Among other antidepressants recently quite often doctors prescribe Rexetin tablets. The instruction states that the drug is based on paroxetine, a sufficiently strong compound that selectively inhibits the reuptake of serotonin (5-HT). The tool has been shown to be effective in treating a wide range of depressive disorders, alleviates the patient’s condition with obsessive-compulsive disorder, and helps with phobias, anxiety, and social disorders, including generalized, post-traumatic, stress-related ones. Tablets are taken in panic conditions. The active compound prevents the reuptake of serotonin in the cellular structures of the brain, which allows it to show a strong, pronounced effect.
Technical points
As follows from the instructions, the antidepressant Rexetin is based on a unique active compound that does not resemble the widely applicable tricyclic, tetracyclic drugs used in depressive disorders. The chemical characteristics of the substance are such that with respect to cholinergic, muscarinic receptors, the affinity is rather low. Animal tests have shown that the anticholinergic qualities of paroxetine are minimal.
In the instructions for the drug "Rexetin" the manufacturer draws attention: one of the main properties of the drug is selectivity. This quality, confirmed by clinical trials, has caused a small affinity for adrenergic receptors alpha-one, alpha-two. This is especially pronounced if we compare the result with the use of tricyclic antidepressants. A slight affinity is observed for histamine, dopamine, and serotonin receptors. There is no reaction with postsynaptic receptors, which was confirmed in the course of specialized studies. As shown by numerous tests, Rexetin does not provoke low blood pressure, does not inhibit the activity of the central nervous system.
Important Features
In the instructions for the drug "Rexetin" the manufacturer indicates that the active compound does not inhibit psychomotor. When ethanol is used in food, there is no interaction leading to an increase in the negative effects of any of the substances. Like other SSRIs, Rexetin can cause increased stimulation of serotonin receptors, if the patient had previously used tryptophan and underwent MAO treatment. To prevent such a result, it is necessary to take a break between the medications taken - two weeks or more. The specific time intervals will be determined by the doctor. Otherwise, as it was found out during experiments on animals, there is a risk of serotonin syndrome.
As specific observations have shown (and this is mentioned in the instructions for use of Rexetin), the drug activates the body systems rather weakly if used in large volumes than are necessary to prevent the process of serotonin reuptake. Observations showed that the activation effects observed at an increased dosage are not similar to those of amphetamine and have a different structure.
Research: check everything!
As indicated in the instructions for use, Rexetin tablets do not cause a negative reaction from the vessels, heart. This is proven in animal tests. Additional research activities were organized with the participation of volunteers. Those who wished to take the drug, while monitoring pressure indicators, ECG, and the frequency of contractions of the heart muscle. During verification, it was found that deviations from the norm, if they are observed, are weak enough so that they can be ignored. Strictly healthy people were invited as volunteers.
Studies were conducted on groups of patients using Rexetin and patients who were treated with drugs that relieved the reuptake of norepinephrine. Comparison of body parameters allows us to say that paroxetine has a low ability to prevent the effectiveness of guanethidine, which corrects pressure indicators in the lower side. At the same time, the effectiveness of taking the medication is fully consistent with the parameters shown by classical antidepressants. There are cases when Rexetin gave good results in the treatment of individuals who do not respond to standard approaches. Using the medication for food in the morning can prevent a negative effect on sleep. Neither the quality nor the duration of a night's rest are affected. Some have improved sleep.
Thoroughly and for a long time
As follows from the instructions for use, Rexetin (reviews confirm this) is intended for continuous therapy. Doctors prescribe this remedy in long-term courses. Studies were organized to determine the degree of effectiveness of such medication for mental disorders. Currently, there is official information regarding treatment lasting 52 weeks. The main task formulated by the doctors sounded like preventing relapse. These were noted in 12% of cases. At the same time, the control group showed a result of 28%. Among the patients of the first group, the dosage of paroxetine per day ranged from 20-40 mg, the second category - the placebo group.
In the instructions of Rexetin, there are references to the results of a study of the use of the drug in OCD. In total, three clinical trials lasting 24 weeks were organized. The task of the doctors sounded similarly - to prevent relapse. One of the results showed a difference of 38% (paroxetine) and 59% (placebo), which allows us to talk about the effectiveness of the medication with the specified diagnosis. In panic disorder, the groups taking Rexetin and placebo showed a significant difference in the recurrence rate: 5% and 30%, respectively.
What's in pharmacies?
