Statistics show that most often people turn to allergists with a phenomenon such as rhinitis. Abnormal reactions to various stimuli are observed with increased sensitivity of the body. Sometimes allergy symptoms are so unbearable that a person cannot do without medication. Our article provides comprehensive information on an effective remedy - Flixonase. Instructions for using the spray will also be described in the review.
What is rhinitis?
Allergic rhinitis is an inflammation of the mucous membrane of the nasal cavity, manifested in the form of a runny nose. The culprits of the acute reaction of the body are allergens. The inflammatory process begins to progress and gradually leads to a chronic disease.
Very often, rhinitis affects young children. This is due to the fact that their body does not have time to adapt to various substances with which they begin to come into contact. In adults, abnormal reactions occur either in the form of rhinitis or an allergic cough.
Acute rhinitis usually disappears after a month, while chronic rhinitis can linger for a long time. Both forms cause great discomfort for a person and negatively affect the quality of his life, affecting social and physical activity. If nothing is done in such situations, this will lead to disastrous consequences - the disease will turn into asthma, which will be much more difficult to deal with than rhinitis.
Next, we will familiarize you with the instructions for use "Flixonase" - a tool that successfully copes with the intolerable symptoms of allergies. In most cases, with its help, it is possible to correct the signs of a seasonal ailment. With too unfavorable environmental conditions and the presence of a high concentration of toxic substances in the atmosphere, additional methods of treatment are required.
What help can the spray provide for the symptoms of rhinitis?
Unfortunately, the causes of an allergic disease are not fully understood. It is reliable that the body reacts sharply to the use of chlorinated water, a large number of medicines, food with antibiotics and polluted air.
Irritating seasonal rhinitis are flowering plants, mowed grass, spores of mushrooms. Signs of year-round allergies can cause: dust, pet hair, household chemicals, perfumes, industrial waste and others. In addition to excessive discharge from the nose, tearing of the eyes and headaches appear.
Treatment of rhinitis can be accompanied by difficulties due to the fact that it is impossible to completely eliminate contact with allergens. However, the process of the course of the disease is reversible and is able to regress after proper treatment and termination of exposure to stimuli. The main thing is to choose the right drug, taking into account the individual characteristics of the body.
The remedy mentioned above is considered one of the best in the fight against allergies. Below we will consider not only the instructions for the use of Flixonase. Reviews, analogs (a list of which you will find), as well as specialist advice will help determine the choice of medicine. Preparations from this group have several advantages:
- Significantly reduce the intensity of the course of symptoms with regular use.
- Suppress the proliferation of polyposis in the nasal cavities, which are often associated with allergic rhinitis, and also eliminate inflammation of a different nature.
- The drugs act only at the local level and do not have an effect on the body as a whole, they do not cause tissue atrophy in the nose.
The composition of the drug and the form of release
In the instructions, "Flixonase" is presented as an anti-allergic, anti-inflammatory and anti-edematous drug used for the common cold with an allergic etiology. It is intended for the treatment of adults and babies, as well as in individual cases for pregnant and breast-feeding women.
The metered-dose nasal spray is a white, opaque, but without separate particles liquid. It is a glucocorticosteroid that is used exclusively intranasally. It is placed in dark-colored glass bottles with the already distributed number of dosages, there can be 60 or 120. The container with the contents is in a cardboard box. Manipulations with the drug are conveniently carried out thanks to the metering device and the adamper.
The drug is developed on the basis of micronized fluticasone propionate. The instructions for use of the nasal spray "Flixonase" also lists additional components that make up its composition. These include: benzalkonium chloride solution, purified water, microcrystalline cellulose, hydrochloric acid (diluted), anhydrous dextrose, microcrystalline carboxymethyl cellulose.
Act
As the manufacturer promises in the instructions for use, the Flixonase spray significantly reduces or stops nasal sinus congestion. At the level of local use, its negative effect on derivatives of pro-inflammatory mediators was noted. It inhibits the production of biological substances such as prostaglandins, histamine, leukotrienes, cytokines. Suppresses the proliferation of lymphocytes, neutrophils, eosinophils, macrophages, mast cells.
