How does the drug "Tenoric"? Reviews of specialists and patients about this medicine can be found in the article. We will also describe in detail the instructions for use, talk about the form in which the drug is produced, what is included in its composition, etc.
Packaging, composition, form of the drug
In what form is the medicine "Tenoric" made? The reviews of those who used this drug say that it can be purchased only in the form of tablets. They are coated, have a biconvex and round shape with a dividing line on one side, and also have white or almost white color.
What is the composition of "Tenorik"? Reviews of experts indicate that this drug includes two active elements: chlortalidone and atenolol.
To date, the drug is produced in two different dosages. One tablet may contain 12.5 mg of chlortalidone and 50 mg of atenolol or 25 mg of chlortalidone and 100 mg of atenolol.
As additional components, the composition of the drug includes corn starch, magnesium stearate, lactose, silicon dioxide, sodium lauryl sulfate, talc, polyvinylpyrrolidone and isopropanol. As for the film membrane, it consists of macrogol, isopropanol, paraffin oil, methylene chloride, titanium dioxide, talc and hypromellose.
In what packaging is Tenorik medicine sold? Reviews of patients say that such a medicine can be bought both in strips and in blisters (100 or 28 pieces), placed in packs of cardboard.
Pharmacological characteristics of the drug
Why is a drug such as Tenoric prescribed? Reviews of doctors indicate that this is a combined antihypertensive drug that produces a fairly long hypotensive effect.
The work of the medication is due to the action of its two components: a diuretic (i.e., chlortalidone) and a beta1-blocker (i.e., atenolol). Consider the features of these substances in more detail:
- Atenolol is a beta1-blocker (cardioselective). Its selectivity decreases with increasing dose. It does not have internal membrane-stabilizing and sympathomimetic effects. It should be noted that, like other beta-blockers, it reduces heart rate and has an inotropic negative effect.
- Chlortalidone is a sulfonamide non-thiazide diuretic. It enhances the release of chlorine and sodium, and also increases the release of magnesium, potassium and bicarbonate. The antihypertensive effect of this substance is associated with sodium excretion. The simultaneous administration of atenolol with diuretics gives a more effective result than the use of each of these elements separately.
How long does the tenoric medicine last? Reviews of experts suggest that the effect of this drug persists throughout the day (after a single oral administration of the drug in a daily dosage).
Pharmacokinetic indicators
What pharmacokinetic features does the medicine “Tenorik” have? Reviews of doctors indicate that each of the components of the drug has its own indicators. Consider them right now.
- Atenolol After oral administration, it is absorbed from the digestive tract by 45-50%. The highest concentration of the active component in blood plasma was detected after three hours. Communication with proteins is very weak and makes up only 5-15%. Experts have proven that atenolol is not subjected to hepatic metabolism. More than 90% of the substance that has been absorbed into the systemic circulation leaves the body unchanged through the kidneys. The half-life of this component reaches 6-9 hours. However, renal failure is often the reason for the increase in this indicator.
- Chlortalidone. After oral administration, it is 60-65% absorbed from the digestive tract. The highest concentration of the active ingredient in the blood was detected after twelve hours. Chlortalidone has a fairly strong connection with proteins. It is about 70-75%. The active substance is excreted through the kidneys. Its half-life reaches fifty hours.
Indications for the use of the medication
What is the purpose of tenoric tablets? Reviews of doctors indicate that this drug is effective in arterial hypertension. However, it is recommended to be used only in complex therapy.
Contraindications to the use of tablets
Are there any contraindications for the medicine "Tenorik"? Reviews of experts speak of many prohibitions. Let's consider their list right now.
It is highly recommended not to use this drug in the following conditions:
- cardiogenic shock;
- severe bouts of bradycardia;
- progressive and severe arterial hypotension;
- metabolic acidosis;
- AV blockade of the 1st and 3rd degree;
- peripheral circulation disorders ;
- SSSU;
- heart failure (in chronic and acute form);
- pheochromocytoma;
- progressive asthma of bronchial;
- vasospastic angina pectoris;
- diabetes mellitus;
- obstructive bronchitis;
- gout
- hypoglycemia;
- myasthenia gravis;
- acute renal failure;
- acute hepatitis;
- minor age;
- hypersensitivity to the components of the drug.
The drug "Tenoric": instructions for use
Reviews about this medicine will be presented at the very end of the article. How should I take this drug for hypertension? Adults are prescribed in the amount of 50-100 mg per day. As for elderly patients, for them the medication is indicated in lower dosages.
People with impaired renal function should, if necessary, reduce the frequency of taking the medicine. In this case, it is required to pay attention to the fact that after a long course the drug is canceled not abruptly, but gradually.
Signs of a drug overdose
In case of an overdose with this drug, the patient experiences severe discomfort from arterial hypotension, bradycardia, heart failure, seizures, bronchospasm and increased drowsiness.
To eliminate these symptoms, in some cases, hospitalization of the patient who is undergoing gastric lavage is required.
Adverse reactions
Few people know, but the drug "Tenoric" can contribute to the appearance of a fairly large number of side effects. Let's list them right now:
- bradycardia, increased symptoms of heart failure, orthostatic hypotension, cold extremities, the appearance of arrhythmia, Raynaud's syndrome, AV blockade, symptoms of intermittent claudication ;
- confusion, paresthesia, dizziness, sleep disturbance, headaches, blurred vision, mood swings, apathy, acute psychosis, hallucinations, increased fatigue, disorientation;
- dry mouth, pancreatitis, nausea, anorexia, gastrointestinal disturbances, increased transaminases of the liver, hepatotoxicity with intrahepatic cholestasis, constipation;
- leukopenia, thrombocytopenia, purpura, eosinophilia, agranulocytosis;
- alopecia, exacerbation of psoriasis, dry eyes, skin rash, psoriasis-like reactions, photosensitivity;
- bronchospasm;
- hyperuricemia, hyponatremia, hypokalemia;
- an increase in the number of antinuclear antibodies, impaired glucose tolerance, a decrease in potency.
Despite all these adverse reactions, most often the drug "Tenoric" is tolerated by patients quite well. Side effects are so rare and weak that they are only transitory in nature.
The drug "Tenoric": reviews of patients (patients) and specialists
The average rating for Tenorik is 3.3 for a 5 point system. The main advantages of this tool, patients include:
- effectiveness (the drug copes well with the task);
- low cost (a drug package can be purchased for only 100-120 rubles).
As for the negative reviews, there are many among the patients. The disadvantages of the drug are:
- pressure pills with prolonged treatment can contribute to impotence and severe hair loss;
- medication very often causes seizures.
According to expert reviews, such a medication is very effective. However, it should be taken only according to indications and only after consultation with your doctor. By the way, many doctors do not recommend taking this drug to the elderly. In this case, it is better to replace it with a safer means of a similar action.