Life with a runny nose loses its charm, because a person is disturbed by headaches, nasal congestion, shortness of breath, irritation of the mucous membrane and a stream of discharge from the nose. At this moment, I want to get rid of the disease as soon as possible, and Tizin Xilo BIO will be an excellent assistant in this situation. He will quickly remove congestion, relieve irritation, and restore normal breathing. It has a natural composition. Even children (from two years old) can use it.
The composition and form of the drug
"Tizin Xilo BIO" is a nasal spray. It has the non-proprietary international name “Xylometazoline”.
Available in a dosage of 0.05% and 0.1% in 10 ml. The drug is packaged in white plastic bottles that have a metering device and a lid. In addition to the bottle, the box contains instructions for use. The volume of the vial (10 ml) is designed for 140 doses.
The drug contains the active component of xylometazoline hydrochloride: 0.5 mg for a dosage of 0.05% and 1 mg for 0.1%. The volume of the active substance in one zilch for 0.05% is 0.035 mg xylometazoline hydrochloride; for 0.1% - 0.14 mg. Auxiliary elements are glycerol, purified water, sorbitol, sodium hyaluronate, sodium dihydrogen phosphate dihydrate, sodium phosphate dihydrate and sodium chloride.
The solution is a colorless and transparent liquid with a slight yellowish tint.
Pharmacological characteristics
Spray "Tizin Xilo BIO" is a decongestant medication (vasoconstrictor).
The active substance - xylometazoline - refers to imidazole derivatives. This alpha-adrenostimulator in a few minutes removes swelling of the nasal mucosa and restores breathing with rhinitis.
Hyaluronic acid delicately helps restore normal functioning of the nasal cavity, removes dryness. Keeps the mucous membrane moist.
The effect of the drug begins 5-10 minutes after administration.
The medicine is intended only for local use and is almost not absorbed by the walls of the nasal cavity. The concentration of the active component in the blood reaches the minimum value when it is not possible to determine it by analytical methods. Human pharmacokinetic studies have not been conducted.
The effect of "Tizin Xilo BIO" during pregnancy and during breastfeeding has not been studied. It is also unknown whether the active substance passes into breast milk. Therefore, in these periods of life, it is better to refuse to use the nasal spray.
Indications for use
The drug helps to remove swelling of the nasal mucosa with rhinitis. It can be hay fever, allergic rhinitis or acute respiratory infections with symptoms of rhinitis.
The medicine contributes to the rapid discharge of mucus with paranasal sinusitis. A similar effect of the spray is observed in inflammatory processes of the middle ear, the cause of which was the common cold.
"Tizin Xilo BIO" for children in the age group of 2-6 years has a dosage of 0.05%. Adults and children from 6 years of age are prescribed a drug with a concentration of the active substance of 0.1%.
Contraindications
When treated with Tizin Xilo BIO, a small number of patients (≥ 1%) may experience unpleasant consequences. Therefore, it is worth abandoning the use of a nasal spray if there is hypersensitivity to any of the substances contained in its composition. A ban on use is atrophic rhinitis, thyrotoxicosis. You should not use the drug to treat newborns and babies up to two years. Do not use the drug in patients with severe forms of cardiovascular disease, such as coronary heart disease, severe atherosclerosis, tachycardia, hypertension, angina pectoris. People who have had brain surgery should refrain from spray therapy.
Carefully administer the drug, carefully considering the benefits and risks, should be used by persons using monoamine oxidase inhibitors (MAOs) or similar agents that increase and intraocular pressure in therapy. Particular attention should be paid to the effect of the drug in narrow-angle glaucoma. Caution should be given to patients with pheochromocytoma, people with metabolic disorders (diabetes mellitus) and patients with prostatic hyperplasia.
"Tizin Xilo BIO": instructions for use
The nasal spray is prescribed by a doctor for topical use only. So, for adults and a children group from six years old, a drug with a dosage of 0.1% is shown. In this case, the drug is used up to three times a day. Each time, only one portion of the medicine is injected into the nasal passage. The daily dose may vary depending on the individual characteristics of the body, sensitivity to the drug and the achievement of the clinical effect.
