"Fluconazole" is used to treat infectious diseases of the oral cavity, intestinal system, genitals and human blood. According to reviews of Fluconazole, it is also used to treat infections caused by fungi in patients whose immune system is very weakened as a result of cancer treatment, organ transplants, or other serious diseases.
Release form
"Fluconazole" is produced in capsules of 50 or 150 mg. The capsules contain a powder of white or almost white.
The cost of "Fluconazole" starts from 10 rubles for a drug containing 150 mg of active substance. Knowing the price of the drug, it can be calculated that the use within six months will cost from 250 to 400 rubles. The price of the medicine depends on the manufacturer. Given that during treatment it will be necessary to use solutions and ointments, it can still be assumed that every person can cure the infection caused by the fungus with the help of Fluconazole, despite its financial condition.
pharmachologic effect
Doctors give positive reviews about Fluconazole as an antifungal drug that has a specific effect on blocking the conversion of lanosterol of fungal cells to ergosterol and increasing the permeability of the cell membrane to disrupt its growth.
"Fluconazole" does not have antiandrogenic activity, that is, it does not reduce the level or activity of male hormones in the human body.
Pharmacokinetics
The drug is well absorbed. Eating does not affect the absorption rate of the drug. According to reviews on the use of "Fluconazole", it quickly penetrates into all liquid media (joint fluid, saliva, urine, breast milk) of the human body. The required value in vaginal secretion is achieved eight hours after ingestion and remains at this level for more than a day. "Fluconazole" penetrates the fluid of the spinal cord. This is important for treating fungal meningitis. The drug is excreted mainly by the kidneys, while 4/5 of the volume of the drug is excreted unchanged.
Indications
"Fluconazole" is prescribed in the following cases:
- Treatment of cryptococcosis.
- Therapy of generalized candidiasis. According to reviews of Fluconazole, treatment with the drug can be carried out in patients with poor-quality new formations, sick people from intensive care units, people undergoing a course of cytostatic or immunosuppressive treatment, if there are reasons predisposing to the development of candidiasis.
- Treatment of candidiasis of the mucous membranes, including the oral cavity and pharynx, the food system, non-invasive bronchopulmonary candidiasis and relapse of oropharyngeal candidiasis in patients with AIDS.
- Therapy of genital candidiasis.
- Therapy of infections caused by fungi in patients with malignant new formations.
- Mycosis treatment.
- Treatment depriving.
Candidiasis Treatment
A disease that begins due to yeast-like fungi that affects the internal organs and external integuments of the human body is called candidiasis. Women most often suffer from genital candidiasis or, in other words, thrush. This is a very common occurrence. Symptoms of this disease are as follows:
- burning and unpleasant odor in the intimate area;
- curdled discharge;
- swelling, inflammation of the genital organs;
- pain during urination;
- pain during intercourse.
If these symptoms are present, women are advised to undergo a comprehensive examination with a gynecologist, find out the causes of the disease and begin immediate treatment. The cause of genital candidiasis in women is the inflammatory process, provoked by a decrease in the number of beneficial bacteria in the vagina and intestines and weakening of the woman's immunity. Gynecologists distinguish the following causes of candidiasis in women:
- acute lack of vitamins;
- acute lack of estrogen;
- impaired immunity before menstruation;
- regular douching;
- poor nutrition;
- intestinal and vaginal dysbiosis;
- regular overwork and stress;
- violation of personal hygiene;
- passive lifestyle;
- antibiotic therapy, hormone pills;
- use of synthetic underwear;
- frequent use of antibacterial agents to care for the genitals.
Today, pharmacies have a large selection of drugs for women with genital candidiasis. In most of these drugs, the active substance is fluconazole. According to women, "Fluconazole" treats thrush promptly and effectively. Prices for medicines for thrush can differ from each other by several times.
According to reviews, "Fluconazole" from thrush is easy to take. If the disease arose for the first time, then it is enough to take the drug once in a dosage of 150 mg. After a few days, it is permissible to take another capsule of the medication. You can supplement the treatment using various vaginal tablets, suppositories, creams for local treatment of the genital organs. The main thing is to remember, despite the positive reviews of Fluconazole from thrush, any drug can be used only as directed by your doctor. The gynecologist appoints the treatment regimen depending on the severity of the symptoms of the disease, the presence of other diseases. Remember, genital candidiasis is often combined with other genital infections. According to women, "Fluconazole" is often used for thrush, and the treatment is well tolerated, without side effects. In 15% of cases, young women are disturbed while taking the drug, digestive system disorders and allergic reactions in the form of a skin rash. Before using the antifungal agent "Fluconazole", all contraindications must be taken into account. It is best to read reviews on how to take Fluconazole, or consult your doctor.
