"Toff Plus" is a combined remedy for the elimination of signs of the common cold and acute respiratory infections.
The drug consists of several components. Paracetamol in its composition has an analgesic and antipyretic effect. Phenylephrine alpha-adrenergic agonist produces a vasoconstrictor effect, helps relieve the patient from nasal congestion, reduce the amount of mucous secretion from its cavity.
pharmachologic effect
Chlorphenamine helps block H1 histamine receptors, has an anti-allergic effect, suppresses allergic rhinitis (reduces vascular permeability, removes hyperemia and swelling of the nasal mucosa).
Dextromethorphan is a cough suppressant that is close in effect to codeine, increases the sensitive threshold of the cough center in the medulla oblongata, inhibits all types of coughs and eliminates irritation caused by unproductive dry coughs. It is well tolerated by any age groups. The drug "Toff Plus" has a certain sedative effect, does not have sleeping pills, drugs and painkillers.
The activity of the ciliated epithelium and the respiratory center does not inhibit. The drug begins to act in 20-30 minutes, its duration is about four hours.
Structure
According to the instructions for Toff Plus, one capsule contains: paracetamol, dextromethorphan hydrobromide, phenylephrine hydrochloride, chlorphenamine maleate. Auxiliary components are as follows: croscarmellose sodium, povidone, talc, gelatin, sodium disulfite, microcrystalline cellulose, sucrose, cellulose acetate phthalate, yellow quinoline dye, diethyl phthalate, blue diamond dye, crimson dye. The shell contains gelatin, water, sodium lauryl sulfate, a blue diamond dye, propyl parahydroxybenzoate and methyl parahydroxybenzoate.
The price of Toff Plus will be presented below. The instruction does not contain such information.
Release form
Manufacturers have developed two forms of release of the drug, which is very convenient for people, since there is the possibility of buying the necessary drug with minimal financial resources.
Aluminum foil and PVC blister packs contain ten capsules. In cardboard packaging - one or two blisters with enclosed instructions.
When is it used?
Toff Plus is prescribed in the following cases:
- inflammatory-infectious (colds) diseases, including influenza, rhinopharyngitis, acute respiratory viral infections, rhinitis;
- rhinorrhea;
- allergic rhinitis.
Contraindications
As indicated by the instructions for Toff Plus, contraindications for use are as follows:
- excessive sensitivity;
- lack of glucose-6-phosphate dehydrogenase;
- the simultaneous use of MAO inhibitors, tricyclic antidepressants, as well as beta-blockers;
- blood pathology;
- angle-closure glaucoma;
- kidney and / or liver failure;
- prostatic hyperplasia;
- thyrotoxicosis;
- arterial hypertension;
- Gilbert's syndrome;
- diabetes;
- pheochromocytoma;
- bronchitis;
- lactation period;
- bronchial asthma;
- pregnancy;
- patient age up to fourteen years.
Caution should be in the presence of GOKMP, angina pectoris and in old age.
Dosage Features
Toff Plus is taken orally, one capsule every 4-6 hours, but no more than four capsules per day. As a means of reducing fever, it is used no longer than three days in the absence of medical advice.
Side effects
When using the drug, there may be the following side effects:
- nervous system, as well as sensory organs: drowsiness, mydriasis, dizziness, excessive irritability, increased pressure inside the eye, paresis of accommodation;
- digestive system: dry mouth, vomiting, epigastric pain, hepatotoxic effect, nausea;
- blood-forming organs: aplastic anemia, thrombocytopenia, anemia, hemolytic anemia;
- urinary system: papillary necrosis (nephrotoxicity), urine retention;
- allergic reactions: skin rash, bronchial obstruction, angioedema, itching;
- other symptoms: increased blood pressure.
The reviews of Toff Plus confirm this.
Overdose
The drug requires very careful handling, so that the use of an excess dose does not harm the patient's health. This is especially true for adolescents, children, the elderly and people who are intoxicated.
That is why with all the strange symptoms, while taking the medicine, you need to see a doctor. As a rule, signs of an overdose occur when taking more than 10-15 grams of the drug.
The main symptoms of excessive use of the drug are as follows:
- pallor of the mucous membranes and integuments of the skin, vomiting, nausea, allergic reactions, decreased blood coagulation;
- allergic manifestations;
- a network of vessels around the ocular cornea;
- palpitations, arrhythmia, arterial hypertension;
- acute urine retention;
- vomiting, jaundice, liver or kidney failure;
- hematopoietic disorders;
- suppression of the nervous system, confusion, drowsiness.
With the manifestation of such symptoms, the treatment is as follows: gastric lavage, taking Polysorb, activated carbon, N-acetylcysteine, methionine. With a strong expression of signs of overdose, immediate intervention by a specialist is necessary.
Drug interaction
In accordance with the instructions for use, Toff Plus increases the effectiveness of ethanol, sedatives, MAO inhibitors.
Antiparkinsonian drugs, antidepressants, antipsychotic medications, phenothiazine derivatives increase the likelihood of delayed urine, constipation and dry mouth.
GCS increase the risk of glaucoma.
Due to paracetamol, the effect of uricosuric drugs is reduced.
Chlorphenamine, which is prescribed at the same time as furazolidone and MAO inhibitors, can lead to hypertensive crisis, high fever and agitation of psychomotor.
Tricyclic antidepressants enhance the sympathomimetic effect, while taking halothane increases the risk of ventricular arrhythmias.
The drug reduces the hypotensive effect of guanethidine, which enhances phenylephrine alpha-adrenostimulating activity.
special instructions
You can not use at the same time other products containing substances that are part of the drug.
In patients with chronic alcohol dependence, taking the drug in a therapeutic dosage can cause serious kidney failure.
During the treatment period, you should refrain from taking ethanol, since hepatotoxic effects may develop. This is confirmed by the instructions for use with Toff Plus.
Also, during therapy, you need to refrain from driving motor vehicles and other potentially dangerous activities that require high concentration and speed of psychomotor reactions.
Terms of purchase at the pharmacy, price
Leave from Toff Plus pharmacies by order without a doctor’s prescription. The price is about one hundred rubles, varies slightly by region.
Storage conditions and terms
The medicine should be stored in a dry place, protected from light and children's access. Storage temperature should not exceed 25 degrees Celsius.
Analogs
“Toff Plus” has the following analogues that are closest in their pharmacological effects: “Tamiflu”, “Efferalgan”, “Rint”, “Rinza”, “Novirin”, “Flikold Knight”, “Maxikold”.
Also popular are Coldrex Knight, Migrenol Extra, Paralin Extra, Pentalgin, Rinzasip, Rinkold, Influblock.
Reviews
People confirm that the drug is very effective and inexpensive. It quickly relieves lethargy and weakness, relieves the common cold and sore throat. The medicine is really time-tested and is used in families to treat all households.
According to reviews, “Toff Plus” eases the symptoms of acute respiratory infections and colds, it contains paracetamol. The composition is quite harmless, the drug relieves symptoms gradually and gently. Affordable price also attracts patients.
The most important thing is to use the medicine correctly. In a few reviews, the lack of proper effectiveness is indicated as a drawback.