What is the Katadolon preparation? Analogs, price and instructions for using this medication will be presented in the materials of this article. From it you will learn about what this tool is intended for, whether it has contraindications and side effects, in what form it is released, what it contains in its composition and so on.
Packaging, release forms, composition
The drug "Katadolon" goes on sale in two different forms. We will consider their description, composition and packaging right now.
- Medication "Catadolon Forte" - biconvex yellow oval-shaped tablets (on one side of the strip) containing various inclusions. The drug contains such an active ingredient as flupirtine maleate, as well as other excipients. Tablets are placed in blisters of 10, 7 and 14 pieces, which are packed in packs of cardboard.
- Capsules "Katadolon Retard" in a shell of red gelatin. The contents of the drug is a green-yellow or yellow tint powder. One capsule contains flupirtine maleate, as well as additional substances in the form of gelatin, magnesium stearate, water, titanium dioxide, E172, silicon dioxide, sodium lauryl sulfate, calcium hydrogen phosphate dihydrate and copovidone. The drug is packaged in packs of cardboard of 30, 50 or 10 capsules.
Pharmacological action of the drug
What is the drug in question and does it have an analogue? "Katadolon" is a non-opioid analgesic that has an antispastic effect and has many different analogues.
The medication is not addictive and can have a centralized effect. After entering the body, it exerts an effect on the G-protein, thereby changing the potential difference in the calcium channels and stabilizing the potential of the membranes of neurons.
What properties does the medication in question and its analogue have? "Catadolone" should be taken in doses that do not exceed the maximum allowable. Only in this case, its active substance will not affect the H- and M-cholinergic receptors, as well as opioid, dopamine, serotonin, alpha2- and alpha1-adrenergic receptors.
After taking the capsules or tablets inside, anesthesia occurs due to the opening of the potassium channels that are in the nerve cells.
According to experts, this medication has a good effect on NMDA receptors. It stops the flow of calcium ions that pass through the semi-impermeable walls of the membranes.
The principle of action of the drug
How does the agent in question and its analogue affect the human body? Katadolon contains flupirtine. It is this substance that does not allow a nerve impulse to respond to nociceptive stimuli. As a result of such exposure, anesthesia occurs.
The medicine does not give rise to pain, and also does not allow their development into chronic ones. In addition, it effectively reduces existing pains.
After taking the drug inside, muscle relaxation occurs (due to blocking of intermediate neurons). It can not be said that this drug is able to protect neurons from the effects of toxins. By activating calcium channels, the drug reduces the content of harmful calcium ions in the cells.
Pharmacokinetics of the drug
When tablets and capsules "Katadolon Retard" enter the gastrointestinal tract, the active substances of the drug are completely absorbed (approximately 90%). At the same time, 75% of the dose taken is metabolized in the liver.
The half-life of the drug from the body is 7-15 hours. Up to 70% of the drug is excreted by the kidneys, and the rest - through the intestines.
In the elderly, as well as patients with impaired liver and kidney function, the elimination half-life increases.
The drug "Katadolon": indications for use
Indications for the use of this drug are pain of various origins (mild to moderate), which are caused by smooth muscle spasms.
So, with what deviations are the considered drug and its analogue prescribed? "Katadolon" is often used for postoperative and headaches, back and neck pain, for malignant neoplasms and tumors, etc.
Contraindications
The medicine "Katadolon" is not recommended for use in diseases of the kidneys and liver, hypoalbuminemia, allergies to the active ingredient or excipients, ringing in the ears, as well as in the treatment of the elderly, children and alcoholics.
The method of use of the drug
How should I take the Katadolon medication? Capsules should never be chewed. The dosage of such a drug is selected only individually.
The instructions for the medication include the following treatment regimens:
- Adults up to 65 years of age are prescribed 100 mg of the drug four times a day (that is, 1 capsule). It is necessary to adhere to the same intervals between doses of the medicine. With severe pain, it is allowed to take two capsules three times a day. It should be borne in mind that the maximum daily dosage should be 600 mg (i.e. 6 capsules).
- Elderly people (after 65 years), the drug "Katadolon" must be taken 100 mg twice a day. Depending on the degree of pain, this dose can be increased to 300 mg per day.
- Patients who suffer from renal failure or hypoalbuminemia are usually prescribed no more than 300 mg of the drug per day.
- With impaired liver function, the medication should not be taken in a dose that exceeds 200 mg per day. The duration of such therapy may be different. However, long-term treatment requires monitoring the activity of liver enzymes.
Analogues of the drug "Katadolon" contain the same active substance as the original. However, when choosing them as a replacement, be sure to consult a doctor and choose the optimal dosage.
Drug overdose
There are isolated reports of cases of overdose with the drug "Katadolon" with suicidal intentions. In this case, the following symptoms are observed: nausea, a state of prostration, tachycardia, confusion, tearfulness, dry mouth, stupidity.
For the treatment of such symptoms, forced diuresis is used. In addition, the patient is given activated carbon and electrolytes are administered. Subject to all the above measures, the patient's well-being improves after 6-12 hours.
Adverse reactions after taking the drug
In some patients, after taking Katadolon tablets or capsules, side effects such as:
- dizziness, general weakness and fatigue;
- flatulence, nausea, and abdominal pain;
- tremor, digestive upset;
- headaches and anxiety;
- allergic reactions;
- drug hepatitis;
- visual impairment.
Side effects can occur unexpectedly and also suddenly disappear during the course of treatment.
Drug interaction
With the simultaneous administration of the drug Katadolon with drugs such as Warfarin and Diazepam, the effect of the former may be enhanced. This is due to the fact that the listed drugs easily bind to proteins, which contributes to the displacement of flupirtine from cells.
Sedatives, muscle relaxants and ethanol enhance their effects under the influence of the drug.
It is not recommended to combine the medication with Paracetamol, Carbamazepine and Flupirtine.
It should also be noted that with the simultaneous use of the drug with "Coumarin", it is necessary to control the prothrombin index.
special instructions
Before using the Katadolon medication, you must read the instructions. She states that:
- This drug should be used only if therapy with other painkillers is contraindicated.
- During the use of the medication in people with reduced kidney function, it is necessary to control the concentration of creatinine in the blood.
- In persons over 65 years of age, as well as patients with hypoalbuminemia and severe renal failure, dose adjustment is required.
- Patients should be warned that during treatment, particular attention should be paid to the symptoms of liver damage. If these signs appear, stop taking the medication and consult a doctor.
- During therapy with the Katadolon medicine, false-positive test reactions to urobilinogen, bilirubin and protein in the urine are possible.
- When using high doses of the drug, the patient may stain urine in green. This is not a clinical symptom of any pathology.
- During treatment, it is necessary to abandon the control of mechanisms and driving vehicles, as patients may develop dizziness and drowsiness.
The drug "Katadolon": analogues, reviews, price
A synonym for this tool is the drug "Flugesik." As for analogues, the following medicines are referred to them: “Akupan”, “Nefopam”, “Milistan” and “Sinmeton”.
The price of the drug in question is very high. As a rule, it varies between 900-1200 rubles (depending on the form and number of tablets, capsules).
According to patient reviews, the Katadolon medication quite effectively and quickly eliminates any pain syndromes. Despite the large number of adverse reactions, drug addicts very often use this remedy for pain relief during withdrawal symptoms.
As for ordinary patients, some of them complain that taking such a medication often causes dizziness and general weakness.
According to doctors, the drug "Katadolon" is often used in surgical practice. It is a very powerful tool, so you should not take it without a doctor’s prescription.