Hypertension and heart failure - diagnoses in the modern world are very common. Both elderly people and patients at the age of thirty complain about them. Currently, these ailments are rejuvenated. Of course, the reasons that cause them have become more in modern times. Stress, malnutrition, nervous tension, overwork have never had an excellent effect on good health.
Arterial hypertension: effective interventions
The treatment of diseases of the circulatory system requires special attention. When the pressure jumps sharply, measures should be taken, it does not stabilize by itself. If this is not done, a person may get a myocardial infarction or stroke, the consequences of which can be very sad.
Arterial hypertension and other diseases associated with pressure instability should be treated under the supervision of a doctor. Any initiative is inappropriate in this matter.
Often, to bring the pressure back to normal, patients are prescribed a very expensive drug, Perindopril. Analogs, synonyms for this medicine, are also not cheap medicines. However, knowing all the properties of the drug, it is still possible to choose a less expensive replacement for it in the modern pharmaceutical market.
Properties of Perindopril
This is an effective tool that is recommended by many experts. So, before looking for an analogue of Perindopril, we’ll find out a little what it really is.
This medicine is a group of ACE inhibitors that affect the restoration of muscle tone of blood vessels, due to which the pressure returns to normal. Pharmacological features boil down to the fact that perindopril, decomposing to perindopilate, reduces the content in the blood of elements that make blood vessels inoperative. Expanding them, it is possible to increase the minute volume of blood and develop a tolerant regime of the heart with such a load. A more detailed description is indicated in the instructions for the drug.
The drug is produced in the form of tablets with the active substance perindopril in the amount of 4 mg, 5 mg, 8 mg, 10 mg.
The effect of the drug is noticeable an hour after taking it. After four hours, it reaches maximum concentration and normalizes blood pressure for a whole day. It does not affect conscious thinking, stimulates the brain, and concentrates. It is excreted through the kidneys.
Reception is very simple, one tablet (the dose is prescribed by the doctor) is drunk once a day before meals. If you take the medicine after eating, it will act slowly.
The drug is produced in Germany and Hungary. The cost of packing tablets varies from 500 to 600 rubles.
Medicines similar to Perindopril (analogues) are not described in the instructions for use. We will consider them a bit below.
Indications for use
This drug is suitable for the treatment of patients with type 1 and type 2 diabetes, which is why it is so popular.
The medicine “Perindopril” is prescribed for arterial hypertension, as well as chronic heart failure, and is used to prevent repeated heart attacks and strokes.
Contraindications
It is not recommended to prescribe this drug to children who are breast-feeding mothers, if there is a manifestation of an allergic reaction to perindopril, with renal diseases, with thrombocytopenia, leukopenia.
Possible side effects
This drug has a fairly wide list of side effects. Topical: dry cough, headache, insomnia, weakness, accompanied by chest pain, cramps, itching, bronchospasm, renitis, shortness of breath, muscle cramps, sexual dysfunctions, depression, pneumonia, taste disturbance.
Medication Prestarium A: perindopril + arginine
The composition of the drug “Perindopril” includes: the active substance perindopril, erbumine salt and auxiliary components - magnesium stearate, anhydrous colloidal silicon dioxide, a mixture of starch and lactose, potassium acesulfame.
Since the composition of the drug was improved over the course of several years, the drug Prestarium A, an analogue of Perindopril, appeared in pharmacies. So the differences between them are in the trade name of the medicine and one component. The drug "Prestarium A" instead of erbumin salt includes arginine. Their effect on the human body is identical. Arginine only allowed to store the medicine for three years longer.
It’s just that Prestarium A is more expensive than Perindopril, its price is 700 rubles per package.
Many doctors advise patients to use the cheap Perindopril analogue (hence, Prestarium A drugs) in the treatment of hypertension - Perinev tablets, which also include perindopril. Its cost varies from 200 to 300 rubles.
The group of analogues of the drug “Perindopril” also includes such drugs as “Parnavel” (costs 300 rubles), “Hypernik” (300 rubles), “Piristar” (250-400 rubles), “Stopress” (360 rubles), “ Arentopres ”(400 rubles),“ Parnavel ”(280 rubles).
If you select substitutes for drugs like "Prestarium A", which contain, in addition to perindopril, arginine, the analogues listed above are also suitable for replacing them.
Cheap analogues of Perindopril, not containing perindopril
If substitute drugs are identical in both composition and effect on the patient’s body, then other similar medicines may contain other components, but have the same effect of treating heart failure and hypertension.
For example, the drug "Lisinopril" is an analogue of "Perindopril", which contains the active substance, in action similar to perindopril - lisinopril. This is also a drug from the group of ACE inhibitors.
The average cost of this analogue is 200 rubles. It is also available in the form of tablets. You can also find in the pharmacies the medicine "Lisinopril" Ukrainian production, German or Israeli. Preference is given to buyers for a drug manufactured in Germany.
This tool is ideal for people suffering from obesity and diabetes, who are very problematic to choose drugs to lower blood pressure, as many of them have a large list of side effects that are dangerous for the lives of such patients.
The medicine "Lisinopril" is widely used in the treatment of patients with pathological diseases of the heart and vascular system.
Of course, this remedy, along with its advantages, also has drawbacks, can cause dizziness, nausea, dry cough, diarrhea.
The drug is contraindicated for administration in diseases of the kidneys and liver, during pregnancy, breast-feeding, children under 18 years of age, with hereditary Quincke edema, with intolerance to lisinopril and other components of the drug.
