As you can learn from the instructions, Biseptol 480 tablets are intended for the treatment of bacterial infections. The tool belongs to the class of antibacterial and is used for a wide range of dangerous diseases. In addition to tablets, a concentrate intended for injective administration is on sale. The rules of admission and the duration of the course, the optimal dose should be selected by the attending physician responsible for case management.
Technical Details
According to the instructions for Biseptol 480 tablets, this medicine in pharmacies is sold only to customers who have a doctor’s prescription. This should be issued on a special form. The medication is made in tablet form, has a white color, a yellowish tint is possible. Each instance is made in the form of a flattened circle. Engraving and chamfering are provided.
The active ingredients contained in each capsule are trimethoprim, sulfamethoxazole. The first component is contained in a tablet in an amount of 80 mg, 400 mg are allocated to the second. As additional compounds, the manufacturer used talc, starch, alcohol, propylene glycol. In the manufacture of magnesium compounds, propyl parahydroxybenzoate, methyl parahydroxybenzoate were used.
Tablets are packaged in blisters. One plate contains 14-20 copies. Inside a cardboard bundle - one or two blisters. The exact number of capsules and the saturation of each active ingredient are recorded not only in the instructions for Biseptol 480 tablets, but also on the outside of the cardboard box where the pharmaceutical product is packaged.
Pharmacology
The instruction of the Biseptol 480 tablets indicates that the drug belongs to the antibacterial category. Pharmaceutical products belong to the type of sulfonamide. This is a combined preparation, in which there are two main ingredients - trimethoprim, sulfamethoxazole. The structure of the molecule of the second substance is somewhat close to PABA, so the compound is able to be included in the reaction instead of four-aminobenzoic acid. This invasion prevents the generation of dihydrofolic acid in the bacterial particle. Trimethoprim increases the effectiveness of this component, as it prevents the transformation of dihydra-in tetrahydrofolic acid. The latter is an active version of folic compounds, indispensable for protein metabolism and cell division.
The instructions accompanying the release of Biseptol 480 tablets specify the affiliation of the drug to bactericidal. A distinctive feature is the breadth of the effectiveness of the composition. The activity of the ingredients in case of infection with a variety of gram-positive life forms has been proven. You can prescribe a drug for invasion of strepto, staphilo, enterococcus, mycobacteria, bacilli, listeria, nocardia. It is allowed to use the composition when infected with some gram-negative aerobes. "Biseptol 480" is effective against Neisseria, Eischeria, Salmonella, Haemophilus influenzae, Klebsiella, Bordetella, Brucella, cyto, Enterobacter, Legionella. You can use the agent in question for the invasion of pseudomonas, shigella, morganella.
The medication shows a good result in the fight against chlamydia, actinomycetes, toxoplasma and other protozoa. It is used if necessary to treat fungal infestation.
Performance Features
As the instructions accompanying the Biseptol 480 tablets issued in tablets indicate, the medication will not help in case of infection with a Corynebacter. It is not used in identifying individual forms of pseudomonas, mycobacterium that provokes tuberculosis. "Biseptol" does not give a reliable effect in the fight against viruses and some varieties of leptospira, treponema.
Observations have shown the ability of active ingredients to inhibit the activity of Escherichia coli. This leads to less production of thiamine in the intestinal tract. Riboflavin, nicotinic acid, necessary for human life, are not so actively generated. Against the background of administration, a decrease in the rate and saturation of the synthesis of other compounds from the class of vitamins B is possible. Changes are localized in the intestinal tract.
The duration of the therapeutic effect was estimated at 7 hours.
Kinetics
Instructions for use of tablets "Biseptol 480 mg" clarifies the ability of the active ingredients to be fully absorbed during the passage of the gastrointestinal tract. The maximum accumulation in blood serum is achievable not less than one hour after applying the drug inside. The period of increase in concentration does not exceed four hours.
Trimethoprim has the ability to leak into biological tissues and fluids of the human body. It is detected in the respiratory system and kidneys, secretions of the salivary glands. Trimethoprim is fixed in the spinal fluid, bile, prostate. It is observed in sputum generated in the respiratory system. With serum proteins, the compound binds halfway. For sulfamethoxazole, this indicator reaches 65%.
The half-life of trimethoprim does not exceed 17 hours, for the second active ingredient it varies between 9-11 hours. Mostly elimination is done by the kidneys. About half of the trimethoprim received in the body is excreted in its original form; for sulfamethoxazole, the proportion of the initial eliminated compound is no more than a third of the substance received in the body.
When will it help?
Before starting the therapeutic course, it is worth checking with the doctor for what "Biseptol" is used. Instructions for use contain a complete listing of indications for admission, but it is difficult to navigate them without a special education and experience. The manufacturer advises using the product when an inflammatory disease or infection has been identified in a person in need, and the root cause of these is infection with microscopic forms that are susceptible to the active ingredients of the drug.
