Having many analogues, Moxonitex is a reliable drug made using moxonidine. The drug is used at elevated pressure. It is prescribed strictly according to the prescription of the attending doctor. Self-medication with this drug is excluded. Consider the main known analogues, as well as analyze the features of the drug.
Is there a replacement?
The modern pharmaceutical market is ready to offer customers a wide variety of drugs similar in their main component. The product in question will not be an exception: there are many analogues of Moxonitex presented by firms from different countries. In general, goods manufactured by American, West European and Japanese manufacturers are considered the most reliable, but among affordable products, domestic products and those manufactured in the nearest neighboring countries attract attention. It is not worth it to choose alternatives to the product prescribed by the doctor yourself. It is reasonable to consult a doctor, explaining why there is no way to buy a previously selected medication. Based on the wishes and requirements of the patient, the specialist will choose the best replacement.
Among the inexpensive analogues of Moxonitex, the drug Moxarel should be noted. The minimum price for packaging starts at about one hundred rubles, but the maximum is set for tablets containing 0.4 mg of the active ingredient and 30 capsules. Such packaging will cost approximately 360 rubles. Moxogamma, presented by German manufacturers, is even a little more expensive. Despite the rather high cost, it is in demand, as it is known for its impeccable quality.
What else to consider?
Among the popular analogues of Moxonitex, the drug Moxonidine deserves attention. Its cost varies from one hundred rubles to almost three hundred. The product is represented by domestic manufacturers "North Star", "Farmzashchita". The product of the domestic enterprise "Canon", presented to the market under the name "Moxonidine Canon", is no less in demand. The maximum concentration and the largest packaging will cost the buyer about 250 rubles.
Noteworthy is the analogue of Moxonitex Tenzotran. One package of this product costs from 160 rubles, the maximum price is just over 800 rubles per pack with 28 capsules, each of which contains 0.4 mg of the active ingredient. German pharmaceutical products on the market under the name Physiotens are similar in price. The strongest effect with 28 capsules per pack will cost the buyer about 960 rubles. In addition, the Zint product has a good reputation.
Should I replace it with an analogue?
There is a Russian analogue of Moxonitex, produced under the name Moxonidine. The most affordable price of such a drug in some pharmacies is only 65 rubles per pack. Of course, for any modern buyer this is more beneficial than a medicinal product, the cost of which is at least one hundred rubles per package. Is it worth chasing financial gain by acquiring the cheapest generic? It makes sense to consult a doctor. In general, domestic pharmaceutical products at a low price are considered less pure than foreign expensive products of world-famous manufacturers, but in each case only a doctor can calculate how important this difference is.
If you want to save money, you can buy a package of Moxarel for one hundred rubles, and if it is impossible to purchase the prescribed drug, stop at Tenzotran. Sometimes the situation is such that there is not a single drug on sale containing moxonidine. In this case, you need to clarify with the doctor the possibility of replacing the medication with another remedy that belongs to the same group of drugs. These include Dopegit, Albarel, Aldomet. Pharmaceutical products Apo-Clonidine and Alfadopa are known for a rather good reputation.
Moxonitex: Basic Information
As you can learn from the instructions for Moxonitex, this drug is available in tablet form. Each capsule has a thin film shell. The tint of the tablet is light or dark pink. Instances are made round, convex on both sides. The main active ingredient is moxonidine. In one capsule it is contained in an amount of 200-400 mcg. As additional ingredients, the manufacturer used povidone, crospovidone, lactose, magnesium elements. The shell is made using opadra, coloring components.
The drug belongs to the category of selectively working drugs that inhibit imidazole receptors. This is an antihypertensive drug that has a central effect and belongs to the category of alpha2-adrenergic agonists.
Pharmacology
The instruction for "Moxonitex" indicates the ability of a substance to make imidazole receptors inactive. The tool is able to reflexively control the sympathetic NS. It is considered that imidazole receptors are located in the ventrolateral block of the medulla oblongata. The active ingredient of the drug is slightly capable of reacting with central adrenoreceptors of the second type of alpha. The tool lowers diastole, systole pressure and with a single use, and in the case of a long therapeutic course.
In the case of a long course, the medication eliminates left ventricular cardiac hypertrophy, eliminates the manifestation of myocardial fibrosis and stabilizes the blood flow to the heart through the capillaries. The drug has the ability to smooth out the manifestations of microarteriopathy, reduce OPSS, reduce resistance in the vessels that feed the lungs.
