What do we know about Diphenhydramine? Instructions for use reports that it is an antihistamine with hypnotic, antiallergic, antiemetic effect. With this medicine, smooth muscle spasms caused by histamine can be removed, reduced or prevented, as well as edema, hyperemia and itching of the same etiology.
The medicine "Diphenhydramine" instructions for use relate to antihistamines of systemic use. It is effective for allergies, is a histamine receptor blocker, and has a depressing effect on the cough center. Also, a sedative effect is observed when using the drug "Diphenhydramine". Composition: in one tablet of the substance - Diphenhydramine hydrochloride 0.03 ;, 0.05; 0.1 years
The drug exhibits activity of interaction with plasma protein. Spreading in fluids and tissues, it can easily penetrate the placental barrier, enter the composition of breast milk. Metabolization is mainly carried out in the liver, with the formation of diphenylmethoxyacetic acid. The withdrawal from the body of a substance is carried out unchanged with urine during the day.
Indications for use of the drug "Diphenhydramine" instructions for use indicate the following:
- Allergies.
- Sleep disturbance. With insomnia, it can be prescribed both separately and with other drugs that have a hypnotic effect.
- Seasickness.
- Dermatoses.
- Airsickness.
- Meniere's syndrome and other pathologies, mainly of an allergic nature.
The effect of the drug with bronchial asthma is inactive and is used in conjunction with bronchodilators.
When prescribing Diphenhydramine tablets in tablets , the dosage is as follows: children over the age of twelve and adult patients receive 0.03 - 0.05 g, up to 0.1 g of this drug as much as possible. It is taken three times a day for ten days to two weeks.
The maximum dose is considered to be a single dose of the drug "Diphenhydramine" - 0.1, daily - 0.25 grams for adult patients. Up to 12 years old, children are prescribed 0.015-0.03 grams per dose.
Among the contraindications to the appointment of the drug "Diphenhydramine", the instructions for use include:
- Hypersensitivity.
- Bronchial asthma.
- Pathology of the prostate gland.
- Glaucoma.
- Stomach ulcer.
- Duodenum ulcer.
- Pregnancy.
Side effects are expressed in drowsiness, weakness, or vice versa - insomnia and nervous excitement. Patients undergoing treatment with the drug may also experience dizziness, impaired coordination, dry mouth, and digestive problems. Trembling limbs, cramps, visual impairment were noted. In patients suffering from brain pathologies, epilepsy, there were epileptic seizures due to treatment with this medicine.
Usually, all such phenomena disappear after discontinuation of the drug or a decrease in the dose consumed. With simultaneous administration with psychotropic drugs and analgesics, it enhances their effect. In particular, this applies to barbiturates, sleeping pills, opioid receptor agonists. Accordingly, the combined use of the drug "Diphenhydramine" and drugs of these groups is undesirable.
Symptoms of an overdose of the drug are largely similar to the side effects of its use. Cases of loss of consciousness should be added to them. As an emergency, gastric lavage, ingestion of activated carbon tablets, the use of salt laxatives, and respiratory control are used.
Taking into account the hypnotic and sedative effects provided by diphenhydramine, it is not prescribed for car drivers, patients whose profession requires constant attention. Do not take this medicine with alcohol or alcohol-containing drinks.