Lincomycin is an antibiotic drug with a wide spectrum of effects. It shows its activity against bacteria that are resistant to penicillin antibiotics. It is allowed for use in the treatment of pediatric patients, the dosage should be selected individually by the doctor. The recommended treatment regimen depends on the disease for the treatment of which the use of “Lincomycin” is directed. The use of the drug is often accompanied by the development of adverse reactions, and therefore it is prescribed infrequently.
Instructions for use with Linkomycin will be presented below.
The manufacturer "Linkomycin" is available in three pharmacological forms - injection solution, capsules, ointments, intended for local use.
Composition, description
According to the instructions for use with Linkomycin, the capsules are gelatinous and have a white color. Inside them is a powder. It can be sealed, however, when pressed with a glass rod, it should disintegrate. Each capsule contains 250 mg of the active ingredient, which is lincomycin. Auxiliary components are: E572, sugar, potato starch. The shell is made of sodium lauryl sulfate, purified water, titanium oxide, glycerol and delatin. People often mistakenly look for Lincomycin tablets in pharmacies. This form of drug release does not exist.
Instructions for use indicate that the injection solution has no color. Each ampoule contains 300 mg of the active component of lincomycin, as well as auxiliary components, which are: injection water, caustic soda, Trilon B.
In accordance with the instructions for use, Lincomycin ointment has a uniform consistency, its color may be yellowish or white. Every 15 grams of ointment contains 300 mg of the main component. As auxiliary ingredients are used: solid petroleum paraffin, zinc oxide, petroleum jelly, potato starch.
Pharmacological group
As indicated by the instructions for use with Linkomycin, the active ingredient is able to inhibit protein biosynthesis in bacterial cells.
The activity of lincomycin is manifested in relation to gram-positive bacteria: mycoplasmas, diphtheria bacilli, bacteroids, clostridia, streptococci, staphylococci (including penicillinase producing strains).
Most gram-negative microorganisms are resistant to lincomycin. It is also inactive against protozoa, viruses, and fungi. Cross-resistance between clindamycin and lincomycin is noted.
Up to 40% of the active component after oral use is absorbed in the digestive tract. The degree and speed of absorption is significantly slowed if the drug is taken with food. Lincomycin is able to penetrate the placental barrier, part of it is metabolized in the tissues of the liver. Evacuation is carried out through the intestines and kidneys. Half the entire dose is excreted within 5 hours.
Indications for use
In accordance with the instructions for use with "Linkomycin," for adult patients, the drug is indicated for use in diseases provoked by bacteria having sensitivity to it:
- Wound infection.
- Infections of the skin, soft tissues (if there are contraindications to the use of penicillin medicines).
- Endocarditis of an infectious nature.
- Osteomyelitis.
- Blood poisoning.
- Inflammatory processes in the lungs, lung abscess.
The ointment form is used for the treatment of purulent-inflammatory skin diseases.
For pediatric patients, “Linkomycin” is prescribed in the presence of similar conditions. It can be used from the age of 1 month.
According to the instructions for use, Lincomycin tablets in dentistry can be used. They are taken orally as anti-inflammatory, for example after removing a wisdom tooth. It is more often used in dentistry for faster wound healing and exclusion of infection.
The active component of the drug is able to overcome the placental barrier and penetrate into breast milk, and therefore its use in the lactation period and when carrying a child is unacceptable. In the lactation period, the drug can be used only if the child has been previously transferred to artificial feeding.
“Lincomycin” should not be prescribed to patients if they have severe pathological disorders in the activity of the kidneys and liver, as well as individual susceptibility to lincomycin or any auxiliary component in the composition of the drug.
Using
As we are informed by the instructions for use with Lincomycin capsules, adult patients are shown three or four times daily use of 500 mg of lincomycin. Capsules should be swallowed without biting or crushing, while drinking water. Reception is best done before or after eating.
An injection medication is indicated for intramuscular administration up to 2 times a day in a dosage of up to 600 mg.
Instructions for use for injections "Linkomycin" confirms this.
Infusion using the drug is carried out by drip. It is first necessary to dilute 600 mg of the drug using glucose solution (5%) and saline in an amount of 250. Instructions for use with "Linkomycin" indicate that if an ointment form of the antibiotic is used, then a thin layer should be applied to the affected skin.
The average duration of therapy is up to 10 days.