Under the influence of funds, heart rate is practically not adjusted. There is no particular effect on cardiac output. The use of the drug is accompanied by a weakening effect of epinephrine, norepinephrine. Renin activity is weakened, the effect of the second angiotensin is reduced. The effect is observed both at rest and in the presence of load. In the presence of a load, the activity of the natriuretic peptide decreases under the influence of the agent. The strength of exposure to serum aldosterone is weakening.
Pharmacological features
In the instructions for use of "Moxonitex", the manufacturer mentions the ability of the active ingredient of the drug to reduce the resistance of tissues to insulin. Evaluation of the effect is about 21%. To refine the indicators, experiments were conducted involving the control group placebo. The tests involved overweight people. Studies have been conducted involving people whose body shows insulin resistance, and high blood pressure is found to be moderately severe. Observations showed a more active release of growth hormone. At the same time, the active ingredient of the Moxonitex preparation does not correct fatty, glucose metabolism.
The duration of the effect is from 12 hours.
Kinetics
Kinetic features of the drug product are described in the instructions for use of "Moxonitex." It follows from this document that shortly after oral administration, the active component is qualitatively absorbed. The processes are localized in the digestive tract, their efficiency is estimated at 90%. The meal does not adjust the degree of absorption. The maximum concentration in the blood serum is observed after at least half an hour, but no more than three hours after taking the drug. On average, indicators are up to 3 ng / ml, although even three times less are considered normal. The temporary difference between the achievement of the maximum content of the drug in the blood and a significant drop in pressure is not more than 10%, and in the case of load - less than 8%.
The bioavailability for single use is estimated at 88%. There is no pronounced primary hepatic metabolism of the drug.
The instruction for Moxonitex 0.2 mg, 0.4 mg indicates the ability of the active ingredient to pass through the internal organic barriers that protect the brain. Even with prolonged use, there is no cumulative effect. The ability to enter into strong bonds with plasma proteins does not exceed seven percent.
Kinetics: finalizing the review
On average, no more than 15% of the substance received in the body is subject to metabolism with a possible deviation of 5% up and down. The result of the reaction is 4,5-dehydromoxonidine. In addition, during metabolism, an aminomethanamidine substance is generated.
The half-life is estimated at 2.5 hours with a possible deviation of 30 minutes in a larger, smaller direction. On the first day, about 90% of the substance is eliminated by the renal system. Up to 75% of this volume is a drug in the form of an initial molecule. About 20% are metabolites. About one percent is excreted by bile. A low percentage can be derived by dialysis.
Specific Technical Features
In the instructions for "Moxonitex" 0.4 and 0.2 mg, the manufacturer indicates the lack of reliable information about the differences in kinetic parameters in people of different ages. If renal performance is normal, specialized dose adjustment is not required for the elderly.
If creatinine clearance is estimated at 30-60 units, when the renal impairment is severe and creatinine clearance is less than 10 units, it should be borne in mind that the elimination half-life increases, the concentration of the active ingredient in the blood serum becomes larger. The increase is doubled, tripled. In severe renal failure, the drug in question is not prescribed in principle. For moderate performance problems, the medication is used with extreme caution, individually determining a safe but therapeutically effective dose.
No special studies have been conducted to determine the characteristics of the reactions occurring in the human body suffering from hepatic impairment. The active ingredient of the drug in this body is almost not processed, therefore, it is believed that impaired organ performance does not affect the kinetic parameters of the drug.
When and how much to take
Not to find in the instructions for use, at what pressure Moxonitex will help, and when it is not necessary or dangerous to use it. The manufacturer indicates an indication in the form of arterial hypertension. The dose for each individual patient should be selected by the doctor. The drug is taken orally, not focusing on the meal, be sure to drink plenty of water. Since the pressure indicators for each individual person are individual, it cannot be said which condition is stable hypertension. Preliminary observation of the patient for some time. If the suspected arterial hypertension is confirmed, the medication in question is prescribed.
Initially shown to receive 0.2 mg of the drug in the morning. If the effectiveness is not sufficiently pronounced, it is necessary to double the portion, after having waited a three-week period. 0.4 mg of the drug is used either at one time, or divided into two portions. In total, up to 0.6 mg of the drug can be taken per day. For one serving, you can not get more than 0.4 mg of the drug.
