Painkillers and anti-inflammatory drugs are especially often used for joint diseases and neuralgia. Such drugs are very effective and effective. They reduce the severity of pain and facilitate the condition of the patient.
Unfortunately, the medications in question quite often cause the development of side effects. Therefore, they are recommended to be used only according to indications and for a short time.
The most popular among specialists and patients is an NSAID such as Movalis (injections). Reviews of doctors, method of use and indications of the mentioned medication, we will consider a little further.
Form, composition, description and packaging
“Movalis” injections, reviews of which are mostly positive, are issued in the form of a clear solution for intramuscular administration. It has a yellow color with a greenish tint and goes on sale in colorless glass ampoules that are placed in plastic contour pallets and cardboard boxes, respectively.
What substances does the drug “Movalis” contain (injections)? The instruction (you can find reviews about the medicine at the end of the article) reports that the active ingredient of this medication is meloxicam. In addition to it, the solution also includes additional elements in the form of glycine, meglumine, glycofurfural, sodium chloride, poloxamer, sodium hydroxide and water.
Pharmacology
What is a solution like Movalis (injections)? Reviews of doctors say that the effectiveness of this medicine is very high. This drug is an NSAID. It has an antipyretic, anti-inflammatory and analgesic effect, and is also a derivative of enolic acid.
The anti-inflammatory property of meloxicam is manifested in the presence of any inflammation. The principle of its action is the ability of the active substance to inhibit the synthesis of prostaglandins.
Studies of this drug showed that the drug in dosages of 15 and 7.5 mg has no effect on bleeding time and platelet aggregation. Also, experts found that adverse reactions from the gastrointestinal tract when using meloxicam occur much less frequently than when using other NSAIDs.
Pharmacokinetics
What kinetic properties do “Movalis” injections have? Testimonials from patients and doctors do not provide an answer to this question. For it, you will have to turn to the instructions according to which, after intramuscular administration, meloxicam is completely absorbed. The relative bioavailability of this drug is almost 100%.
After administration of the drug in a dose of 15 mg, its highest concentration in the blood is reached after 60-80 minutes.
The drug binds well to plasma proteins (99%), and also quickly penetrates the synovial fluid. Its metabolism is carried out in the liver, resulting in the formation of 4 inactive derivatives.
It is excreted by meloxicam through the intestines and through the work of the kidneys. The half-life is 14–26 hours.
Indications
What diseases can the Movalis solution be prescribed for? Reviews (injections cause fewer adverse reactions than oral agents) of doctors say that this drug is very effective in the initial period of treatment of pain syndromes. It is also used for short-term symptomatic therapy of ankylosing spondylitis, osteoarthritis, rheumatoid arthritis, degenerative joint diseases and arthrosis.
Contraindications
What contraindications do Movalis injections have? Reviews of experts report that this drug can manifest itself on the negative side, if taken with:
- liver or heart failure;
- hypersensitivity to the main components of the drug;
- Crohn's disease or ulcerative colitis;
- erosion or ulcer of the digestive tract;
- progressive kidney disease;
- taking anticoagulants;
- renal failure;
- liver diseases;
- pregnancy
- bleeding in the digestive tract;
- surgical pain (coronary artery bypass grafting);
- breastfeeding;
- minor age.
Solution "Movalis": instructions for use
Injections, reviews of which are very common, with osteoarthritis are prescribed at a dose of 7.5 mg per day. If required, this amount is increased to 15 mg.
With ankylosing spondylitis and rheumatoid arthritis, the drug is recommended to be used at a dosage of 15 mg per day. Depending on the therapeutic effect, the indicated amount can be reduced to 7.5 mg.
People with an increased risk of side effects begin treatment with the lowest possible dose.
Is it possible to take “Movalis” injections simultaneously with other NSAIDs? Experts say that such combinations are undesirable.
Intramuscular administration of the drug is indicated only at the very beginning of therapy. Subsequently, they switch to oral drugs.
The medication is injected deep into the gluteal muscle. The drug should not be used intravenously, as well as mixed with other drugs (in the same syringe).
Side effects
What side effects can the mentioned medication cause and its use? Movalis (injections) often contributes to the development of the following reactions:
- thrombocytopenia, anemia, changes in the number of blood cells, leukopenia;
- drowsiness, headaches, dizziness;
- anaphylactic shock, hypersensitivity reactions, anaphylactoid or anaphylactic reactions ;
- vertigo, visual impairment, conjunctivitis, tinnitus, blurred vision;
- mood changes, disorientation, confusion;
- increased blood pressure, palpitations, flushing;
- abdominal pain, gastritis, dyspepsia, stomatitis, diarrhea, bloating, nausea, gastroduodenal ulcers, gastrointestinal bleeding, belching, constipation, esophagitis, colitis, gastrointestinal perforation;
- bronchial asthma;
- hepatitis, transient changes in liver function indicators;
- angioedema, Stevens-Johnson syndrome, pruritus, erythema multiforme, skin rash, toxic epidermal necrolysis, bullous dermatitis, urticaria, photosensitivity;
- changes in the performance of the kidneys, acute renal failure, impaired urination, urinary retention;
- cytopenia, glomerulonephritis, renal medullary necrosis, nephrotic syndrome.
The drug "Movalis": reviews
Movalis injections are very painful. This is the opinion most patients adhere to. But despite this, they are often used for joint diseases. This is due to the fact that the drug in question is very effective.
The main disadvantage of this medication is the presence of a large number of adverse reactions and contraindications.