In the article, we will consider reviews about "Byzantine" with endometriosis.
The most common pathologies of the modern world is infertility. One of the main causes of difficulties with conception is endometriosis. It is a frequently diagnosed genetic disease, which is characterized by the growth of the inner uterine layer (endometrium) outside the organ and in its cavity. Affected foci can be located in any organs and tissues of the reproductive system, for example, in the ovaries or fallopian tubes. This disease is very insidious and can have serious complications, so it requires timely treatment.
Hormone therapy
When determining endometriosis, the patient must be prescribed long-term hormonal therapy. For this purpose, various hormonal drugs are used, and among them one of the most popular is Vizanna, a new-generation drug developed specifically for the treatment of this pathology.
Many gynecologists agree that with endometriosis, Vizanne shows excellent results and helps to eliminate unpleasant clinical manifestations. The drug produces a complex effect, reduces the intensity of the clinical signs of the disease and stops the pathological tissue growth. Reviews about the tablets "Vizanne" are most often positive.
Dienogest
The main active ingredient - dienogest - is a synthetic analogue of natural progesterone, which, penetrating the body, reduces the concentration of estrogen in plasma and ovaries, which allows to obtain a significant gestagen effect. While taking the drug, the growth of the endometrium stops, the affected foci gradually atrophy. The medicine is absorbed into the bloodstream very quickly and after an hour and a half reaches the highest concentration. It is available in the form of tablets and can be bought at any pharmacy.
Reviews about the "Byzantine" are abundant.
The essence of endometriosis
A disease such as endometriosis refers to the pathological growth of the inner uterine lining (endometrium) and the further spread of tissue outside the organ. Fragments of the uterine endometrium, penetrating into other organs, continue to grow and undergo cyclic changes under the influence of sex hormones. Lining cells, increasing in volume, stretch the inflamed organ and cause bloody discharge and pain.
Symptoms and prognosis of the development of pathology are determined by the location of endometrial cells: for example, endometriosis in the genital area can disrupt the menstrual cycle, cysts will appear in the ovaries and infertility will occur due to inflammation of the fallopian tubes and gonads.
In addition to pain and other unpleasant symptoms and presumed infertility, the disease increases the likelihood of developing some types of ovarian cancer. Experts suggest that the growing cells of the uterine epithelium can be malignant, that is, become malignant.
But at the same time, the epithelial lining, spreading, retains the possibility of subordination to hormonal "signals". This means that the propagation speed of endometrial cells can be controlled by reducing the amount of estrogen - hormones that affect them. For therapeutic purposes, with endometriosis, antigonadotropic drugs are used that reduce the production of hormones that regulate the functioning of the glands of the reproductive system (Danazol), gestagens (Norethisterone, Progesterone, Gestrinone, etc.), gonadotropin releasing hormone agonists ( "Triptorelin", "Goserelin").
The composition of the drug
According to reviews, "Vizanna" with endometriosis is very effective. The effect of the drug is based on the progestogen effect of its main active ingredient. The active substance, that is, dienogest, is a derivative of nortestosterone and is characterized by antiandrogenic activity. Although it weakly (no higher than 10%) binds to progesterone, dienogest in a living organism actively binds to the receptors of this hormone and thus reduces the production of estrogens and their concentration in the blood plasma.
The immunological effect of the active component makes it possible to prevent the acquisition of malignant endometrium or stops the process as much as possible. This is stated in the instructions to the "Byzanne." Reviews are of interest to many.
The properties
The main advantage of dienogest is its low mineral and glucocorticoid activity, which eliminates the strong effect of the drug on the metabolism and bone tissue of patients during treatment.
The main aspects of the effect of the drug in uterine endometriosis:
- normalization of hormone balance, reduction of estrogen production and their effects on epithelial tissue;
- slowing down the cell proliferation of the endometrium (excessive thickening of the lining slows down, endometriosis develops);
- inhibition of the formation of a network of vessels, which nourishes pathological foci;
- destruction of cellular endometriotic structures outside the uterus;
- reduction in the number of nerve endings in the foci of the disease and inhibition of prostaglandin production (anesthetic effect);
- suppression of inflammation that occurs with the growth of endometrial tissue.
The high effectiveness of the drug is not offset by a negative effect on the body during treatment: the drug does not have a significant effect on the ovulation process, unlike other hormonal drugs, and also does not affect the metabolism.
Reviews on the drug "Vizanna" confirm that it is well tolerated most often.
Indications for use
The main indication for the use of the drug is endometrioid disease (endometriosis) at various stages of a particular localization. The use of dienogest is especially effective when the epithelium grows in the ovaries and uterus.
The treatment course with Vizanna tablets lasts about six months. The medicine is taken regardless of the phase of the menstrual cycle: during menstruation, therapy does not stop, breaks are not provided, unlike many hormonal drugs. Continuity of influence enhances the effectiveness of Byzantine.
