In the article, we consider the analogues of Glidiab.
This medication belongs to the category of hypoglycemic drugs for oral administration. The active substance of this medication - glyclazide, is a derivative of sulfonylurea of the II generation.
Therapeutic effect
Therapeutic effects of gliclazide:
- stimulation of insulin production by pancreatic β-cells;
- increased insulin sensitivity in peripheral tissues;
- restoration of the initial peak in the production of this hormone;
- reducing the time interval from the moment of eating to the start of insulin production;
- stimulation of the functionality of intracellular enzymes, for example, glycogen synthetase;
- increased insulin secretory effects of glucose;
- decrease in postprandial increase in the level of the latter;
- normalization of microcirculation processes, which is manifested in the form of a decrease in platelet aggregation, normalization of vascular permeability, obstacles to the development of microthrombosis and atherosclerosis, restoration of parietal fibrinolysis;
- inhibition of the development of diabetic retinopathy at the non-proliferative stage;
- against the background of prolonged use in diabetic nephropathy, it significantly reduces the severity of proteinuria;
- decreased sensitivity of vascular receptors to adrenaline.
The instructions for use of this medication indicate that it should be taken one tablet during breakfast daily. The shelf life of Glidiab and its analogues is two years.
In what cases is the drug not prescribed? About it further.
Contraindications
Contraindications to taking the medication are:
- type 1 diabetes mellitus;
- diabetic precoma / coma;
- diabetic ketoacidosis;
- conditions accompanied by impaired absorption of food, the development of hypoglycemia (with infectious pathologies);
- hyperosmolar coma;
- leukopenia;
- paresis of the stomach;
- severe renal or hepatic insufficiency;
- intestinal obstruction;
- extensive injuries, surgical interventions, burns and other conditions in which insulin therapy is necessary;
- combination therapy with Danazol, Miconazole or Phenylbutazone;
- age less than 18 years;
- lactation, pregnancy;
- intolerance to the components of the drug.
This must be considered before taking the remedy.
Analogs of Glidiab
Among the substitutes for the drug, the most popular are:
- "Diabeton MV";
- "Gliclazide Canon";
- "Diabefarm MV";
- Diabetalong
- "Gliclada";
- "Diabefarm";
- Diabinax.
Below we consider some of the above drugs, their pharmacological properties and dosage regimen.
Diabeton MV
This drug is a Russian cheap analogue of Glidiab MV, made on the basis of the same substance. It is distinguished from similar medications by the presence of an N-containing heterocyclic ring with the presence of an endocyclic bond.
Gliclazide helps reduce blood glucose, enhances insulin secretion through β-cells of islets of Langerhans. An increase in the level of C-peptide and postprandial insulin is observed after 2 years of using this medication. In addition to affecting carbohydrate metabolism, this pharmacological substance has a hemovascular effect.
In diabetes mellitus of the second type, this medicine helps to restore the initial peak in hormone secretion, as a response to glucose intake, strengthens the second phase of insulin production. A significant increase in secretion is noted in response to stimulation due to food intake and glucose administration.
Glyclazide reduces the likelihood of thrombosis in small vessels, having a direct effect on the mechanisms that cause the development of complications of diabetes. Selectively inhibits platelet adhesion / aggregation and a decrease in the functionality of platelet activation factors.
According to the instructions for use, the Glidiab analogue increases the activity of tissue plasminogen activators and restores the fibrinolytic functionality of the vascular endothelium. The pronounced glycemic control based on the use of the medicine “Diabeton MV”, in comparison with the traditional glycemic control, reduces the micro- and macro-vascular complications arising from type 2 diabetes mellitus. This advantage is due to a significant reduction in the risk of worsening of the main vascular conditions, the onset and progression of nephropathy, microalbuminuria, macroalbuminuria and renal failure.
The Glidiab analogue “Diabeton MV” should be taken once a day during breakfast, in long courses, on the recommendation of a specialist. The shelf life of this medicine is 2 years.
Glyclazide Canon
This is another Russian cheap analogue of Glidiab, which is a hypoglycemic oral drug of the second generation sulfonylurea category.
This medication helps to increase insulin secretion by β-cells located in the pancreas, increase insulin sensitivity of peripheral tissue cells. In addition, this drug presumably stimulates the activity of enzymes inside the cells (muscle glycogen synthetase) and shortens the start time of insulin production after eating.
The active substance of the drug "Gliclazide Canon" reduces platelet aggregation and adhesion, which helps to slow down the formation of parietal thrombi, increase vascular fibrinolytic activity, and normalize vascular permeability. The medication also has some anti-atherogenic qualities: it lowers total cholesterol in the blood, increases the concentration of HDL-C, and also inhibits the level of free radicals, prevents the occurrence of microthrombosis and atherosclerosis, reduces the sensitivity of capillaries to adrenaline. Against the background of prolonged use with the development of diabetic nephropathy, an intense decrease in proteinuria is noted.
How to take an analog?
According to the instructions for the medication, the initial daily dose is 80 mg of the drug, the average dosage per day is 160-320 mg. Take this pharmacological agent 2 times a day before meals. The dosage regimen is determined individually depending on the severity of glycemia 2 hours after eating and on an empty stomach, as well as on the clinical symptoms of the pathological process. The shelf life and shelf life of this medicine is 2 years.
