The drug "Aminocaproic acid" is a drug that is used in the treatment of bleeding due to increased fibrinolytic activity, aplastic, hypoplastic anemia. It is used to prevent secondary hypofibrinogenemia, which are complications of massive transfusions of canned blood.
The drug has found application in the treatment of fibrinolytic bleeding, which are associated with surgical interventions (surgery on the vessels, heart, stomach, lungs).
The main form of release: solution for infusion.
The drug "Aminocaproic acid." Instructions: composition, pharmacokinetics, pharmacodynamics
As part of the drug, the active substance is aminocaproic acid. Auxiliary components: sodium chloride, purified water.
With intravenous administration, the effect occurs in twenty minutes. The drug does not have the ability to bind to plasma proteins, it is excreted by the kidneys in almost unchanged form. The elimination half-life reaches seventy seven minutes. This indicator increases with impaired renal function. The content of the drug substance in the blood in this case increases sharply.
The drug has a specific hemostatic effect, which is provided by blocking plasminogen activators, inhibiting the action of plasmin. The drug inhibits kinins, biogenic polypeptides, reduces the permeability of small vessels. It also exhibits an anti-allergic effect, inhibits the formation of specific antibodies, and increases the detoxification function of the liver.
The drug "Aminocaproic acid." Instruction: method of application, dosage
This medication is intended for intravenous administration. The pharmaceutical product “Aminocaproic acid” is not used for inhalation.
The daily dose of the drug: five to thirty grams. During the first hour five grams are introduced, then this indicator is reduced to one gram (if necessary). The injection lasts eight hours. For children, the dosage is made according to weight (one hundred milligrams per kilogram).
The drug "Aminocaproic acid." Instructions: side effects, contraindications
Among the possible side effects that are caused by taking the drug, there are arterial hypotension, bradycardia, arrhythmias, nausea, dizziness, vomiting, shortness of breath, diarrhea. In severe cases, renal failure, rhabdomyolysis, myoglobinuria, muscle weakness develop, hearing is reduced.
Contraindications to the use of the drug:
- hypersensitivity to components;
- DIC syndrome ;
- tendency to embolism, thrombosis;
- impaired renal function, cerebral circulation;
- pregnancy.
The drug "Aminocaproic acid." Instructions: drug interactions, special instructions, overdose
The use of this solution is combined with the infusion of isotonic glucose solutions , anti-shock substances, hydrolysates. When used with anticoagulants, the coagulation effects of the drug are reduced.
When prescribing this drug, it is necessary to check the fibrinolytic activity of blood plasma, the content of fibrinogen. Caution should be used in diseases of the kidneys, heart. With bleeding that is localized in the upper part of the urinary system (due to the high probability of developing intrarenal obstruction), it is forbidden to use the drug "Aminocaproic acid". Inhalations of this drug are dangerous, as they can cause unwanted systemic effects. The drug is undesirable for the prevention of labor bleeding, because the risk of thromboembolic complications increases.
Symptoms of an overdose are similar to side effects, but have a pronounced intensity. To prevent these conditions, constant monitoring of the level of creatine phosphokinase is necessary.