How is the drug “Syresp” (syrup) used and for what purpose? Instructions for use and indications for the use of the suspension will be described later. You will also learn about whether it is possible to give this drug to children, whether it has side effects, contraindications, etc.
Composition, packaging, description
In what packaging is the drug “Syres” (syrup) sold? Instructions for use of the drug are enclosed in a pack of cardboard. It also contains a dark plastic bottle corked with a screw-on polyethylene cap with a guarantee ring.
The drug in question is orange in color, and also contains such an active substance as fenspiride hydrochloride. In addition, the suspension also contains additional ingredients in the form of methyl parahydroxybenzoate, glycerol, propyl parahydroxybenzoate, potassium sorbate, sodium saccharinate, orange and yellow dye, sucrose, honey flavor, vanilla flavor, citric acid monohydrate and purified water.
Pharmacological properties
How does the drug “Siresp” (syrup) work? The instruction says that the active substance of this drug has an anti-inflammatory effect, and also counteracts bronchoconstriction.
The indicated properties of the drug are the result of the interaction of interrelated mechanisms:
- The anti-inflammatory effect is associated with a decrease in the production of pro-inflammatory factors. By the way, some of them have a bronchoconstrictive effect. Although such effects are observed only at very high concentrations or doses of the drug.
- The antagonistic activity of the drug occurs at the level of histamine H1 receptors.
Pharmacokinetics
What pharmacokinetic parameters does Syres syrup have? Reviews of experts report that after taking the suspension inside, its maximum concentration is reached after 6-8 hours.
As for the half-life, it is 12 hours. The active substance of the drug is excreted through the kidneys.
Indications for use
What diseases are prescribed “Siresp” for? Syrup for children and adults is used for rhinopharyngitis, otitis media, laryngitis, bronchitis, sinusitis, rhinotracheobronchitis, maintenance therapy for complicated and isolated bronchial asthma, symptoms of the respiratory tract in the presence of measles, flu and whooping cough.
Contraindications for taking drug syrup
Does the medicine “Sirep” have contraindications for use? Cough syrup is not prescribed for patients with hypersensitivity to the main substance or additional ingredients that make up its composition. Also, the suspension is not recommended for children under two years of age.
According to the instructions, this drug contains sucrose. Therefore, it is not prescribed for people with rare genetic diseases that are associated with poor absorption of galactose-glucose syndrome, fructose intolerance or isomaltase-sucrose deficiency.
The drug "Sires" (syrup): instructions for use
It is necessary to take this drug inside, immediately before a meal. Its dosage depends on the type of disease, as well as the age of the patient and his weight.
Children over the age of two years are usually prescribed 4 mg of the drug per kg of body weight per day.
- Up to 10 kg: 20 ml of syrup or 4 scoops per day (i.e. 40 mg of fenspiride hydrochloride).
- Over 10 kg: 60 ml of syrup or 12 scoops per day (i.e. 120 mg of fenspiride hydrochloride). The indicated dose is recommended to be divided into three doses.
How are adolescents and adults prescribed Syres® (syrup)? The instruction reports the following dosages:
- 50-90 ml of syrup or 10-18 measured spoons per day (i.e. 100-180 mg of fenspiride hydrochloride). The indicated dose of the drug should be divided into several doses.
To determine a more accurate dose of the drug in the package there is a measuring spoon with a scale of 5 ml, 2.5 ml and 1.25 ml. It should also be noted that 5 ml of the suspension contain 3 g of sucrose (i.e. 0.25 bread units) and 10 mg of fenspiride hydrochloride.
The duration of treatment with this agent is determined by the attending doctor.
Overdose cases
In case of an overdose of Siresp, patients may experience adverse reactions such as nausea, drowsiness, vomiting, agitation, and tachycardia.
To eliminate these symptoms, gastric lavage is performed, and an ECG is also performed.
Side effects
What side effects can occur while taking the drug "Sires". A syrup for children, reviews of which are positive, sometimes causes the following phenomena:
- heart disorders and moderate tachycardia (the latter stops after a dosage reduction);
- vomiting and diarrhea;
- on the part of the digestive tract, the patient quite often experiences nausea, gastrointestinal upsets, and pain in the stomach;
- drowsiness;
- allergic reactions in the form of erythema, Quincke's edema, rash, fixed pigment erythema;
- due to the presence of para-hydroxybenzoate in the syrup, the patient may develop urticaria;
- disturbances in the work of the nervous system;
- dizziness.
The occurrence of any of the listed side effects, as well as those that were not included in the list, should be immediately reported to the treating doctor.
Drug interaction
Is it possible to combine the drug “Syresp” (syrup) with other medicines? The instruction does not contain any information in this regard. But, taking into account the antihistamine properties of this medication, negative reactions should be expected during the interaction of the drug in question:
- with barbiturates;
- other antihistamines, narcotic, analgesic and sedatives, as well as MAO inhibitors and alcohol.
Special recommendations for the use of medicinal syrup
What should the patient be warned about before prescribing the drug “Sires” (syrup for children)? The instruction says that for diseases of an infectious nature, treatment with this medication is required to be carried out in conjunction with standard antibiotic therapy.
Due to the content of such preservatives in the suspension as propyl parahydroxybenzoate and methyl, its intake can cause allergic reactions (possible effects with a delayed effect).
Patients with diabetes need to know that 5 ml of medicinal syrup contains about 3 g of sucrose. This should be considered when taking the suspension.
The composition of the drug "Siresp" includes the dye yellow "sunny sunset". As practice shows, this component often causes allergic reactions in both adults and children (effects with a delayed effect are possible).
Does the “Sires” medication affect the patient’s ability to control complex mechanisms and drive vehicles? No studies have been conducted on this subject.
Analogues and cost of the drug
How can I replace Syres cough syrup? The following drugs are analogues of this drug: “Erespal”, “Eladon”, “Erispirus”.
As for the price, the suspension in question is not very high. You can buy 150 ml of medicinal syrup for 200-230 rubles.
Reviews of patients about the drug "Sires"
The drug "Cyres" is very popular among patients. This is due primarily to the fact that it has a relatively low cost, and also has high therapeutic efficacy.
Most of the reviews about this medication are left by the parents of young children and adolescents. According to their reports, Syres syrup quickly eliminates the unpleasant symptoms of diseases such as sinusitis, rhinopharyngitis, otitis media, laryngitis, bronchitis and rhinotracheobronchitis. He also effectively fights flu and bronchial asthma.
As for the negative reviews, most of them are associated with the appearance of the following adverse reactions: nausea, rash, stomach pain, urticaria.