Cream "Advantan" is classified as a local glucocorticoid, it is intended for external use. The drug itself is produced in several medicinal options, for example, in the form of an ointment, cream and emulsion. We will consider the cream, analyze the instructions for use in detail, get acquainted with its analogues and find out what people write in reviews about this tool.
Cream composition
The active component in the composition of the cream "Advantan" is methylprednisolone aceponate. It is a non-halogenated synthetic steroid. Excipients are decyloleate along with glycerin, cetylsteryl alcohol, solid fat, softisan, polyoxyl, disodium, benzyl alcohol and purified water. The cream is white and almost opaque in color. As for the pharmacotherapeutic group, this drug is referred to as topical glucocorticosteroids.
What are the forms of release? “Advantan” cream is produced in aluminum tubes, which are closed with a plastic cap. One tube contains 15 grams of the drug. To a tube of cream in a cardboard box placed instructions for use.
Pharmacodynamics
According to the instructions for the Advantan cream, when used externally, the product can reduce the inflammatory and allergic reactions of the skin. It also inhibits reactions that are associated with enhanced proliferation. Thus, the use of a cream leads to a decrease in objective symptoms in the form of erythema, edema and lichenification. In addition, this cream eliminates subjective sensations in the form of itching, irritation and pain. Is Advantan Cream suitable for children? The instruction contains information about this.
With the external use of methylprednisolone aceponate in an effective dosage, the systemic effect is usually minimal. After repeated application of the product to large areas (from forty to sixty percent of the skin surface), as well as when using it under an occlusive dressing, as a rule, no adrenal gland dysfunctions are noted. Thus, the volume of cortisol in the blood plasma along with its circadian rhythm remains within normal limits. In addition, a decrease in cortisol levels is not observed in urine. During clinical trials with the use of Advantan for up to twelve weeks, no skin atrophy was detected in adult patients. Severe rashes were also not noted.
Methylprednisolone aceponate, especially its main metabolite, binds to glucocorticoid intracellular receptors. In turn, the steroid receptor complex binds to certain regions of DNA, which causes a series of biological effects. Binding of the receptor complex to DNA leads to the process of induction of macrocortin synthesis. The latter, in turn, can inhibit the release of arachidonic acids. Inhibition of prostaglandin synthesis leads to a vasoconstrictor effect.
Pharmacokinetics
As the instructions for Advantan cream indicate, methylprednisolone aceponate (the main component of the cream) is able to hydrolyze in the epidermis and dermis. The main and most active metabolite is methylprednisolone, which has a high affinity for corticoid skin receptors, which indicates its biological activation.
The intensity of absorption directly depends on the condition of the skin. Absorption in adolescents and adults who suffer from neurodermatitis or psoriasis is less than 2.5%. This differs insignificantly from absorption through intact skin.
After entering the systemic circulation, methylprednisolone conjugates rather quickly with glucoronic acids and then inactivates. The metabolites of the active component of the cream are eliminated mainly by the kidneys for about sixteen hours. Next, find out in what cases the patients are prescribed Advantan cream.
Indications for use
This tool is used against a background of inflammatory skin diseases. Indications for the use of Advantan cream are given below:
- The development of atopic dermatitis, neurodermatitis, or childhood eczema.
- The occurrence of true eczema.
- The development of microbial eczema.
- The presence of occupational eczema.
- The presence of dyshidrotic eczema.
- The appearance of simple contact dermatitis.
- The development of an allergic form of contact dermatitis.
- The occurrence of seborrheic dermatitis or eczema.
- The presence of photodermatitis or sunburn.
What else does the application instruction for Advantan cream tell us?
Contraindications
The presented cream is not suitable for use in a number of the following cases:
- The presence of tuberculosis or syphilitic processes in the field of application of the drug.
- The presence of viral diseases in the area of ​​application of the drug. For example, this cream can not be used for chickenpox, as well as for the appearance of shingles.
- The presence of rosacea or perioral dermatitis in the area of ​​application of the drug.
- You should not apply this cream to areas of the skin with manifestations of reactions to vaccination.
- “Advantan” cream is not suitable for children under the age of four months.
- The presence of hypersensitivity to the components of the cream.
Dosage and administration
In accordance with the instructions for use, the cream "Advantan" is used once a day. A thin layer is applied to the affected foci of the skin. As a rule, the duration of continuous daily therapy with Advantan should not exceed twelve weeks for adults. For children, the duration of continuous treatment should not exceed four weeks. According to reviews, the cream "Advantan" is suitable for children.
