The medicine "Reopyrin" is a comprehensive tool. A medication is available in the form of a dragee and an injection solution. The composition of the drug contains aminophenazone and sodium phenylbutazone. The medicine has a pronounced analgesic and anti-inflammatory effect. With oral administration, a high absorption rate is observed. The active components bind to plasma proteins by 98%. The average elimination half-life is about 77 hours. About 27% of the drug is excreted in feces, approximately 61% in urine.
Appointment
Indications include non-infectious arthritis of various nature of occurrence. Among the pathologies in which the Reopirin is recommended, the instruction indicates lumbago, retinitis, iridocyclitis, iritis, and parametritis. Prescribe medication for polyserositis (on the basis of severe pain), pericarditis, adnexitis, polyneuritis. The tool is used to eliminate manifestations of pathologies of extraarticular soft tissues and spine, neuralgia, neuritis.
Medication Reopirin. Instructions for use
With rheumatic pathologies, the drug is recommended orally per day for four to six tablets. Therapy is continued until the symptoms are completely eliminated. Means "Reopyrin" (injections) for these diseases are administered in 5 ml every day or with a break per day. The injection is carried out deep into the buttock for one to two minutes using a long needle. With adnexitis or parametritis, the drug is recommended intramuscularly. The dosage is also 5 milliliters. The duration of the course is four or five days. For children from 7 to 14 years of age, the drug “Reopyrin” (the instructions for use contain such information) is administered orally in half or a whole dragee per day or injected into the muscle 0.5-1 ml every other day or every day.
Side effects of the medicine
The drug "Reopyrin", reviews of patients about which after the treatment in most cases are positive, with medical prescription, is well tolerated. However, side effects in some patients were noted. A medication can cause negative consequences from the hematopoietic system. In particular, thrombocytopenia, leukopenia or anemia occurs. With prolonged therapy in high doses, agranulocytosis develops. These manifestations are relatively rare. Based on the treatment, tachycardia, increased stool, and lesions in the digestive system of an erosive ulcerative nature are likely. Some patients have epigastric pain, vomiting, drowsiness, urticaria, and nausea. Undesirable effects include increased stool, sodium and water retention, and skin rash. When treated with Reopirin (the instructions for use warn about this), hematuria, glucosuria, tubular renal necrosis are likely (with prolonged use at an increased dose). From local reactions, an abscess in the injection site or painful sensations is observed.
Contraindications
The drug "Reopyrin" instructions for use does not allow for defects, heart rhythm disturbances, chronic cardiomyopathy. They do not recommend medicine for edematous syndrome (including a history), hypersensitivity to components, pathologies of the hematopoiesis system.
Prescribing the drug to pregnant and lactating
In the prenatal period, therapy is allowed if there are strict indications. Due to the enhancement of chromosomal aberrations (mutations) in lymphocytes under the influence of Reopirin, the instructions for use recommend strict medical monitoring of the patient’s condition. Safety during lactation has not been established. If necessary, carry out treatment during this period should stop feeding.
Additional Information
Prescribing medication to children is carried out in exceptional cases. The therapy is carried out under stationary conditions under the supervision of a doctor. In the process of treatment, it is necessary to ensure strict monitoring of urine, peripheral blood, and liver activity. Parenteral administration is not recommended for susceptibility to epilepsy. On the basis of prolonged treatment, a weekly monitoring of the number of leukocytes should be carried out.
Overdose
The state of intoxication is manifested by vomiting (most often with blood impurities), convulsions (in children), psychosis, hallucinations. The use of high doses of the drug provokes liver failure, jaundice, disorders of the hematopoietic system, ECG changes. These phenomena become pronounced in two to seven days. Poisoning is also accompanied by high temperature, disturbances in electrolyte metabolism. In the absence of a specific antidote, standard measures are recommended.
Are there any analogues of Reopirin?
To begin with, it should be said that, despite the high efficiency, the medication was withdrawn from sale in Russia. Exact analogues of Reopirin are also not available. Perhaps the only drug that has a similar effect is the Butadion medicine. This remedy contains phenylbutazone present in Reopirin.