Doctors often use amlodipine-based medicines to lower blood pressure. One such remedy is the Stamlo drug.
Description
This medication is produced by the Indian company Dr. Reddy's Laboratories Ltd.
The medicine "Stamlo" has a long and dose-dependent therapeutic effect.
Being a dihydropyridine derivative, the active component amlodipine belongs to the second generation of Ca 2+ antagonists, which close the channels that pass calcium ions.
Dosage form
The tool is available in two dosages: 0.005 and 0.010 g of the component of the active substance.
The instruction describes the smaller dose of the Stamlo medication as round tablets with a white or almost white surface, which is flat and has a beveled shape at the edges. In order to mark the medicine on one plane there is an extrusion of "R 177", on the other - a dividing risk is applied.
A large dose of the medicine "Stamlo" is characterized by annotation as oval tablets with a white or almost white biconvex surface. In order to mark the medicine on one plane there is an extrusion "R", on the other - the digital designation "178" is applied. Dosed solid units are produced in blisters of 14 pieces, each pack contains two cell packs.
Drug components
The active ingredient of the drug is an amlodipine salt of the besilate type, in an amount of 6.42 and 12.838 mg, equivalent to 0.005 and 0.010 g of pure amlodipine.
In the structure of the Stamlo tablet, you can find inactive components, which are represented by microcrystalline cellulose particles, sodium starch glycolate, dehydrated aerosil, and magnesium stearate.
Mechanism of action
Amlodipine molecules combine with the receptor outgrowths of the dihydropyridine type, block the channels of slow penetration of calcium ions belonging to the second level, which provides antianginal and antihypertensive activity.
Instructions for use "Stamlo" characterizes it as a medicine that reduces the transmembrane transition of Ca 2+ ions into smooth muscle cells of the vascular wall.
With antianginal activity, large and small arterial vessels of the coronary and peripheral type expand. In the presence of pain behind the sternum, a decrease in the manifestation of the ischemic state of the heart muscle occurs.
The drug has a weak natriuretic effect, inhibition of platelet aggregation, increased filtration rate in the glomeruli.
The expansion of distant arterioles causes a decrease in resistance in the common peripheral vascular bed, a reduction in preload on myocardial tissue, and a decrease in the amount of molecular oxygen needed for the heart.
Acceptance of funds by patients with diabetic nephropathy does not make microalbuminuria more pronounced.
The effect of the medication does not change the metabolic processes and lipid level in the bloodstream.
Therapeutic activity occurs after a few hours and lasts for one day.
Why use
Pills help to treat pain behind the sternum spontaneously and with physical activity.
Instructions for use "Stamlo" recommends taking with increasing blood pressure. It can be used alone or combined with another antihypertensive medication.
How to use
With "Stamlo M" pills, the instructions for use advise you to treat hypertensive arterial condition and pain behind the sternum with an initial dosage of 0.005 g, which is drunk 1 time per day. The maintenance amlodipine amount at elevated pressure is 0.005 g per day. The maximum allowable daily dosage should not exceed 0.010 g.
Angina pectoris is spontaneous and during physical exertion is treated with a dose of 0.005 to 0.010 g per day.
Correction of the amount of medication “Stamlo M” is not carried out if it is combined with diuretic thiazide inhibitors of the enzyme angiotensin converting, beta-adrenergic blocking and nitrate drugs of long-term effect and sublingual nitroglycerins.
With antihypertensive activity for a patient aged, with short stature, with low muscle mass, with improper liver function, the dose of the drug at 0.0025 g is initially used. For such a patient, a dosage of 0.005 g is prescribed for antianginal treatment.
If there is kidney failure, then adjust the amount of amlodipine is not necessary.
Treatment features
For the medicine "Stamlo" the instructions for use report the possibility of its use in many patients for monotherapy. If there is insufficient hypotensive activity, then inhibitors of angiotensin converting enzymes, diuretic thiazide elements, alpha and beta-blocking drugs are added to the drug.
During the course of taking the medicine, control of the body mass and sodium intake is necessary, dietary recommendations should be followed.
Tablets can be included in monotherapy, they are combined with antianginal medications for patients who are immune to the effects of therapeutic dosages of nitrate and beta-blocking substances.
To prevent bleeding, pain and tissue overgrowth in the gums, constant dental prophylaxis and periodic visits to the dentist are required.
Substances that block the slow penetration of calcium ions through the channels do not cause the body to respond to drug withdrawal, however, to refuse treatment, the dosage should be gradually reduced.
The content of potassium cations, glucose, cholesterol, triglyceride molecules, uric acid and creatinine in the blood does not change under the influence of Stamlo tablets.
In the initial stages of therapy, patients may be drowsy and dizzy, which requires caution when driving vehicles.
Who should not be taken
Instructions for use "Stamlo" without fail contains a list of contraindications in which patients are not prescribed pills. These include:
- severe arterial hypotension, when the systolic pressure indicator is below 90 millimeters of mercury;
- collapse and shock cardiogenic state;
- unstable pain behind the sternum, except for a spontaneous appearance;
- the period of gestation and breastfeeding;
- excessive susceptibility to the ingredients of the drug and to dihydropyridine substances.
