In the article, we consider the instructions for use with Paracetamol Extratab.
Pain and fever are characteristic signs of an inflammatory reaction, and therefore drugs that can stop pathogenic manifestations are constantly in demand. Paracetamol has long remained a popular drug that is prescribed for various diseases manifested by hyperthermic and pain syndrome - its use is rarely accompanied by side effects from the patient’s body systems, and the medication can be prescribed at any age in the appropriate dosage.
During treatment, it must be remembered that the drug does not eliminate the direct cause of the disease. The drug is recommended in the form of symptomatic therapy, which can temporarily cope with the signs of the pathological process, and therefore its use should be short-lived. The effectiveness of treatment should be evaluated by a qualified doctor - only a specialist is able to correctly assess the risks of therapy and prescribe the effective dosage required by the patient, as well as timely see unwanted changes in his condition.
Thanks to ascorbic acid, the permeability of blood vessel walls, as well as the synthesis of a number of hormones in the human body, is regulated - due to this, the effect of paracetamol is potentiated.
Clinical trials and experiments have shown that two components of the drug in their combination potentiate the effect of the drug. This favorably affects the patient's condition - the likelihood of side effects that develop with the use of vitamin C and paracetamol is reduced.
Composition "Paracetamol Extratab"
One tablet has the following composition: active ingredients - 0.5 grams of paracetamol, 0.15 grams of ascorbic acid; excipients: hypromellose (hydroxypropyl methylcellulose), macrogol 6000 (polyethylene glycol 6000), stearic acid, corn starch.
Description: the drug is available in the form of tablets from white to yellowish-white, oblong biconvex with a dash on one side and rounded ends. A small “marbling” of the product is acceptable.
In the package "Paracetamol Extratab" 500mg + 150mg, 20 tab. either 10 tablets.
Indications for use of this drug
We will figure out in which cases the drug is prescribed.
"Paracetamol Extratab" is prescribed to patients in the following situations:
- in the diagnosis of hyperthermic syndrome in humans of varying severity, especially when high temperature is a symptom of inflammatory and infectious diseases (influenza, acute respiratory viral infections, respiratory infections);
- with the appearance of a pain syndrome (moderate or weak severity), which accompanies dental pathology;
- for the treatment of headaches accompanying various diseases;
- in the form of a symptomatic drug that can relieve joint and muscle pain;
- with pain, which accompanies cyclic changes in menstruation;
- with neurological pathologies.
In each case, the patient should discuss with the doctor the feasibility of using Paracetamol Extratab medicine - his instructions for use say that the treatment course should be as short as possible, and without the appointment of a doctor it is forbidden to take the drug for more than three days in a row.
Pharmacodynamic properties of the drug
According to the instructions, "Paracetamol Extratab" is characterized by antipyretic and analgesic effects. The drug blocks 1 and 2 cyclooxygenase mainly in the central nervous system, affecting the centers of thermoregulation and pain. Cellular peroxidases in inflamed tissues neutralize the effect of the substance on cyclooxygenase, which explains the almost complete absence of an anti-inflammatory effect in paracetamol.
The tool does not adversely affect the retention of water and sodium (water-salt metabolism) and the mucous membrane of the intestines and stomach, due to the absence of effects on prostaglandin synthesis in peripheral tissues.
The formation of methemoglobin is unlikely.
Vitamin C (ascorbic acid) in the human body is not formed, it comes only with food. Physiological functions: acts as a cofactor in a number of amidation and hydroxylation reactions - transfers electrons to enzymes, endowing them with a reducing equivalent.
It takes part in the reactions of hydroxylation of lysine and proline residues of procollagen with the formation of hydroxylisine and hydroxyproline (post-translational collagen modification), oxidation of lysine side chains in proteins and the formation of hydroxytrimethyl lysine in the process of synthesis of folic acid and metabolism to metabolism and metabolism the formation of norepinephrine. It enhances the activity of amidating enzymes that take part in the processing of cholecystokinin, antidiuretic hormone and oxytocin. Participates in the adrenal glands in steroidogenesis. The main significance at the tissue level is the role in the synthesis of proteoglycans, collagen and other organic elements of the intercellular substance of bones, teeth and capillary endothelium.
Instruction "Paracetamol Extratab"
In combination with vitamins C, "Paracetamol" is administered orally. Patients after twelve years of age and adults are prescribed one tablet of the drug every six hours (depending on the severity of symptoms), but the daily dosage of Paracetamol Extratab should not exceed four tablets (in terms of acetaminophen 2000 mg).
For children from six to twelve years of age, the drug is given half a tablet three to four times a day. Up to six years, the medication is not prescribed for patients - in this age category they use analogues that are available in the form of syrups or suppositories (the dosage is determined by the weight of the child).
When recommending a drug for pain relief, it is recommended to use the medicine for a maximum of five days in a row. If the patient has hyperthermia, the medication is limited to three days.
Contraindications
"Paracetamol Extratab" is undesirable to appoint in the following cases:
- when diagnosing a patient with serious chronic diseases of the kidneys and liver, accompanied by a violation of the activity of these organs;
- if the patient has changes in the functioning of the hepatic enzymatic systems;
- with exacerbation of inflammation processes that affect the digestive system;
- during bleeding of the intestines and stomach;
- during breastfeeding and bearing a child;
- with individual sensitivity to a particular substance in the composition;
- against the background of genetic hyperbilirubinemia that accompany Gilbert syndrome, Dubin-Johnson and Rotor;
- with defects in hematopoiesis (mechanism for the production and maturation of shaped blood elements);
- when diagnosing a patient with genetic anemia;
- in patients who abuse alcohol;
- with bronchial asthma, especially in forms whose nature is worsened by the use of NSAIDs.
