Diseases of the musculoskeletal system cause a lot of inconvenience and pain. A person suffering from such ailments can be limited in movement, he constantly experiences unpleasant sensations in the joints and bones, his performance decreases.
In some cases, doctors may recommend taking Nimulide. Instructions for use and reviews about this tool are of interest to many patients. This is what we will talk about in this article.
Can I use the medicine for children? Instructions for use "Nimulida" and reviews of this tool show that in pediatrics the drug is used quite actively, but its use depends on the form of release and dosage of the main component.
Briefly about the active substance
The main component of this drug is nimesulide. It is a non-steroid sulfonalilide. Thanks to this component, the product has analgesic, anti-inflammatory and even antipyretic effects.
Let's talk about the forms of release
Dosage forms of "Nimulide" are:
- Lingual tablets (for resorption). They are light yellow rounded pills.
- Tablets for oral administration. They are also rounded, painted in a light yellow color.
- One percent gel. According to the instructions for use, Nimulide ointment is used for external application. The gel is a homogeneous translucent mass of light yellow color.
- Suspension. According to the instructions for use, the syrup "Nimulide" for children and adults has a pronounced fruity taste and is prescribed for oral administration.
Depending on the age of the patient, the degree of his illness, and also on the basis of other clinical factors, the attending physician will prescribe the necessary form of the drug and prescribe the regimen.
However, before you figure out how to take the drug, you need to familiarize yourself with its main components.
More on the composition of the medication
The components that make up the drug differ depending on its form of release. What do Nimulide resorption tablets consist of? Instructions for use describe in detail the composition of the drug. Each pill includes one hundred milligrams of the active substance, as well as sodium croscarmellose, mannitol, magnesium stearate, sodium carboxymethyl starch, colloidal silicon dioxide, sodium methyl parahydroxybenzoate, aspartame, sodium propyl parahydroxybenzoate, purified water, and orange flavoring.
And what is written in the annotation about the oral tablets “Nimulide”? The instructions for use provide an accurate list of the components of this drug. First of all, it is nimesulide in the amount of one hundred milligrams. Also, the composition of the product includes corn starch, lactose, croscarmellose sodium, colloidal silicon dioxide, polysorbate, aspartame, povidone, sodium docusate. Purified water and hydrochloric acid are removed during the manufacturing process.
Many people using the drug for external use are interested in what does the Nimulide gel consist of? The instructions for use explain that the composition of the product includes components such as carbomer, purified 95% ethanol, hyprolose, phosphoric acid, triacetin, dimethylacetamide, flavors 0106-G and MSC-03, as well as purified water.
The amount of active substance in the preparation reaches 10 milligrams per gram of gel.
It was already mentioned above that in medical practice the drug is used quite often for both adults and children. Instructions for use of the suspension "Nimulide" describes in detail the composition of the syrup. First of all - the active substance. Its suspension contains ten milligrams per milliliter of the drug. The auxiliary components of the agent are a 70% non-crystallized solution of sorbitol, macrogol glyceryl hydroxystearate (or Cremophor RH-40), xanthan gum, sodium methyl parahydroxybenzoate, citric acid monohydrate, glycerin, sodium propyl parahydroxybenzoate, sodium sulfate, sodium hydrogen chloride, sodium chloride, acid chloride purified water, as well as yellow dye (quinoline) and flavor (mango and vanilla).
In what cases are nimesulide-based drugs prescribed?
When is the medicine used
The attending physician may consider it appropriate to prescribe this drug for such diseases:
- Rheumatoid arthritis. This disease is autoimmune in nature and causes inflammation in the joints, provoked by malfunctions of the immune system due to the production of antibodies that affect their own cells.
- Psoriatic arthritis. It manifests itself as inflammation of the joints due to severe psoriasis.
- Osteochondrosis. The disease is characterized by damage to the intervertebral joints and the development of the inflammatory process in them. May be complicated by infringement of the spinal roots.
- Ankylosing spondylitis. A disease manifested against the background of an autoimmune lesion of the intervertebral joints.
- Osteoarthrosis. The disease is accompanied by damage to the cartilaginous joint tissue, provokes pain and inflammation.
- Myalgia (or muscle pain) of various origins.
- Joint pain due to exacerbation of gout.
- Inflammatory processes of ligaments (tendovaginitis) and periarticular bag (bursitis).
Depending on the form of release, the drug can be prescribed for other diseases or unpleasant symptoms. For example, according to reviews and instructions for use, Nimulide tablets effectively relieve pain and inflammation in various injuries, in the postoperative period, and in fevers of an infectious-inflammatory nature. Moreover, the pills can help with headaches or toothaches. Quite often, in the above cases, a suspension of Nimulide is prescribed, especially when it comes to treating small patients.
