The drug "Vikasol" (tablets), the instructions indicate contain 15 mg of sodium menadione bisulfite.
The drug "Vikasol" in the form of a solution for intramuscular injection contains in each ampoule 10 mg of sodium menadione bisulfite.
The drug belongs to the clinical and pharmaceutical group of hemostatic agents. The pharmaceutical effect is based on the fact that the drug "Vikasol" is a synthetically created analogue of vitamin K, soluble in water. Prevents the formation of prothrombin. Beneficial effect on substances involved in blood coagulation, activated in the liver; helps restore blood coagulation.
The action of menadione in the body is observed twelve hours after administration. The drug "Vikasol" (tablets) is perfectly absorbed by the body. In the blood interacts with plasma proteins, this process is reversible. Depot of accumulation of the drug in the body is the liver, spleen, myocardium. At a certain stage of metabolism, vitamin K2 is formed from sodium menadione bisulfite .
The breakdown products of vitamin K are monosulfates, phosphates and digducuronide-2-methyl-1.4-naphthoquinone; up to 70% of the residues are excreted in the urine.
The drug "Vikasol": instructions for use. Indications
The drug is prescribed:
- with hemorrhagic syndrome associated with hypoprothrombinemia;
- with a lack of vitamin K in the body (for patients undergoing treatment for jaundice, hepatitis, cirrhosis, prolonged diarrhea);
- with hemorrhagic disease in newborns;
- with significant blood loss as a result of injury, trauma and surgery;
- with heavy uterine bleeding in gynecology;
- with menorrhagia;
- with bleeding resulting from medications included in the group of indirect anticoagulants, as a specific antagonist;
- during pregnancy in the third trimester of pregnancy, to prevent bleeding in newborns;
- in preparation for surgery, after surgery;
- with bleeding caused by a stomach ulcer or duodenal ulcer;
- with heavy hemorrhoidal and nosebleeds.
The drug "Vikasol": instructions for use. Dosage
The doctor prescribes for adults for oral administration of menadione sodium bisulfite with a dose of 15 mg to 30 mg. The intramuscular dose is 10 mg to 15 mg.
Children under the age of one year are prescribed a dose of 2-5 mg of the drug.
Children under the age of 2 years are prescribed 6 mg.
Children from 3 years to 4 years of age are prescribed 8 mg.
Children from 5 years to 9 years are prescribed 10 mg.
Children aged 10 to 14 years are prescribed 15 mg.
The indicated doses of Vikasol are prescribed 2-3 times a day. The doctor sets the duration of the course of treatment individually.
Do not exceed the daily dose of the drug for adults - 60 mg orally, 30 mg intramuscularly. You can not set a single dose of the drug for adults higher than 30 mg orally, 15 mg intramuscularly.
The maximum allowable daily dose of the drug "Vikasol" for newborns is 4 mg.
The drug "Vikasol": instructions for use. Side effects
In clinical trials, rarely allergic reactions were observed, which are manifested by skin rash, itching, erythema, urticaria, bronchospasm.
Disturbances in the functioning of the blood coagulation system can be manifested by hemolytic disease of the newborn.
The drug "Vikasol": instructions for use. Contraindications
Do not prescribe the drug:
- with increased blood coagulation;
- with symptoms of thromboembolism;
- with increased sensitivity to sodium menadione bisulfite.
Pregnant women and mothers who breastfeed, the drug "Vikasol" is prescribed according to indications.
special instructions
Patients who have established violations associated with the outflow of bile, the drug is administered parenterally. In the treatment of patients suffering from hemophilia and Werlhof disease, the drug "Vikasol" does not give positive results.
The use of the drug simultaneously with oral anticoagulants reduces the anticoagulant effect.