In the article, we will consider what is “Cerucal” with metoclopramide.
The medication is an antiemetic with a central type of exposure. Its therapeutic effect is based on the ability to block dopamine receptors.
Composition, pharmacological form of the drug
What is the composition of the drug “Cerucal”? The manufacturer produces it in several forms: tablets are intended for oral use, the solution is for administration intramuscularly, intravenously.
The active component in the composition of the drug is metoclopramide hydrochloride monohydrate. What this substance is from, we will tell below.
Auxiliary components of tablets - lactose monohydrate, potato starch, magnesium stearate, silicon dioxide, gelatin; solution - sodium chloride, sodium sulfite, injection water, disodium edetate.
Indications for the use of the medication
"Cerucal" with metoclopramide should be used to eliminate the following conditions:
- Diabetic gastroparesis.
- Postoperative hypotonic phenomena in the stomach, due to which discomfort, nausea, and a feeling of heaviness develop.
- Vomiting, bouts of nausea, triggered by chemotherapy.
- Vomiting, nausea, having a different origin - provoked by pathologies of the pancreas, stomach, food poisoning.
Contraindications
According to the instructions for use with Cerucal with metoclopramide, contraindications must be excluded before use. Among them:
- The first trimester of pregnancy.
- Age to 14 years.
- Epilepsy.
- Extrapyramidal disorders.
- Prolactin-dependent tumor.
- Intestinal obstruction.
- Stenosis of the gastric pylorus.
- Particular intolerance to the substances that are part of the drug.
In addition, “Tserukal” has relative contraindications (when the remedy can be used with caution and only in extreme situations):
- The second and third trimesters of pregnancy.
- Age over 65 years.
- Parkinson's disease.
- Pathology of the liver, kidneys.
- Bronchial asthma.
- Arterial hypertension.
Recommended Dosage
Take Cerucal tablets with metoclopramide before meals, for half an hour. It is necessary to wash them down with water in a large volume. It is recommended to take the medicine three times a day for 5-19 mg. The maximum single dosage can reach 20 mg, daily - 60 mg.
Injection solution for patients from 14 years of age is indicated to be administered slowly intravenously, or intramuscularly 1-3 times a day, 1 ampoule.
For patients 2-14 years old, the dose is calculated individually - 0.1 mg / kg. A day is allowed to use no more than 0.5 mg / kg.
The average duration of a therapeutic course is 1-6 months. If the patient has deviations in the activity of the kidneys, liver, accompanied by dysfunction of other organs, the dosage of the drug must be selected individually.
Negative impact
During therapy with the Cerucal drug with metoclopramide, the patient may develop the following negative symptoms:
- Erectile dysfunction, menstrual irregularities, gynecomastia, female galactorrhea (the appearance of colostrum, not associated with lactation).
- Increased flatulence, bloating, constipation, heaviness in the stomach, belching, heartburn, dry mouth.
- Tachycardia, pressure surges.
- Tremor of the extremities, spasms of the facial muscles, twitching of the facial muscles, tinnitus, unreasonable fear, apathy, lethargy, feeling tired, insomnia, dizziness.
If the patient has one or more of these side effects, you should refuse to use the medicine and consult a doctor.
Drug overdose
If you accidentally or intentionally take an increased dose of the drug, intoxication can occur, which is clinically manifested by an increase in negative symptoms - bradycardia, heart rhythm disturbance, increased blood pressure, convulsions.
If you stop using the medication at this stage, all unpleasant symptoms will disappear after a day. All this time the patient must be under medical supervision. This is necessary to ensure the normal functioning of vital organs.
If the poisoning is pronounced, it is recommended to carry out the gastric lavage procedure and prescribe symptomatic therapy. Currently, the antidote of the drug is not known, hemodialysis is ineffective.
Interaction of Cerucal with other medicines
The active component of the drug is able to enhance the absorption of tetracycline and penicillin antibiotics, that is, when combined with antibacterial drugs, their effect becomes more pronounced.
With parallel use with paracetamol and other NSAIDs, the likelihood of toxic liver damage increases.
Under the influence of metoclopramide, the therapeutic effectiveness of drugs that depress the central nervous system increases. Such an interaction increases the possibility of developing dizziness, lethargy, and drowsiness.
Simultaneous use with antipsychotics enhances the likelihood of extrapyramidal disorders - impaired coordination, paresthesia, tremor of the extremities.
Parallel therapy with hepatotoxic agents increases the possibility of impaired liver function, damage to the liver tissue.
Simultaneous administration with bromocriptine leads to an increase in the plasma concentration of the latter.
special instructions
Do not use the tablet “Cerucal” in the treatment of patients under 14 years of age. A similar ban is due to the fact that clinical studies on the safety of funds for patients of this age category have not been conducted. Injection "Cerucal" is allowed for use in the treatment of children from 2 years.
With drug therapy, you should abandon the use of alcoholic beverages, since alcohol significantly increases the likelihood of toxic liver damage, central nervous system depression.
Also, when taking medication, it is recommended to stop driving vehicles and performing work that requires increased care, as tablets can cause such negative manifestations as drowsiness and sudden dizziness.
Analogues of "Tserukala"
If necessary, “Tserukal” can be replaced by “Vero-metoclopramide”, “Metamol”. Another complete analogue of Cerucal is Metoclopramide. It is the same? Yes, these tools are completely identical.
If there is a need to replace the medicine with one of its analogues, it is important to consult a doctor, as well as carefully study the manufacturer's annotation attached to the analogue.
Cost
“Tserukal” is an affordable antiemetic - the cost of one package varies around 130 rubles. It depends on the region and the pharmacy network.