For children aged 2 to 6 years old, “Tizin Xilo BIO” is shown (the instructions for use advise you to consult a doctor before using the product, as improper treatment can provoke the most negative consequences for the body) with an active substance concentration of 0.05%. The medicine is administered in a single dose to each nostril once or twice a day.
Nasal spray should not be used for more than five days. Repeatedly this drug can be used only after a few days.
In chronic rhinitis, the drug is used only under the supervision of a doctor, since there is a risk of atrophy of the nasal mucosa.
Side effects
Not so harmless is the Tizin Xilo BIO nasal spray. For children (instructions for use are attached and should be studied before treatment), the use of this tool can result in negative reactions, however, adults can also suffer. The drug can cause slight irritation of the nose, which manifests itself in the form of sneezing or burning.
According to experts, quite often after withdrawal of the drug, reactive hyperemia or swelling of the nose is observed. Prolonged use of xylometazoline or exceeding the recommended doses sometimes lead to a burning sensation in the nose and excessive dryness of the mucosa. Even in this situation, nasal congestion with progressive drug rhinitis may occur. Some patients have paresthesia, hypersecretion, and sneezing. Similar phenomena can continue for a week after completion of treatment. Long-term use in some cases provokes the development of chronic inflammatory processes of the nasal mucosa, which cause the formation of dry crusts and are diagnosed as dry rhinitis.
On the part of the nervous system, headache, sleep disturbance, insomnia, depressive states, excessive fatigue, and malfunctioning of the visual apparatus were revealed.
In isolated cases, the cardiovascular system was affected. Intranasal use of sympathomimetics has caused a number of phenomena such as arrhythmia, increased heart rate, tachycardia and an increase in blood pressure.
Overdose
Spray "Tizin Xilo BIO" (the instruction strongly recommends adhering to the indicated doses) in cases of overdose or in case of accidental administration of the drug may cause the following symptoms:
- dilated pupils;
- nausea and vomiting
- fever
- muscle cramps;
- cyanosis of the skin;
- tachycardia and arrhythmia;
- collapse;
- cardiac arrest;
- hypertension
- neuropsychiatric failures;
- violation of normal breathing;
- pulmonary edema.
An overdose can provoke a suppression of the functioning of the entire central nervous system of the body, in which drowsiness, a decrease in body temperature, bradycardia, a significant decrease in blood pressure, respiratory arrest, and coma are observed.
If the volume of the drug was injected into the body in excess of the norm, then you should drink activated charcoal and rinse the stomach. In some cases, artificial respiration with oxygen is indicated.
To reduce the pressure, doctors recommend using 5 ml of “Phentolamine” diluted with saline for intravenous administration. You can also take 100 mg of this drug by mouth. Do not use vasopressor agents. If necessary, you can resort to antipyretic or anticonvulsant drugs.
special instructions
As already mentioned, the use of the drug “Tizin Xilo BIO” for children (reviews say that it helps to quickly restore breathing, but at the same time causes a burning sensation in the nose) can turn into troubles. Therefore, you should not use the drug for more than seven days, as this can provoke reactive hyperemia of the nasal mucosa. As a result, a feeling of congestion is constantly observed, which makes us use the spray again and again. Addictive to the drug. This process provokes chronic swelling of the nose, the lake.
In order to avoid dependence on the drug, with prolonged use, the solution should be administered alternately in one and the other nostril. This will reduce the effects of sympathomimetics and provide partial respiration.
Drug Interactions
When a Tizin Xilo BIO nasal spray is combined with MAO inhibitors from the tranylcypromine category or with tricyclic antidepressants, an increase in blood pressure can be observed. And also a violation of the cardiovascular system.
"Tizin Xilo BIO": reviews
Nasal spray caused a lot of different disputes. People say that the drug is good, but only for short-term use, as it is addictive, so it must be used strictly according to the instructions and not more than a week. Patients note that it quickly removes puffiness and restores the breathing of “Tizin Xilo BIO”.
Reviews pay attention to the fact that it removes allergic congestion, runny nose, spray is convenient to use. The drug is inexpensive, while completely coping with its task. Does not dry the nasal mucosa due to the presence of hyaluronic acid in the composition. Economical. Has a long tip, convenient to use.