How much does Monural help? Few women know the answer to this question. In this regard, in the presented article, we decided to tell you about what the medication is used for, how and how long it works, whether it has contraindications and so on.
Packaging, composition, shape
About how much Monural helps, you can find out from the instructions that are attached to the drug. It is placed in a cardboard box containing laminated multilayer sachets with a medicinal substance.
The drug in question goes on sale in the form of white granules with a tangerine aroma. They are designed to prepare a solution for oral administration.
The answer to the question of how much Monural helps is closely interconnected with its composition. The active substance of this medication is fosfomycin trometamol. It also contains additional components in the form of saccharin, tangerine and orange flavoring, as well as sucrose.
Pharmacological characteristics
Many patients who have been prescribed this drug are interested not only in the question of how long "Monural" acts, but also whether it is an antibacterial agent.
According to the attached instructions, the medication in question is a modern broad-spectrum antibiotic. It is used in the treatment of many inflammatory diseases of the urinary system.
Before answering the question of how much Monural helps, it should be said that it is a derivative of phosphonic acid. This drug is able to have a bactericidal effect, which is explained by the suppression of the synthesis of bacterial cell walls.
As an analogue of phosphoenolpyruvate, the active substance interacts with the enzyme N-acetyl-glucosamin-3-o-enolpyruvyl transferase. As a result, its irreversible, selective and specific inhibition occurs, which ensures the absence of cross-resistance with other antibiotics, as well as the possibility of synergism with them.
Monural is active against many gram-positive bacteria and most gram-negative microorganisms. Its active substance reduces the adhesion of bacteria on the epithelial layer of the urinary tract.
Pharmacokinetics
How long does Monural operate? The active substance of the drug is absorbed from the digestive tract almost immediately after administration. At the same time, it accumulates rather quickly in the urine.
With a single use of the drug solution, its bioavailability is 35-65%. The active substance of the drug does not bind to plasma proteins, but in the human body it dissociates into trometamol and fosfomycin and is no longer metabolized.
When taking a single dose of "Monural" in an amount of 3 g, its concentration in the urine reaches a high level (99%) of bactericidal activity against many pathogens of urinary tract infections.
So after how many hours does Monural help? According to the attached instructions, its maximum concentration is reached after approximately 120-160 minutes. After this period of time, the drug begins its active effect.
The drug is excreted unchanged (about 95%) through the kidneys. At the same time, its highest concentrations are observed in urine. Also 5% of the active substance is excreted along with bile.
The half-life of the antibiotic is four hours.
Pharmacokinetic indicators in special cases
How long does Monural help patients with a moderate decrease in renal function? In this category of people, the effect of the drug is also noted after two hours. It is during this period of time that the drug reaches high concentrations in the blood. However, in such patients, the half-life of fosfomycin from plasma is slightly increased.
How much does Monural help with cystitis? Two days is enough for the patient to develop a lasting therapeutic effect.
Indications for use
As mentioned above, this medication is used to treat various diseases of the urinary system. In particular, this drug helps with:
- acute attacks of recurrent bacterial cystitis;
- acute bacterial cystitis;
- asymptomatic massive bacteriuria in pregnant women;
- postoperative urinary tract infections;
- bacterial non-specific urethritis.
It should also be noted that the oral solution is often used as a prophylactic against urinary tract infections during diagnostic transurethral studies and during surgery.
Contraindications
As evidenced by the reviews available about the pharmaceutical industry product we are considering (the Monural medicine) reviews, its effect is rather effective with cystitis. However, do not forget that any medication has contraindications. According to the instructions, this drug is not recommended for:
- severe renal failure;
- hypersensitivity to additional and basic substances of the drug;
- as well as for the treatment of children under five years old.
The drug "Monural": how to take?
With cystitis, as well as other diseases of the urinary system, the contents of one sachet must be dissolved in 1/3 cup of ordinary water. The resulting solution should be taken 2 hours before meals or 120 minutes after. It is not recommended to use the medication during food intake, as this will noticeably slow down its absorption in the body.
According to the instructions, it is advisable to take the drug in question at night. This should be done after emptying the bladder.
For one course of treatment, one sachet of the drug is enough. It should be noted that it is forbidden to combine Monural with a drug such as Metoclopramide. This is due to the fact that a combination of these agents can significantly reduce the concentration of fosfomycin in the blood and urine. As a result of the effect of therapy, you will not achieve it.
People who suffer from diabetes should be aware that sucrose is part of the Monural medication. It should also be noted that during its reception it is forbidden to drink any alcoholic beverages.
Dosage of the drug for adults
"Monural" for cystitis (contraindications and use of the drug were described above), as well as for other diseases, adults should take a dosage of 3 g (once a day). In this case, the solution is used once.
If necessary, the attending physician can prescribe a second dose of the drug to his patient, but only after a day.
As a rule, such therapy is required for a recurring bacterial infection, a severe course of the disease (for example, in the absence of a proper result after a single dose), as well as in old age.
To prevent various urinary tract infections with urological intervention or diagnosis, this medication is also prescribed twice. The solution is taken three hours before the planned manipulations or any medical studies. In this case, the interval after the first dose should be 24 hours.
People with renal insufficiency, the drug "Monural" should be prescribed with extreme caution. Such patients need to increase the time interval between medications or reduce the dose.
Can I give children?
This medication can be prescribed to children, but only to those who have reached 5 years of age. For children, the drug is recommended to be taken once in an amount of 2 g. A child up to the indicated age is not prescribed “Monural” due to the unformed renal-pelvis system (that is, the baby has a poorly developed kidney filtration system).
Pregnancy and breastfeeding
During pregnancy, the fairer sex is often worried about cystitis. The Monural solution effectively treats this disease and at the same time does not cause pathologies in the fetus.
The biggest advantage of this drug is its single dose, while most antibiotics need to be taken for at least 5-7 days. It should also be noted that this medicine has virtually no side effects and contraindications. As a rule, it is well tolerated by patients. However, only an experienced doctor can prescribe this remedy for pregnant women after a thorough examination. Indeed, many experts know that the active substance of "Monural" easily overcomes the placental barrier. Therefore, in the first trimester of pregnancy, its administration is extremely undesirable.
As for lactation, then during this period the drug in question is generally prohibited to use. If there is an urgent need for it, breastfeeding should be discontinued, since fosfomycin passes into milk.
"Monural" with cystitis: effectiveness and reviews of the drug
The drug "Monural" for the treatment of cystitis is best suited. Experts have proved that this medication is effective against many bacteria that cause this disease.
In addition to the fact that the product has bactericidal properties, it still significantly reduces the ability of microorganisms to attach to the walls of the bladder.
Therapy of acute cystitis should be started immediately. This is necessary in order to prevent the transition of the disease into a chronic form.
As for exacerbation of chronic cystitis, then you should take an antibiotic on the first day. The solution is used once in the dose indicated above.
There are many reviews of such a drug as Monural. Most patients leave exclusively positive comments about him, although occasionally negative feedback can be found.
So, according to reviews, the positive side of this drug is its high efficiency - the result is observed after a single dose of the solution. Moreover, it almost never causes any side effects.
The process of treating this remedy by many patients is called convenient, and its cost is quite acceptable.
Negative reviews report that this medication is ineffective. But at the same time, patients do not say at what indications and when Monural was taken, whether its dosage was observed, whether the doctor prescribed it, or if the patient was self-medicating.