People have had skin problems at all times. There are many drugs that make them easy to solve. A disease like rosacea causes great discomfort in patients, so it should be treated immediately. In solving this problem, Solantra Cream helps a lot. Consider his instructions for use, possible analogues, as well as the available reviews.
The components of the drug
Many users are interested in: “Solantra” hormonal cream or not? ”. You can answer this question only by studying the composition of the drug. The main active ingredient is ivermectin. It belongs to the group of avermectins. It is a semi-synthetic substance, less toxic and has undergone better purification, it is well tolerated by the body.
In the manufacture of the cream used the following excipients:
- Isopropyl palmitate.
- Glycerol.
- Carbomer copolymer type B.
- Citric acid monohydrate.
- Disodium edetate.
- Dimethicone 20.
- Cetyl and stearyl alcohol.
- Sorbitan stearate.
- Methyl parahydroxybenzoate.
- Phenoxyethanol.
- Propylene glycol.
- Oleyl alcohol.
- 10% sodium hydroxide solution.
- Propyl parahydroxybenzoate.
- Purified water.
The drug is available in the form of a cream of white or light yellow color.
Having examined the cream "Solantra" composition, we can conclude that it is not hormonal. This allows you to safely use it for more patients.
What is the effect of the drug?
Cream "Solantra" refers to antimicrobial and anti-inflammatory drugs. A positive effect is manifested due to the active active substance - ivermectin. It suppresses inflammatory cytokines caused by lipopolysaccharides. The substance also has a detrimental effect on parasites and on the Demodex tick.
When treating skin for rosacea, the main factor is that the cream is an antiprotozoal agent. With the death of a tick, the manifestation of inflammatory processes is significantly reduced, since parasites provoke their development. But the action of the cream in this disease has not been fully studied, so you should use it with extreme caution.
Suction and distribution processes
To determine how the “Solantra” cream works, special studies were conducted on patients with severe papulose-pustular rosacea. For their treatment, the maximum dose of the drug was prescribed. After two weeks of therapy, the following results were noted:
- The maximum concentration of the substance is observed within 8-10 hours after application.
- Systemic accumulation of the active component occurs at the end of the second week of treatment.
- The level of ivermectin in the blood during systemic use is much lower than after applying 6 mg orally.
- Ivermectin binds to plasma proteins and is more than 99%.
- The active substance does not inhibit the activity of isoenzymes 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, ZA4, 4A11
- Metabolized by CYP3A4 inhibitors.
- The active substance ivermectin does not contribute to the conversion of CYP450 enzymes in human hepatocyte culture.
- Metabolic products reach equilibrium by the end of the second week and do not accumulate until 3 months of treatment. The metabolites after applying the cream are lower than after using ivermectin inside.
- The half-life with the maximum dose of cream for 3 weeks was 6 days.
- The degree of absorption of the cream after external use affects the rate of excretion from the body.
The study involved people who did not have impaired kidney and liver function.
Drug use
Prescribe "Solantra" cream for the treatment of rosacea. Mostly papulopustular form in adults and with a large number of inflammatory processes.
But the varying degree of the disease and the severity of its course may require a combination with other drugs, these issues are discussed with the attending physician, who prescribes the therapy.
Who should not use the drug?
If you want to use the Solantra cream, the instruction contains information about contraindications for its use:
- It is not recommended to use the drug in the presence of special sensitivity to the components of the cream.
- No studies have been conducted in the category of persons under 18 years of age. Therefore, there is no need to take risks, it is better to choose another remedy.
- During lactation, it is not recommended to use this drug.
- Women during the bearing of the baby are also better to refrain from such therapy.
It is worth noting that studies have not been conducted on the effects of ivermectin when applied topically, on its effect on human milk. But such tests were carried out with the participation of animals. It was found that when ingested, part of the active substance passes into breast milk, so the risk for the baby remains. Doctors recommend interrupting the feeding of the baby for the period of use of the drug.
The effect of ivermectin during pregnancy on the fetus was studied by animal testing. Proven weak systemic effects with external use of the cream. There are low risks of fetotoxicity, therefore, doctors do not recommend using the drug during pregnancy. How to cure rosacea "Solantra" is described below.
Instructions for use
First of all, you can use the cream only for external use, avoiding contact with the mucous membranes and into the body. It is applied exclusively to the face. The recommendations are as follows:
- Before using the drug, the skin must be cleaned of dust and dirt.
- Hands should also be dry and clean.
- It is enough to use a small amount of cream, about a pea.
- Apply a uniformly thin layer on the forehead, cheeks, nose, and chin.
- Apply cream on massage lines.
