Why is the medicine "Menopur" necessary? Instructions for the drug, its methods of use and dosage will be described in this article. From it, you will learn about what indications this medication has, whether it has side effects and contraindications, what patients say about it, what is its cost, etc.
Composition, drug release form
In what form is the Menopur medicine sold? Instructions for use of the drug contain information that this drug is available in the form of a lyophilisate, which is intended for the preparation of a solution for intravenous or subcutaneous injection.
The drug is a white or practical white briquette without any smell. A colorless and clear solvent is also included.
What does the Menopur medicine contain? The instruction says that the active substance of the medication is follicle-stimulating, as well as luteinizing hormones. It will also include excipients in the form of polysorbate 20, lactose monohydrate, sodium hydroxide and hydrochloric acid.
The solvent is a solution of sodium chloride (isotonic).
Drug packaging
The drug goes on sale in bottles of 2 ml. Along with it is a solvent (ampoule with 1 ml of substance). In one cardboard package can be 5 or 10 sets.
Pharmacological action of the drug
What is the medicine "Menopur"? Instructions for use indicate that this drug is a means of a high degree of purification of human gonadotropin (menopause). It belongs to the group of menorotopins, and also contains LH and FSH in a ratio of 1 to 1. The medication is obtained from postmenopausal female urine.
In representatives of the weaker sex, this tool stimulates the proliferation of the endometrium, the maturation and growth of ovarian follicles, and also causes an increase in the level of estrogen in the blood.
As for the stronger sex, this drug leads to an increase in the concentration of testosterone. In addition, it stimulates spermatogenesis by acting on the cells of the tubules (seminal).
Pharmacokinetics of the drug
How long is the Menopur drug absorbed? The instruction states that the maximum concentration of FSH in the blood is reached approximately 7-24 hours after intramuscular injection. After that, its volume gradually decreases. The half-life of menotropins is 5-12 hours.
Indications for the use of the medication
Instructions for the drug "Menopur" suggests that it can be used not only for the weaker, but also for the stronger sex.
So, consider the indications for use for women:
- to conduct reproductive techniques (auxiliary) with the aim of the onset of conception (that is, to stimulate the growth of follicles);
- for the treatment of infertility, which is caused by hypothalamic-pituitary disorders (to stimulate the growth of the 1st dominant follicle).
For what purposes men prescribe Menopur medication? Instructions, reviews, applications will be presented later. As for the testimony, they include the following:
- to stimulate spermatogenesis (it is recommended to combine with medicines of human chorionic gonadotropin).
Are there any contraindications to the medication?
When it is impossible to prescribe the medicine "Menopur" (lyophilisate)? Instructions for use include the following contraindications:
- tumor of the hypothalamic-pituitary region;
- abnormal development of the genital organs, as well as the presence of uterine fibroids, which is incompatible with pregnancy;
- adrenal and thyroid diseases;
- hyperprolactinemia;
- ovarian enlargement (persistent), the appearance of cysts (if the disease is not associated with polycystic ovary syndrome);
- cancer of the ovaries, uterus or mammary glands;
- vaginal bleeding of unknown origin;
- primary ovarian failure;
- pregnancy time;
- prostate cancer, as well as other tumors (androgen-dependent) in the stronger sex;
- lactation time;
- sensitivity (increased) to menotropins, as well as medications that contain FSH or LH.
The drug "Menopur": instructions for use, abstract
The description of this medication was presented above. As for this section of the article, we will tell you about the dosage in which the medicine in question should be taken.
The drug is administered intramuscularly. An injection solution is prepared only before use, using the solvent that is included in the kit.
In the event that the attending physician has not prescribed any other therapy, it is recommended to adhere to the following scheme.
Women
For the treatment of infertility, which is due to the presence of problems with the hypothalamic-pituitary region, in order to stimulate the growth of the first dominant follicle, the dose of the drug is set individually. The optimal volume of the drug, as well as the duration of therapy, are selected based on an ultrasound scan of the ovaries, clinical observation, and determination of estrogen levels. By the way, it is by the latter value that the follicle maturation is judged.
