In the article, we consider the instructions for use with Diazolin.
The medication is a blocker of histamine H1 receptors. He is able to stop attacks of allergic reactions, have anesthetic, anticholinergic, antiexudative, antipruritic effect. It has a slight hypnotic and sedative effect.
Description and composition
The manufacturer produces the drug in two dosage forms - in the form of tablets and dragees. The dosage may be 50 mg and 100 mg.
Dragee spherical, have a white color. The tablets have a rounded shape, white color.
According to the instructions for "Diazolin", the main component in the composition of the medication is mebhydrolin. Dragee, in addition to the active substance, contain auxiliary components: sunflower oil, talc, beeswax, white molasses and sucrose.
The drug is able to have an antiallergic effect, reduce swelling of the mucous membranes.
“Diazolin" stops the action of histamine on the intestines, uterus, bronchi and other internal organs that have smooth muscles. Mebhydrolin reduces the hypotensive effect of histamines, eliminates the increased vascular permeability.
The drug does not have a pronounced hypnotic and sedative effect. This is due to the fact that the active component penetrates the BBB in small quantities.
The drug is intended for oral administration. After ingestion, the active substance is rapidly absorbed in the digestive tract. The bioavailability variability is 40-60%. The metabolism of the active component occurs in the liver. As a result, the synthesis of microsomal liver enzymes is enhanced. The active substance is excreted from the body by the kidneys, along with urine.
Indications for admission
As the instructions indicate, "Diazolin" is indicated for use with:
- Seasonal allergic rhinoconjunctivitis.
- Urticaria.
- Angioedema.
- Allergic dermatoses, manifested in the form of itching and eczema.
- An allergic reaction to medications.
- Bronchial asthma as one of the drugs of complex therapy.
It can be prescribed for similar diseases for children from 3 years old - in the form of dragees, from birth - in the form of tablets.
What else does the instruction manual for Diazolin for adults tell us?
Contraindications
"Diazolin" in any pharmacological form is contraindicated in patients if they have one of the following diseases or conditions:
- Pregnancy.
- Heart rhythm disturbances (mebhydrolin is able to exert a vagolytic effect, as a result of which there is an improvement in AV conductivity, supraventricular arrhythmia develops).
- Epilepsy.
- Inflammation of the digestive tract, in the acute phase.
- Enlarged prostate.
- Lactation period.
- Pyloric stenosis (pyloric stenosis).
- Gastric ulcer.
- Angle-closure glaucoma.
- Individual hypersensitivity to any of the components of the drug.
The use of "Diazolin" in the form of dragees in the treatment of children under 3 years is contraindicated. This is due to difficulties when swallowing this form of the drug.
Dosage and Administration
In accordance with the instructions, "Diazolin" in any dosage form is prescribed in a daily dose of 100-300 mg. The maximum dosage for a single dose is not more than 300 mg, the maximum daily dosage is not more than 600 mg.
The drug should be taken directly with food, or immediately after it. It is recommended to swallow dragees and tablets in their entirety, avoiding crushing and grinding.
The duration of therapy should be determined by the attending physician, based on the tolerance of the medication and the clinical picture of the disease.
When treating children from birth, it is necessary to prescribe "Diazolin" in the form of tablets in the following dosages:
- Up to 2 years - per day from 50 mg. The maximum daily dose is not more than 100 mg.
- 2-5 years - per day from 50 mg. The maximum daily dose is not more than 150 mg.
- 5-10 years - per day from 100 mg. The maximum daily dose is not more than 200 mg.
- From 10 years - dosages are used similar to those used in the treatment of adult patients.
The instruction for Diazolin tablets is very detailed.
The drug in the form of dragees can be prescribed for children over 3 years of age in the following dosages:
- 3-5 years - a day once or twice at 50 mg.
- 5-12 years - 2-4 times 50 mg per day.
- From 12 years - per day 1-3 times 100 mg each.
Side effects
Against the background of taking the drug in the form of dragees or tablets, such negative effects as may develop:
- Allergy, manifested in the form of urticaria, angioedema, rash and itching - from the immune system.
