The drug "Pantoprazole Canon" is produced in tablet form and belongs to the class of substances that inhibit the proton pump. The medication is prescribed for intestinal or stomach ulcers, a number of similar diagnoses. It has several analogues, including the popular Omez, Omeprazole. Consider the main features of a pharmaceutical product.
Technical information
"Pantoprazole Canon" is produced in tablet form. The tool got its name from the active ingredient, which ensures the effectiveness of the reception. The main substance is pantoprazole sodium sesquihydrate. One tablet contains 22.57 mg or 45.14 mg. This volume corresponds to 20 (40) mg of the initial form of pantoprazole. This is the value indicated on the outside of the medicine package.
As auxiliary ingredients, the manufacturer used magnesium, calcium, silicon compounds, povidone, crospovidone, mannitol, macrogol. In the manufacture of the shell used mellose, opadra, acrylic, silicon, sodium, iron compounds, coloring additives, talc, titanium dioxide, triethyl citrate.
Pharmacokinetics
"Pantoprazole Canon" is designed as a means of inhibiting individual ATP-ase. It affects the final stage of the production of hydrochloric acid. Due to the active ingredient, the secretion activity of this compound in the gastric cavity decreases. The stimulated process provoked by all varieties of irritating factors is equally corrected, and the basal one.
In the case of an intestinal ulcer associated with Helicobacter pylori colonies, a decrease in the secretory capacity of the stomach increases the susceptibility of the pathological form of life to antimicrobial agents. Pantoprazole also has an antibacterial effect, observed with respect to this variety of bacteria.
How to use?
"Pantoprazole Canon" is intended for oral use. One capsule is consumed whole, without violating the integrity of the shell. Do not chew, dissolve, cut, break a tablet. The capsule is washed down with a reasonable amount of water without additives. It is recommended to take the drug before the first meal per day. If the doctor advised you to use twice daily, the second portion is consumed shortly before the evening meal.
If studies have shown a gastric or intestinal ulcer, gastritis complicated by erosion, including due to the use of non-hormonal anti-inflammatory, 40-80 mg of the drug should be used per day. The duration of the therapeutic program with exacerbation of peptic ulcer disease reaches a couple of weeks. With a relapse of a gastric ulcer, a course from a month to two is indicated. If it is necessary to prevent a relapse of such a disease, Pantoprazole Canon is prescribed in an amount of 20 mg per day.
Diagnoses and rules
The instruction "Pantoprazole Canon" is recommended for the eradication of Helicobacter pylori. Typically, the patient is shown a three-component course. The drug in question can be combined with amoxicillin and clarithromycin. The first is recommended in a dose of 20-40 mg, the second in grams, the third in half a gram. All pharmaceutical products are consumed twice daily. The therapeutic course lasts from a week to twice as much time.
You can combine "Pantoprazole Canon" with metronidazole, clarithromycin. Medicines are used twice daily. The first is prescribed in a dose of 20-40 mg, the second and third - in half a gram. The duration of treatment is similar to that indicated previously.
Finally, Pantoprazole Canon and amoxicillin, metronidazole can be combined. Medications are used for a week or two twice daily. The first is shown in a dose of 20-40 mg, the second is consumed per gram, the third - half a gram at a time.
The instructions for Pantoprazole Canon recommend that you continue the three-component treatment course with the medication in question. The purpose of such an event is to activate regenerative processes in the field of ulcerative damage to the mucous membranes. For intestinal ulcers, you can take Pantoprazole Canon in addition from a week to a three-week period.
Instructions for use "Pantoprazole Canon" allows the use of this drug for some complications of renal function. If the patient suffers from a severe stage, creatinine clearance is less than 20 units, hemodialysis is indicated, eradication treatment should be avoided.
GERD
If the disease manifests itself with mild symptoms, you can use the drug in question to stop it. The drug is prescribed if you are concerned about heartburn and nausea, belching sour.
The manufacturer advises taking 20 mg daily. To achieve marked progress in a short time, you probably need to take the medicine for at least three consecutive days. To stably get rid of manifestations, you need a course of at least a week. If the condition gets worse in the first three days, you need to see a doctor. Once the symptoms are completely gone, the therapeutic program is completed.
