The article describes the instructions for use for the MIG 400 preparation.
These tablets are the representative of the clinical pharmacological group of medicines related to non-steroidal anti-inflammatory drugs. They are used for symptomatic and pathogenetic therapy of various inflammatory processes in the human body, which are accompanied by the appearance of a pain syndrome.
The composition and form of the drug
According to the instructions, "MIG 400" is produced in the dosage form of tablets, which are coated with an enteric coating. They have an oval oblong shape with a biconvex surface. These pills are white. The main active component of the drug is ibuprofen, which in one tablet is contained in an amount of 400 milligrams.
Excipients
In addition, the composition of the drug includes auxiliary components in the form of silicon dioxide, corn starch, magnesium stearate, sodium carboxymethyl starch, titanium dioxide, macrogol, hypromellose and povidone. MIG 400 tablets are packaged in blisters of ten pieces. A cardboard pack contains one or two blisters along with instructions for use of the drug.
Pharmacological effects
As indicated by the instructions for the MIG 400, the active component of the tablets is ibuprofen, which suppresses the enzyme cyclooxygenase. Such suppression leads to a decrease in prostaglandins in the tissues of the area of the inflammatory process and contributes to the following therapeutic effects:
- Decrease in intensity of pain.
- Decreased hyperemia.
- Reducing the severity of edema.
Instructions for use with the "MIG 400 mg" are very detailed.
Like other non-steroidal anti-inflammatory drugs, this drug reduces platelet aggregation along with the formation of blood clots, and, in addition, reduces the activity of the protective factor of the gastric mucosa, increasing the risk of ulcers in it.
After taking these tablets inside, ibuprofen is rapidly absorbed from the intestinal lumen, evenly distributed in the tissues of the body. The presented preparation is metabolized in the region of the liver to inactive decay products, excreted mainly in urine. The half-life of the active component from the blood plasma is about four hours.
Indications for use of tablets
What else does the application instruction for MIG 400 tell us?
Reception of these tablets is indicated for symptomatic and pathogenetic therapy of inflammatory processes accompanied by pain:
- For headaches, including migraines.
- Against the background of painful omissions in joints and muscles, regardless of their origin.
- With painful menstruation in women.
- Against the background of neuralgia, when pain appears due to aseptic inflammation of the peripheral nerves.
- In the presence of toothache.
In addition, tablets are used to lower the temperature in the presence of a febrile condition, in particular provoked by infectious processes in the body.
Instructions for the "MIG 400" must be followed.
Contraindications
Taking these tablets is strictly contraindicated in a number of the following pathological and physiological conditions:
- The patient's hypersensitivity to ibuprofen, and, in addition, to its auxiliary components, as well as the presence of individual intolerance to acetylsalicylic acid or other representatives of the pharmacological category of non-steroidal anti-inflammatory drugs.
- The presence of erosive and peptic ulcers of the digestive system. For example, this drug is not suitable for use in peptic ulcer of the intestine in the acute stage.
- In the presence of hemophilia, hemorrhagic diathesis and other pathological disorders of blood coagulation.
- Against the backdrop of the aspirin triad, when a person suffers intolerance to acetylsalicylic acid, nasal polyposis and bronchial asthma.
- The presence of bleeding in the body of different intensity and localization.
- The lack of the enzyme glucose phosphate dehydrogenase, which is required for the normal functioning of red blood cells.
- The presence of various pathologies of the optic nerve.
- The period of pregnancy at any time.
This is confirmed by the instructions for "MIG 400 mg."
When is the drug taken with caution?
With great caution, it is required to use this drug in the following cases:
- In the presence of arterial hypertension or heart failure.
- Against the background of a decrease in functional liver activity.
- In the presence of a chronic course of peptic ulcer during remission.
- Against the background of inflammation of the stomach, that is, in the presence of gastritis.
- With enteritis and colitis of the intestine.
- Against the background of hyperbilirubinemia, when the concentration of bilirubin in the blood rises.
- Against the background of blood pathologies of unknown origin.
Thus, before you start taking "MIG 400" you need to make sure that there are no contraindications.
Dosage and administration
According to the instructions, "MIG 400" is taken orally after a meal. Taking the drug after meals is extremely important, as this reduces the negative effect of the active ingredient on the stomach and intestines. The tablets can not be chewed, they are washed down with plenty of water.
The initial therapeutic dosage for adults and children over the age of twelve is 200 milligrams three times. If necessary, the dose is increased to 400 milligrams three times a day, and after the therapeutic effect is achieved, the amount of the drug is reduced. You can not take these pills for more than seven days. If pain persists, consult your doctor. For patients who have concomitant pathologies of the heart, kidneys or liver, the dosage is reduced.
So it is said in the instructions for use for the drug "MIG 400".
