The drug has a trade name - serotonin adipinate (Latin name - Serotonin adipinate). Available in the form of a solution in ampoules. The active substance is serotonin adaptate in an amount of 0.01 grams per 1 milliliter. Excipients are unitiol and water for injection. In general, the drug is often prescribed to people suffering from various heart diseases. Reviews of adipinate serotonin indicate that it is often prescribed to restore the body after surgery. The drug, as a rule, is used in combination with other drugs, such as diuretics, inhibitors. It should be noted that the components of this drug do not accumulate in blood plasma. After entering the human body, they act on it, and after a while lose their properties.
Instructions for serotonin adipate are listed below.
Clinical Pharmacology
For the first time, a substance such as serotonin was discovered by a chemist-scientist from Italy - Vittorio Erspamer. Serotonin was removed from the intestinal mucosa. The newly discovered substance tended to contract smooth muscle. Initially, everyone thought it was adrenaline. But two years later, Vittorio proved that the substance found is still an amine unknown to science. Ten years later, serotonin was isolated from blood serum. Serotonin extracted from blood has been described as a substance that has a strong vasoconstrictor effect. Already in 1953, its presence was also detected in the central nervous system. Since then, serotonin has been the subject of many scientific studies.
On the territory of the Russian Federation, large-scale scientific studies of serotonin-based drugs were also carried out.
Between 2000 and 2003 In the hospital, N. N. Burdenko, studies were conducted on the use of the drug. The drug was used in patients who were diagnosed with heart disease. These include cardiovascular failure, coronary heart disease. Also among the number of patients were people after surgical interventions of various degrees of complexity. In total, 118 people took part in the studies. All people were divided into two groups depending on their diagnoses.
In the first group, patients suffering from coronary heart disease were identified. In total, there were 63 men in the group. Their age ranged from 45 to 88 years. More than half of the patients were diagnosed with myocardial infarction. More than two-thirds of patients suffered from cardiosclerosis. Some patients had circulatory failure. 15 people were sick with diabetes, and 35 suffered from arterial hypertension.
All patients in the group underwent general complex therapy. Their health status was observed using a daily monitoring system. Patients underwent cardiac electrocardiogram, echocardiography and other studies.
After fixing the start data, 10 milligrams of the drug was administered to patients for an hour. After administration of the drug, an improvement in myocardial contractile function was recorded in patients with various forms of coronary heart disease.
The size of the second group was 56 people. Only 11 women and 45 men. In this group, the age of patients ranged from 22 to 79 years. The main part of the group, two-thirds of its size, were patients who underwent surgery in conditions of cardiopulmonary bypass.
After complex surgical interventions, patients of the second group suffered from dysfunction of smooth muscles. All of them were in the department of surgical resuscitation and were on mechanical ventilation. Serotonin adipate was added to the number of general therapeutic measures carried out in this situation. The drug was administered to patients intravenously. And, as a result, increased peristalsis was observed in patients. Restoration of motor-evacuation function of the intestine. The introduction of the drug contributed to an increase in pO2 in the blood. Which in turn leads to the normalization of metabolic processes in the liver, brain and myocardium.
As a result, a positive effect of the drug on the patient's body was noted.
Description of the drug
Brief description of the drug:
- Transparent liquid with a slight odor of hydrogen sulfide.
- Pharmacotherapeutic group
- Hemostatics.
Pharmacological actions of serotonin adipate
After entering the body, the drug is well absorbed by its tissues. In blood plasma, it lasts about eight hours. The drug normalizes the contractile activity of smooth muscles of the internal organs. It has a hemostatic effect. Helps increase platelet count and capillary resistance. Helps reduce bleeding time.
Indications for use
The main indications for the appointment of serotonin adipate:
- Shock state.
- With circulatory disorders. For example, the drug is prescribed as a means of complex therapy for vascular insufficiency.
- With a decrease in the amount of oxygen in the blood. Hypoxemia.
- Often, the drug is used for acute poisoning.
- Intestinal obstruction.
- Diseases of smooth muscle dysfunction.
- Diseases that are accompanied by hemorrhagic syndrome.
- Various forms of anemia.
- To increase the level of hemoglobin in the blood.
Contraindications to the use of the drug
The drug is not recommended for use in the following cases. Hypertensive crisis. Impaired renal function. Bronchial asthma. Thrombosis of arteries and veins.
The drug is not contraindicated for use during lactation. Since there is no risk that the components of the drug enter the baby’s body through milk. Since serotonin is not secreted with milk. It is also not recommended to use the drug for people suffering from diseases that are accompanied by increased blood coagulation.
The use of the drug and dose
The dose of the drug is determined in each case by a doctor. As a rule, the course of treatment does not exceed ten days on average.
Before injecting the drug into the body, one ampoule is dissolved in 200 milliliters of saline. As already noted, the dosage should be determined by an experienced specialist, based on the patient’s diagnosis.
For example, with bleeding, five milliliters of the drug is administered intravenously. If after its administration there are no side effects, the dose is increased. In any case, you should not independently determine the dose, and before using this drug, you should definitely consult an experienced specialist. The authenticity of serotonin adipate in our state is proved by all necessary studies. Therefore, you can buy it without fear, but by prescription.
Side effects
With intravenous administration of the drug, pain is possible. Pain in the injection area is possible with intramuscular administration. To avoid such effects, it is recommended to administer the drug slowly. Other side effects not related to the introduction of the drug into the body include nausea, abdominal pain. Diarrhea is also possible. An increase in blood pressure can also be a reaction of the body to the administration of serotonin adipate. Sensations of heaviness in the head.
As a rule, side effects pass quickly enough and without further complications. If side effects do not go away, then anti-allergic and antihistamines can be used to relieve them. In case of side effects that are not indicated in the instructions, you should consult a doctor.
Overdose
With the appearance of hyperemia of the skin, it is necessary to stop the administration of the drug. Resume maintenance after ten minutes. And it is advisable to continue the administration of the drug at a half rate.
To purchase serotonin adipate, a prescription is needed. The shelf life of the drug is two years. But in some cases, there may be more. Before use, you should definitely look at the shelf life of the drug. It must be stored in a dark place, and avoid direct sunlight at temperatures from +15 to +25 degrees Celsius.