The drug is prescribed for sinusitis, otitis media, gonorrhea. It is used for infection of soft tissues, skin, gastrointestinal tract, respiratory, urinary and reproductive systems. Indications for the appointment of "Biseptolum" are pyoderma, typhoid and paratyphoid, bronchitis and pulmonary abscesses and inflammation, pleural empyema and prostatitis. The medication is used to combat pyelonephritis and inflammation of the urethra, in the treatment of furunculosis and dysentery, diarrhea and salpingitis. They resort to it if cholera is diagnosed.
How right?
As can be concluded from the accompanying documentation, the drug is prescribed for both children and adults. Instructions "Biseptolum" is recommended for oral use after a meal. The medicine should be drunk abundantly with clean water without additives. The dosage is determined by the doctor, focusing on age, diagnosis, severity of the disease, the presence of concomitant diseases and the susceptibility of the patient.
The instructions for use of the Biseptol 480 tablet are allowed for children from the age of three. For the age category not older than five years, you can use 240 mg of the drug per day twice. For children older, but not overstepping the border of twelve years of age, it is recommended to take 0.48 g of the drug twice a day.
If pulmonary inflammation is diagnosed, it is necessary to select a dose based on the weight of the patient. For every kilogram, 100 mg of sulfamethoxazole should be given. The amount obtained is the daily norm, which is divided into several portions. Between the use of the medicine, you must observe six-hour pauses. The duration of the therapeutic program is two weeks.
Diagnoses and rules
The instruction of Biseptol tablets is recommended for adults with gonorrhea. A single volume of the drug is 2 g of sulfamethoxazole. The medicine must be consumed twice a day. Between receptions withstand twelve-hour pauses.
In case of infection and inflammatory foci, children over the age of twelve, adults are recommended to use 0.96 g of the drug twice daily. In the case of a long course, you should use the drug twice daily in half the dose. The instruction of the Biseptol 480 tablet is recommended for children and adults for a course lasting from five days to two weeks. If the disease develops more severely, the infection is formed by the chronicle, they increase the one-time volume of the drug by a third or half of the dose.
If the patient is shown receiving an antimicrobial agent for longer than five days in a row, exceeding the standard volume, the task of the doctor monitoring the case is to regularly check peripheral blood. If violations are detected, the patient is prescribed folic acid. Daily shown to take 5 mg of a substance or twice as much.
The nuances of using
The instruction on the use of Biseptol 480 tablets for adults and children recommends that the timing and frequency of taking the medicinal composition be extremely carefully observed. If the patient missed the time of using the medication, you need to reimburse the dose as soon as possible. If the moment is approaching the next dose, the previous one is skipped. Do not use double volumes, trying to compensate for a pause.
In case of insufficient functioning of the kidneys and creatinine clearance within 15-30 units, it is necessary to reduce the dosage by half relative to the standard. If creatinine clearance per minute is less than 15 units, it will be wise to abandon Biseptolum.
Undesirable consequences
This, as practice shows, is rare. The antibacterial medication is well tolerated by the vast majority of people in need of therapy. Instructions, reviews of "Biseptolum" recorded the possibility of meningitis, oppressed psycho-emotional status, tremor. Some patients noted that during treatment the head ached and was dizzy, vomited and vomited, appetite worsened, and stool was disturbed. There is a danger of bronchial spasm, cough, inflammatory foci on the oral mucosa. Hepatitis, jaundice, and colitis were occasionally detected.
As can be seen from the reviews, the instructions of the Biseptol 480 tablets, in an extremely small percentage of patients, the administration provoked leuko-, neutro-, thrombocytopenia, eosinophilia. There are risks of hemato-, olig-, an-, polyuria, nephropathy. Allergic responses, mi, arthralgia are possible. There is a risk of lowering sodium, glucose in the blood, as well as an increase in the percentage of potassium.
Sometimes you can’t
The instructions for the use of Biseptol 480 tablets for adults and children prohibit the use of this pharmaceutical product if parenchymal liver damage, severe renal failure, or lack of glucose-6-phosphate dehydrogenase are detected. In childhood, hyperbilirubinemia is an absolute contraindication. Women are forbidden to use an antimicrobial drug during the period of bearing a child, breastfeeding. The tablet is not prescribed for children under the age of three.
As can be seen from the instructions for use, Biseptol tablets are forbidden to adults and children, if an increased susceptibility of any ingredient used in the manufacture of the drug is established by the body. This applies to both active substances and additional compounds. You can not use the drug with a high susceptibility to sulfonamides.