In the instructions of Rexetin, the release form of the medication is mentioned. Opening the package, the patient must check the conformity indicated in the accompanying documentation and present in reality. If there is a discrepancy, it is necessary to contact the pharmaceutical point where the drug was purchased for a replacement. Normally, the package contains round white tablets in a shell. Each of them is convex on both sides, is marked on one half of "X 20". One tablet is a source of the active compound in an amount of 22.76 mg, similar to 20 mg of paroxetine.
Additionally, the instructions for use of Rexetin (doctors' reviews urge you to pay attention to this) have a list of substances used in the manufacture of the product. Persons suffering from intolerance to various compounds should study it. This will prevent severe allergic reactions. In addition, the doctor prescribing the drug should be informed about the intolerance of any substance. The doctor will immediately give recommendations on what exactly it is possible to replace the medication if Rexetin does not work.
Alternative option
In addition to the indicated dosage, Rexetin containing 30 mg of the active compound is on sale. Such tablets are identified by the symbols "X 30". Of course, there is a mention of this in the attached instructions for use. Rexetin in this form has a more striking effect and is used in the treatment of severe cases.
The drug is presented on pharmacy shelves in cardboard boxes with the name, manufacturer and dosage. Inside the package is a blister pack of 30 tablets. Before purchasing, it is important to check the expiration date, also printed on a cardboard box.
It works without fail
As can be seen from the reviews, instructions, Rexetin is an SSRI that is especially effective for anxiety disorders. Many patients taking the drug, note its positive result, while side effects are minimized. Paroxetine, on which the medication is based, is bicyclic, affects the vesicles, which leads to an increase in the amount of serotonin in the synaptic cleft. Paroxetine activates the reuptake of dopamine, norepinephrine.
As indicated in the instructions, Rexetin (expert reviews confirm this fact) is rapidly absorbed. Adsorption occurs in the intestinal tract. Soon after administration, the active substance is already distributed throughout the body. The medication can be used regardless of meals, drinking. Once in the body, the active compound soon binds to plasma proteins and spread evenly through the circulatory system. Equilibrium concentration is achieved approximately two weeks after the start of the therapeutic course, the achieved effect is supported by taking the drug at the same level until the end of the program. The withdrawal of funds from the human body occurs through the urinary system after transformation in the liver cells. The average elimination half-life is two days.
When to use?
As can be seen from the instructions, reviews, Rexetin is prescribed for a variety of depressive disorders, regardless of the genesis of the pathology. The use of the drug becomes especially relevant if the course is complicated by anxiety. OCD, known as the obsession syndrome, is successfully eliminated by a sufficiently long therapeutic course. “Rexetin” is indispensable for stress disorders due to trauma. You can prescribe medications with paroxetine for panic disorders. The tool helps to improve the condition of patients with agoraphobia, that is, people who panic when in the crowd.
In the instructions for use of Rexetin, the manufacturer advises using the medication for social phobia, generalized disorders of GAD. You can resort to a well-established composition when there is a need for therapy in order to prevent relapse.
Sometimes you can’t
In the instructions for use of Rexetin, there is an indication of absolute and relative contraindications. The first group includes a therapeutic course in which the patient uses thioridazine, as this can cause arrhythmia, tachycardia, sudden death. You can not use the drug simultaneously with MAO, as well as within two weeks from the termination of such a course, otherwise the likelihood of serotonin syndrome increases. Rexetin is not intended for the treatment of minor patients, since there is no official information on the possible consequences, there is no registered clinical experience with use. The product is not suitable for women during the period of gestation, breastfeeding. Finally, Rexetin is strictly prohibited if the human body is hypersensitive to any of the compounds used in the production.
Relative contraindications are also listed in the instructions for use of Rexetin, that is, cases where the use of the medication is possible only with constant monitoring of the patient's condition. Among these pathologies are prostatic hyperplasia, problems in the functioning of the heart, blood vessels, kidneys, liver, epilepsy in the history of the disease. It is known that under the influence of Rexetin, seizures similar to epileptic are possible. When such a syndrome appears, the remedy should be urgently canceled. Accuracy requires a combination of the name and antipsychotics, drugs with lithium. In patients with glaucoma, when using Rexetin, the risk of mydriasis increases. Particularly responsible attitude is required by elderly patients.
How to use correctly?
Reasonable use is the key to minimizing the likelihood of side effects of Rexetin. Instructions for use (this is confirmed by reviews) contains clear instructions on the rules for using the medication. The product is intended for oral use, if possible in the morning. It is wise to take it during a meal without chewing a serving. One dose per day is enough. Once every three weeks, the doctor can prescribe a correction in the amount of the drug used, while focusing on the patient's condition.
