To combat the increased concentration of cholesterol in the circulatory system, it is recommended to eat properly and introduce dosed physical activity into your daily routine. If such gentle measures do not give the desired result, the doctor prescribes drugs that lower cholesterol. In pharmacies, there are several types of drugs that are effective for different root causes of the pathological condition. Consider the main ones.
Statins
This category of cholesterol lowering drugs is prescribed more often than others. They are designed specifically to reduce the concentration of a dangerous compound in the circulatory system. Medicines inhibit the activity of specific liver enzymes, through which the chemical reaction of the generation of cholesterol proceeds. The product resulting from this reaction is important for the operation of a number of cellular structures, organic tissues, but its excessive content provokes atherosclerosis. The term designate pathology, accompanied by the generation of cholesterol plaques on the vascular walls. These interfere with blood flow and can completely block the vessel. Statins that lower the content of a dangerous substance in the circulatory system, reduce the likelihood of an angina attack, are considered a reliable method of preventing stroke, heart attack.
Pharmaceutical companies have developed various cholesterol lowering drugs that belong to the class of statins. They are distinguished by active ingredients. Atorvastatin, rosuvastatin are the most powerful and pronounced effect. The mildest and weakest result is observed if the patient consumes fluvastatin. There are also Lova-, Meva-, Pitava-, Prava-, Simva-, Cerivastatin. There are quite a few items under which in pharmacies medicines from the class of statins are presented. So, the medicine “Lipitor” contains atorvastatin. If the doctor believes that the patient will be most likely to benefit from simvastatin, Zokor will probably be prescribed. The drug "Prakhorachor" is produced using pravastatin. The active ingredient in Crestor is rosuvastatin. If it is recommended to take fluvastatin, you can buy Leskol. The medicine "Vitorin" is a combined pharmaceutical product containing ezetimibe, simvastatin. Red rice is a natural source of mevastatin. This compound is the only substance in the category of statins found in a natural product.
How does it work?
Statins are drugs that lower cholesterol due to inhibition of the enzyme HMG-COA reductase. This chemical is involved in the process of hepatic cholesterol generation. Additional enzyme compounds present in the hepatic cell structures perceive a decrease in cholesterol generation activity and respond to this with the release of proteins. At their expense, the number of low-density lipoprotein receptors is growing, that is, the most dangerous variant of cholesterol. Receptors are distributed in cell membranes and quickly bind all passing low-density and very low-density lipoproteins. Next, the processing processes in the liver begin.
Taking statin drugs to lower cholesterol, many have a goal of five or less. On average, a decrease in cholesterol concentration by a quarter or a third compared to the original is expected. If it is not possible to achieve the desired results, the dose is increased. In most cases, the therapeutic program lasts after stabilization of the parameter at the desired level. This helps rule out atherosclerosis in the future.
How to use?
To lower cholesterol, drugs are taken for heart disease, atherosclerosis. Medicines reduce the risks of progressing a pathological condition, prevent the deterioration of the situation. Often they are prescribed to diabetics or people with other diseases that are more likely to cause atherosclerosis. If there is an indication of heart attacks in the family history of the disease, a person is shown taking statins. This is especially true if such attacks occurred in close relatives at a young age. Often, an indication for the use of statins becomes old age.
According to experts, an increased concentration of cholesterol in the blood is the most common factor in the use of statins. Such drugs help reduce the likelihood of heart pathologies, as they prevent atherosclerotic changes, but it is important to remember that an attack can occur even with normal cholesterol levels in the blood. The predominant percentage of cases is due to plaques, but exceptions are possible. Studies have shown that plaques can form with low cholesterol in the circulatory system. Statins are used if for a person the risk of atherosclerosis is higher than normal, and sometimes even in cases of relatively low cholesterol in the blood.
Could there be flaws?
Drugs that lower blood cholesterol can cause side effects. The predominant percentage of people who are forced to use statins does not note those or complains about relatively weak phenomena. There are known cases of pain in the stomach, others hurt and feel dizzy. Taking medications may be accompanied by tingling in the stomach, increased gas formation and upset stool. There is a possibility of nausea and vomiting, skin rashes. Very rare cases of a severe variant of the inflammatory process of muscle tissue are known.
There are two options for severe side effects that can occur while taking statins: failure of the liver and pathology of the muscles that support the skeleton. Muscle damage is officially called rhabdomyolysis, it belongs to the class of myopathies. The phenomenon usually indicates itself at first soreness in the muscles, gradually progressing. Cells die, while kidney failure is observed. Without adequate support, there is a danger of death. There is a higher risk of rhabdomyolysis, if the patient takes several types of drugs at once to lower blood cholesterol. If statins are combined with other medications, the use of which can provoke rhabdomyolysis, as well as when combined with drugs, under the influence of which the content of statins in the circulatory system increases, the danger of severe pathology is greater.