Unfortunately, 5% of women develop chronic candidiasis, which is very problematic to treat. Relapses of thrush begin to occur regularly. A single dose of Fluconazole is not enough, then a gynecologist usually prescribes longer treatment regimens. For example, "Fluconazole" can be taken twice a week for two weeks, then once a month for six months at 150 mg.
Nail fungus treatment
People suffering from nail fungus experience acute discomfort. A person should choose a medication for nail fungus that can penetrate the nail, destroy all harmful spores of the fungus and traces of its activity. Modern medicines for nail fungus are available in various forms: solutions, ointments, capsules and tablets. External use of medicines, as a rule, can only help at the initial stage of infection and subject to strong immunity and the absence of other skin diseases. The fungus on the nails, as a rule, is already detected upon infection of the predominant part of the nail; at this stage of the disease, it is necessary to include an antifungal medication that acts from the inside of the body and negatively affects the development of fungal spores, preventing their negative impact on other organs. "Fluconazole" from a fungus on the legs, according to many doctors, is a domestic highly effective medicine. There are several stages of infection of human nails with fungi:
- At the initial stage, the nail slightly changes color, loses its luster.
- In the second stage, the nail thoroughly changes color, becomes brittle and brittle, itching and irritation appear.
- At the last stage, a systemic change in the nail becomes very pronounced, a strong pain syndrome appears. Treatment becomes mandatory. The attending physician usually prescribes, according to reviews, "Fluconazole" in capsules or tablets.
The presence of a fungal infection on the nails will deliver many negative points to any person suffering from this disease for a long period. And the point here is not only the discomfort experienced by a person, but also a cosmetic defect. This drawback reduces a person’s self-esteem, forcing to worry and hide their affected nail from prying eyes. According to reviews, "Fluconazole" quickly, efficiently and safely relieve a person from this disease.
Another indisputable advantage is the low cost. For the entire period of treatment, sometimes taking up to one and a half years, you can spend about one and a half thousand rubles on medicines. Due to the operational effectiveness of Fluconazole, it is prescribed in a small dosage: one tablet per week. Instructions for use of "Fluconazole" from nail fungus, according to reviews of people suffering from this disease, speaks of contraindications. Although in the treatment of nail mycosis with a dosage of 150 mg once a week, the negative consequences are not worth much fear.
According to reviews of Fluconazole from a fungus, it helps to cure nail infection. Many patients are satisfied with the convenient use of the drug, since there is no need to remember the need to drink the medicine every day, just select one day a week and take the medicine on these days. According to reviews of "Fluconazole" from the fungus, it destroys the walls of the fungal spores. This subsequently leads to a deterioration in life, and then to the subsequent death of the fungus. The drug kills not only fungi in the nails, but also fungal infections, that is, affected interdigital areas on the feet. When using "Fluconazole" other means should be excluded from therapy. For greater effectiveness of the drug it is necessary:
- apply it using external agents such as ointments, emulsions and solutions;
- do soap baths;
- to remove the layer of the nail plate from above;
- apply antifungal solutions;
- avoid re-infection.
Patients who opted for Fluconazole indicate restoration of the nail plates within a few months after the first use of the drug. We list the advantages of the medication in the treatment of nail fungus:
- lack of severe side effects;
- a small number of contraindications;
- convenient method of use (capsule per day);
- the ability to change dosages according to the age of the patient;
- lack of concomitant complications;
- therapy of mycoses of the foot and hands with one drug;
- reasonable cost.
Stop the use of the drug at the slightest appearance of improvement in the nail is prohibited. The fungus at the beginning of treatment is not yet completely destroyed, it will again begin to multiply after all the components of the drug cease to affect the body and their action stops. Complete cure of the nails on the hands occurs in six months of use, toenails acquire a healthy look in a year or a half. Negative feedback on the instructions for "Fluconazole" from nail fungus is often left by patients who have not completed the entire course prescribed by the doctor. Remember, this medicine for nail fungus is not recommended for people with serious damage to such important internal organs as the liver, heart. This is very important information that should not be neglected.
Studies in Finland, USA have shown that Fluconazole cures candida nail fungus and, in addition, effectively helps with foot nail fungus caused by red trichophyton.
