For many years in medicine, the problem of treating severe infections and sepsis has remained an urgent problem. Often, against the background of pathologies, secondary immunodeficiencies and infectious complications develop, which increases the risk of death for patients. That is why substitution treatment with intravenous immunoglobulins, which are highly effective, is used for the treatment of seriously ill patients. Therefore, it will be useful to familiarize yourself with the instructions for use of Gabrilobin, the first and only domestic intravenous immunoglobulin characterized by good tolerance and safety in use, as evidenced by numerous tests. The drug is quite effective in treating different categories of patients.
Description and description of the medication
According to the instructions for use, Gabrilobin is an immunoglobulin that contains maltose. The drug is available in the form of a clear solution for intravenous infusion in the amount of two and a half grams. The package also contains a solvent bottle with a capacity of fifty or twenty-five milliliters.
Gabrilobin (IgG) contains a large number of antibodies against pathogens. It compensates for the lack of IgG antibodies, reduces the likelihood of secondary immunodeficiencies and infections.
Usually, the drug is prescribed for autoimmune diseases. The list of diseases in this category includes the following ailments:
- Blood pathology.
- Primary immunodeficiencies.
- Wiskott-Aldrich Disease.
- Dwarfism with shortened limbs.
- Ataxia-telangiectasia.
- Thrombocytopenic purpura.
- Various arthritis.
- Lymphoproliferative syndrome.
- Thrombocytopenia.
In addition to autoimmune diseases, the list of diseases for which the medicine is used includes:
- Lymphocytic leukemia.
- Cytomegalovirus infection.
- Kawasaki Syndrome.
- Bacterial and viral infections.
- Lupus erythematosus.
- Malignant tumors.
- Burn disease.
- Severe myasthenia gravis.
- Sepsis.
- AIDS (acquired immunodeficiency syndrome).
- Myeloma
- Nephrotic syndrome.
- Neuropathy.
- Bronchial asthma.
- Multiple sclerosis.
- Chronic sinusitis.
- Evans disease.
- Gastritis.
- Anemia.
- Postoperative complications.
The effect of the drug
βGabrilobinβ is an immunological preparation presented in the form of a protein fraction containing a huge amount of antibodies, which was isolated from human blood serum, previously tested for the absence of HIV and hepatitis. The active substance of the drug is immunoglobulin G, which includes a huge spectrum of antibodies against various pathogens. The medicine does not contain preservatives and antibacterial agents, as an additional component it contains maltose. The tool reduces the risk of infections in people with immunodeficiencies.
With intravenous administration, the drug is completely absorbed into the body. Its maximum concentration is observed over twenty one days, the elimination period is more than one month.
Usage Summary
The described medication has many indications for use. "Gabrilobin" is prescribed in that dosage and with such a frequency of use that are permissible and necessary in a particular case. Treatment with the drug is carried out in a hospital using an infusion system. Before intravenous administration of the drug, it is kept at a temperature of twenty degrees Celsius for about two hours. If the solution contains a precipitate, it cannot be used.
For children, the dosage is four milliliters per kilogram of weight. The drug is administered daily for five days. The drug is administered slowly, at ten drops per minute.
For adults, the dosage is fifty milliliters. The course of therapy is ten transfusions, which spend the day alternating. First, the rate of administration of the drug is twenty drops per minute, after fifteen minutes it is increased to forty drops. Quickly introducing a medicine is prohibited, as there is a risk of collapse.
In the treatment of AIDS, as well as other immunodeficiencies, treatment is carried out for one month until the concentration of IgG in the blood increases. If the antibody level does not increase, increase the dosage of the drug.
In order to prevent the development of infections in premature babies, drug treatment is carried out for two weeks.
Usage restrictions
Instructions for use "Gabrilobin" suggests that there are some contraindications in the use of funds:
- High susceptibility to the components of the drug.
- Anaphylactic shock in the anamnesis.
- IgA immunodeficiency.
With caution, a medication is prescribed for those who suffer from diabetes mellitus, renal and heart failure, women during the period of bearing and breastfeeding of the child.
The use of "Gabrilobin" with antibacterial drugs is allowed. When vaccinated against infections, the drug can weaken the effect of vaccines for three months. When using the drug in a large dosage, its effect may persist for one year.
You can not use the drug simultaneously with calcium gluconate.
Complications and consequences
During the first days of using the medicine, an allergic reaction, headache, shortness of breath, pressure fluctuations may occur. In this case, you do not need to cancel the medication.
In some cases, the development of side effects is possible:
- Anaphylactic shock.
- Vomiting
- Pain in the abdomen or chest.
- Collapse.
- Fainting.
- Numbness.
- Hypotension.
If unpleasant symptoms occur, a doctor's consultation is required. Symptomatic therapy with antihistamines, adrenergic agonists and glucocorticosteroids is also performed.
Cases of overdose are not recorded.
Gabrilobin: specific instructions
The drug is mixed only with a 0.9% sodium chloride solution. For those people who have autoimmune pathologies, the drug is administered together with appropriate treatment. In the case of the use of the drug during the lactation period, this drug passes into breast milk, so the baby can receive antibodies with it.
Exceeding the rate of administration of the drug is unacceptable, since the risk of collapse increases. After the introduction of the drug, it is necessary to monitor the patient's condition for thirty minutes: in case of negative symptoms, symptomatic therapy is carried out. Doctors should always have anti-shock drugs at hand.
When treated with Gabrilobin, an increased antibody content is observed in the blood, so the results of serological studies may be false.
Additional Information
Instructions for use "Gabrilobin" indicates that the medication should be stored in a dry, dark place with an air temperature of two to ten degrees Celsius. The shelf life of the solution is two years, then it must be disposed of. Children should not have access to medication.
Transportation of the drug should be carried out in an enclosed space, while the temperature should be from two to ten degrees.
The medicine is dispensed by prescription. Its cost is about three thousand one hundred rubles per package.
Opinions about the drug are mostly positive. Many doctors use it in their practice. The medicine helps to cure many diseases. Judging by some reviews, Gabrilobin helped many women who could not bear pregnancy due to autoimmune diseases to get pregnant and have healthy children. The medicine has also proven itself in the treatment of purpura.
Conclusion
Gabriglobin is not inferior to its counterparts in foreign production, neither in quality nor in efficiency. This domestic product has a relatively affordable cost, so it can be used in different branches of medicine. The drug helps to neutralize various pathogens. It contains antibodies that make up for the lack of such in the body. Therefore, with its help it is possible to reduce the likelihood of developing infectious diseases in primary or secondary human immunodeficiency.