Features of the reception
Statins are effective and fairly safe drugs that lower blood cholesterol, but they can not be used for severe hepatic impairment or serious pathologies of this organ. If liver disease progresses with medication, discontinue therapy. During the period of bearing a child, lactation, during preparation for conception, it is necessary to abandon the use of the drugs in question. People forced to take statins should refrain from protease inhibitors used in AIDS therapy. Do not take erythromycin and diltiazem. Limitations apply to verapamil and itraconazole. It is contraindicated to combine statins and clarithromycin. It is strictly forbidden to use statins and fibrates at the same time. Both classes of drugs are designed to lower cholesterol in the circulatory system, but they do not combine with each other.
Persons forced to consume statins should refrain from including grapefruits and natural juice obtained from these fruits in the diet. The active ingredients of citrus can enter into chemical interaction with medications.
Statins and Fibrates
There are two types of drugs that lower blood cholesterol: the statins discussed above, fibrates. They differ in the mechanism of influence on the human body. Statins inhibit the generation of cholesterol, while preventing the production of the tenth coenzyme. Lack of this substance in the body provokes excessive fatigue of a person, a weak state, can cause cardiac and vascular failures. Soreness in muscle tissue is due precisely to the insufficiency of this coenzyme. Headaches and digestive problems are another reason to abandon statins. Use drugs of this group can only be under the supervision of a doctor. The patient is prescribed a combined course in order to make up for coenzyme deficiency.
Fibrates, in turn, provoke an increase in the concentration of beneficial cholesterol fractions in the circulatory system with a parallel decrease in the content of triglycerides by a quarter, and sometimes by half. Due to changes in blood quality, the vascular walls are strengthened, the activity of inflammatory foci in the circulatory system is inhibited. Fibrates help prevent atherosclerosis and reduce the risk of death. However, here it was not without drawbacks, drugs of this type are used very carefully, and the daily dose is chosen strictly individually, since there is a possibility of heart failure. The doctor, explaining how to reduce blood cholesterol medication, will definitely pay attention to the risk of pathologies of muscle tissues, brain structures if taken improperly. There is a possibility of digestive disorders. Some complain of headaches, sleep disturbances, someone was bothered by skin rashes and soreness in the stomach.
Inegi
As can be concluded from reviews of drugs that lower cholesterol, this remedy is tolerated by most patients very well. The medication has a pronounced hypolipidemic effect due to the combined composition. Active ingredients prevent the absorption of cholesterol fractions by cells of the intestinal tract, while inhibiting the generation of a substance in the body. There is no effect on the absorption of bile and fatty acid compounds. The medicine does not correct the level of progesterone and does not affect the concentration of other substances vital to humans and obtained with food. Inegi is used in combination with a special nutrition program aimed at reducing the amount of cholesterol-rich foods. If you do not adhere to such a diet, there will be no benefit from therapy.
Caduet
Among drugs that lower blood cholesterol, this medication is considered one of the famous and reliable. It not only corrects the cholesterol content in the circulatory system, but also facilitates the course of angina pectoris, a transient myocardial ischemic disease. The drug has a positive effect on blood pressure, stabilizing its performance to normal. Such a multifaceted effect is due to the combined composition - atorvastatin and amlodipine are in the medication. The first ingredient lowers the content of low-density and very low-density lipoproteins in the circulatory system, the other relaxes the muscle vascular tissues, so that the gaps become larger. As a result, the pressure decreases.
Mevacor
Considering how to lower cholesterol with drugs, it is worth taking a closer look at this effective remedy. Its main active ingredient is lovastatin. The medicine belongs to the class of statins. Refers to lipid-lowering drugs. Positive effect on the inner choroid. Under the influence of the drug, the activity of atherosclerosis decreases. In the event that it has not yet begun, the medicine reliably warns it; at the early stage of the pathology, it is likely to reverse the process. Under the influence of the active ingredient, the level of blood viscosity is adjusted. Taking the drug prevents the appearance of blood clots. The antioxidant qualities of the drug, antiproliferative effect are proved.
Omega-3
This medication is a reliable natural cholesterol drug that positively affects blood quality. The substance stabilizes the fat profile and eliminates arrhythmia, increases the concentration of beneficial cholesterol fractions. Omega-3 helps reduce the risk of heart and vascular disease. There are practically no side effects. The alternative name by which the drug is known is Omacor.
"Lipanor"
If the task is to choose non-statins, this medicine can become the medicine for lowering cholesterol in the circulatory system. It belongs to the category of fibrates. The tool is hypolipidemic. It features an extensive efficiency profile. The active ingredient that ensures the health of the drug is ciprofibrate. This compound helps reduce the amount of triglycerides in the blood, and also inhibits the biological production of cholesterol by the liver cells. Under the influence of the drug, cholesterol decomposition becomes faster, the elimination of the compound with bile is activated. The drug stabilizes the lipoprotein profile of blood serum. The concentration of beneficial cholesterol fractions becomes greater against the background of a decrease in the content of hazardous ingredients. A long therapeutic course helps to achieve the optimal ratio of different types of cholesterol.