Side effects
Taking the drug can lead to the development of many undesirable reactions, for example:
- The digestive system may respond to taking this drug with nausea, heartburn, vomiting, decreased appetite, abdominal pain, flatulence, constipation or diarrhea, dry mouth and pain. Inflammatory reactions of the oral mucosa are also possible, followed by the formation of various defects in it in the form of, for example, aphthous stomatitis. Liver inflammation, pancreatitis and gingivitis are not ruled out.
- The nervous system can respond to taking such pills with headache, insomnia or drowsiness, dizziness, anxiety, irritability, nervousness, depression, psychomotor agitation and confusion with the subsequent development of hallucinations. Aseptic meningitis, which is an inflammation of the membranes of the brain, rarely occurs.
- Possible increased pressure along with the development of heart failure and tachycardia.
- In the blood, a decrease in the number of leukocytes, red blood cells, granulocytes and platelets can be noted.
- It is likely the development of bronchial spasms and shortness of breath.
- Hearing impairment is also possible along with a decrease in its acuity, the appearance of tinnitus, toxic damage to the optic nerve and visual impairment. In this case, blurred vision is quite likely, and, in addition, double vision. Perhaps the appearance of scotomas.
- In laboratory indicators, an increase in the duration of capillary bleeding can be noted along with a decrease in hematocrit and hemoglobin. An increase in the blood concentration of creatinine and the activity of liver enzymes is not excluded.
- As an allergic reaction, a rash may appear along with itching of the skin, urticaria, severe necrotic damage to the tissue. Quincke's edema is not excluded allergic inflammation of the nasal mucosa and anaphylactic shock.
The likelihood of side effects, as a rule, increases with prolonged use of the drug. In case of adverse reactions, its use should be stopped immediately.
Such information is contained in the instructions for the drug "MIG 400".
special instructions
Immediately before you start taking the drug, you should carefully study the instructions and make sure that there are no contraindications. It is extremely important to pay attention to the list of special instructions regarding its use:
- Signs of internal bleeding require immediate withdrawal of the medicine.
- Taking a medication can mask the symptoms of pathological processes, which should be taken into account during the implementation of diagnostic measures.
- The development of pain in the abdomen with the use of these pills requires a thorough examination in relation to the likely occurrence of peptic ulcer.
- Alcohol is completely excluded during treatment with the drug.
- Presented tablets may interact with various pharmacological groups.
- During prolonged treatment with this drug, monitoring of laboratory indicators of functional liver activity should be carried out, and it is also necessary to monitor the state of the blood.
- If there is a need to perform laboratory determination of the number of ketosteroids, the medication should be stopped two days before the test.
- During the use of the drug, it is recommended to abandon activities that require increased attention and speed of the psychomotor reaction.
In pharmacies "MIG 400" dispensed without a prescription. In case of questions or any doubts about the use, consult a doctor.
Overdose
The instruction for the MIG 400 preparation indicates that if the recommended therapeutic dosage is exceeded, overdose symptoms develop, which include abdominal pain along with nausea, vomiting, lethargy, and coma. Depression, drowsiness, headaches, tinnitus, acute kidney failure, and, in addition, a critical decrease in blood pressure are also likely. A heart rhythm disturbance is not ruled out.
Overdose therapy consists, first of all, in washing the stomach, taking sorbents, and symptomatic treatment is also necessary.
So reports the instructions for use.
"MIG 400" and analogues
Similar medicines of this medicine, which are identical with the MIG 400 tablets in terms of their therapeutic effect and composition, are Nurofen and Ibuprofen. It should be noted that the presented analogues are most often prescribed to patients to replace the MIG 400 drug.
Storage conditions and price
In accordance with the instructions for use for tablets "MIG 400", the shelf life of the described drug is exactly three years from the date of its manufacture. These tablets should be stored in a dry place, which should be darkened and inaccessible to children. The temperature of the drug should be no higher than thirty degrees.
The average price for ten tablets in Russian pharmacies varies from sixty to eighty rubles.
Reviews about the drug
It should be said right away that on the Internet the reviews about this drug are positive, and its rating rating is almost ninety percent. It is noted that this drug helps to cope with any kind of pain very well.
Consumers write about this drug that its effect occurs twenty to twenty-five minutes after taking the pills. People like that such an effective medication is very inexpensive and is available to absolutely every buyer.
A negative moment spills out various contraindications, and, in addition, side effects. For example, people say that against the background of taking this medicine, their blood pressure increased, dizziness was observed, and nervousness arose. Patients are also afraid that using this medicine can harm various organs, since the drug is very strong and not entirely safe.
In addition to the negative comments, it is reported that the MIG 400 is not effective enough when very severe pains appear, and it also costs its customers a bit more than its Ibuprofen counterpart.
Thus, most people find this medicine to be very effective and effective. But it should be borne in mind that in the presence of very strong pain, you should choose a suitable substitute.
We examined the instructions for the MIG 400 tablets.