As follows from the instructions for use, Rexetin (analogues too) is effective in depression. With this diagnosis, the composition is prescribed in an amount of 20 mg every day. The positive effect increases gradually, after two to three weeks a full examination of the patient is carried out in order to determine whether there is a need for dosage adjustment. The manufacturer recommends increasing the dose by no more than 10 mg per week until a pronounced therapeutic effect is achieved. The maximum possible daily dose is 50 mg of the active compound.
Other programs
As the instruction “Rexetin” says (analogues in its bulk, too), the drug can be used for sociophobia. The initial dosage is 20 mg, maintained for at least two weeks. In the absence of a noticeable improvement in the patient's condition, it is necessary to gradually increase the amount of medication - by 10 mg per week or slower. The maximum volume per day - as in the case described above, is 50 mg. If the tool is chosen as a measure of maintaining the patient's condition, the optimal dose is 20 mg.
Use programs are also possible:
- OCD - 20 mg at the beginning of the course, an increase of 10 mg per week, maximum 60 mg;
- panic disorders - 10 mg, a weekly increase of 10 mg to 40 mg (maximum - 60 mg);
- stress disorders caused by injuries, GAD - 20 mg at the beginning of the course, an increase of 10 mg every week, a maximum of 50 mg.
A specific approach to the treatment of panic disorders is recommended not only by the Rexetin instruction. Analogs should also be used with such a mental disorder with greater accuracy, since at the beginning of the course there is a high probability of a more active manifestation of the disease.
Special cases
In order to prevent relapse, it is necessary to practice maintenance treatment, even if the patient's condition is assessed as good. When the symptoms of depression are completely exhausted, Rexetin treatment is continued for up to six months. With OCD, panic disorders, the support course can last for years. Avoid abrupt cancellation of the composition.
Particularly noteworthy are the elderly, weakened by the disease. In such cases, start with 10 mg, gradually increasing in increments of 10 mg per week to a dose of not more than 40 mg. If creatine clearance is estimated at 30 ml / min or less, Rexetin for a day is prescribed in a volume of 20 ml. An increase is possible if the patient's condition allows such a measure, but the manufacturer recommends keeping the lowest possible dosage for as long as possible.
Troubles: what to prepare for?
All possible side effects are listed in the instructions for use of Rexetin. Here, estimates of the probability of occurrence of various conditions are given. It is known that most of the negative phenomena become weaker over time, are observed much less frequently, therefore, drug withdrawal is not required. At the beginning of therapy, you may encounter a craving for sleep, increased fatigue. Some patients have sleep disturbances, weakness, and a risk of tremor. Occasionally, persons undergoing therapy become irritable, complain of a headache, dizziness. There is a chance of somnambulism.
The use of Rexetin can cause a violation of the digestive tract, stool disorders, and in extremely rare cases leads to liver disorders. Some patients experience fainting, irregular rhythms, and heart rate. Patients often complain of dry mouth. Some have activated sweat glands. There is a chance of adjusting libido, but clinical trials show that this is not often observed. With glaucoma, Rexetin can cause mydriasis. There are known cases of an allergic reaction, often manifested on the skin, anaphylactic response of the body. Very rarely, the administration of drugs provokes bleeding, hypoglycemia, and an adjustment in the activity of taste buds. It is known that in isolated cases Rexetin was the cause of the increase in temperature and a condition similar to the flu. Some experts are of the opinion that the medication can provoke thrombocytopenia, but at the moment there is no official evidence of this fact (nor a refutation).
What to replace?
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It is known that when treating an elderly patient with Rexetin, there is a possibility of hyponatremia if a person takes diuretics. If the antidepressant is canceled, the sodium level will soon return to normal. Hypoglycemia when taking the drug is extremely rare, but there is a risk of increased bleeding, sometimes doctors diagnose purpura, ecchymosis. In case of depression, Rexetin treatment is accompanied by constant monitoring of the patient's condition until a period of remission begins, since people in this state have a suicidal way of thinking and aggression in relation to themselves. Clinical studies and official statistics confirm that in the early stages of improving the patient's condition, the likelihood of a suicide attempt increases. In the treatment of persons suffering from other forms of mental disorders, it is also important to consider the likelihood of such attempts. Specific control is required if a history has already had similar acts, behavior, thoughts. A special risk group is people aged 18-29 years.