- Avoid contact with mucous membranes, as well as lips and eyes.
- Use cream 1 time per day every day. You can apply the product before bedtime or in the daytime.
- The cream is well absorbed. After it dries, you can use cosmetics.
- After applying the cream, it is recommended to wash your hands.
- The course of treatment is 4 months.
- If after 3 months of therapy there are no positive results, then they are not recommended to use the drug further.
After use, the tube must be tightly closed and removed to a place inaccessible to children. Storage temperature no more than 30 degrees. Apply "Solantra" cream can only be prescribed by a doctor.
Possible side effects
As a rule, the drug is safe and does not cause any negative effects. But in some cases, the following side effects may occur:
- Most often, after use, patients experience a burning sensation, which after a while passes.
- Sometimes itching and skin irritation are felt. Also, in some patients, the cream provoked dry skin.
Such adverse reactions were noted in only 1% of patients. Manifestations were not very pronounced and with further use of the drug weakened, manifested in a mild form, and eventually passed completely. Unlike other similar drugs, the cream does not cause contact dermatitis and allergic reactions.
Features of the use of the drug
Before using the cream "Solantra", the instructions must be studied. It contains information about the features of the use of the drug in connection with the constituent components that can cause unwanted reactions:
- Stearic and cetyl alcohol often cause contact dermatitis.
- Propylene glycol often provokes irritation of the skin.
- Propyl parahydroxybenzoate and methyl parahydroxybenzoate contribute to the development of delayed allergic reactions.
- When using the cream in patients with impaired renal function, dose adjustment is not required.
- In older people, the dosage does not require changes.
- In case of impaired liver function, the cream must be used with caution. Do not exceed the dose and monitor the treatment by a doctor.
Before applying the drug and after it is necessary to wash your hands. When using the cream "Solantra", you can drive vehicles and mechanisms that require increased attention, since it has no effect or very little effect on concentration.
Cases of exceeding the recommended dose
Overdose of "Solantra" cream is not registered. But if swallowed or inhaled, as well as on the surface of the mucous membranes, with parenteral administration of the active substance ivermectin, the following symptoms are possible:
- skin rashes;
- contact dermatitis;
- headaches;
- swelling of the face, eyelids;
- nausea, vomiting, abdominal pain;
- diarrhea;
- cramps
- shortness of breath
- ataxia.
In order for the drug that got inside not to be absorbed further, it is necessary to induce vomiting, rinse the stomach. Take measures to eliminate intoxication. Symptomatic therapy is performed. Fluids and electrolytes are introduced, they support breathing and control blood pressure.
Using Cream with Other Medicines
No studies have been conducted on the compatibility of Solantra with medications. But it is known that the combined use of drugs with the active substance ivermectin and with powerful inhibitors of CYP3A4 increase the concentration of the active substance in blood plasma. And this can cause the manifestation of adverse reactions or symptoms of an overdose.
Those who cured rosacea "Solantra", it is recommended to consult a doctor before starting therapy. Discuss with him medications that you take regularly for compatibility with the cream, to avoid unwanted adverse reactions.
What can be replaced?
I would like to note that currently there are no creams of Solantra analogues with the same active substance. In case of drug replacement, consult a doctor. He will select the right drug with the same pharmacological effect, but with a different active substance.
Reviews on the use of cream
Doctors often prescribe Solantra rosacea for the treatment of the papulopustular form of rosacea. Reviews cream has mostly only positives.
Many say that after a long search for a suitable treatment, the drug is a real salvation. The effect of using the product is noticeable a week after the start of use. It relieves inflammation, thanks to its antiparasitic properties. The cream is well tolerated and practically safe, since with external use, penetration into the blood plasma is a small percentage. The manifestation of side effects was practically not observed.
Very few noted the appearance of burning at the beginning of applying the cream on the face, as well as mild itching after drying. Those who cured rosacea "Solantra" and used the drug for a long time, noted dry skin. But this can be easily combated using moisturizing cosmetics that are recommended by a dermatologist.
Women noted the peculiarity of Solantra. The cream received good reviews because after drying it can be used decorative cosmetics, which is very convenient. With proper use of the product in a tube of 30 g may last for 2 months. We can assume that the drug is consumed quite economically.
But the drug has several disadvantages. Not everyone is happy with its value. In addition, this antiprotozoal agent can not be bought at every pharmacy. Also, patients do not like that the drug is sold only on prescription.
For the treatment of such a complex disease as rosacea, Solantra cream is an excellent drug. But treatment requires an integrated approach, so be sure to visit a dermatologist.
It is much easier to cope with skin problems if you do not start a pathology and consult a specialist in a timely manner, and he will already select an effective medicine.