Contraindications for the appointment of an antimicrobial medication are pronounced renal failures, which do not allow controlling the content of the medication in blood serum. The drug is not used for severe blood diseases. It can not be prescribed for some types of anemia, agranulocytosis and leukopenia.
Features and Security
Very careful use of Biseptol 480 tablets is necessary if folic acid deficiency is detected. Particularly noteworthy are people suffering from bronchial asthma. Increased risks are associated with thyroid pathologies. If the allergic history of the disease is burdened, the medication is prescribed, but as accurately as possible.
Some diseases require a long course. This is considered to be more than a month. If the patient is shown just such a treatment program, you need to regularly donate blood for a full study. Take into account that prolonged use of an antibacterial agent can provoke hematological corrections, often not accompanied by symptoms. Such changes can be reversed if folic acid is prescribed to the patient on time. The purpose of this tool practically does not reduce the effectiveness of the main course of treatment.
Particularly cautious should be doctors leading cases of elderly patients and people who have folate insufficiency. With prolonged use of the drug, especially at a high dosage, folic acid intake is especially advisable.
Additional aspects
As you can see from the reviews, the instructions for use of Biseptol recommends changing the patient's nutrition program for the treatment period, and many note that doctors called for special attention to be paid to this. It seems reasonable to exclude PABA-rich foods. You should abandon the use of green elements of plants. Tomatoes and carrots are temporarily removed from the diet.
To prevent crystalluria, it is important to control the amount of urine excreted. The risk of allergies and toxic complications associated with the use of sulfonamides increases if renal filtration functionality is interrupted.
During the course, it is recommended to avoid ultraviolet radiation and prolonged exposure to direct sunlight.
The risk of side effects is greater in AIDS patients.
Will it help or not?
As you can see from the reviews, the instructions for the use of Biseptol 480 tablets contain accurate information about the effectiveness of the drug and the rules for its use. The correctness of the description of side effects is noted. People who used the tool believe that the accompanying documents are accurately and correctly drawn up, understandably. According to reviews, the instructions for the use of Biseptol 480 tablets give an accurate and good idea of the features and risks associated with antibiotic therapy.
People who use a pharmaceutical product recognize its reliability. There is a low incidence of side effects, which makes Biseptol look more attractive than a large number of alternative medicinal formulations. Many people who used these pills noted their effectiveness, reliability, quick and pronounced effect of the course. Mostly such responses can be seen from those who used the product under the supervision of the attending physician. Unauthorized admission is very likely to cause complications or be ineffective in a particular case.
Features and combinations
As observations have shown, the use of the drug Biseptol should be avoided in case of pharyngitis, tonsillitis, if the disease is provoked by class A beta-hemolytic streptococcus. Among this pathological form, strains are especially common, which are characterized by resistance to the combined agent.
The use of "Biseptolum" is associated with a risk of correction of the results of checking the plasma content of methotrexate. This is due to the presence of trimethoprim. The higher the probability of an incorrect result when studying the enzymatic method. To exclude risks, it is necessary to check the quality and profile of the blood by a radioimmunological method.
The Jaffe reaction using picric acid can be accompanied by a ten percent increase in results due to Biseptolum. This must be taken into account if a creatinine concentration in the circulatory system is to be checked.
The composition of the drug contains benzoates, potentially initiating an allergic response of the body. Propylene glycol present in tablets can provoke symptoms similar to alcohol consumption.
Special features
If the medicine has not been used properly, it must be disposed of so that it does not constitute a danger to the outside world. Do not throw pharmaceutical products into household waste containers or sewage. A pharmacist will tell you more about disposal rules.Observing the established norms, a person protects the environment from negative influences. Each region of our country has special rules and programs for the disposal of pharmaceutical products.
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At the moment, it was not possible to identify which dose of the drug is dangerous to human life. There is a risk of chronic poisoning. This is observed if a person takes a high dose of medication for a long time; accompanied by inhibition of bone marrow work, thrombocytopenia, leukopenia, anemia.
If necessary, to combat overdose, the drug is canceled and its components are removed from the digestive tract, if no more than a couple of hours have passed after administration. The patient is shown to drink a lot if renal function is preserved. Calcium folinate recommended. The acidity of urine activates the elimination of trimethoprim, but this is accompanied by the danger of the appearance of sulfanilamide crystals in the renal system.
Is there an alternative?
As you can assume, analyzing the instructions of “Biseptol” in aspects of the listing of active ingredients, the analogues of this tool are:
- "Bactiseptol."
- "Bi-sept."
- "Raseptol."
Sometimes doctors recommend considering Triceptol. A good substitute is Bikotrim. Bactrim and Bi-tol drugs have proven themselves to be reliable effects. The choice of replacement should be entrusted to the attending physician, explaining to him why it is impossible to purchase the initially prescribed drug.