"Propranolol" is a medicine that is part of the group of selective adrenergic blockers. The drug has an antianginal effect, antiarrhythmic and hypotensive. The drug is prescribed for the treatment of coronary heart disease, thyrotoxicosis, hypertension. The medication is effective for neurocirculatory dystonia, migraine. It is used in the treatment of heart failure, angina pectoris. The drug benefits the body with myocardial infarction. They treat arrhythmia and hypertrophic cardiomyopathy. When Propranolol is not suitable for the patient, analogues are considered by a specialist, a medication is prescribed, which is optimal for the patient.
Release form
You can buy a drug of two types - the drug "Propranolol" and the drug "Propranolol Nycomed." These are the same drugs that are produced by different manufacturers in tablets.
Medicine components
The drug is made on the basis of the active substance propranolol. The dose of the main component may be different - 10, 40, 80, 160 mg in each tablet.
The auxiliary ingredients in the manufacture of tablets are different and depend on the manufacturers. In order to know exactly what the medicine consists of, you must read the instructions before using it.
Therapeutic effect of the drug
Displays the ability to block beta-adrenergic receptors funds "Propranolol" instructions for use. Analogs have a similar effect on the body. Tablets affect the receptors of the walls of blood vessels beta 1 and 2. The inhibitory effect on these receptors leads to relaxation of the walls of blood vessels, which eliminates many problems - high blood pressure, increased heart demand for oxygen, poor supply of tissues and organs with nutrients and oxygen.
The antiarrhythmic effect of the drug contributes to the appearance of positive changes in the body, such as normalizing the automatism of the sinus node, reducing the conductivity of the atrioventricular node, eliminating the increased excitability of the cells that make up the myocardium. Thanks to Propranolol, normal heart function is restored, there is no reaction to external stimuli that can negatively affect its rhythm.
"Propranolol", analogues contribute to the development of the antianginal effect, which is manifested by an improvement in the state of the heart muscle, a decrease in the amount of oxygen necessary for its work. This means that the heart needs less oxygen to contract, and the frequency of these contractions is also reduced.
The antihypertensive effect is based on an increase in the lumen of the vessels and the relaxation of their walls. The use of a single dose of tablets leads to a decrease in blood pressure, the effect remains for at least 20 hours, about a day. Persistent hypotensive effect is observed after two weeks of regular use of tablets. The drug is not suitable for stopping conditions accompanied by a sharp increase in pressure, it is indicated for prolonged therapy for hypertension.
Long-term use of the drug leads to the development of a cardioprotective effect. Testimonies indicate a decrease in the likelihood of recurrence of myocardial infarction after such therapy with Propranolol, reviews, instructions. The risk of sudden death occurring is also significantly reduced. It is known that the drug has a positive effect with increased intraocular pressure.
Pharmacokinetics
After ingestion, the main part of the drug is absorbed (approximately 90%), while the bioavailability indicator is negligible. Communication with proteins corresponds to 93%. The drug is removed from the body with urine, into which metabolites enter. An invariable look has no more than one percent of the drug.
Indications
"Propranolol" analogues can be prescribed for the treatment of certain conditions and diseases. They treat portal and arterial hypertension, myocardial dystrophy, thyrotoxicosis. The medication helps to alleviate the condition with a narrowed aortic lumen, essential tremor, panic attacks, can be used as a means for prophylactic use in migraines. The tablets are suitable for therapy with neurocircular dystonia, myocardial infarction, extrasystole. The drug is prescribed for patients with mitral valve prolapse. Indications include supraventricular tachycardia and sinus. The purpose of the drug is made with withdrawal symptoms, angina pectoris, akathisia, resulting from the use of antipsychotics. The medication is prescribed for patients with pheochromocytoma for complex therapy. The drug is used for weak labor, after menopause to eliminate its negative manifestations.
