardiology
In the course of clinical studies, it was found that the pharmaceutical agent in question should be prescribed both in complex and in monotherapy. It is indicated for the treatment of not only chronic, but also acute conditions.
The drug "Preductal" (instructions for use informs) after being absorbed into the digestive tract is absorbed quite quickly. The maximum concentration of the drug is reached after five hours. It is noted that the tool in question can be used regardless of food intake. The half-life is approximately seven hours. If the patient's age is more than sixty-five years, this period increases to twelve hours. Basically, the drug is excreted by the kidneys.
Taking the drug "Preductal", the instructions for use are recommended in the following cases:
- long-term treatment of coronary heart disease and prevention of an attack of angina pectoris (as part of mono-or complex therapy).
- elimination of tinnitus, dizziness, hearing impairment and other symptoms of cochleovestibular malfunctions of ischemic origin.
- therapy of chorioretinal vascular disorders with an ischemic component.
The medication in question is prescribed, as a rule, one tablet twice a day (preferably in the morning and evening hours). The duration of the therapeutic course is determined individually by the specialist.
As a result of the use of the drug, nausea, vomiting (rarely enough), as well as allergic reactions can occur.
The drug "Preductal" (instructions for use contains this information) is contraindicated in the presence of individual intolerance to its components, as well as during breastfeeding (if necessary, lactation must be stopped). He is also not prescribed during the expectation of the child, since there is no clinical data on the safety of using the drug at this time. In addition, for a similar reason, this medication should not be taken by patients suffering from impaired liver function, as well as patients with severe renal failure.
As a result of treatment with the agent under consideration, already on the fifteenth day in patients with angina pectoris, the coronary reserve increases, which prevents the occurrence of ischemic failures as a result of physical exertion. In addition, the number of angina attacks is significantly reduced.
As a result of the use of the pharmaceutical in question, digestive system disorders may occur.
The drug is recommended to be stored at an air temperature not exceeding thirty degrees Celsius.
The shelf life of the drug is six months. After its expiration, the drug should not be used.
In pharmacies, the drug "Preductal" can be purchased only with a prescription.