If a medicine from nitrofurans is needed, then Furamag is an excellent representative of this group. The drug has an antifungal effect. Great for combating urogenital and gynecological infections, and also effective in infecting skin and burns in severe forms.
Release form. Capsule composition
"Furamag" is available in capsule form in 50 and 25 mg (usually prescribed for children). There are 3 blisters in a carton box, each containing 10 tablets. The manual is attached.
For one capsule, 43.70 mg of furazadin is necessary - the active substance corresponding to 50 mg of potassium furazidine.
Excipients include: 50 mg of magnesium hydroxycarbonate, 3 mg of talc, 2.5 mg of corn starch and 0.5 mg of stearyl fumarate.
All components are contained in a durable gelatin capsule No. 3: titanium dioxide 1.32%, yellow pigment (quinoline) 1.2%, gelatin 97.48%.
The instructions for use "Furamaga" describes the capsules and their contents. Externally, the capsules are dark yellow in color, no smell, as well as taste. Inside the capsules is a bright orange powder (for example, brown-orange and red-brown shades). The powder content allows particles of different shades: white, orange, brown.
Pharmacodynamics
The tool is antimicrobial and has an extensive spectrum of action. Resistance to the drug develops slowly and does not reach a high concentration. Many antimicrobial agents during therapy can negatively affect the human immune system, inhibiting it. "Furamag" acts in the opposite direction and, conversely, stimulates the immune system.
When the influence of the group occurs, then the process of suppressing the respiratory chain and the cycle of tricarboxylic acids occurs inside microbes and bacteria. In addition, the remaining biochemical inflammatory processes are blocked. As a result, microbial membranes (cell membranes) are destroyed. Microbes from exposure to nitrofurans begin to secrete significantly less toxic substances. Due to this fighting effect, an improvement in the patient's condition to a pronounced suppression of microflora growth is observed.
"Furamag" is productive in the fight against gram-positive cocci, gram-negative sticks. The reaction mechanism is associated with a slowdown in the synthesis of nucleic acids. Depending on the concentration, it has the ability to kill bacteria and inhibit their reproduction in the human body. Instructions for use "Furamaga" indicates that the drug is the most active among all nitrofurans.
Pharmacokinetics
Instructions for use of tablets "Furamag" indicates that absorption begins in the small intestine, by inactive ingestion. Absorption of nitrofurans from the immediate part of the small intestine absorption from the central segment exceeds 3 times. Nitrofurans are difficult to penetrate into the colon, and this should be taken into account when taking other drugs in the treatment of urogenital infections and diseases of the gastrointestinal tract.
Higher bioavailability of the drug is achieved with oral use as a mixture of furazidine potassium and magnesium hydroxycarbonate in a ratio of 1: 1. Based on the instructions for the use of tablets "Furamaga", in the acidic environment of the stomach does not occur the conversion of potassium furazidine.
The medicine is evenly distributed within the body. A large accumulation of the active substance in the lymph is very important, since it can block the spread of infections along the lymphatic tract. Saliva is able to accumulate about 29% of the component from its accumulation in the blood. The lowest concentration is observed in cerebrospinal fluid. But bile accumulates a much larger number than in blood and tissues.
A small concentration in the blood contributes to the rapid leaching of the substance. The maximum saturation in the blood is maintained, reaching 8 hours. In urine, the component is detected after 4 hours from taking the capsule in higher concentrations in comparison with blood and tissues.
Instructions for use "Furamaga", as well as patient reviews, confirms that the pH of urine does not change after taking the tablets. Excretion occurs through the kidneys by glomerular filtration and tubular secretion, and reverse absorption in the tubules is selectively observed.
Furazidine in oxidized urine does not separate, since it belongs to a weak acid. With alkalization of urine, the output of furazidine is enhanced. The substance is slightly biotransformed, with a decrease in the excretory function of the kidneys, the metabolic rate increases.
Indications for use
Urogenital infections, namely: urethritis (acute course), cystitis, pyelonephritis. Infectious diseases that are caused by the sensitivity of microorganisms to furazidine. Also skin infections, infected burns (severe) and gynecological diseases.
The instructions for the use of tablets "Furamag" noted that a course of therapy for urological surgery, cystoscopy, catheterization and so on is allowed.
Contraindications
The drug is forbidden to take with:
- hypersensitivity to drugs of the nitrofuran group;
- pregnancy and lactation;
- renal failure (chronic form);
- children's age - up to 3 years.
Instructions for use "Furamaga" warns of cautious therapy for deficiency of glucose-6-phosphate dehydrogenases.
Side effects
The drug is low toxic. When treating with drugs from the nitrofuran group, it is rare, but side effects such as:
- dizziness and headache;
- loss of appetite, nausea and vomiting;
- polyneuritis;
- impaired liver function;
- skin reactions (allergy in the form of a rash, rash, or itching).
