What is a drug like Ganaton? What does this remedy help with? You will find the answer to these questions in this article. You will also find out what patients have about this medicine, whether it has contraindications, and how to take it correctly.
The form of the medication, its packaging, composition, description
In what form is the preparation "Ganaton" made? Instructions, reviews claim that such a tool can be purchased in the form of tablets that are white, the shell (film), round, engraving "HC 803" on one side and risk on the other.
The active ingredient of the medication in question is itoprida hydrochloride. As an auxiliary component, this medicine includes lactose, carmellose, corn starch, anhydrous silicic acid, macrogol 6000, magnesium stearate, titanium dioxide, hypromellose and carnauba wax.
On sale, such tablets come in blisters, which, in turn, are packaged in packs of cardboard.
The principle of action of the drug
What is Ganaton? What helps this drug? It is used to increase motility and tone of the digestive tract.
The active ingredient of this tool is itoprida hydrochloride. This substance specifically affects the upper digestive system, and also accelerates the elimination of food from the stomach. It should also be noted that the component under consideration is capable of exerting an antiemetic effect.
Drug properties
What is remarkable for a tool like Ganaton? From what it helps, we will tell further.
The medication in question is a stimulant for the release of acetylcholine. Its main substance activates the motility of the stomach (propulsive). This is due to antagonism with dopamine D2 receptors, as well as a dose-dependent inhibition of acetylcholinesterase activity.
Itoprida hydrochloride activates the release of acetylcholine, and also inhibits its destruction.
Kinetic features of the drug
Where is the absorption of a drug like Ganaton? Instructions for use, reviews claim that the active component of this medication is very quickly and almost completely absorbed from the intestine. Its relative bioavailability is approximately 60%. This is due to the metabolism of the drug, which occurs during the first passage through the liver. Eating does not have any effect on the bioavailability of the drug.
After eating (oral) 50 mg of itopride hydrochloride, its peak concentration is reached after 0.5-0.75 hours and is about 0.28 μg / ml. Repeated administration of the drug in a dosage of 50-200 mg three times a day for a week causes linear pharmacokinetics. In this case, the cumulation is minimal.
The relationship of the drug with plasma proteins is approximately 96%. It is actively distributed in all tissues, and also in high concentrations is found in the liver, kidneys, adrenal glands, small intestine and stomach. The medication penetrates the BBB in small quantities. It is also excreted in breast milk.
Excretion of itopride hydrochloride and its derivatives occurs with urine. Renal excretion of the active substance after a single dose in therapeutic doses is about 75%. The final half-life of this agent is approximately six hours.
The drug "Ganaton": what helps?
This tool is actively used in the treatment of gastrointestinal problems that are associated with non-ulcer functional dyspepsia (including chronic gastritis), as well as delayed gastric motility.
So in what cases should you use the medication "Ganaton"? The use of this tool is indicated for:
- anorexia;
- bloating;
- heartburn;
- vomiting
- a feeling of fullness in the stomach after a meal;
- pain or discomfort in the epigastric region;
- nausea
Prohibitions for taking medication
Now you know how remarkable such a tool as "Ganaton" is. What this drug is treating, we also found out. It should be especially noted that the medication in question is contraindicated for use with:
- pregnancy
- gastrointestinal bleeding, mechanical obstruction or perforation of the gastrointestinal tract;
- under the age of 16;
- breastfeeding;
- hypersensitivity to itoprid or another auxiliary ingredient of the drug.
Cautious use of the drug
This drug is prescribed with caution to the elderly due to the frequent decrease in the work of the kidneys and liver, as well as the presence of concomitant diseases or other treatment.
Due to the enhanced action of acetylcholine, the medication in question is recommended with special caution to patients in whom the development of cholinergic side effects can aggravate the course of the underlying disease.
How to take Ganaton?
The tablets in question should be taken orally before meals. They are washed down with plain water.
The drug does not have any effect on the person’s ability to drive vehicles, as well as complex mechanisms. When using Ganaton by elderly people or people with impaired kidney and liver function, they need constant medical supervision.