Since the composition is a therapeutic form with a low fat content, its use is advisable in the treatment of almost any acute inflammatory process. The drug is especially good for treating the wetting stage of eczema against oily skin. In addition, it is suitable for use in the localization of pathological processes not only on smooth skin, but also on hairy areas. Cream "Advantan" from allergies also quickly relieves.
Side effect on the background of the use of the drug
Usually, as practice shows, this drug is well tolerated by patients. In isolated cases, local reactions are sometimes observed in the form of itching, burning, erythema and the formation of vesicles. Similar to the external use of other glucocorticosteroids, with the use of this drug, in rare cases, phenomena such as folliculitis along with hypertrichosis, perioral dermatitis and allergic reactions to one of the components of the drug can be observed. This is confirmed by the instructions and reviews for the cream "Advantan".
Overdose
In the study of acute toxicity of the main component of the cream (methylprednisolone aceponate), no risks of acute intoxication were revealed against the background of excessive single skin use (when applying the product to a large area under favorable conditions for absorption). As a result of unintentional ingestion, no risks should also be detected.
Against the background of an excessively long and intensive local use of glucocorticosteroids, skin atrophy can develop, as a result of which it is likely to thin out a bit. In case of skin atrophy on the background of this kind of overdose, the drug must be canceled.
Which is better - cream or Advantan ointment? About it further.
Precautionary measures
In the presence of bacterial dermatosis or dermatomycosis as a supplement to the Advantan treatment, it is advisable to carry out specific antibacterial therapy. In the event that the skin is too dry against the background of prolonged use of Advantan cream, then it is necessary to switch to the medicinal option with a higher content of fat in the agent. For example, Advantan ointment is perfect for these purposes.
It is very important to avoid getting this drug in your eyes. Similar to cases with systemic corticosteroids, glaucoma may occur after using large doses of this medicine. Against the background of too long use, as well as when applying the cream to the skin around the eyes, there are also risks of undesirable reactions.
Indications cream "Advantan" must be strictly observed.
Pregnancy
If you need to use Advantan cream against the background of pregnancy or feeding, you must carefully weigh the potential risks with the expected benefits of the treatment. At this time, women are not recommended to use this drug for a long time on extensive skin surfaces. Doctors do not recommend nursing women to apply cream on the mammary glands.
Many are interested in the hormone cream "Advantan" or not?
Storage conditions
The presented cream is stored at a temperature that should not exceed twenty-five degrees for three years. The medicine is stored in places inaccessible to children. This product must not be used after the expiration date indicated on the package.
This cream can be purchased at any pharmacy without a medical prescription.
Advantan cream or ointment - which is better?
For dry skin, it is better to choose an ointment, it is on a fat basis. With chronic ailments, this form will be more effective. For weeping areas, cream is used. It does not retain fluid and does not provoke a thermal effect.
Structural analogs
Analogs that contain the same active ingredient as the main medicine are called structural. One structural analogue of Advantan cream is Metizolon. Indications for its use are the presence of atopic dermatitis, as well as any eczema in patients, regardless of their age. Contraindications to the use of this drug are in many respects similar to those described in the instructions for Advantan. Among them, individual intolerance is indicated along with skin diseases of viral etiology, tuberculosis, syphilis and allergic reactions to the components of the drug.
At the beginning of pregnancy, this analogue categorically can not be used. During feeding, it can be used only after consultation with your doctor. Apply the cream, as a rule, to the affected areas once a day with a thin layer. Adult patients should not use Metizolon for more than two weeks.
Another structural analogue of Advantan is a cream for external use called Sterocort. This composition is allowed for children from six months of age, and it is often prescribed for the treatment of diaper dermatitis. In addition, among the indications for using this medication is called neurodermatitis, along with contact and atopic dermatitis.
Both of the structural analogues of Advantan presented are able to completely replace it. Directly at cost, they are even slightly cheaper. For example, Metizolon can be bought at a pharmacy for about two hundred rubles. For comparison, it is worth noting that Advantan will cost the buyer six hundred rubles per tube.
Among the creams "Advantan" has no analogues. The remaining funds, similar to it in indications for use, differ in the other active substance in their composition. In this regard, their appointment must necessarily be coordinated with a dermatologist.