Drug treatment is prohibited in case of individual intolerance of the patient's body to any substance that is part of the drug.
Precautions for use
What else does the instructions for use with Paracetamol Extratab tablets tell us? For patients under six years of age, the drug is not prescribed - in this age category, candles and syrups are recommended, which include paracetamol (Cefecon, Efferalgan, Panadol).
If complex therapy lasts more than five days, but the expected effect is not achieved, a doctor’s consultation is mandatory.
When prescribing Paracetamol Extratab for more than five days, mandatory monitoring of the general blood test is required. Patients suffering from liver pathologies (hepatoses, cirrhosis, hepatitis), it is necessary to monitor the performance of liver samples.
During treatment, it is undesirable to donate blood for uric acid and glucose - the drug distorts the result of tests that are aimed at diagnosing gout and diabetes.
Patients suffering from addiction to alcohol, it is undesirable to prescribe "Paracetamol" - the drug provokes toxic liver damage.
During treatment, there is no need to refuse to drive a vehicle - the drug does not affect the concentration of attention.
Cross Interactions with Other Medicines
Before starting therapy, it is necessary to inform the doctor about all the medicines that are taken by the patient - compliance with this recommendation will avoid negative effects.
As indicated by the instructions for use, "Paracetamol Extratab" with vitamin reduces the effectiveness of drugs prescribed for the treatment of gout.
If it is prescribed simultaneously with indirect anticoagulants, the chance of developing serious bleeding increases due to acetaminophen.
The drug can not be prescribed along with other NSAIDs to patients who suffer from kidney failure - this increases the risk of complications associated with this organ.
Intestinal sorbents (Atoxil, Enterosgel) impair the absorption of Paracetamol in the intestine.
With the simultaneous use of "Paracetamol" and drugs that affect the liver enzyme systems, the concentration of the active substance of the first can sharply increase, even with a small overdose.
In combination with alcohol, acetaminophen negatively affects the liver, causing pancreatic disorders.
The absorption and absorption of iron, which is contained in medicines and food, is increased due to vitamin C, but negatively affects the metabolism of anticoagulants and activates blood coagulation.
Alkaline mineral waters, contraceptives, aspirin and freshly squeezed juices reduce the absorption of ascorbic acid. Steroid hormones that are produced by the adrenal cortex, NSAIDs of other groups and calcium chloride accelerate the excretion of vitamin C.
Side effects
The drug "Paracetamol Extratab" provokes the following side effects:
- from the gastrointestinal tract: stool disorders, vomiting, pain in the stomach, nausea, causes symptoms characteristic of pancreatitis and cholecystitis;
- from the hemopoietic organs: leukopenia, anemia;
- from the immune system: urticaria, rashes, anaphylactic shock;
- from the central nervous system: weakness, weakness.
Vitamin C is able to affect the hematopoietic system (leukocytosis, anemia), increase the concentration of sugar in the blood serum.
Overdose symptoms
If the recommended dosage of Paracetamol is significantly exceeded, the drug may cause:
- skin pallor and a decrease in blood pressure;
- vomiting, abdominal pain, nausea, poor appetite;
- dizziness, headache;
- defects in the functioning of the kidneys and liver.
An overdose of vitamin C has the following manifestations:
- frequent urination
- sleep disorders
- disorders of the stool, vomiting, abdominal pain of a spilled character, nausea;
- a sharp decrease in glucose in blood serum.
The specific antidote (antidote) of Paracetamol Extratab is methionine or acetylcysteine - these drugs activate liver enzymes, forced diuresis is prescribed to treat poisoning provoked by vitamin C.
Cost
Paracetamol Extratab in Salekhard and Moscow can be purchased at a price of 50-80 rubles. for packing. It depends on the pharmacy network.
Analogs
Efferalgan, Panadol and other drugs that contain acetaminophen are similar in composition to the drug.
- "Panadol." The main active ingredient is paracetamol. It is produced in the form of coated tablets, instant tablets, tablets with accelerated release of paracetamol, rectal baby suppositories and intended for oral administration of syrup.
- "Panadol", unlike "Paracetamol", is a one-component remedy, however, the list of indications, complications and contraindications is identical. The main advantage of the drug is the ability to choose a convenient form of release for each patient. Disadvantages: the price of the medicine is slightly higher than that of Paracetamol Extratab.
- "Efferalgan." It is produced in the form of effervescent tablets and rectal children's suppositories, as well as syrup.
In the line of drugs you can find both a single-component agent and a complex drug, which contains vitamin C and paracetamol.
Advantages: the ability to choose the form that best suits the patient. Cons: the cost of the drug is several times higher than that of Paracetamol Extratab.
Reviews about this medicine are presented below.
Reviews
Patients, among the advantages of the remedy, note: high efficiency, quick action, lowering heat and relieving pain. The drug helps, while vitamin C in the composition is clearly not superfluous. Some patients say that it is an inexpensive and reliable remedy for flu and colds.
Among the shortcomings are noted: the absence of the claimed effect, high price, the appearance of side effects. Patients believe that he is no better than the usual "Paracetamol."
Sometimes a medicine causes a severe allergic reaction, and people also don’t like the bad taste in their mouth after taking it, even if the drug helps.
We reviewed the instructions for use with Paracetamol Extratab.