Sometimes a doctor may correct the recommended dosage. If a large amount of the drug is accidentally swallowed, standard measures such as symptomatic treatment and gastric lavage are required.
At what dosage should the patient use the Ganaton medication? The use (reviews of the drug are discussed below) of this drug should be carried out only after consulting a doctor. The daily dosage of the drug in question for adults is 150 mg. If necessary, the specified amount can be changed by a specialist.
As a rule, this drug is recommended to be taken three times a day, one tablet before meals (50 mg). The duration of treatment is determined by the doctor and can be approximately 5-8 weeks.
Side effects
What adverse reactions can the Ganaton medication cause? This remedy helps with many diseases of the digestive tract, however, it can provoke the appearance of the following undesirable effects:
- Endocrine system: gynecomastia, increased prolactin levels.
- Hematopoietic system: thrombocytopenia, leukopenia.
- Allergic reactions: pruritus, flushing, anaphylaxis, rash.
- CNS: headaches, dizziness, tremors.
- Digestive tract: jaundice, diarrhea, increased salivation, constipation, nausea, abdominal pain.
- Changes in laboratory tests: increased levels of bilirubin and alkaline phosphatase, as well as the activity of ALT, AST and GGT.
Drug Interactions
The metabolic interaction in this drug is impossible. This is due to the fact that itopride is metabolized not under the influence of isoenzymes of the cytochrome P450 system, but under the influence of flavin monooxygenase.
The active substance of the drug in question enhances gastric motility, which may affect the absorption of other drugs used simultaneously inside. Caution must be observed when taking medications with a low therapeutic index. The same applies to enteric-coated preparations and sustained release of the main component.
When combining Ganaton with Diazepam, Warfarin, ticlopidine hydrochloride, diclofenac sodium, nicardipine hydrochloride and Nifedipine, no changes were observed in the binding of itopride to plasma proteins.
Antiulcer drugs such as Ranitidine, Cimetidine, Cetraxate and Teprenone do not affect the kinetic features of itopride.
Anticholinergic medicines weaken the effect of the active substance of the agent in question.
Feeding and pregnancy
Currently, there is no sufficient data on the use of itopride hydrochloride during pregnancy. The use of this tool in the process of bearing the fetus is possible only in the absence of alternative therapy, as well as with potential benefits for the mother, which exceeds the risk to the fetus.
It should also be noted that against the background of the use of this drug, there is a risk of side effects in the infant. In this regard, if it is necessary to use the medicine during breastfeeding, lactation must be stopped.
Similar means and cost of the drug
Do you know how much the medication we are considering is worth? If you do not own such information, we will provide it to you. The price of this tool depends on the extra charge of the first-aid kit of the network and is approximately 250 rubles per 10 tablets.
If a drug with the same name could not be found, then it can be replaced by an analog. Such medicines include drugs with the same active substance, that is, with itoprid. “Itomed”, “Itoprid”, “Itopru” and “Primer” are very often used as them.
Reviews of patients and specialists
Does Ganaton help with Helicobacter pylori? Experts report that the drug in question is a drug that improves the tone and motility of the digestive tract. This is not an antibacterial medicine that can overcome the bacteria mentioned above. However, in some cases, it is still prescribed for such a disease, but only in combination therapy with antibiotics and other antiulcer drugs.
Almost all patients who have ever taken the drug in question speak of its high effectiveness. According to them, after a course of treatment for this drug, the drug completely eliminates the feeling of nausea and discomfort in the epigastric region, as well as heaviness and pain in the stomach.
Some patients respond well to this medication as a drug for the episodic elimination of heartburn and vomiting.
As for reports of adverse reactions, "Ganaton", they are single. As a rule, while taking this drug, some patients have increased salivation, drowsiness, or dizziness.
There have been no reviews of cases of overdose with this drug to date. The price of a drug like Ganaton is perceived by consumers as acceptable or high.