Non-structural analogues
Among the non-structural analogues of this cream, the following medications are as close as possible to it by the method of its effect, as well as by indications:
- Means "Beloderm". This cream is made on the basis of betamethasone. It is used to combat dermatitis, eczema, psoriasis, lichen, lupus erythematosus and erythema. Beloderm cannot be used for pathologies such as tuberculosis, syphilis, viral diseases, fungal infections, wounds and ulcers, as well as for tumors on the skin. This product is allowed for children from six months of age, but it is forbidden to apply it to the skin under dressings or diapers. Thus, Beloderm is a drug with a wider range of effects compared to Advantan, but it is quite capable of replacing it. In the role of structural analogues of Beloderm, Betamethasone is usually used along with Betazone, Betlibene and Mesoderm.
- Cream "Eloson". This drug is made on the basis of mometasone. It is used to eliminate itching and skin redness, it is also suitable for the treatment of dermatitis, eczema and psoriasis. You can not use "Elozon" in relation to babies up to two years, and in addition, to persons suffering from an allergic reaction to the main components of the cream. This product is applied to the skin once a day. Therapy lasts no more than twenty days. During the period of gestation, this drug can be used only in cases of emergency. Analogues of "Eloson" are such drugs as "Moleskin" along with "Momezon" and "Elokom".
- The drug "Prednitop." This is an inexpensive analogue of Anvantan cream. The main component is predicarbat. This tool is used to treat skin inflammation, as well as eye pathologies. In the treatment of fungal and bacterial infections, Prednitop should be combined with antibacterial drugs. This cream should not be prescribed to infants. The main contraindications include some bacterial and viral pathologies along with individual intolerance. Sometimes, against the background of using this cream, side effects occur in the form of skin redness, itching, poor wound healing, and so on. During pregnancy, it is better to refuse to use this medication. The therapeutic composition is applied to the skin only once a day. If necessary, the dosage can be increased to two times the use. The general course of treatment is usually two weeks.
- Means "Flucin". The main active ingredient in this case is fluocinolone acetonide. This ointment is actively used to treat eczema, psoriasis, seborrheic dermatitis and lichen. Among the contraindications are diseases that are caused by fungi, and in addition, various bacteria and viruses. This analogue is not suitable for children whose age is less than two years. Against the background of the use of this ointment, side effects may appear, allergic symptoms that occur on the skin are predominantly noted. In the event that this drug gets into the eyes, itching may occur. As a result of prolonged exposure, the development of glaucoma or cataracts is not ruled out. This medicine is completely prohibited for pregnant women. Flucinar ointment is applied to the skin once a day, and the total duration of therapy is usually no more than two weeks. The analogues of this drug are Sinaflan and Flutsar.
- Cream "Kutivate." In that case, if a person is looking for a cheap substitute for Advantan, then it is advisable to use Kutiveyt cream. The role of the active component is fluticasone propionate. The spectrum of action of this cream is very wide. For example, it can be used for diseases such as dermatitis along with eczema, psoriasis, lichen, lupus, erythroderma, and this composition also helps with insect bites. Cream "Kutivate" is suitable for babies, but after a year. Contraindications to the use of this medication are individual sensitivity, the presence of acne, viral and fungal infections. Also, this cream is not suitable for use with perioral dermatitis. To apply this tool should be on the affected area of ​​the skin no more than twice a day. This drug is not allowed to be used for more than two weeks.
- Means "Lacking". The main active ingredient of this medicine is halobetazole. This drug is used for dermatoses, in addition, it is effective against the background of dermatitis, eczema and psoriasis. For children under the age of twelve, this cream is strictly contraindicated. The presented preparation should be applied in a thin layer. You can use the cream no more than twice a day. You can not use this tool for more than two weeks. It is also not recommended to use the cream “Halovat” for acne, skin diseases that are caused by fungi, pathogenic bacteria or viruses. Against the background of its use, the occurrence of side effects in the form of itching and redness is not ruled out.
Reviews about analogues and pricing
All of the above analogues differ not only in the spectrum of their impact, but also in price. So, for example, Beloderm differs little in value from Advantan. It, like Advantan, can be purchased for six hundred rubles. "Elozon" is sold for four hundred rubles per tube. And Afloderm will cost the buyer five hundred rubles.
All reviews about Advantan, as well as its analogues, are extremely contradictory, which proves that the drug should be replaced only with the permission of the doctor. , .
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