Choosing analogues for the Perindopril medication, you can also stop on the Enalapril medicine. It includes a substance similar in effect to the patient’s body with perindopril, enalapril maleate. This medicine is also an ACE inhibitor, therefore, reduces blood pressure and at the same time reduces the load on the heart, preventing the complex effects of hypertension.
The medicine is produced in Serbia, Macedonia. The drug has established itself in medical practice as reliable. Release form - tablets. The cost of one package of pills is from 100 to 200 rubles.
It is necessary to pay attention to the fact that this drug is contraindicated in diabetes mellitus, pregnancy, renal and liver failure, breastfeeding, it is not intended for the treatment of children.
The following side effects can cause: dizziness, asthenia, skin rash and itching, fatigue, drowsiness, anxiety, dry cough. Also, this drug can cause a sharp decrease in pressure, so its intake should be accompanied by the supervision of the attending doctor, since an incorrect dose can cause an overdose, therefore, the patient's condition worsens.
Many substitutes for the drug Perindopril. Analogues of the drug can also be selected from the group of ACE inhibitors containing in their composition the active substance captopril, similar to perindopril. Such is the drug Captopril, which is applicable in the treatment of arterial hypertension, coronary heart disease and heart failure.
The drug is produced in Slovenia and Ukraine. The average cost of this medicine is 300 rubles.
The drug “Capotopril” is not prescribed during pregnancy, breast-feeding, children under 18 years of age, with severe renal and liver dysfunction, cardiogenic shock, in the presence of obstruction of the outflow of blood from the left ventricle of the heart, Quincke's edema.
This medicine may also cause side effects such as blurred vision, fatigue, headaches, thrombocytopenia, decreased appetite, stomatitis, skin itching, tachycardia, acidosis.
Before using cheap analogues of the drug "Perindopril", you should carefully study the instructions for them. Only the attending physician should prescribe them. Each of them has its own list of side effects and a list of contraindications that should not be underestimated.
The treatment of hypertension is not simple, each patient has his own propensity for tolerance of one or another component of drugs, and it is not so easy to choose the drug that will not cause discomfort during treatment.
An individual therapeutic agent can only be selected by the method of testing drugs.
Noliprel, Ko-Pyrenev: perindopril + indapamide
For many patients, taking Perindopril alone is not sufficient to normalize the pressure; the therapy is supplemented with several more effective agents. To facilitate the work of doctors, pharmacists have created combination preparations with the basis of perindopril.
So, perindopril +
indapamide analogues of perindopril with increased exposure to the patient's body are composed of such as Noriprel and Ko-Pyrenev. Naturally, combination drugs are more expensive than pure perindopril. The cost of the Noriprel medicine (perindopril + arginine + indapamide) is 800 rubles, the Co-Pyrenev drug (perindopril + erbumin + indapamide) is 650 rubles.
Cheaper containing indapamide and perindopril, synonyms analogs from the group of combined preparations: tablets "Prilamid" cost from 200 to 400 rubles, tablets "Co-Preness" - 400 rubles, "Perindid" - 300 rubles. The difference in price, as you see, is palpable.
For the combination of perindopril plus indapamide, analogues can also be selected from the group of combined ACE inhibitors, which include other active substances. For example, Ampril Hd tablets (ramipril + hydrochlorothiazide) cost 400 rubles, and similar Euroramipril tablets cost 200 rubles.
The quality containing perindopril + indapamide analogues are not particularly noted. Low price is not always a guarantee of preserving the properties of original drugs.
Prestans, Dalneva medicines: perindopril + amlodipine
The experiments on indapamide did not end, because perindopril shows its effect very well in combination with amlodipine. Recently, the combined preparations Prestance (perindopril + arginine + amlodipine) have appeared, their cost is from 700 to 900 rubles, and Dalneva (perindopril + erbumin + amlodipine) - 500 rubles.
Cheaper analogues containing perindopril + amlodipine can be selected from the group of substitutes, for example, Amlessa tablets, their price is 400 rubles, and from the group of combined ACE inhibitors that do not contain perindopril and amlodipine, for example, Akkupro tablets (quinapril ) at a price of 200-300 rubles.
Which of the medicinal combinations is suitable for the patient, only the doctor knows, who has a picture of the diagnosis before his eyes after a thorough examination of the patient. If you need to choose analogues for Perindopril, the doctor is also involved in this task, since only he can evaluate in practice the effectiveness of a particular drug.
Reviews of physicians and patients about the drug "Perindopril"
The pharmaceutical market is filled with drugs with ACE inhibitors. Of these, there are a lot of drugs that replace the Perindopril medication. Analogs and replacement, as you have already seen, can be identical both in composition and in effect on the body. But, despite such a variety of cheap substitutes for the drug in question, many patients still prefer to be treated with the original, as evidenced by their reviews.
Of course, if treatment with the original is not affordable for the patient, then there is a transition to cheap combination medicines, among which doctors have identified more or less high-quality ones. Naturally, even among cheap drugs, doctors choose European-made medicines, among which there are practically no fakes.
The medicine “Perindopril” in medical practice has established itself as reliable and effective. Thanks to it, doctors today manage to restore the health of 80% of patients with arterial hypertension and heart failure, as well as prevent 50% of them from complications in the form of myocardial infarction and stroke.
Having, of course, knowledge of which medicines can replace Perindopril, it is much easier to navigate in a large list of medicines for ACE inhibitors. And with appointments, it becomes easy to understand what the doctor specifically recommends for therapy - the original drug or its cheap counterpart.