Gastrointestinal ulcer can occur suddenly. For the treatment of such a disease, you should immediately contact an experienced gastroenterologist.
After a thorough examination, the doctor is required to prescribe anti-ulcer drugs. The most effective of them include the medicine "Lantsid." The price of this medicine will be indicated below. In addition, you will learn about what properties are inherent in the mentioned tool, whether it has analogues and how to correctly take it.
Release form, description, packaging and composition
The drug "Lantsid" is available in the form of gelatin capsules (hard). They have a turquoise color and contents in the form of white granules.
The active ingredient in this medication is lansoprazole. Capsules also include the following auxiliary elements: mannitol, povidone, lactose monohydrate, cetyl alcohol, sucrose and hypromellose phthalate.
The medication in question goes on sale in blisters and cardboard packs.
Drug action
What is the medicine "Lantsid"? Instructions for use states that it is a specific inhibitor of K + -H + -ATPase (proton pump). Its metabolism is carried out in the cells of the (parietal) stomach. In this case, active sulfonamide derivatives are formed.
This drug blocks the secretion of hydrochloric acid, reducing the stimulated and basal secretion.
Having high lipophilicity, this agent penetrates into the stomach cells (parietal) quite easily, and then, concentrating in them, has a cytoprotective effect, increasing the secretion of bicarbonate and increasing the oxygenation of the mucous membrane of the main digestive organ.
The degree and rate of inhibition of stimulated and basal secretion of hydrochloric acid are dose-dependent. Its pH increases after 1-2 hours and 2-3 hours after taking 15 and 30 mg of the drug, respectively.
This medication does not affect the motility of the digestive tract. The inhibitory effect of the drug manifests itself in the first four days of administration. After treatment for 40 hours, acidity remains at less than 50% of the basal level.
Withdrawal syndrome for such a drug is not characteristic.
Drug properties
The drug “Lantsid” (tablets) in the mucous membrane of the stomach forms specific IgA for Helicobacter pylori, inhibiting their growth and increasing the anti-Helicobacter pylori activity of other medicines.
Also, this tool inhibits the production of pepsin and increases the concentration of pepsinogen in the blood.
Drug kinetics
Is the medicine "Lantsid" absorbed? Instructions for use states that the absorption of this agent begins immediately after the drug leaves the stomach. The peak concentration of lansoprazole in the blood is observed after 1.7 hours.
Eating food reduces the absorption and bioavailability of the drug.
The half-life of lansoprazole is about two hours. This does not affect the duration of suppression of gastric secretion.
The withdrawal of the drug from the body is carried out along with bile and urine.
Indications
What diseases does the Lantsid medication most effectively manifest itself in? Reviews say that this remedy well treats the following diseases:
- reflux esophagitis;
- non-ulcer dyspepsia;
- peptic ulcer (in the acute phase) of the digestive tract;
- esophagitis erosive and ulcerative;
- gastrointestinal ulcer stressful;
- Zollinger-Ellison syndrome.
Contraindications
When can’t you take Lantsid capsules? The instruction for use states that the following conditions of the patient are contraindications for the drug in question:
- breast-feeding;
- first trimester of pregnancy;
- malignant neoplasms in the digestive tract;
- hypersensitivity to the elements of the drug.
With caution, this drug is prescribed to people with liver failure in the second and third trimesters of pregnancy, elderly patients and minor patients.
Medication "Lantsid": instructions for use
The considered capsules are taken orally. They should be swallowed whole without chewing.
With erosive and ulcerative esophagitis and gastric ulcer, the medication is prescribed at 30 mg per day for 4-8 weeks. If required, the dosage is increased to 60 mg per day.
For stressful ulcers and peptic ulcer of the duodenum, the drug is recommended to take 30 mg per day at a time. It is advisable to do this in the morning, at breakfast, for 2-4 weeks.
With Zollinger-Ellison syndrome, the dosage of the drug is selected individually.
With reflux esophagitis, the medication is taken for a month in an amount of 30 mg per day.
To eliminate Helicobacter pylori, the drug is recommended to use 30 mg twice a day. To improve the therapeutic result, the medication is combined with antibiotics such as Clarithromycin or Amoxicillin. Treatment should last at least a week.
With non-ulcer dyspepsia, the drug is used for 2-4 weeks at a dose of 15-30 mg per day.
With liver failure, as well as in elderly people, therapy begins with half doses. Then they are increased to the recommended, but not more than 30 mg per day.
Side effects
Lantsid Kit can cause the following adverse reactions:
- headache, anxiety, malaise, drowsiness, dizziness, depression;
- decreased or increased appetite, hyperbilirubinemia, nausea, gastrointestinal candidiasis, abdominal pain, increased activity of liver transaminases, diarrhea, ulcerative colitis, constipation;
- cough, upper respiratory tract infection, pharyngitis, flu-like syndrome, rhinitis;
- skin rash, erythema multiforme exudative, photosensitization;
- anemia, thrombocytopenia;
- alopecia, myalgia.
Drug interaction
The drug "Lantsid Kit" slows down the elimination of drugs that are metabolized in the liver through microsomal oxidation (for example, such as "Phenytoin", "Diazepam" and indirect anticoagulants).
The simultaneous use of lansoprazole slows down the pH-dependent absorption of drugs belonging to the groups of weak acids. Also, the medication in question accelerates the absorption of drugs that belong to the base groups.
Lantsid inhibits the absorption of Ketoconazole, iron salts, Ampicillin and Digoxin.
Lansoprazole reduces the clearance of "Theophylline" by 10%.
Sucralfate reduces the bioavailability of lansoprazole by 30%. In this regard, it is imperative to observe the interval between the reception of the mentioned funds (in 30-40 minutes).
Lansoprazole is compatible with Indomethacin, Ibuprofen, Diazepam, Warfarin, Propranolol, oral contraceptives, as well as Prednisolone and Phenytoin.
Antacids must be prescribed 60 minutes before or 2 hours after taking "Lantsida", as they significantly slow down and reduce the absorption of the latter.
Special recommendations
Before and after therapy with Lantsid, endoscopic monitoring of the patient's condition is required. This is necessary to exclude the development of a malignant tumor, since treatment can mask the signs of the disease and delay the correct diagnosis.
Price and analogues
How much do Lantsid capsules cost? Their price is about 200 rubles. If necessary, this tool can be replaced with other drugs. To do this, consult a gastroenterologist.
The analogues of the drug in question are Akrilanz, Lansoprazole, Helikor, Lanzaptor, Lanzap, Lanzabel, Loensar-Sanovel, Lansofed, Epicurus.
Reviews
Most patients respond to the drug "Lantsid" (analogues of the drug were presented above) only on the positive side. Consumers say that after several days of treatment, the unpleasant symptoms of peptic ulcer immediately disappear. Moreover, in combination with other medicines, this tool promotes the speedy healing of erosion and ulcers on the mucous membrane of the digestive tract.
The disadvantages of this medication include a large number of adverse reactions. Although, if all the requirements of the doctor are observed, their appearance can be avoided.