- Do not use the drug until the age of 18, since its safe activity has not been proven.
Caution is required in the use of patients who have decompensation deficiency of a chronic type of cardiac muscle, a mild or moderate increase in arterial pressure, an aortic and mitral form of vasoconstriction, acute myocardial infarction, excessive sugar, impaired liver function and fat metabolism.
Adverse reactions
Instructions for use "Stamlo" mentions all the unpleasant consequences that can occur after taking the medicine.
Amlodipine has an effect on the cardiac and vascular systems with the appearance of frequent heartbeats, shortness of breath, a clear decrease in pressure, fainting, vasculitis reaction, edematous process in the lower parts of the legs and arms.
The medication acts on the nervous and respiratory system with the occurrence of pain in the head, fatigue, mood swings, fainting, shortness of breath, depression, cough or rhinitis.
From taking the medicine, you may feel sick, vomit, have stomach aches, develop pancreatitis, gastritis and jaundice, dry out the oral cavity, peristalsis may be disturbed, and the concentration of liver enzymes may increase.
Changes in the genitourinary system are manifested by frequent or painful urges to emit urine, impaired discharge, nocturia, and a decrease in potency.
Skin reactions are associated with xeroderma, hair loss, purpura, inflammation of the epithelium, itching, rash, angioedema with allergies.
Musculoskeletal amlodipine negatively affects the system with the appearance of arthralgia, arthrosis, back pain and muscle weakness.
The sensory organs may suffer from the development of double vision, inflammation of the conjunctiva, visual disturbance and a sense of taste perception, ringing in the head, ocular accommodation, dryness in the cornea and mucous membrane.
How does it interact with medicines
The instructions for use of the tablet attached to the Stamlo medication do not recommend combining with substances that inhibit microsomal oxidation. Under their influence, the plasma level of amlodipine rises, the number of undesirable processes increases. The combination with inducers that accelerate microsomal liver enzymes gives the opposite effect.
Antihypertensive activity weakens under the influence of a non-steroidal anti-inflammatory drug. Sodium is retained by indomethacin and prostaglandin synthesis in the kidneys is blocked, and the excretion of Na + ions is also slowed down by alpha-adrenostimulants and estrogens, a sympathomimetic effect appears.
Warfarin, cimetidine and digoxin do not change the pharmacokinetic characteristics of the tablets.
Antianginal and hypotensive effects can be enhanced by thiazide, "loop" diuretics, beta-blockers, verapamil, angiotensin converting enzyme inhibitors and nitrates.
By substances containing Ca 2+ ions, the blocking effect on calcium channels is reduced.
The manifestation of the neurotoxic effect of lithium medications is enhanced by amlodipine, which is characterized by nausea, diarrhea, vomiting, tremor, ataxia, and tinnitus.
Amiodarone, alpha-adrenergic blockers, quinidine, antipsychotic drugs of the antipsychotic type increases hypotensive activity.
Overuse
In case of an overdose of the medicine "Stamlo", the instruction describes changes characterized by a clear decrease in pressure, a frequent reduction in cardiac, excessive peripheral vasodilation.
Also considered measures to eliminate the excess of medicine associated with gastric lavage, the appointment of sorbents. It is important to restore the activity of the lungs, heart and blood vessels, to control their performance. Limbs should be kept in an elevated state, urine volume should be monitored.
To normalize vascular tone, vasoconstrictors are used. To eliminate the effects of tubular blockage, calcium is used intravenously in the form of gluconate.
Similar drugs
For the medicine "Stamlo" analogues are also available in two dosages: 0.005 and 0.010 g of amlodipine. The qualitative composition of the inactive ingredients of tablets from different manufacturers may vary slightly, which does not affect bioavailability.
Amlodipine is manufactured by ALSI Pharma CJSC. It is considered one of the cheapest analogues of the Indian medicine. It has hypotensive and antianginal activity.
Russian analogues are the medicine “Vero-Amlodipin”, manufactured by the company “Veropharm” OJSC, and the drug “Amlodipin-Biocom” of the plant “Biocom” CJSC.
The medicine "Amlodipine-Teva" exists in two doses: 0.005 and 0.010 g. Both dosages are presented in white tablets having a round biconvex shape, engraved with "AB 5" or "AB 10". Produced by the Hungarian pharmaceutical company TEVA Private Co. Ltd. "
The drug Amlodipine Sandoz is produced by the Slovenian company Sandoz in the form of flat, round tableted units with a risk and a bevel.
Reviews
Many patients like this tool because of its effectiveness and affordable price. About the medicine "Stamlo" reviews can be heard both positive and negative. For some patients, pills help reduce high blood pressure, while others fail to eliminate hypertension.
In addition, the medicine can provoke fatigue, dizziness, increased fatigue, mood swings, drowsiness, and nausea. In this case, you should refuse to take the tablets.