Many have to deal with psoriasis today. This is a chronic disease of a non-infectious nature, which manifests itself in the form of a rash or peeling on the skin. The disease can begin at any age, but, according to statistics, mainly affects young people. Scaly plaques appear on the patient’s skin, which are located on the elbows, knees, and head. If there are such symptoms, then you need to consult a dermatologist. He will conduct an examination and prescribe treatment. One of the common and popular drugs to eliminate the causes of the disease is the drug Methotrexate. Instructions for use in psoriasis, reviews - you will learn all this information from the article.
Act
The medicine belongs to the group of antitumor drugs. Available in tablet form. The main substance of the drug is methotrexate. The medicine is packaged in polymer jars of 50 tablets each. The drug inhibits the synthesis, repair of DNA cells, their mitosis. The most sensitive to the drug are fast-repairing tissues of the bone marrow, intestines, bladder, and oral cavity. Also, the drug has an immunostimulating property. The drug is administered orally.
When taking a dose of 30 mg, the drug is well absorbed in the stomach. The average bioavailability is 60%. If all therapeutic recommendations are observed, then the main substance does not penetrate the blood-brain barrier. The main part of the drug is metabolized in the liver, and the rest - in the intestinal walls. It is excreted by the kidneys and bile. This effect is exerted by the drug Methotrexate. Reviews for psoriasis patients leave mostly positive.
Indications and contraindications
The drug can be prescribed for the following diseases:
- acute lymphoblastic leukemia and non-Hodgkin lymphomas;
- trophoblastic tumors ;
- severe forms of fungal mycosis;
- chronic stages of psoriasis;
- rheumatoid arthritis, if all other treatment methods have not given a positive effect.
Contraindications:
- pregnancy;
- lactation;
- pathology of the liver and kidneys;
- hematologic disorders;
- HIV
- infectious diseases;
- age up to 3 years;
- hypersensitivity to components;
- gastric and duodenal ulcer;
- ascites;
- ulcerative colitis;
- gout.
Before starting the treatment process, it is necessary to thoroughly study all contraindications to taking the drug "Methotrexate". With psoriasis, reviews about the drug indicate that the tablets help in a short time to get rid of itching and rashes on the skin.
Dosage and overdose
The medicine is taken orally according to an individual scheme, which is prescribed by a specialist taking into account the severity of the process. With psoriasis, the drug is used from 10 to 25 mg per week. The increase in dose should be gradual. With a positive dynamics of the disease, the daily norm decreases. The course of treatment takes several months. It is advisable to take pills in the morning and drink a little water. Quite often, dermatologists prescribe Methotrexate tablets for psoriasis. Reviews show that the drug is really effective in this ailment.
Basically, the medication is well tolerated. Only often increases its concentration in plasma. In this situation, you must immediately enter the antidote (calcium folinate) in the first hour of poisoning. Still need to perform alkalization of urine and hydration of the body. Also, before each administration of the drug, it is necessary to determine the pH of the urine until the substance in the plasma reaches 0.05 μmol / L, which will ensure a pH of urine above 7.
Interaction with other means
It is not recommended to prescribe a medicine with the following drugs:
- derivatives of coumarin and indandion;
- funds that are used for gout;
- Amiodarone
- folate-containing preparations;
- Neomycin
- hematotoxic drugs;
- "Cytarabine";
- dinitrogen oxide.
Joint administration will lead to an increased plasma content of Methotrexate (reviews for psoriasis show that it is possible to cure a skin ailment quickly enough). At the same time, the risk of developing side effects increases.
Pregnancy and lactation
The medicine has a teratogenic property, which can lead to the death of the fetus and its congenital malformations. If a woman becomes pregnant during treatment, then it is necessary to raise the issue of abortion due to the high risk to the fetus. The product is transferred with breast milk, so you can not feed the baby during the treatment period.
During therapy, the following side effects may develop:
- anemia;
- thrombocytopenia;
- nausea;
- vomiting
- anorexia;
- stomatitis;
- gingivitis;
- gastric bleeding;
- dizziness;
- acute hepatitis, fibrosis and cirrhosis of the liver;
- pancreatitis
- drowsiness;
- conjunctivitis;
- visual impairment;
- pneumonia;
- encephalopathy;
- renal failure;
- nephropathy and other symptoms.
If side effects occur, you should consult a doctor who will correct the daily rate of the Methotrexate medication. With psoriasis, reviews of doctors show that the medication shows good results when used in the minimum dosage.
special instructions
It is necessary to store the drug at a temperature not exceeding 25 degrees in a dry place inaccessible to children. Shelf life of the drug is 3 years. After the expiration of the implementation period, you cannot use the product. In the pharmacy, the medicine is dispensed with a prescription.
Prescribe a medicine that has a complex chemical structure and a large number of side effects, can only be a doctor with experience who is familiar with the patterns of its use in psoriasis. Before starting treatment, the doctor should tell the patient about all the indications and contraindications, symptoms of intoxication. Also prescribe clinical blood and urine tests. The drug affects the central nervous system. Therefore, it is not recommended to drive vehicles or potentially dangerous mechanisms during the treatment period.
It is rather difficult to treat psoriasis with Methotrexate. Reviews of experts show that it is possible to achieve positive dynamics of the disease if the treatment regimen is developed correctly.
The drug "Methotrexate-Ebeve" - a substitute for the drug "Methotrexate"
The medicine is available in the form of a yellow or clear solution for intravenous and intramuscular injections at a dose of 1 and 5 ml. The main substance in the composition of the drug is methotrexate. It belongs to the group of antitumor drugs that are considered antimetabolites and folic acid analogues. Also, the medicine enhances immunity. When the drug is administered intramuscularly, its maximum concentration in plasma is observed after 1 hour.
Indications and contraindications
It is used for severe forms of psoriasis. Helps eliminate itching, peeling and discomfort.
Contraindications:
- renal and liver failure ;
- alcoholism;
- disorders in the functioning of the blood;
- HIV
- infectious diseases;
- pregnancy;
- breast-feeding.
At the beginning of the treatment process, all contraindications to the use of the Methotrexate-Ebeve remedy for psoriasis should be examined. Reviews of doctors and patients indicate a high potential of the drug in the treatment of this disease. The medication is stored away from children, at a temperature not exceeding 30 degrees. The pharmacy is available only with a prescription. The dosage is established by a specialist individually. The solution is administered intravenously or intramuscularly, slowly.
The drug "Methotrexate": reviews for psoriasis
In the treatment of many autoimmune diseases, which include psoriasis, cytostatics are widely used. As a result, the drug has an immunosuppressive property and gives the desired rate. The drug "Methotrexate" has a cytostatic effect. Reviews for psoriasis are good, the drug gives visible improvements. It helps to suspend the process of cell division of the skin. Due to the presence of many side effects, self-medication is not recommended. A dermatologist develops a scheme for the patient, taking into account the severity of psoriasis and the individual characteristics of the body.
Basically, the medicine is prescribed in combination with other drugs that will help remove the symptoms of psoriasis. Good reviews can be heard about the cost of the drug. The medicine is affordable and comes in the form of tablets and solution. The approximate price in pharmacies of the Russian Federation is 600 rubles per package.