So how should you use the medicine "Menopur"? The method of administration and dose of the drug are always indicated in the attached instructions. The initial volume of the drug can be 75-150 IU (or 1-2 bottles per day).
If there are no ovarian reactions, then the amount of the drug is gradually increased until the growth of follicles and an increase in estrogen levels. This dose is left unchanged until the moment when the concentration in the blood of the latter reaches the preovulatory value. With a sharp increase in estrogen levels at the beginning of stimulation, it is desirable to reduce the dosage of the drug.
After the last injection, after 2 days, 5-10 thousand IU of hCG is administered once. Do this in order to induce ovulation.
To men
How should representatives of the stronger sex use the drug Menopur? The instruction says that to stimulate spermatogenesis, men need to enter 1-3 thousand IU of hCG three times a week. Do this until normalization of testosterone levels. After that, for several months three times a week, the medication is administered in 75-150 IU (or 1-2 bottles).
Side effects of the drug use field
Now you know how much Menopur should be administered. Instructions, applications, reviews are presented in this article. However, I want to note that this drug can cause a number of side effects.
- Endocrine system: increased (sharp) excretion of estrogen with urine, mastalgia, the formation of ovarian cysts, a moderate increase in ovaries, gynecomastia (in the stronger sex).
- Digestive tract: vomiting, colicky pain, nausea.
- Local reactions: redness, swelling, and also itching at the injection site.
- Allergy: skin rash, fever, arthralgia, the formation of antibodies, which leads to a decrease in the effectiveness of the treatment.
- Others: oliguria, weight gain, low blood pressure, multiple pregnancy.
It should also be noted that the use of the drug in question can cause the appearance of ovarian hyperstimulation syndrome. Early signs of such a deviation include pain (expressed) in the lower abdomen, vomiting, ascites, weight gain, nausea, hypovolemia, electrolyte imbalance, hydrothorax, an increase in the number of red blood cells, hemoperitoneum and thromboembolic syndrome.
Special instructions for using the product
What you need to know before using the medicine "Menopur"? Instructions and reviews state that before prescribing this medication the patient needs to undergo appropriate treatment (in the presence of insufficiency of the adrenal cortex, concomitant hypothyroidism, tumor of the hypothalamic-pituitary region, hyperprolactinemia).
Before starting infertility therapy, it is necessary to assess the condition of the ovaries. For this, an ultrasound examination is performed, and the level of estradiol in the blood is also checked. Throughout the course, these studies must be carried out every other day or every day.
It must be borne in mind that, against the background of the use of hMG agents, there is a chance of developing ovarian hyperstimulation. As a rule, it becomes clinically pronounced only after administration of the drug for the purpose of ovulation and manifests itself in the form of the formation of large cysts. In such cases, patients may experience hydrothorax, ascites, thromboembolic syndrome, and arterial hypotension.
When the first symptoms of ovarian hyperstimulation appear, drug therapy should be stopped immediately.
When treated with hMG, a multiple pregnancy is very often formed.
In representatives of the stronger sex with a high level of FSH in the blood, this medication is ineffective.
What is the cost of the drug?
How much does Menopur cost? Instructions, the price of this tool are presented in this article. The cost of this medicine is very high. For 1 bottle of the drug you will have to give about 1000-1400 Russian rubles. Given the average course of treatment in 5-10 days, such therapy is very expensive for the patient.
Drug Reviews
There are a huge number of positive reviews about the medicine "Menopur". According to them, this drug treats infertility well, several times increasing the likelihood of conception. By the way, in a large number of patients after using this tool, a multiple pregnancy develops.
The only drawback of the drug in question is its cost. Most patients cannot afford such a drug. Although pharmacists claim that the price of this medication is fully justified. After all, after its proper use, there is a huge probability of a long-awaited conception and, as a result, the birth of a long-awaited child. Therefore, most young couples who cannot conceive a baby acquire this remedy without any hesitation.