Angioprotectors include a whole group of drugs that play a large role in the combination therapy of various heart and vascular diseases.
Such drugs exhibit antispasmodic activity, improve microcirculation and rheological properties of blood, and also cause vasodilation and normalize their permeability. In addition, angioprotectors reduce tissue swelling and activate metabolism in the walls of blood vessels.
The most prominent representatives of such drugs include the drug "Doxy-Hem." Instructions for use, analogues and reviews of the tool will be presented below.
Form, description, composition and packaging of the drug
The drug "Doxy-Hem", the instruction of which is contained in a cardboard package, is available in the form of hard gelatin capsules with an opaque light yellow body and a dark green lid. Their contents are a yellowish powder. Also, it allows the presence of conglomerates, which are transformed into a loose mass when lightly pressed with a glass rod.
What are the components of Doxy-Hem? Instructions for use state that the active ingredient of this medication is dobesilate calcium monohydrate. Also, its composition includes such auxiliary elements as magnesium stearate and corn starch.
The medication in question goes on sale in blisters.
Drug characteristics
How does the drug "Doxy-Hem"? Instructions for use, reviews of experienced doctors say that it is an angioprotector (i.e., vein and capillary protector), which affects the vascular endothelium and normalizes metabolic processes in it.
After taking the drug in question, vascular permeability and blood microcirculation are significantly improved. The stability of capillaries also increases, edema and hemorrhagic syndrome decreases, blood viscosity and platelet aggregation decrease .
The therapeutic efficacy of the drug in question is associated with an increase in plasma kinin activity.
Kinetic features of the drug
What kinetic properties are characteristic for the Doxy-Hem drug? Instructions for use claims that this drug is absorbed quite slowly from the digestive tract. After about 5.5 hours, a peak in its concentration in the blood is observed. About 20-25% of the active substance binds to plasma proteins.
This medication is excreted during the day through the intestines and kidneys.
Drug indications
For what purpose are patients prescribed an angioprotector such as Doxy-Hem? Instructions, reviews indicate that this medicine is very effective in:
- varicose veins or venous insufficiency, which is accompanied by pain syndromes, superficial phlebitis, congestive dermatosis and trophic ulcers;
- increased capillary permeability (including with diabetic nephropathy and retinopathy);
- microangiopathy, which developed against a background of cardiovascular disease.
Contraindications to taking capsules
In what cases should not be prescribed medication "Doxy-Hem"? Instructions for use informs that this medicine is contraindicated in:
- gastrointestinal bleeding;
- exacerbation of peptic ulcer;
- kidney and liver diseases;
- hemorrhage, which arose on the background of taking anticoagulants;
- under the age of 13;
- hypersensitivity to the drug;
- in the first trimester of pregnancy.
The drug "Doxy-Hem": instructions for use
Analogs of this tool will be listed at the end of the article.
Take this medication only as directed by a doctor. Capsules are swallowed whole while eating.
According to the instructions, the average dosage of this medicine is 500 mg twice a day. It should be taken for three weeks. If necessary, the indicated dose is reduced to 500 mg per day.
With the development of retinopathy, this medication is prescribed 500 mg three times a day for 4-5 months (with a gradual transition to 500 mg per day).
Also, this remedy is often prescribed for prophylactic purposes.
If after taking the drug “Doxy-Hem” the patient has a fever, chills, swallowing pains and inflammation of the oral mucosa (that is, symptoms of agranulocytosis have arisen), you should definitely consult a doctor.
Side effects
What undesirable consequences may occur while taking Doxy-Hem? Instructions for use report the following conditions:
- nausea, allergic reactions, diarrhea, chills, vomiting;
- fever, disorders of the subcutaneous tissue and skin;
- itching, arthralgia, rash;
- disorders of the connective and musculoskeletal tissue;
- disorders of the lymphatic system and blood;
- agranulocytosis (such a reaction is reversible and disappears after discontinuation of therapy).
Special recommendations
The drug can be used for prevention.
In severe renal failure, which requires dialysis, the dosage of the drug must be reduced.
This drug is not recommended for pregnant women and children. It is not recommended to take it to women who are breastfeeding. It should also be noted that this drug has no effect on a person’s ability to control complex mechanisms and drive vehicles.
Price and similar drugs
The cost of Doxy-Hem angioprotector is about 300 rubles. In some cases, it is replaced by such means as Calcium Dobesylate, Doxium, Doxium 500, Doxilek.
Reviews
According to experts, calcium dobesilate has a more pronounced effect on vascular permeability than etamzilate. Therefore, this drug is very often used as a therapeutic and prophylactic agent for various diseases of the cardiovascular system.
Patients claim that this medication is a highly effective angioprotector that people with diabetes regularly take. After therapy with Doxy-Hem, patients with retinal edema decrease and the prognosis of diabetic retinopathy improves .