In addition, in accordance with reviews and instructions for use, Nimulide gel is actively used for the treatment of sciatica and even lumbago.
And yet, despite the effectiveness of the drug, many doctors agree that the medication does not affect the progression of the disease. How then does nimesulide act when it enters the human body?
Pharmacological possibilities
The active substance inhibits the enzyme cyclooxygenase, which inhibits the synthesis of certain mediators responsible for inflammatory processes. Since the concentration of prostaglandins decreases, the inflammatory reaction also decreases, due to which pain, swelling and hyperemia.
Since the main component of the drug suppresses only COX-2, it practically does not affect the level of prostaglandins located in the gastric mucosa, as well as platelet aggregation. Due to this, the drug causes fewer side effects from the digestive tract and the hematopoietic system than similar analogues with other chemicals.
Pharmacokinetic features
After taking Nimulide inside, the main component quickly penetrates into the plasma and is distributed almost immediately to tissues and cells. Nimesulide easily enough penetrates into the foci of inflammation, synovial fluid and female genital organs. Its half-life varies between two to five hours. It is metabolized in the liver, and excreted through the kidneys (about 65 percent) and through bile (about 35 percent).
When you can not take the drug
Many patients are interested in contraindications to the use of Nimulide. In what cases can not use the medication for treatment?
First of all, we are talking about individual patient intolerance to certain components of the drug.
Also, you can not take the drug with exacerbation of peptic ulcer of the stomach or intestines, as well as with bleeding from the digestive tract. Severe hepatic and renal impairment are also grounds for not appointing Nimulide therapy.
And what about the cardiovascular system? If a patient is diagnosed with heart failure of a decompensated type, hyperkalemia (a high indicator in blood tests of potassium ions), various bleeding disorders, bronchial asthma or nasal polyposis, then the drug is also not prescribed. You can not take tablets in the postoperative period after coronary artery bypass grafting.
Future and lactating mothers are also not prescribed “Nimulide” in tablet form, since its administration can entail the development of serious pathologies in the fetus or newborn.
And what about the use of the gel? This form of medication has fewer contraindications. Often, the gel is prescribed with extreme caution with high blood pressure, type 2 diabetes mellitus, severe renal or hepatic insufficiency. Elderly people, children under seven years of age and pregnant women are also prescribed Nimulide ointment in extreme cases.
In what cases the doctor decides
According to the annotation to the drug, there are situations when the drug should be treated with extreme caution and under close supervision of a specialist. Such circumstances include various human diseases that may be aggravated by the use of Nimulide. First of all, it is moderate heart failure, cardiac ischemia, diabetes mellitus, cerebral atherosclerosis, a healed ulcer, stroke. Also, with extreme caution, the drug should be prescribed to the elderly.
Children's age up to seven years is one of the main contraindications of the gel. Pills are not recommended for the treatment of small patients up to twelve years. How to take the suspension in childhood will be described below.
How to take the drug for children
Instructions for use "Nimulida" explains that a suspension can be prescribed for small patients. However, the dosage of the drug should be carefully calculated. The attending physician will prescribe the necessary medication schedule.
A single dosage of the drug is calculated by the formula: one and a half milligrams per kilogram of the baby’s weight. The resulting amount of the drug should be taken orally two or three times a day.
How to take the drug for adults
It all depends on the form of the drug.
Lingual tablets must be slowly absorbed under the tongue half an hour before meals. Patients over twelve years of age should take one tablet twice a day.
Tablets for oral administration should be drunk after a meal with a necessary amount of water. The recommended dosage is one tablet twice a day. Depending on concomitant diseases, the number of doses can be reduced to one.
How to use Nimulide gel? The drug should be applied to the skin in the area of inflammation, but it can not be rubbed. The amount of agent used and the frequency of administration depends on the stage of the disease and the condition of the patient. The specialist can prescribe the use of the gel up to four times a day for ten days.
Can adults take Nimulide suspension? Instructions for use explain that patients over twelve years of age can also use syrup in treatment, observing a dosage of one hundred milligrams twice a day.
Talk about side effects.
Adverse reactions from the body may accompany treatment with this drug. This is confirmed not only by individual patient reviews, but also by instructions for use.
When taking “Nimulide" inside, side effects such as tachycardia, hot flashes, hemorrhages, and less commonly, increased pressure can occur. Also, very often people are disturbed by disorders of the gastrointestinal tract, accompanied by nausea and even vomiting, diarrhea, as well as an increase in the activity of certain liver enzymes. Less commonly, patients may be distressed by bloating, constipation, and even gastritis. There are also isolated cases of the development of such serious ailments as stomatitis, bleeding of the digestive tract, ulcers, hepatitis, jaundice and so on.
