“ACC” is a mucolytic medication prescribed to facilitate the process of coughing up viscous sputum. The medicine is characterized by a detoxifying property, it is included in the group of vital medicines.
Pharmacological form of inhalation solution, composition
The main active component in the “ACC” is acetylcysteine, which is a chemical substance with an expectorant effect.
The drug is produced in various pharmacological forms: tablets, granules intended for the manufacture of syrup. "ACC" for inhalation, used with a nebulizer, is marketed under the name "Acetylcysteine." Another name for the drug is Fluimucil.
“ACC” for inhalation is a clear solution without color. The drug is packaged in ampoules of 5 ml. Each package contains 10 ampoules. The concentration of the active substance in each milliliter of the solution is 20%.
In addition, such auxiliary components as injection water, sodium hydroxide, disodium edetate are present in the “ACC” inhalation solution.
Pharmacological effects
“ACC” is a mucolytic. Under its influence, sputum changes its viscosity, liquefies, becomes more viscous. The active component transforms complex plasma proteins (polymeric mucoproteins) into monomers by breaking molecular bonds. As a result, the process of sputum discharge intensifies, mucociliary clearance increases - local protection of the respiratory mucosa. Atrial epithelium acquires resistance to the influence of harmful external factors - allergens, infections. The drug retains its activity regardless of the nature of sputum (purulent, serous).
“ACC” for inhalation acts as an antioxidant. Under its influence, free radicals are neutralized and neutralized, toxic substances are removed from the body. In addition, the medicine protects cell structures from damage in cases of severe inflammation.
The prophylactic use of an inhalation solution reduces the likelihood of infection of a bacterial origin, prevents the development of complications in patients with chronic pathology of the respiratory system (cystic fibrosis, bronchitis, accompanied by increased secretion of mucus).
After penetration into the respiratory tract, the drug is rapidly absorbed through the mucous membranes, falling into the systemic circulation, easily overcoming the placental barrier, the BBB.
Indications for use
"ACC" for inhalation is indicated for use in the treatment of pathologies of the respiratory system, which are accompanied by the formation of difficult to separate, viscous sputum, including purulent in nature:
- The period of rehabilitation after surgery.
- The accumulation of sputum in the respiratory tract on the background of injury.
- Falling lung lobe (atelectasis), accompanied by the formation in the bronchi of the mucous plug.
- Lung abscess is a local inflammatory process, accompanied by suppuration.
- Exudative otitis media.
- Chronic, acute forms of sinusitis - ethmoiditis, frontal sinusitis, sinusitis.
- Cystic fibrosis is a hereditary pathology, which is a severe form of functional impairment of the respiratory system.
- Bronchiolitis is an inflammatory process in the small bronchi leading to their blockage.
- Bronchial asthma.
- Bronchiectatic disease is a chronic pathology that causes suppuration and irreversible changes in the bronchi.
- Pneumonia.
- COPD, obstructive changes in the airways.
- Laryngotracheitis.
- Chronic, acute bronchitis.
- Tracheitis of bacterial, viral origin.
Use of medication
What does the instruction for “ACC” for inhalation for children and adults tell us?
In order to treat obstructive diseases of the lungs and bronchi, the drug must be delivered to the respiratory system. A nebulizer is ideal for this. Using the apparatus, the solution turns into particles of fine dispersion, when inhaled, the active component of the drug enters deep into the structures of the bronchial tree.
Any nebulizer for inhalation with the “ACC” can be used in any modification. In accordance with the rules for using the device, medication in its pure form can not be used. It should be diluted with saline in equal parts.
In order to avoid the occurrence of an undesirable chemical interaction that can reduce the effectiveness of the medication, “ACC” should be added to the saline solution, and not vice versa.
A mucolytic can instantly penetrate the mucous membranes and begin its effect only if it has the same temperature as internal media, that is, 37.5 degrees. In the case when the nebulizer does not have the function of heating the drug, the solution should be independently heated before use.
Dosage of this drug
For one procedure, it is necessary to use 2-5 ml of solution. The exact dose will be determined by the doctor based on the age of the patient, the diagnosis. It is recommended to carry out inhalation three or four times a day, mainly on an empty stomach, between meals.
The medicine can be used to treat newborns (from 10 days from birth). Since the baby is not able to control breathing through the mouth, a special mask should be used. With it, the medicine is inhaled in the usual way, there is no need for deep breaths.
The average duration of one inhalation is 5-15 minutes. The duration of the therapeutic course in acute forms of infectious and inflammatory pathologies is up to 10 days. If the pathology has a chronic form, a specialist can recommend a longer treatment.
Negative effects of “ACC”, contraindications for use
According to the instructions, “ACC” for inhalation is contraindicated in patients who have an increased susceptibility to the main component of the drug - acetylcysteine. Also, you should not use the medicine for pulmonary hemorrhage, hemoptysis.
Inadmissible is the use of “ACC” for inhalation for children whose medical history contains data on renal failure, hepatitis of various origins. “ACC” is able to cause the accumulation of nitrogen-containing substances in the body - ammonia, nitrates, purines.
In general, the inhalation solution is well tolerated by patients. Negative manifestations develop extremely rarely, since the use of a nebulizer allows you to clearly dose the medicine.
However, the development of side symptoms cannot be completely ruled out. “ACC” can provoke the following phenomena:
- A slight increase in blood pressure, increased heart rate.
- Headache, dizziness, tinnitus.
- Stomatitis (if the drug is inhaled by mouth).
- Rhinitis.
- Irritation of the mucous tract breathing, provoking a reflex cough.
- Nausea (develops due to the fact that the medicine has a specific smell).
It is important to exercise caution when prescribing an inhalation solution to patients suffering from bronchial asthma in the lactation period, during pregnancy.
This is confirmed by the instructions for use with the “ACC” for inhalation.
Analogs of this drug
If necessary, “ACC” can be replaced by one of the following analogues: “Atsestin”, “Ambrol”, “Bromhexin”, “Ambrobene”, “Lazolvan”, “Mukaltin”.
In some sources there is information that “Acetylcysteine” can be replaced by “ACC Inject”. However, this drug is intended for intravenous, intramuscular administration. It has a different concentration and dosage, and the official annotation does not include information about the possibility of using the drug for inhalation with a nebulizer. In this regard, it is not recommended to use this form of “ACC” for inhalation.
Cost of medication
The average cost of the drug is approximately 65 rubles. Thus, "Acetylcysteine" is not only effective, but also an affordable medication.