A powerful anti-inflammatory effect is due to the connection of the drug with glucocorticosteroid hormone receptors. Thanks to their interaction, a positive result is achieved on average 3 hours after the first injection of the drug. Along with this, after a short period of time, the symptoms of the allergy itself begin to gradually decrease: sneezing, tearing of the eyes, itching in the nasal cavities, pain in the sinuses. According to the instructions, "Flixonase" protects the body from the effects of allergens during the day.
For high-quality treatment of rhinitis, the drug is combined with eye drops, which are able to stop the ophthalmic symptoms of a seasonal ailment.
If a week has passed from the beginning of the prescribed course of treatment, and the expressed effect has not occurred, then you need to go to the hospital, probably, identical symptoms indicate another disease.
There is one more plus point indicated by the instruction - “Flixonase” absolutely does not suppress the central nervous system. Also, it does not produce inhibition in psychomotor reactions. During treatment, it is allowed to drive vehicles and other complex mechanisms.
Stages of pharmacokinetics
From the mucous membrane of the nasal passages, absorption of the main substance is unlikely due to its low water solubility, and also because most of the fluticasone propionate is swallowed. Subject to the recommendations indicated in the Flixonase application for use with respect to the daily dosage, the product will not have a systemic effect. It is almost impossible to determine its maximum plasma concentration at a daily norm of 200 μg. A significant part of the drug enters the digestive system, where its absorption reaches only about 1%. Its interaction with plasma proteins is slightly more than 90%. When absorbed into the circulatory system, the result of the first passage is observed, in hepatocytes there is a metabolism of fluticasone propionate, with the participation of the CYP3A4 isoenzyme. The resulting metabolite is inactive. Decay products are excreted through the intestines along with bile.
Under what conditions can a nasal agent be used?
A narrow-line medicine is prescribed for the treatment and prevention of seasonal and chronic rhinitis with allergic etiology. Like any remedy that has useful properties, it has contraindications. Let's see what is said about the use of "Flixonase" in the instructions and reviews of experienced professionals. Medical practice has shown that you cannot nasally administer the medicine in the following conditions:
- the presence of ulcers on the mucous membrane of the nasal passages;
- individual intolerance to the main substance;
- after surgery in the nose or recent injuries;
- infectious diseases of the nasal sinuses;
- you can not simultaneously use corticosteroids in different forms of release: tablets, ointments, eye drops, creams, preparations for bronchial asthma, similar sprays;
- in order to prevent an increase in the concentration of the active substance in plasma, it is forbidden to use products containing a CYP3A4 isoenzyme inhibitor;
- during pregnancy only on the recommendation of a doctor;
- treatment of children with fluticasone propionate can begin only after 4 years;
- with herpes, the drug should be used with caution.
Side effects and overdose
As a result of clinical studies, unwanted symptoms were detected after treatment with Flixonase spray. The instructions also indicate possible allergic exacerbations:
- Local manifestations: inflammation of the nasopharynx, excessive nasal congestion, burning sensation, bleeding from the nasal cavity, increased dryness of the mucous membrane.
- Headaches, in rare cases, treatment can lead to perforation of the nasal septum (after operations, in particular, in the anamnesis).
- Allergy aggravation: skin rash, bronchial spasms, swelling of the tongue or face, anaphylactic manifestations.
Cases with an overdose of the drug were not noted with its correct use (confirmation of this fact is in the instructions and reviews about "Flixonase"). The risk of an excess of the drug in the human body arises only a week after its use. With an increase in the prescribed dose, there is a possibility of malfunctions in the functioning of the adrenal glands. The reason for this may be the use of additional funds from the group of glucocorticosteroids. In such cases, treatment should be carried out under the strict supervision of a physician. This involves monitoring the work of the adrenal glands, which consists in giving blood for tests. With severe exacerbations, there is a need for drug withdrawal and symptomatic treatment.
It should be borne in mind that the spray can enhance the therapeutic effect of nasal drops, which have a vasoconstrictor effect.
Dosage
Adults are prescribed a single injection per day for 2 allotted doses (in each cavity), for children over four years of age - 1 dose. Upon reaching the permissible age, the standard rate can also be used for children. In the instructions for use, "Flixonase" is recommended after 12 years to gradually increase the introduction of drugs. Such patients are prescribed for any form of allergic rhinitis, as well as for its prevention.
Relief usually occurs on the 5th day after the manipulation. Sometimes the doctor may prescribe the maximum allowable rate of the drug, which does not exceed 4 nasal sprays.