Rarely on the part of the respiratory system can manifest such undesirable symptoms as shortness of breath, exacerbation of asthma or bronchospasm.
The nervous system can respond to dizziness, nervousness, a sense of fear, nightmares. Very rarely manifestations of drowsiness and headache are possible.
When using the drug inside, edema, retention or urinary incontinence can also occur. Very rarely, as side effects, patients are faced with the appearance of nephritis, renal failure, oliguria.
Against the background of taking "Nimulide" there is a risk of developing serious ailments such as anemia, thrombocytopenia, and purpura. However, according to observations, these conditions are very rare.
Also, the patient may be disturbed by urticaria, increased sweating, rash, itching, general weakness.
When used in the treatment of the gel, side effects are less pronounced. Most often these are local negative reactions, such as urticaria, a change in the color of the epidermis, peeling of the skin, itching. Less commonly, dizziness, nausea, vomiting, ulceration in the digestive tract, anemia, thrombocytopenia may disturb the patient.
As soon as you encounter one of the symptoms listed above, you must consult your doctor and tell him about your condition. It may be necessary to cancel the drug and prescribe a replacement for it.
Interaction with other medicines
According to numerous studies, "Nimulide" potentiates the effect of drugs that reduce blood coagulation. On the other hand, the remedy we are interested in reduces the therapeutic effect of furosemide, as well as antihypertensive drugs.
The combined use of nimesulide and methotrexate contributes to side effects.
Other usage recommendations
Instructions for use prohibit the application of gel on the mucous membranes of the body and open wounds. Also, you can not rub the product into the skin and cover the place of application with an occlusive dressing.
Drug therapy should be started with small doses, gradually increasing them to obtain the necessary therapeutic effect.
Since nimesulide can cause dizziness and drowsiness, when taking it, you should be careful to deal with cases that require a special concentration of attention.
How to save a medicine
According to the instructions for use, the drug should be stored in a dry place, protected from direct sunlight, at a temperature not exceeding 25 0 C. The gel is not recommended to be stored in the refrigerator.
Reviews of real patients
Many people almost unanimously claim that “Nimulide” is an effective remedy for temperature, which cannot be brought down by other antipyretic drugs. According to numerous reviews, this drug in the form of a suspension was used even for young children with teething when the temperature was kept for days.
You can also often hear that “Nimulide” is a rather effective remedy for joint diseases. In such cases, patients use tablets or gel, so that pain in the joints and muscles quickly disappears.
However, almost all people taking the drug complain about a large number of side effects. Patients agree that the medication should be taken only in special cases and only after the appointment of the attending physician.
"Nimulide" is a serious potent medicine, so you can not use it for colds and ordinary headaches. The drug is prescribed for severe ailments or in situations where other drugs have been ineffective.
Analogues of the drug
And what about drug substitutes? Below we consider the generic “Nimulide” for the active substance - nimesulide.
The most common substitutes for Nimulide are Nise tablets. They are prescribed for radiculitis and osteochondrosis, arthritis and myalgia, injuries and lumbago, gout and sciatica. Children are not recommended to take this drug until they are twelve years old. Also, tablets should not be taken by pregnant and lactating women, people suffering from bronchial asthma and atopic dermatitis, as well as patients with a history of bleeding from the digestive tract, serious liver and kidney problems. The drug is used twice a day for fifty to one hundred milligrams. Previously, the tablets are dissolved in a tablespoon of water, the prepared solution is drunk, and then washed down with water or juice.
Sulaydin is a nimesulide based gel. The amount of active substance in the preparation reaches ten milligrams per gram of product. The drug is prescribed for bursitis, osteoarthritis, lumbago, periarthritis, as well as severe muscle or ligament sprains. According to the instructions, the gel is applied three or four times a day to the affected area. The course of treatment is one to two weeks.The drug is not recommended for children under twelve years of age, future and nursing mothers. Also, do not apply the product on open wounds.
Nemulx is the next analogue of Nimulide, produced in the form of granules from which a suspension can be prepared. In one sachet of the drug is one hundred milligrams of nimesulide. According to the instructions, the granules from one sachet are dissolved in one hundred milliliters of water, after which the suspension is drunk. The prepared medicine tastes good, as the granules include sucrose and orange flavor. The tool is taken one sachet twice a day. Indications for use are pain of various origins, osteoarthritis, arthritis and many other ailments.
Only the attending physician is entitled to prescribe medications and determine the regimen. Do not self-medicate! This can lead to irreparable consequences.
We have reviewed the instructions for use "Nimulida". Analogs and reviews about the drug were also presented in the review.