- Drowsiness, tremors of certain parts of the body, increased fatigue, impaired sensitivity, headaches, dizziness - from the side of the National Assembly.
- Agranulocytosis from the hematopoietic system. Under the influence of the drug, the number of leukocytes in the blood may decrease, as a result, the body's susceptibility to bacteria and viruses increases.
- Urinary retention, various disorders of urination - from the genitourinary system.
- Irritation of the gastric mucosa, difficulty in emptying the intestines, epigastric pain, heartburn, vomiting and nausea, dry mouth - from the gastrointestinal tract.
In rare cases, against the background of the use of the drug in children, paradoxical reactions such as excessive excitability, tremors, sleep disorders can be observed. This is confirmed by the tool "Diazolin" instructions and reviews.
Interaction with other medicines
Mebhydrolin significantly enhances the effects of ethyl alcohol. Under its action, the therapeutic effect of sedative drugs is also enhanced.
So it is said in the instructions to "Diazolin."
Special instructions for use
Mebhydrolin is ineffective in the treatment of anaphylaxis and bronchial asthma.
It should be used with extreme caution in prescribing the drug to patients in whom liver and kidney function deficiency is noted. If there are similar diseases, it is necessary to adjust the dosage, as well as increase the time interval between two doses of the drug.
Therapy may be accompanied by the occurrence of negative reactions from the central nervous system. The appearance of dizziness is not ruled out. Therefore, for the period of treatment, it is recommended to refrain from driving and working with mechanisms that require attention.
Overdose
According to the instructions for use with "Diazolin" for adults, with an overdose of this medication, a significant increase in side effects is observed. A specific antidote is currently not known to medicine. If there are signs of an overdose, you should immediately stop taking the drug, wash the stomach, take diuretics, which will accelerate the elimination of the active component from the body. To eliminate the symptoms of intoxication, symptomatic treatment is prescribed.
Analogs
There is no structural analogue of Diazolin. Among the analogues for the therapeutic effect exerted:
- "Erius." The main active substance in its composition is desloratadine. The effect occurs within half an hour after oral administration of the drug, lasts up to a day. The drug is produced by the manufacturer in the form of a syrup, which can be used in the treatment of children from one year old, as well as in the form of tablets indicated for use by patients from 12 years old. Pregnant as well as lactating women, the drug is contraindicated.
- Tavegil. The main active component in its composition is clemastine. The drug has three dosage forms - tablets, syrup, solution for injection. Tablets can be prescribed for children from 6 years old, syrup - from 1 year. Pregnant and lactating women, the drug is contraindicated. In addition, it should not be prescribed if the patient has individual intolerance, pathologies of the lower respiratory system, or if he is undergoing therapy using MAO inhibitors.
- Suprastin. The main active ingredient in its composition is chloropyramine, as well as mebhydroline, which belongs to the blockers of H1-histamine receptors. Suprastin has two pharmacological forms - tablets and injection. The drug can be prescribed to pregnant women in the first and last trimester, if there is an urgent need. There are no reliable data on the effect of the drug on the fetus. If therapy is carried out during breastfeeding, it should be suspended for the period of taking the medicine.
- Fenistil. The main component in the composition of the drug is dimetinlen. "Fenistil" in the form of oral drops is acceptable for use in children from 1 month. Use is contraindicated during lactation, in the first trimester of pregnancy, with individual sensitivity, prostate adenoma, angle-closure glaucoma, bronchial asthma. The drug can be prescribed from the 14th week of pregnancy, but only if there is an urgent need.
Further, after the information regarding the instructions for use with Diazolin tablets, we will review the reviews about this drug.
Reviews
This drug is deservedly considered one of the most effective in the treatment of allergic reactions. Patients report that the drug is high-quality and effective, and its cost is more than affordable. The main drawback that all patients note is that the drug has sedative effects, which makes drowsiness appear.
We reviewed the instructions for use with Diazolin tablets for adults.