In old age, patients need constant correction of the dosage regimen.
You need to keep the medicine away from children, in places with limited exposure to daylight and a temperature of + 18-22 ° C. With the right storage conditions, the drug can be used for two years.
How to use the dispenser?
It will help you figure out how to correctly administer the medicine “Flixonase” (drops in the nose), instructions with an algorithm of actions:
- First of all, it is good to clean the nasal passages from the mucous secretions and wash them;
- Insert the tip of the dispenser into one nasal cavity, and cover the second with a finger.
- In this case, the head should be tilted slightly forward, and the bottle with the medicine should be placed vertically.
- Inhale the air through the nose and spray it, then exhale through the mouth.
- Then, in the same way, inject the drug into the second passage of the nose.
- Wipe the dispenser tip with a disinfectant and close with a cap.
Analogs
Before starting the discussion of drugs, I would like to recall an important detail, which was very clearly explained in the instructions: the nasal spray "Flixonase" in no case can be combined with analogues. These means can only be replaced if necessary, for example, with increased itching or the opening of nosebleeds. Here are the most popular structural preparations that are similar in active substance:
- Flixotide. Aerosol is available in aluminum inhalers, somewhat concave at the base and equipped with a spray. Placed in a cardboard box with dispensing device. Suspension for inhalation is white. It has pronounced anti-allergic and anti-inflammatory effects. It is prescribed for the treatment of chronic bronchitis, obstructive pulmonary disease and at various stages of the development of bronchial asthma.
- "Cutivein." A representative of the class of glucocorticosteroids, found in the form of a cream. Thanks to the hormonal substance contained in the composition, it is able to restore the damaged epidermis as a result of allergic reactions. It is also prescribed for insect bites, psoriasis, dermatitis, eczema and neurodermatitis.
- "Nazarel." Spray of white color with a homogeneous structure, opaque. The drug in therapeutic doses relieves edema and exhibits a strong anti-allergic effect. Indication for use is seasonal and year-round rhinitis.
- "Fluticasone Propionate." The agent for intranasal administration is available in glass bottles with plastic pallets. According to the pharmacological action and packaging, the drug is identical to Flixonase.
- There is another popular drug - "Nazonex", which is considered to be a corticosteroid analogue related to the hormonal type. However, it cannot be called identical to the above group, since most of its composition falls on the active component - mometasone.
Below is another list of analogues of Flixonase. Instructions for the use of these funds help to understand that the drugs are similar in pharmacological properties. These include: Oxycord, Benacort, Avamis, Aldetsin, Bekonase, Ingakort, Kenalog, Ultraproct, Cortisone, Elokom, Sofradeks, Proctosedil ".
Prevention of Allergic Rhinitis
Timely use of medications will help protect against an overly acute condition. People predisposed to seasonal allergic diseases need to start administering them even before the plants bloom. Most nasal preparations can be used this way according to their instructions. Drops "Flixonase" is no exception and are great for the prevention of rhinitis. To help them act more efficiently, precautionary measures should be followed:
- If possible, minimize contact with allergens.
- Use the medicine only as directed by your doctor.
- Regularly carry out wet cleaning in the living room.
- In case of exposure to professional harmful substances, change the type of activity.
- Use air conditioning and an air purifier, which will reduce the accumulation of fungal spores and dust.
- To prevent dermatoses and respiratory diseases.
- Exclude foods that provoke allergic reactions.
- In summer, do not rest in the regions of mountains and forests with a stormy and long flowering period of plants.
What patients say
The instructions for the use of "Flixonase" and reviews contain information that the product is effective, but does not relieve allergic rhinitis forever. People suffering from an abnormal illness, note that it perfectly fights symptoms and greatly facilitates well-being. Although in general the opinion about the drug was positive, it is not suitable for everyone. In some patients, the spray did not remove the swelling, hypersensitivity was observed, expressed in rare watery discharge and nasal congestion.
Allergists this product is in good standing, but they believe that they should not be used constantly. If treated with the same medicine for several years, then it will lose its positive effect on the body. When the course of treatment lasts more than 6 months, then the patient needs to visit a doctor regularly and monitor the condition of the body.
Output
We hope that the data from the Flixonase instructions for use and the analogues given above will help you make certain conclusions about corticosteroid preparations. , , . , . .