"Pentalgin-ICN" is a complex drug that has antipyretic, as well as analgesic and anti-migraine effects. The drug is available in tablet form and in capsules.
The tablets are white with cream or yellow color, as well as a biconvex shape. Capsules have a flat lateral texture, on one side there is a risk, on the other - PENTALGIN engraving.
Composition "Pentalgin-ICN"
There are one or two contour cells in the package, one of them has six, ten, twelve pieces. The active components in the composition of one tablet are:
- paracetamol;
- caffeine;
- metamizole sodium;
- codeine phosphate;
- phenobarbital.
Additional substances are:
- potato starch;
- polyvinylpyrrolidone;
- octadecanoic acid;
- salt of calcium and stearic acid.
Sample recipe "Pentalgin-ICN" in Latin:
Rp: Tab. Mentalginum
Dtd: N 10 in tab.
S: 1 tablet 2-3 times a day.
Pharmacological properties
The drug "Pentalgin" is one of the complex medicines that have antipyretic, as well as analgesic and anti-migraine effects, due to the properties of the active substances:
- Paracetamol is considered an antipyretic analgesic. It blocks cyclooxygenase, usually in the central nervous system, by influencing thermoregulation and pain. Paracetamol has an analgesic and antipyretic effect.
- Metamizole sodium is considered a pyrazolone derivative, as well as an antipyretic analgesic. This component has a pronounced analgesic effect.
- Caffeine acts as a psychostimulant. It reduces the intensity of headaches of vascular origin, and also helps to improve well-being.
- Phenobarbital is considered a barbiturate. It increases the analgesic effect of paracetamol and metamizole sodium.
- Codeine has an analgesic effect, which is due to the excitation of opioid nerve endings in different parts of the central nervous system, which leads to a change in the emotional perception of pain and activation of the antinociceptive system.
Indications
"Pentalgin" is prescribed in the presence of the following conditions:
- Pain syndrome of weak or medium intensity of various origins.
- Arthralgia (pain in the joints, which appear in the absence of pronounced signs of damage, but may precede a more serious disease).
- Myalgia (a pathology for which the appearance of muscle pain is considered characteristic).
- Radiculitis (an inflammatory lesion of the nerve roots that enter the intervertebral openings).
- Algodismenorea (unpleasant pulling pain in the lower abdomen and lower back before the onset of menstruation, which can last until the end of critical days).
- Neuralgia (damage to the peripheral nerves, which is caused by bouts of pain in the innervation zone of a nerve).
- Migraines (a neurological disease characterized by persistent severe and painful headaches in different parts of the head).
- Toothache.
- Colds.
Contraindications
According to the instructions for use with Pentalgin-ICN, it is known that the drug has certain prohibitions, for example:
- Diseases of the liver and kidneys.
- A deficiency of the cytosolic enzyme (a disease that is inherited, is characterized by a decrease in the activity of the cytosolic enzyme, which leads to increased destruction of red blood cells and anemia).
- Alcohol intoxication.
- A disease caused by respiratory depression.
- Leukopenia (a pathological condition in which the number of white blood cells in the blood becomes less than the standard).
- Bronchial asthma (a chronic inflammatory lesion of the respiratory system involving a variety of cellular elements).
- Anemia (a disease in which the number of red blood cells and hemoglobin in the blood decreases).
- Myocardial infarction (a source of ischemic myocardial necrosis, which occurs subsequently in acute disturbances in coronary circulation).
- Pregnancy.
- Cerebral hypertension (a pathological condition in which pressure increases inside the skull).
- Breast-feeding.
- Glaucoma (a chronic pathological process of the organs of vision, which is caused by an increase in intraocular pressure, as well as the appearance of optical neuropathy and visual impairment).
- Arrhythmias (a pathology that leads to a violation of the frequency, as well as the rhythm and sequence of excitation and contraction of the heart).
- Age to twelve years.
- Arterial hypertension (persistent increase in blood pressure).
- Peptic ulcer of the stomach and duodenum.
- Elderly age.
Method and dosage
According to the instructions, Pentalgin-ICN is taken orally, one tablet from one to three times a day, up to a maximum of four tablets per day.
Without the supervision of a doctor, the drug as an antipyretic and analgesic should not be used for more than five days.
Adverse reactions
According to the instructions for use with Pentalgin, it is known that with incorrect or uncontrolled dosing, negative phenomena can occur:
- Tachycardia (a type of arrhythmia characterized by a heart rate of more than 90 beats per minute).
- Heartbeat
- Drowsiness.
- Dizziness.
- Granulocytopenia (reduced concentration of granulocytes in the peripheral blood).
- Leukopenia (a pathological process in which the number of white blood cells in the blood becomes less than certain values).
- Agranulocytosis (a disease characterized by a decrease in the level of granulocytes in blood plasma).
- Vomiting.
- Nausea.
- Drug addiction.
- Intestinal obstruction.
- Itching
- Skin rashes.
- Urticaria (a disease of allergic origin, which is characterized by the formation of blisters on the skin and on the mucous membranes).
- Addictive.
- Liver and kidney disease.
Treatment is aimed at reducing the absorption of active substances, if necessary, complex therapy is carried out.
Features
When treated with this drug in athletes, the results of doping studies may change. When carrying out long-term therapy (from 7 days), it is important to monitor the functioning of the liver and the picture of peripheral blood. In acute pain, the use of "Pentalgin-ICN" may complicate the diagnosis.
The likelihood of increased sensitivity is higher in people with pollinosis and atopic bronchial asthma. During the use of the drug by patients from driving and working, which requires quick reactions and increased attention, it is necessary to abstain.
According to the instructions, "Pentalgin" during the "interesting position" and breastfeeding is not appointed. Using the medication at the age of twelve years is prohibited.
Drug interaction
The drug "Pentalgin" has an inhibitory effect on the central nervous system; an increase in the severity of a depressing effect on the respiratory center and a calming effect may occur.
Non-opioid painkillers increase the toxic effect. Ethyl alcohol increases the effect on the psychomotor reaction.
Analogs
Pentalgin-ICN generics are considered:
- Sedalgin.
- Pentalgin.
- Sedal-M
- Santoperalgin.
Keep the drug in a place that is protected from light and moisture, at a temperature of up to twenty-five degrees. Place the medicine should be away from children. Shelf life is thirty-six months. Dispensed by prescription.
Opinions
Reviews about the tablets "Pentalgin-ICN" are usually positive. In most situations, it effectively eliminates pain of various origins. The rate of development of the analgesic effect has a significant individual intolerance.
Some people indicate that with migraines and pains of intense intensity, Pentalgin is used simultaneously with other medicines. The cost of the drug varies from 180 to 250 rubles.