The drug should be taken every day, for this purpose it is better to establish a specific time and adhere to equal intervals between doses in the future. It is recommended to drink it with a large amount of mineral or pure still water.
What factors are taken into account?
Prescribing the drug "Vizanna" to the patient, the doctor takes into account several factors - the anamnesis, the state of health of the woman, compatibility with other drugs of a non-hormonal and hormonal origin.
Treatment can begin on any day of the cycle, but experts advise you to wait until the onset of menstruation. Often, the drug is not prescribed separately, but as part of a comprehensive treatment after surgery on the ovary or uterus. The therapeutic regimen and combination of drugs is determined by the stage of the disease, the woman’s history and other medications prescribed to her.
Feedback on the reception of "Byzantine" will be presented at the end of the article.
Special instructions for the treatment of endometriosis
Distinctive features of the drug "Visanne" are the following:
- Not used during breastfeeding and pregnancy. During the tests, no toxic and other negative effects on the female body were revealed during the bearing of the baby, but the medicine is not used, since there is no need for hormone therapy.
- During lactation, the active substance dienogest passes into breast milk, and therefore, if absolutely necessary, doctors advise interrupting feeding for the full treatment of endometriosis.
- When using the drug in patients, inhibition of ovulation may be noted, but using the medication as a protection against unwanted pregnancy is very unreliable. The doctors' comments about Vizanne confirm this.
The instructions for use do not prohibit the use of the drug for diabetes mellitus compensated type, migraine, heart failure, hypertension, but in these situations, any progestogen therapy is prescribed very carefully, at a lower dosage or with careful laboratory and medical supervision.
During the treatment of endometriosis, especially when planning maternity, after the end of the therapeutic course, it is undesirable to drink strong alcohol.
Careful reception
With caution, "Vizanne" is also used in the presence of a history of depression, thrombophlebitis and ectopic pregnancy.
Before and during treatment, it is not recommended to start using oral contraceptives. The duration of their use during therapy must be agreed with a specialist. If possible, diaphragms, spirals and condoms (barrier contraception) should be preferred.
If the treatment course is selected correctly, this will give stability to the menstrual cycle: a similar effect will be achieved after 2-3 months of using the medicine.
Side effects
According to reviews of Vizanne, in the first months of therapy with this drug, irregular and spotting vaginal bleeding, discomfort in the mammary gland, mood swings, headaches and rashes on the epidermis (acne) can be observed.
Other side effects of the drug:
- decreased libido;
- slight weight gain;
- sleep disturbances;
- irritability;
- vomiting and nausea;
- pains rarely occur in the abdomen;
- increased gas formation;
- hair thinning;
- lack of critical days for several cycles;
- breast swelling;
- fatigue;
- backache;
- general malaise and weakness.
According to reviews of Vizanne, side effects cease after a few months of administration.
With a frequency of from 0.001 to 0.01, a decrease in hemoglobin in the blood (anemia), impaired concentration, loss of body weight, anxiety, dry cornea of the organs of vision, ringing in the ears, increased heart rate, unclear blood circulation pathology, constipation or diarrhea, dermatitis, sweating, lesions of the mucous membranes, pigmentation defects, vaginal dryness, candidiasis due to changes in hormonal levels, edema and compaction in the mammary gland.
Despite this, the doctors ’comments on Vizanne are positive.
Contraindications
The drug cannot be used for a number of actively progressing diseases against the background of progestogen treatment. These include:
- acute form of thrombophlebitis, deep and peripheral vein thromboembolism;
- liver tumors of various levels of differentiation (including benign) in the anamnesis or at the beginning of treatment;
- diabetes mellitus, which is complicated by vascular disorders;
- identified malignant hormone-dependent neoplasms or the implementation of further studies in this case;
- diseases of the heart and blood vessels of atherosclerotic origin, ischemic defects (history or at present);
- vaginal bleeding of unknown origin;
- cholestatic jaundice in the past or during pregnancy;
- excessive sensitivity to the active or auxiliary substances of the drug (dienogest, talc, lactose, crospovidone, potato starch, magnesium stearate, microcrystalline cellulose).
In severe liver pathologies, including an anamnesis, the drug should be prescribed carefully and only after examining the organ samples.
Reviews about the "Byzantine"
Most gynecologists agree on the relatively high efficacy of the drug in the treatment of endometriosis. Over 73% of the patients who took the pills for a long time noted improvements after three months of treatment. The woman found that during the use of the drug pain during menstruation decreases, overall health and mood improves. Reviews about "Vizanne" in the presence of endometriosis are mostly positive.
The disadvantage is the price
The drug has one drawback - its high price, due to the use of the latest technologies and imported substances in the manufacture. However, efficiency exceeds all expectations, and therefore it is better not to save on your health.
We examined the Vizanna product instructions for use and reviews of doctors and patients.