With moderate impairment of renal function and creatinine clearance within 30-60 units, you should receive up to 0.2 kg of the drug at a time, no more than 0.4 mg per day.
Unwanted effects
Moxonitex containing moxonidine can cause bradycardia, severe pressure drops, and dizziness. Some had sleep disturbances, others were worried about a headache. There are known cases of fainting, excessive agitation, ringing in the ears. Some dry mucous membranes. There is a possibility of upset stools, abdominal pain, vomiting. It is known that some recorded allergic reactions, mainly in the form of skin areas of rashes, itching. Less commonly, allergy manifested itself as angioedema. Others noted pain in the back, in the neck. Asthenia is possible. Taking the drug is accompanied by a risk of peripheral swelling.
Sometimes you can’t
The Moxonitex pressure is not found in the instructions for use, but the manufacturer writes in sufficient detail about the conditions and features under which it is strictly prohibited. A medicine cannot be prescribed if, for hereditary reasons, a person cannot tolerate lactose, when there is a lack of lactase in his body. It is forbidden to prescribe a medication to those who suffer from glucose-galactose malabsorption syndrome. You can not use the product in a minor age. Contraindication is a strong violation of cardiac rhythm, bradycardia, blockade, weak sinus node.
The drug is not prescribed to nursing mothers. It can not be taken with a failure of the heart in the form of a chronicle, if the functional class is the third or fourth. It is forbidden to use the drug in case of severe renal weakness, when creatinine clearance is less than 30 units, the plasma creatinine content exceeds 160 units. Do not prescribe the drug to people who are shown dialysis.
Safety nuances
As with all analogues, the instructions for use of "Moxonitex" warns against prescribing this drug to persons excessively sensitive to the active ingredient of the drug. Do not prescribe a pharmaceutical product with increased susceptibility to any other ingredient used by the manufacturer. It is forbidden to use the drug if a person is undergoing a course of treatment, including tricyclic antidepressants. Before prescribing a medication, it is important to analyze what funds the patient receives, which drugs have been discontinued recently.
You can, but very carefully
Moxonitex may be used for the first degree of atrioventricular block, but only if it is possible to regularly monitor the patient's condition, as the risk of bradycardia is increased. The same accuracy requires the appointment of a drug for diseases of the coronary arteries and peripheral blood flow. If intermittent claudication is established, Raynaud's disease is detected, you need to constantly check what the effect of the drug on the human body is.
Extremely carefully, the medicine is prescribed to epileptics, people who have depression or Parkinson's disease. Precautions require the appointment against the background of glaucoma, kidney failure with creatinine clearance in the range of 30-60 units. It is necessary to responsibly use the product in case of bearing a child or weak liver.
Is it worth using: consumer opinions
In general, reviews dedicated to Moxonitex indicate the reliability of the drug. A relatively small percentage of people who used the drug experienced side effects. People forced to take the drug for a long course and at a high dosage recognized that it was quite expensive for the budget. In addition to price features, the negative qualities of this drug were practically not observed.
As you can conclude from the reviews, most often people at the reception were worried about headache and nausea, but the phenomena were mild, passed quickly, generally without creating serious discomfort. Many recognized that the drug stabilizes blood pressure well, and the positive aspects of its administration far outweigh the negative aspects.
"Interesting" position
You can find out by studying the instructions for use of "Moxonitex" 0.2 and 0.4 mg, that no reliable tests have been conducted to determine the effect of the main drug compound of the pharmaceutical product on the female body during the period of gestation. Tests were conducted involving animals, during which it was possible to detect an embryotoxic effect. Clinically confirmed information on the negative effect on the bearing of the fetus is not available. It is recommended to use the medication only in cases when the obvious benefit for the woman significantly exceeds the possible risks for the child.
The main active compound of the tablets is found in breast milk of a nursing woman. If there is a need for feeding, for this period refuse to accept funds. If it is impossible to stop the therapeutic course, it is reasonable to transfer the child to an alternative type of nutrition.
Safe Reception Features
Instructions for use "Moxonitex" 0.2 mg, 0.4 mg is recommended only when it is possible to regularly check the pressure and frequency of contractions of the heart muscle. .
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