What other Glidiab counterparts are available?
Diabetalong
This is one of the cheapest analogues of the Glidiab drug manufactured by Russian manufacturers. It is a systemic medicine that is used as part of monotherapy or complex treatment regimens for type 2 diabetes. This medication is produced in tablets, which are prescribed in the absence of the necessary effect of physical activity and dietary correction of the patient, corresponding to his physiological characteristics and age.
Treatment with this drug should be combined with diet (table No. 9), which is very important to prevent the occurrence of hypoglycemic attacks and enhance the effectiveness of therapy. A feature of this medication is the prolonged release of the main active substance, which allows to reduce the daily dosage of the drug and to ensure a uniform decrease in the level of glucose in a unit of blood.
The therapeutic effect of the Glidiab analogue of 80 mg is due to the properties of its active element, glyclazide, among which are observed:
- increased production of their own insulin, which helps to reduce the dose of the hormone injected;
- stimulation of the activity of beta cells that make up pancreatic tissue and provide its basic functions;
- normalization of carbohydrate metabolism;
- inhibition of platelet adhesion and prevention of thromboembolism, thrombocytopenia and thrombosis.
Instructions for use of the drug "Diabetalong" recommends taking it 1-2 times a day in the morning. Despite the fact that taking tablets is allowed between meals, the effectiveness of therapy will be higher if you do this 10-20 minutes before eating. If the patient forgot to take the pill, it is necessary to resume therapy from the next dose prescribed by the dosage regimen. An increase in dosages is not allowed, as this can lead to the onset of an acute attack of hypoglycemia and coma, especially in patients after 65 years of age. It is allowed to store the drug for 2 years, after which its shelf life expires. Analogs and substitutes for Glidiab should be selected by a doctor.
Diabefarm
The medicine “Diabefarm” is the Russian analogue of “Glidiab”. It has a stimulating effect on the formation of a hormone in the structures of the pancreas, increases the sensitivity and affinity of insulin receptors to its effects. The drug also significantly enhances the reflex principle of insulin production for high glucose levels.
Effects of use
The main effects of using this Glidiab analogue 30 mg are as follows:
- activation of muscle glycogen synthetase - an enzyme located inside the cells and responsible for the production of glycogen in the muscles;
- significantly reduces glucose after eating;
- activates an early peak in insulin production through an immediate cell response;
- Intensively reduces the time interval from eating to the hormone entering the bloodstream.
As additional effects from the use of this pharmaceutical preparation, an analogue of Glidiab MV 30 mg, it may be noted:
- stabilization of microvasculature cells:
- decrease in platelet plate activity during gluing together;
- stabilization of the vascular walls;
- reduction in their permeability to potentially pathogenic agents;
- activation of the processes of proper fibrinolytic cleavage of thrombomass;
- a decrease in vascular receptor sensitivity to the effects of adrenaline, which provokes a reduction in the walls of arteries and veins;
- reduction in triglycerides and cholesterol;
- inhibition of the progression of diabetic retinal damage, an obstacle to the development of retinopathy in diabetes;
- a decrease in the likelihood of developing diabetic neuropathic encephalopathy and damage to the renal vessels;
- weight loss in patients who adhere to a special diet for obesity.
Instructions for use: drink the medicine in a daily dosage of 0.16-0.33 g, which is adjusted individually by the attending endocrinologist. The medicine is suitable for two years from the date of manufacture.
Diabinax
This drug is an analogue of Glidiab MV, a derivative of sulfonylurea of the II generation. It has a stimulating effect on the secretion of insulin by the pancreas, increases the sensitivity of peripheral tissues to insulin. Also, the activity of the activity of intracellular enzymes is stimulated. Due to its effect, the period of time from ingestion to the beginning of insulin secretion increases. The peak of hyperglycemia after eating is reduced.
In addition to the effect on carbohydrate metabolism, microcirculation also changes. The drug reduces platelet adhesion and aggregation, slows down the development of a thrombotic wall. The permeability of blood vessels is normalized, the risk of developing microthrombosis is reduced, the process of physiological parietal fibrinolysis is restored.
The sensitivity of blood vessels to adrenaline decreases. The medication has anti-atherogenic properties, due to which the concentration of total cholesterol in the blood decreases. At a non-proliferative stage, the development of diabetic retinopathy slows down. In the presence of diabetic nephropathy, especially if taking the drug is long, proteinuria significantly decreases. The drug does not provoke an increase in body weight, since it has a predominant effect on the early peak of insulin secretion and does not cause hyperinsulinemia.
Diabinax, following an appropriate diet, reduces body weight in obese patients.
The dose of the drug is set individually, it depends on the age of the patient, symptoms of pathology and the level of fasting glycemia (two hours after eating). The initial daily dose will be 80 mg, the average - 160 mg, the maximum - 320 mg. "Diabinax" is taken orally twice a day (in the morning and in the evening) half an hour or an hour before meals. The shelf life of this medicine is 2 years.
We reviewed the instructions and analogues of Glidiab.