If the patient has liver and kidney dysfunction, then the dosage of lincomycin is important to reduce by a third or half, and increase the interval between uses.
When treating children, the treatment regimen should be selected individually.
Children from 14 years of age are shown the use of adult dosages.
Capsule form "Linkomycin" can be used in the treatment of children from 1 month. In this case, up to 60 mg per kilogram of body weight of a small patient is prescribed.
If necessary, intravenous use up to 20 mg of the drug per kilogram. Intravenous infusions should be made at intervals of 8 to 12 hours.
Pregnant women should not use Linkomycin. In the lactation period, the drug can be used in conventional dosages. However, a preliminary transfer of the child to artificial mixtures is required.
What else does the instructions for use of Linkomycin tell us? In dentistry, the drug is prescribed 1 capsule three times a day for 5 days.
Negative impact
Against the background of the use of the drug, the following negative reactions may develop:
- Pseudomembranous colitis, a transient increase in blood activity of bilirubin and liver enzymes, stomatitis, inflammation of the tongue, stomach pains, loose stools, vomiting, nausea.
- Decreased platelet count, white blood cells, neutrophils.
- Thrush.
- Allergic reactions in the form of exfoliative dermatitis, anaphylaxis, angioedema, urticaria.
If the drug is administered intravenously, the development of phlebitis is not ruled out. With an excessively fast introduction of the solution, the following can be observed:
- Muscle relaxation of the skeleton.
- Vertigo.
- General weakness.
- The fall of blood pressure.
Interaction with other medicines
When used concurrently with Erythromycin, Chloramphenicol, penicillin and cephalosporin antibiotics, antagonism of antibacterial effects is noted.
Joint use with aminoglycosides causes a synergy of antimicrobial effects.
Concurrent use with medications intended for inhalation anesthesia and curare-like drugs can increase neuromuscular blockade, which can cause respiratory arrest.
The effect of "Linkomycin" is weakened if it is used in conjunction with antidiarrheal drugs.
There is a pharmaceutical incompatibility of Linkomycin with preparations of heparin, calcium gluconate, theophylline, barbituric acid, magnesium sulfate, ampicillin.
Combination of injectable "Linkomycin" with "Novobiocin" and "Kanamycin" is not allowed.
Special instructions for use
If the course of therapy with Lincomycin is long, the patient should monitor the functionality of the liver and kidneys.
Use of the drug should be stopped if the patient develops pseudomembranous colitis. "Lincomycin" in such cases can be replaced by bacitracin or vancomycin drugs.
Overdose
If the patient exceeds the recommended dose, nausea, indigestion, and vomiting may occur. With the rapid introduction of undiluted injectable "Linkomycin" cardiac arrest is not excluded.
Linkomycin does not have a specific antidote, therefore, in case of an overdose, symptomatic therapy should be prescribed to the patient.
Analogs, price
If necessary, Lincomycin can be replaced by one of the following analogues:
- Hemomycin. The main component in this drug is azithromycin. It is allowed for use in the treatment of children from six months and pregnant women. Breastfeeding with the use of an antibiotic should be suspended.
- "Augmentin." It is a pharmacological analogue of Linkomycin. It can be prescribed to children from birth, pregnant women, as well as during lactation.
- Macropen. Therapeutic substitute "Linkomycin." The manufacturer produces in tablet form and in granules, which are used to make the suspension. Allowed for the treatment of infants and pregnant women. In the lactation period, the antibiotic is contraindicated.
- Clindamycin. Clinical and pharmacological analogue of Linkomycin. There are several pharmacological forms: vaginal cream, suppositories, capsules, injection. It can be used in children from 3 years. It should not be used in the lactation period and during pregnancy.
If you need to replace the drug, it is important to consult a doctor.
In Russian pharmacies, the average cost of Linkomycin is 87 rubles.
Reviews about "Linkomycin"
Patients undergoing therapy using Lincomycin report that the drug can effectively and quickly stop the signs of infectious diseases. Accessibility of the medication and its affordable cost are separately noted. However, no less rarely, along with positive reviews, there is information that "Linkomycin" causes a number of unpleasant adverse reactions. In this regard, recently “Linkomycin” is prescribed to patients quite rarely, because there are safer analogues.
It is important to remember that the appointment of any medication, especially antibacterial, should be carried out by a doctor.