If side effects were noticed during a course of Furamag therapy, then it is necessary to seek advice from your doctor.
There was no effect on the control functions of the vehicle and other electromechanisms.
Dosage and administration
The package contains the complete instruction "Furamaga", where its use is described in detail, therefore, if the doctor’s prescription is lost or incomprehensible, do not worry.
The medicine is consumed strictly after eating, washed down with a sufficiently large volume of liquid.
Adults are prescribed 50-100 mg three times a day (i.e. 1-2 capsules). The course of treatment is about 10 days. If necessary, the course is repeated after a 15-day (maximum) break.
If the drug is prescribed as a prophylaxis before surgery, then 50 mg will be enough. Take once and half an hour before the procedure.
If you forgot to drink a pill, then you should refrain from a double dose to replace the missed dose. The next reception at the usual time of the course.
When taking the medicine, strictly follow the instructions for the use of "Furamaga", the price and properties do not allow uncontrolled and free therapy.
Overdose
Intoxication of the body is possible. Symptoms of a neurotoxic nature, ataxia and tremor are observed.
In case of an overdose, the patient should drink the maximum amount of water, be sure to take antihistamines, stopping the acute symptoms.
Special instructions and interactions
To eliminate the occurrence of side effects, Furamag is washed down with plenty of water. Symptoms are inherent in patients who have decreased excretory function of the kidneys. If such are the place to be, then stop using the drug.
It is forbidden to consume alcoholic beverages during the entire course of therapy, since it is possible to provoke the occurrence of side effects.
To reduce the risk of inhibition of hematopoiesis, it is forbidden to use Furamag in parallel with ristomycin, chloramphenicol and sulfonamides. It is also worth excluding the use of drugs that are able to "acidify" urine (including ascorbic acid and calcium chloride).
The drug is allowed for sale from pharmacies by prescription.
Storage conditions and shelf life are indicated in the instructions for the use of tablets "Furamag". The price of the drug for 30 capsules of 50 mg is 860 rubles.
Analogues of the drug
Due to the cost of the drug, many patients are interested in analogues. These include "Furagin." Both medicines contain furazidine. The difference lies in the mechanism of action, since the auxiliary components of the composition are not the same. Instructions for use "Furamaga" and the analogue is different, plan based on body weight. The price for it is from 190 to 300 rubles.
Furadonin also belongs to the nitrofuran group. It is used in the treatment of the bladder. The drug is able to quickly relieve pain syndromes. The instruction for the use of Furamag tablets is a bit simpler than the budget equivalent, since the second is taken taking into account the patient’s weight 3 times a day. But the price of tablets is 89 rubles for 20 pieces of 50 mg. Usually prescribed for women in whom cystitis occurs in a chronic form.
An excellent antibacterial drug for diseases of the genitourinary system - "5-NOC". It is convenient to use, based on the instructions for use of the Furamagu analogue. The price is 188 rubles for 50 tablets of 50 mg. The downside of the drug is the duration of therapy from 15 to 30 days.
"Urofuragin" is an anti-microbial agent with a wide range of effects. The principle is based on delayed nucleic acid metabolism. A package with 30 tablets of 50 mg each costs 265 rubles. It’s almost impossible to find this analogue on drug store windows of pharmacies.
Reviews about "Furamag"
Instructions for use, containing a detailed description of the drug, in practice coincides with the main purpose. Many patients who have experienced urological infections report an improvement in their general condition after an 8-day course of therapy. They also emphasize the effectiveness of the drug, which actively manifests itself in reducing the urge to urinate (a few hours after taking the dose) and relieving pain syndromes on the 2nd day of administration.
Very few cases confirming the occurrence of side effects, which are described in the instructions for use. The price of Furamag tablets is expensive, but 1 package is usually enough for treatment, since the course of therapy is prescribed for no more than 10 days.
Some patients claim that after taking the drug for cystitis, burning and intolerable pains go away literally in 10-15 minutes. And after completing the course, they forgot about the ailment for several years. The main thing is to strictly follow the instructions for use. The price of "Furamaga" (reviews confirm) is justified by its effectiveness.
Also, patients claim that when taking the drug, the urine stains in a bright acid color, which immediately normalizes after the end of therapy. And someone even notes relief in the inflammatory process of the upper respiratory tract (prevents the spread of infection through the lymph).
But no matter what the symptoms appear, it is worth discussing it with your doctor to make sure that everything is within normal limits. In each patient, the body is individual and can give an unpredictable reaction to any drug. But "Furamag" is still an agent that refers to antibiotics, which means that therapy should be carried out under the strict supervision of a specialist.