Zollinger-Ellison disease
According to the instructions for use, "Pantoprazole Canon" with such a diagnosis is recommended in the amount of 40-80 mg per day. With severe impairment of renal function, the dosage is reduced to 40 mg taken once every two days. The course is prescribed if it is possible to regularly check blood biochemistry. If there is an increase in the activity of liver enzymes, therapy is stopped.
Special occasion
Pantoprazole Canon tablets are allowed to appoint to persons of advanced age. Dosage adjustment is not required based on age alone. It is advisable to take the drug per day in an amount of 40 mg. Exceeding this standard is not recommended by the manufacturer; exceptional is considered the case of a combined therapeutic program for the detection of Helicobacter pylori colonies. The patient, even if an elderly person, should still receive 40 mg twice daily.
If a severe form of renal failure is established, creatinine clearance does not exceed 20 units, the patient undergoes blood dialysis, no more than 40 mg of the drug can be consumed per day.
As a prophylactic, they do not use medicine.
What do patients say?
If you believe the reviews, "Pantoprazole Canon" is a reliable tool to improve the condition of peptic ulcer disease, to ease the course of the acute phase. Doctors note the effectiveness of this tool, its comparative safety. Against the background of taking the medicine in accordance with the instructions and under the supervision of a doctor, patients usually have no negative impressions. The drug is practically not able to provoke severe reactions of the body. At the same time, it can be seen in the responses that there were still minor inconveniences during treatment.
The likelihood of side effects is confirmed by reviews and instructions for use of Pantoprazole Canon. Mostly minor effects are observed that do not require discontinuation of treatment. Side effects will be discussed later. But the responses about the independent practice of taking the drug without the appointment of a doctor are not so positive: many have encountered intolerance to the body or the failure of the course, since the disease required the appointment of a completely different treatment. Doctors and pharmaceutical manufacturers strongly recommend taking drugs only after consulting a doctor.
Is it possible or not?
The drug is not used if hypersensitivity to the active component is established. You can not apply the composition in the hypersensitivity reaction of the body to auxiliary ingredients. Hepatitis and hepatic cirrhosis are contraindications, if such conditions developed simultaneously with insufficient liver function in severe form. Do not use medication with creatinine clearance of less than 20 units if the patient requires treatment against the background of Helicobacter pylori invasion.
Some people who are contraindicated in the composition under consideration are wondering if there is any difference between Pantoprazole and Pantoprazole Canon: suddenly one of them is contraindicated, and the second can be taken. The main difference is the manufacturer. There may be differences in the choice of auxiliary ingredients. General indications, contraindications, limitations and rules are similar.
Undesirable consequences
The instruction, which tells how Pantoprazole Canon helps (all the diagnoses for which the drug is prescribed, are listed earlier), also gives a detailed idea of what undesirable consequences are possible when using the drug. It is known that some had disturbed stools, were sick and dizzy, and the quality of sleep worsened. There is a possibility of impaired vision and hearing, increased gas formation, skin reactions, hair loss. Occasionally, dermatitis, hyperglycemia, and fever were recorded. In the circulatory system, the concentration of eosinophils, lipoproteins can increase. There is a risk of hypercholesterolemia, hyperglycemia. In a small percentage of cases, patients noted muscle pain and discomfort in the stomach, allergic reactions in the form of Quincke's edema, urticaria, itchy and rash-covered skin areas.
Is there a replacement?
If you need to choose an analogue of Pantoprazole Canon, you should consult the doctor who prescribed this medication. There are quite a few alternatives on the market, but picking the right one among them is not easy. Take into account not only the active ingredient, but also additional components, indications and contraindications, especially the patient’s condition, the individual reaction of the body to different drugs. Sometimes the patient is interested in what is better: "Nolpaza" or "Pantoprazole Canon". These drugs are known to some extent by similar parameters, but at the same time they have a number of differences that do not allow us to say unequivocally which is preferable. For some patients, the remedy in question will be more useful; for others, Nolpaza or something else will be better.