Contraindications
There are some contraindications for the propranolol drug. Analogs can be selected in cases where this medicine is not suitable. Contraindications include:
- intolerance to the components of the product;
- cardiogenic shock;
- bradycardia, in which the number of heart contractions per minute is 55 beats;
- metabolic acidosis;
- chronic or acute heart failure;
- vasomotor rhinitis;
- sinoatrial block, atrioventricular (2nd, 3rd degree);
- Prinzmetal angina pectoris ;
- low blood pressure;
- insulin use;
- a syndrome accompanied by weakness of the sinus node;
- the presence of a period during which prolonged fasting was present;
- problems with peripheral circulation (decompensation stage);
- previous instructive diseases in which the respiratory tract, asthma, the presence of bronchospasm are affected.
There are conditions in which caution is required. In the following cases, you can choose instead of the drug "Propranolol" analogues, synonyms:
- myasthenia gravis;
- diabetes mellitus (stages of decompensation, subcompensation);
- insufficiency of the heart muscle (decompensated), liver, kidneys;
- spastic colitis;
- depressive states;
- atrioventricular block (first degree);
- psoriasis;
- increased thyroid function;
- chronic bronchitis;
- low blood sugar
- emphysema;
- elderly age;
- period of pregnancy, breast milk feeding.
Drug treatment
Patients with hypertension should take a medicine at a dose of 40 mg twice a day at a time. Its increase is possible within 14-28 days. If necessary, you can drink tablets daily in a dosage of 80 to 160 mg. The frequency of taking the drug is the same.
With tachyarrhythmias, adult patients drink three to four times daily from 10 to 30 mg for each dose of Propranolol. Analogs can be used if this drug does not fit. For small patients with the same problem, a medication is prescribed in an amount of 0.2 to 0.4 mg per kilogram of weight. The frequency of use of the drug is also three to four times a day.
For prophylactic purposes, patients who have been diagnosed with angina are prescribed four doses of this medicine daily. A single dose is 20 mg. Its increase is possible for seven days. 40 mg of the drug is taken at the same frequency, 80 mg - a little less often (twice).
After myocardial infarction, prevention is required. It can be performed with the propranolol medication. The size of a suitable single dose is 40 mg; there should be three daily doses of the drug. Increase the dose to a maximum of 80 mg.
For migraines, preventive measures must be taken using 40 mg of the drug twice a day. A dose increase of up to 80 mg is required, there can be two or three doses of medicine per day, and in children three or four. Dose calculation for small patients is carried out taking into account their weight, from 1.5 to 2 mg per kilogram.
Thyrotoxicosis is a disease in which the drug is prescribed from 10 mg, but not more than 40 for taking three or four times a day.
If you plan to perform pheochromocytoma therapy, the drug is combined with alpha-blockers.
Side effects
You should pay attention to what determines the side effects of the drug "Propranolol" instructions for use. Analogs, reviews are also no less important information that affects the choice of medications for treatment. To minimize the risk of developing negative reactions of the body, you must carefully read the instructions, it will be useful to familiarize yourself with the reviews.
The medication, if used improperly, can harm the cardiovascular system, cause disruptions in the central nervous system, endocrine system. Negative manifestations from the digestive tract are possible, the condition of the mucous membranes and skin may be disturbed. Among the side effects indicated in the instructions are problems with the respiratory system. Other side effects may occur.
Analogs, price
Before purchasing the drug "Propranolol", analogues, the price is often studied by patients. You can buy tablets for 16-75 rubles. The price is determined by the number of tablets in the package. You can replace the drug with Propranobene, Obzidan or Anaprilin medicines. You can also make treatment with Inderal LA, Inderal.
When familiarizing yourself with the medicine "Propranolol", instructions for use, price, analogues provide important information that allows you to make the most correct decision when choosing medications and the method of treatment.
Reviews
The reviews are mostly positive. They report that drug treatment is often effective. In addition, many are satisfied with the low price of the medicine. "Propranolol" manages to maintain blood pressure at a normal level, to quickly get rid of heart palpitations. The medication reduces the manifestations of heart disease, relieves a person of excitement. People usually leave negative reviews due to serious side effects that can occur during therapy. Sometimes there is severe weakness, trouble sleeping, nightmares.