Lipantil 200 M
Understanding how to lower cholesterol in the circulatory system with drugs, it is worth taking a closer look at this popular drug from the class of fibrates. The active ingredient, which provides a pronounced effect of the drug, lowers cholesterol in the circulatory system. Under its influence, the percentage of low-density, very low-density lipoproteins becomes smaller. At the same time, the concentration of high-density compounds of this type is growing. The active substance of a pharmaceutical product activates lipase, lipolysis processes are faster and more pronounced, therefore, elements saturated with triglycerides are removed from the circulatory system faster. Under the influence of the drug, the concentration of glucose in the blood decreases. This is especially important for diabetics. In case of dyslipidemia against the background of diabetes mellitus, the use of Lipantil 200 M helps to significantly improve the state of health, even if severe complications of metabolic processes have developed. The drug reduces the concentration of uric acid by 15-25%, due to which it is shown to suffer from gout and hyperlipidemia at the same time.
Tricor
The use of medications is one of the easiest ways to lower blood cholesterol, although it requires a combination with proper nutrition and adequate loads. If necessary, fight with an increased concentration of a dangerous compound, you can use the drug "Tricor". Its active ingredient is fenofibrate. This substance effectively lowers the concentration of triglycerides in the circulatory system, while blood saturation decreases with cholesterol. Use under the supervision of a specialist can completely solve the problem of cholesterol deposits outside the vascular system. At the same time, blood coagulation activity decreases. Due to this, the drug compound is considered prophylactic with an increased risk of blood clots. The concentration of inflammatory markers is reduced.
Fibrates: when shown?
These cholesterol lowering drugs are recommended for people who have an increased triglyceride concentration in the circulatory system. Means of this group are prescribed for combined type dyslipidemia, if the disease is familial. Such a diagnosis is made if a lipid balance failure is detected in the blood plasma, and the cause of the phenomenon is a hereditary factor or features of the person’s lifestyle. Fibrates are recommended for dyslipidemia against a background of a diabetic disease. Means of this group are used to reduce the content of dangerous cholesterol fractions in the body while saturating the blood with useful components.
Sometimes you can’t
The doctor, explaining to the patient which drugs lower cholesterol in the blood, always focuses on possible contraindications. In particular, fibrates, although they are generally well tolerated by patients, are prohibited due to insufficient liver and kidney activity. They are not prescribed in case of hepatic cirrhosis and a high level of susceptibility of the active ingredient by the body. It is forbidden to take such medicines for a number of rare diseases that are inherited and make it impossible for the body to absorb the components used in the pharmaceutical industry. We are talking about galactosemia, fructosemia.Sometimes it is impossible to apply funds due to diseases covering the gallbladder. Contraindication for the appointment of fibrates - addiction to alcohol in a chronic form. Medicines are not used for allergies to peanuts, soya lecithin.
Simple and affordable: for those who don't like medicine
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Pharmacology
Atorvastatin is one of the medications that quickly lowers blood cholesterol. The drug belongs to the class of statins, it is known for its hypolipidemic effect. The substance in selective format inhibits HMG-COA reductase, which is able to transform into mevalonic acid, the compound from which sterols are formed. The use of a pharmaceutical product helps to adjust the concentration of cholesterol, affects the content of lipoproteins in blood serum. The process of cholesterol production by the liver cells becomes less saturated due to an increase in the concentration of receptors. The content of low-density cholesterol is reduced even in the case of the familial format of hypercholesterolemia, a pathological condition characterized by increased resistance to agents for correcting blood quality.
Atorvastatin, on average, shows a stable, pronounced result a couple of weeks after the start of the course, which allows it to be ranked as a drug that lowers blood cholesterol quickly, gently and safely. If you compare this result with the use of traditional medicine and herbal medicines, Atorvastatin gives a significantly faster result. The rate of influence in some patients is higher compared to taking other statins and fibrates. On average, maximum performance is observed by the fourth week of the course and is maintained as such throughout the period of admission.
Dosage and danger
Studies have been conducted to determine the dangers associated with taking Atorvastatin tablets. In experimental dogs with a three-month program of use in the amount of 120 mg / kg, cerebral hemorrhage was recorded daily. In females after 11 months of consuming 280 mg / kg, not only cerebral hemorrhage was observed daily, but also the emergence of vacuoles of the nervous system responsible for the nutrition of the eyes. When using 120 mg / kg daily, systemic exposure was on average 16 times greater than when using 80 mg per day. For a person, the daily maximum is 80 mg.
Tests were conducted on dogs that were given drugs similar to the Atorvastatin class. Cases of swelling, cell infiltration of the mononuclear type have been recorded. The processes covered perivascular spaces. Degenerative processes in the visual ophthalmic system were revealed, depending on the dose.