It is necessary, when choosing an alternative, to navigate in describing the active ingredient and indications for receiving instructions for use. The analogues of Pantoprazole Canon are Ocid, Omez, and Omezol. Sometimes the doctor advises you to pay attention to "Lanzap" or "Epicurus". As a replacement, they can recommend:
- "Lantsid."
- Pepticum.
- Nexium.
- "Helicide."
- "Soars."
You can conclude by comparing the instructions: the analogue of Pantoprazole Canon is the medicine Bereta, which is quite popular in the modern market due to its excellent reputation.
Reliable analogues: Omez
Among all drugs from the class of oppressing proton pump, this drug is, perhaps, to be prescribed more often than others. Available in several forms; especially demanded - tableted. Capsules have a light yellowish tint. The active ingredient is omeprazole. This compound is a weak base that can accumulate in an acidic gastric environment, activating and inhibiting ATPase. The compound affects the last stage of hydrochloric acid generation. The effect is determined by the dosage. The substance equally affects the basal level and prevents the release of acid under the influence of irritating factors.
As clinical observations have shown, regular daily intake of omeprazole inside helps to quickly and effectively reduce the amount of acid generated in the gastric cavity. Maximum performance is recorded four days after the start of the course. With an intestinal ulcer, 20 mg daily can achieve a stable decrease in acidity for 24 hours. On average, weakening indicators by 80%. The maximum concentration of hydrochloric acid decreases against the background of the penetration of pentagastrin into the body. The daily effect is estimated at 70%.
Action Features
In case of intestinal ulcer, the administration of Omez with a dose of 20 mg stabilizes the acidity of the stomach medium to a level above three units. On average, the result is observed within 17 hours. The effect of inhibition is largely determined by the distribution curve of omeprazole in the body. This quality affects more than the content of the active ingredient in the blood serum at a particular point in time.
In laboratory conditions, omeprazole showed a bactericidal effect when studying the effect on Helicobacter pylori. Eradication in combination with antibiotics is accompanied by an early relief of symptoms and an increased quality of regeneration. Remission with such treatment is longer, the risk of complications is reduced, bleeding is less likely to develop. Eradication with omeprazole is considered as effective as stable supportive treatment.
Omez: kinetics
The active ingredient is rapidly absorbed during the passage of the gastric tract. The maximum concentration in the circulatory system is achievable 30-60 minutes after administration. Bioavailability is estimated at 30-40% after a single use, with daily stable use it reaches 60%. Meals do not adjust the parameter. Plasma protein binding is estimated at 95% on average. The volume of distribution reaches 0.3 l / kg.
A certain percentage of the substance received in the body is transformed systematically in the liver cells. Reactions proceed with the participation of isoenzymes. Metabolites that do not have pronounced activity are generated. Plasma clearance is estimated at 0.3-0.6 l / min. The half-life is about 40 minutes, sometimes it reaches one and a half hours. Up to 80% is eliminated by urine, and others - by secretions of the intestinal tract.
When will it help?
"Omez" is prescribed for intestinal and stomach ulcers. The drug is effective for GERD. The medicine facilitates a state of increased secretion. This is possible with an ulcer due to stress, Zollinger-Ellison disease, mastocytosis in a systemic form. The use of "Omez" with multiple adenomatosis is allowed. When a Helicobacter pylori colony is detected, the pharmaceutical product is used for eradication. If the patient is shown the use of non-hormonal anti-inflammatory, "Omez" is prescribed as a preventive measure to prevent a violation of the integrity of the gastric, intestinal mucous membranes. If the use of NSAIDs provoked ulcerative processes, Omez is indicated for their treatment. It is used for peptic ulcer and for the prevention of Mendelssohn’s syndrome, with dyspepsia.
Allowed the appointment of "Omez" for children. GERD is the indication if the patient is over two years old and weighs more than 20 kg, intestinal ulcer due to Helicobacter pylori. With this diagnosis, "Omez" is allowed from the age of four and weighs more than 20 kg. For other diseases, there is no information about the safety or effectiveness of taking the drug by minors, so the manufacturer recommends avoiding such therapeutic practice.