Contraindications
According to reviews of the instructions for fluconazole tablets, it identifies contraindications for taking the drug:
- Hypersensitivity to the drug.
- The simultaneous use of terfenadine and drugs that extend the QT interval.
- Age to four years.
According to reviews of Fluconazole, it should be taken with caution in the following cases:
- Poor functioning of the liver, kidneys.
- The appearance of an allergy in the form of a rash on the background of the use of the drug.
- Concomitant use of potentially hepatotoxic drugs.
- Treatment of patients with risk factors that cause arrhythmia.
- Pregnancy. The use by pregnant women is impractical, with the exception of life-threatening forms of fungal infections, when the benefits of taking Fluconazole for a woman outweigh the risk for the unborn child. The concentration of the drug in the mother’s milk and in the plasma is the same; it is contraindicated to use "Fluconazole" during breast-feeding.
Dosage
"Fluconazole" is taken orally according to the following scheme:
- Adults and children over fifteen years old with cryptococcal infections take eight capsules of 50 mg on the first day, and in the next four to eight capsules of 50 mg once a day. The duration of treatment is determined by the attending physician.
- Patients with AIDS, for the prevention of relapse of cryptococcal meningitis, take a medicine in four capsules of 50 mg per day for a time determined by the doctor.
- Patients in the treatment of candidiasis take the drug on the first day, eight capsules of 50 mg, and in the next four to eight capsules of 50 mg once a day.
In case of an overdose, hallucinations and the corresponding behavior are possible.
Side effects
Taking "Fluconazole" can have a number of side effects:
- Perhaps a decrease in appetite, a change in taste, vomiting, diarrhea, abdominal pain, vomiting, impaired functioning of the liver from the digestive system.
- Dizziness, fatigue, or cramps.
- Leukopenia, neutropenia.
- Allergy in the form of a rash, itching on the skin.
- Impaired renal function.
Special moments
Treatment with "Fluconazole" in capsules, according to patients, should not be stopped until the onset of remission, otherwise relapses are possible.
Vacation and storage conditions
The drug is dispensed without a prescription from pharmacy stalls. "Fluconazole" must be stored in a dry, dark place at a temperature of no higher than + 25 ° C. Shelf life is three years, according to reviews on the instructions for use of "Fluconazole".
Analogs
Always after the expiration of the patent with the original formula of the drug, pharmaceutical companies create copies of the drug, the so-called generics. According to the law, only a ready-made formula of a patented product without a method of producing a molecule is at the disposal of enterprises.
The instructions for the use of "Fluconazole", according to patients, contain a number of contraindications, and therefore, patients need to familiarize themselves with analogues of the drug:
- Diflucan. The drug is available in capsules, powder or solution for intravenous administration. The original drug "Diflucan" has a large spectrum of action. It shows its activity against mold fungi, dermatophytes, yeast-like fungi from the genus Candida. Diflucan, containing fluconazole as an active substance, is constantly used to treat candidal lesions of the skin, nails, mucous membranes of the mouth, and genitals.
- Flucostat. Domestic analogue is produced in the form of a solution for intravenous administration and in capsules. It is not recommended to use while carrying a child and breastfeeding.
- "Mikosist". One of the most expensive analogues of "Fluconazole" is made in Hungary. The drug is available in the form of a solution for infusion.
- Mikomaks. Imported antifungal agent manufactured in the Czech Republic. The drug is available in capsules, syrup and solution for infusion.
- "Diflason". Capsule antifungal drug. An inexpensive analogue of "Fluconazole" worth about 200 rubles. It is not recommended to use during pregnancy and lactation. Treatment can be started in the absence of seeding results or other tests done in the laboratory. If you have tests, you should consult a doctor with a course of treatment.
- "Tsiskan". The antifungal drug is the strongest selective inhibitor of styrene synthesis in the fungal cell.
- Nofung. The medication helps with mycoses.
Summary
It is clear that sick people with nail fungus experience terrible discomfort. It is impossible to remove shoes in public places (bathhouse, beach), swim in the pool or at sea. People are constantly worried about itching, pain, an unpleasant fetid smell emanates from their feet, nails crumble. This is extremely inconvenient. Sometimes it’s difficult to treat nail fungus. According to reviews, "Fluconazole" is exactly the tool that can solve this problem of people. Even treatment with this drug can take months. To reduce the process, it is necessary to use the medicine according to the prescribed dosages. And then, "Fluconazole" from nail fungus, according to people, will prove itself as an effective and efficient tool.